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miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL
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| Zeitschriftentitel: | Journal of Cellular Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | Journal of Cellular Physiology, 235, 2020, 9, S. 6139-6153 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Li, Jing Wang, Sufang Li, Yuhui Zhang, Nu Gribskov, Michael Zhang, Xi Lin, Min Shao, Dongyan Zhang, Chen Dai, Liangliang Qin, Chuanguang Duan, Xianglong Li, Juntang Xu, Feng Yang, Hui Li, Jing Wang, Sufang Li, Yuhui Zhang, Nu Gribskov, Michael Zhang, Xi Lin, Min Shao, Dongyan Zhang, Chen Dai, Liangliang Qin, Chuanguang Duan, Xianglong Li, Juntang Xu, Feng Yang, Hui |
|---|---|
| author |
Li, Jing Wang, Sufang Li, Yuhui Zhang, Nu Gribskov, Michael Zhang, Xi Lin, Min Shao, Dongyan Zhang, Chen Dai, Liangliang Qin, Chuanguang Duan, Xianglong Li, Juntang Xu, Feng Yang, Hui |
| spellingShingle |
Li, Jing Wang, Sufang Li, Yuhui Zhang, Nu Gribskov, Michael Zhang, Xi Lin, Min Shao, Dongyan Zhang, Chen Dai, Liangliang Qin, Chuanguang Duan, Xianglong Li, Juntang Xu, Feng Yang, Hui Journal of Cellular Physiology miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL Cell Biology Clinical Biochemistry Physiology |
| author_sort |
li, jing |
| spelling |
Li, Jing Wang, Sufang Li, Yuhui Zhang, Nu Gribskov, Michael Zhang, Xi Lin, Min Shao, Dongyan Zhang, Chen Dai, Liangliang Qin, Chuanguang Duan, Xianglong Li, Juntang Xu, Feng Yang, Hui 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29543 <jats:title>Abstract</jats:title><jats:p>Atherosclerosis is one of the leading causes of morbidity and mortality, mainly due to the immune response triggered by the recruitment of monocytes/macrophages in the artery wall. Accumulating evidence have shown that matrix stiffness and oxidized low‐density lipoproteins (ox‐LDL) play important roles in atherosclerosis through modulating cellular behaviors. However, whether there is a synergistic effect for ox‐LDL and matrix stiffness on macrophages behavior has not been explored yet. In this study, we developed a model system to investigate the synergistic role of ox‐LDL and matrix stiffness on macrophage behaviors, such as migration, inflammatory and apoptosis. We found that there was a matrix stiffness‐dependent behavior of monocyte‐derived macrophages stimulated with ox‐LDL. What's more, macrophages were more sensitive to ox‐LDL on the stiff matrices compared to cells cultured on the soft matrices. Through next‐generation sequencing, we identified miRNAs in response to matrix stiffness and ox‐LDL and predicted pathways that showed the capability of miRNAs in directing macrophages fates. Our study provides a novel understanding of the important synergistic role of ox‐LDL and matrix stiffness in modulating macrophages behaviors, especially through miRNAs signaling pathways, which could be potential key regulators in atherosclerosis and immune‐targeted therapies.</jats:p> miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL Journal of Cellular Physiology |
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| title |
miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_unstemmed |
miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_full |
miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_fullStr |
miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_full_unstemmed |
miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_short |
miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_sort |
mirna‐mediated macrophage behaviors responding to matrix stiffness and ox‐ldl |
| topic |
Cell Biology Clinical Biochemistry Physiology |
| url |
http://dx.doi.org/10.1002/jcp.29543 |
| publishDate |
2020 |
| physical |
6139-6153 |
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<jats:title>Abstract</jats:title><jats:p>Atherosclerosis is one of the leading causes of morbidity and mortality, mainly due to the immune response triggered by the recruitment of monocytes/macrophages in the artery wall. Accumulating evidence have shown that matrix stiffness and oxidized low‐density lipoproteins (ox‐LDL) play important roles in atherosclerosis through modulating cellular behaviors. However, whether there is a synergistic effect for ox‐LDL and matrix stiffness on macrophages behavior has not been explored yet. In this study, we developed a model system to investigate the synergistic role of ox‐LDL and matrix stiffness on macrophage behaviors, such as migration, inflammatory and apoptosis. We found that there was a matrix stiffness‐dependent behavior of monocyte‐derived macrophages stimulated with ox‐LDL. What's more, macrophages were more sensitive to ox‐LDL on the stiff matrices compared to cells cultured on the soft matrices. Through next‐generation sequencing, we identified miRNAs in response to matrix stiffness and ox‐LDL and predicted pathways that showed the capability of miRNAs in directing macrophages fates. Our study provides a novel understanding of the important synergistic role of ox‐LDL and matrix stiffness in modulating macrophages behaviors, especially through miRNAs signaling pathways, which could be potential key regulators in atherosclerosis and immune‐targeted therapies.</jats:p> |
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| author | Li, Jing, Wang, Sufang, Li, Yuhui, Zhang, Nu, Gribskov, Michael, Zhang, Xi, Lin, Min, Shao, Dongyan, Zhang, Chen, Dai, Liangliang, Qin, Chuanguang, Duan, Xianglong, Li, Juntang, Xu, Feng, Yang, Hui |
| author_facet | Li, Jing, Wang, Sufang, Li, Yuhui, Zhang, Nu, Gribskov, Michael, Zhang, Xi, Lin, Min, Shao, Dongyan, Zhang, Chen, Dai, Liangliang, Qin, Chuanguang, Duan, Xianglong, Li, Juntang, Xu, Feng, Yang, Hui, Li, Jing, Wang, Sufang, Li, Yuhui, Zhang, Nu, Gribskov, Michael, Zhang, Xi, Lin, Min, Shao, Dongyan, Zhang, Chen, Dai, Liangliang, Qin, Chuanguang, Duan, Xianglong, Li, Juntang, Xu, Feng, Yang, Hui |
| author_sort | li, jing |
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| container_start_page | 6139 |
| container_title | Journal of Cellular Physiology |
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| description | <jats:title>Abstract</jats:title><jats:p>Atherosclerosis is one of the leading causes of morbidity and mortality, mainly due to the immune response triggered by the recruitment of monocytes/macrophages in the artery wall. Accumulating evidence have shown that matrix stiffness and oxidized low‐density lipoproteins (ox‐LDL) play important roles in atherosclerosis through modulating cellular behaviors. However, whether there is a synergistic effect for ox‐LDL and matrix stiffness on macrophages behavior has not been explored yet. In this study, we developed a model system to investigate the synergistic role of ox‐LDL and matrix stiffness on macrophage behaviors, such as migration, inflammatory and apoptosis. We found that there was a matrix stiffness‐dependent behavior of monocyte‐derived macrophages stimulated with ox‐LDL. What's more, macrophages were more sensitive to ox‐LDL on the stiff matrices compared to cells cultured on the soft matrices. Through next‐generation sequencing, we identified miRNAs in response to matrix stiffness and ox‐LDL and predicted pathways that showed the capability of miRNAs in directing macrophages fates. Our study provides a novel understanding of the important synergistic role of ox‐LDL and matrix stiffness in modulating macrophages behaviors, especially through miRNAs signaling pathways, which could be potential key regulators in atherosclerosis and immune‐targeted therapies.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Li, Jing Wang, Sufang Li, Yuhui Zhang, Nu Gribskov, Michael Zhang, Xi Lin, Min Shao, Dongyan Zhang, Chen Dai, Liangliang Qin, Chuanguang Duan, Xianglong Li, Juntang Xu, Feng Yang, Hui 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29543 <jats:title>Abstract</jats:title><jats:p>Atherosclerosis is one of the leading causes of morbidity and mortality, mainly due to the immune response triggered by the recruitment of monocytes/macrophages in the artery wall. Accumulating evidence have shown that matrix stiffness and oxidized low‐density lipoproteins (ox‐LDL) play important roles in atherosclerosis through modulating cellular behaviors. However, whether there is a synergistic effect for ox‐LDL and matrix stiffness on macrophages behavior has not been explored yet. In this study, we developed a model system to investigate the synergistic role of ox‐LDL and matrix stiffness on macrophage behaviors, such as migration, inflammatory and apoptosis. We found that there was a matrix stiffness‐dependent behavior of monocyte‐derived macrophages stimulated with ox‐LDL. What's more, macrophages were more sensitive to ox‐LDL on the stiff matrices compared to cells cultured on the soft matrices. Through next‐generation sequencing, we identified miRNAs in response to matrix stiffness and ox‐LDL and predicted pathways that showed the capability of miRNAs in directing macrophages fates. Our study provides a novel understanding of the important synergistic role of ox‐LDL and matrix stiffness in modulating macrophages behaviors, especially through miRNAs signaling pathways, which could be potential key regulators in atherosclerosis and immune‐targeted therapies.</jats:p> miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL Journal of Cellular Physiology |
| spellingShingle | Li, Jing, Wang, Sufang, Li, Yuhui, Zhang, Nu, Gribskov, Michael, Zhang, Xi, Lin, Min, Shao, Dongyan, Zhang, Chen, Dai, Liangliang, Qin, Chuanguang, Duan, Xianglong, Li, Juntang, Xu, Feng, Yang, Hui, Journal of Cellular Physiology, miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL, Cell Biology, Clinical Biochemistry, Physiology |
| title | miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_full | miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_fullStr | miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_full_unstemmed | miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_short | miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| title_sort | mirna‐mediated macrophage behaviors responding to matrix stiffness and ox‐ldl |
| title_unstemmed | miRNA‐mediated macrophage behaviors responding to matrix stiffness and ox‐LDL |
| topic | Cell Biology, Clinical Biochemistry, Physiology |
| url | http://dx.doi.org/10.1002/jcp.29543 |