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Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children
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| Zeitschriftentitel: | Journal of Clinical Laboratory Analysis |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Clinical Laboratory Analysis, 33, 2019, 2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Cao, Junhua Tian, Lijun Li, Zhenguang Zhang, Chonglin Ji, Qiang Zhang, Chuanling Qian, Tong Cao, Junhua Tian, Lijun Li, Zhenguang Zhang, Chonglin Ji, Qiang Zhang, Chuanling Qian, Tong |
|---|---|
| author |
Cao, Junhua Tian, Lijun Li, Zhenguang Zhang, Chonglin Ji, Qiang Zhang, Chuanling Qian, Tong |
| spellingShingle |
Cao, Junhua Tian, Lijun Li, Zhenguang Zhang, Chonglin Ji, Qiang Zhang, Chuanling Qian, Tong Journal of Clinical Laboratory Analysis Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children Microbiology (medical) Biochemistry (medical) Medical Laboratory Technology Clinical Biochemistry Public Health, Environmental and Occupational Health Hematology Immunology and Allergy |
| author_sort |
cao, junhua |
| spelling |
Cao, Junhua Tian, Lijun Li, Zhenguang Zhang, Chonglin Ji, Qiang Zhang, Chuanling Qian, Tong 0887-8013 1098-2825 Wiley Microbiology (medical) Biochemistry (medical) Medical Laboratory Technology Clinical Biochemistry Public Health, Environmental and Occupational Health Hematology Immunology and Allergy http://dx.doi.org/10.1002/jcla.22675 <jats:sec><jats:title>Background</jats:title><jats:p>Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin‐7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms (<jats:styled-content style="fixed-case">SNP</jats:styled-content>s) on interleukin‐7 gene and the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We genotyped eight <jats:styled-content style="fixed-case">SNP</jats:styled-content>s of interleukin‐7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these <jats:styled-content style="fixed-case">SNP</jats:styled-content>s with the risk of asthma in children.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A missense <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 (odds ratio (<jats:styled-content style="fixed-case">OR</jats:styled-content>) = 2.185, 95% confidence interval (<jats:styled-content style="fixed-case">CI</jats:styled-content>) = 1.561‐2.252, <jats:italic>P</jats:italic>‐value = 8.69468E‐19) of the interleukin‐7 gene is associated with the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study reveals that <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 of interleukin‐7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma.</jats:p></jats:sec> Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children Journal of Clinical Laboratory Analysis |
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10.1002/jcla.22675 |
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Biologie Medizin Technik Chemie und Pharmazie |
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Wiley, 2019 |
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Wiley, 2019 |
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0887-8013 1098-2825 |
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| title |
Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_unstemmed |
Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_full |
Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_fullStr |
Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_full_unstemmed |
Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_short |
Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_sort |
interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| topic |
Microbiology (medical) Biochemistry (medical) Medical Laboratory Technology Clinical Biochemistry Public Health, Environmental and Occupational Health Hematology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/jcla.22675 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:sec><jats:title>Background</jats:title><jats:p>Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin‐7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms (<jats:styled-content style="fixed-case">SNP</jats:styled-content>s) on interleukin‐7 gene and the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We genotyped eight <jats:styled-content style="fixed-case">SNP</jats:styled-content>s of interleukin‐7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these <jats:styled-content style="fixed-case">SNP</jats:styled-content>s with the risk of asthma in children.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A missense <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 (odds ratio (<jats:styled-content style="fixed-case">OR</jats:styled-content>) = 2.185, 95% confidence interval (<jats:styled-content style="fixed-case">CI</jats:styled-content>) = 1.561‐2.252, <jats:italic>P</jats:italic>‐value = 8.69468E‐19) of the interleukin‐7 gene is associated with the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study reveals that <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 of interleukin‐7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma.</jats:p></jats:sec> |
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| author | Cao, Junhua, Tian, Lijun, Li, Zhenguang, Zhang, Chonglin, Ji, Qiang, Zhang, Chuanling, Qian, Tong |
| author_facet | Cao, Junhua, Tian, Lijun, Li, Zhenguang, Zhang, Chonglin, Ji, Qiang, Zhang, Chuanling, Qian, Tong, Cao, Junhua, Tian, Lijun, Li, Zhenguang, Zhang, Chonglin, Ji, Qiang, Zhang, Chuanling, Qian, Tong |
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| description | <jats:sec><jats:title>Background</jats:title><jats:p>Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin‐7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms (<jats:styled-content style="fixed-case">SNP</jats:styled-content>s) on interleukin‐7 gene and the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We genotyped eight <jats:styled-content style="fixed-case">SNP</jats:styled-content>s of interleukin‐7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these <jats:styled-content style="fixed-case">SNP</jats:styled-content>s with the risk of asthma in children.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A missense <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 (odds ratio (<jats:styled-content style="fixed-case">OR</jats:styled-content>) = 2.185, 95% confidence interval (<jats:styled-content style="fixed-case">CI</jats:styled-content>) = 1.561‐2.252, <jats:italic>P</jats:italic>‐value = 8.69468E‐19) of the interleukin‐7 gene is associated with the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study reveals that <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 of interleukin‐7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma.</jats:p></jats:sec> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9qY2xhLjIyNjc1 |
| imprint | Wiley, 2019 |
| imprint_str_mv | Wiley, 2019 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0887-8013, 1098-2825 |
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| language | English |
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| publisher | Wiley |
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| recordtype | ai |
| series | Journal of Clinical Laboratory Analysis |
| source_id | 49 |
| spelling | Cao, Junhua Tian, Lijun Li, Zhenguang Zhang, Chonglin Ji, Qiang Zhang, Chuanling Qian, Tong 0887-8013 1098-2825 Wiley Microbiology (medical) Biochemistry (medical) Medical Laboratory Technology Clinical Biochemistry Public Health, Environmental and Occupational Health Hematology Immunology and Allergy http://dx.doi.org/10.1002/jcla.22675 <jats:sec><jats:title>Background</jats:title><jats:p>Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin‐7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms (<jats:styled-content style="fixed-case">SNP</jats:styled-content>s) on interleukin‐7 gene and the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We genotyped eight <jats:styled-content style="fixed-case">SNP</jats:styled-content>s of interleukin‐7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these <jats:styled-content style="fixed-case">SNP</jats:styled-content>s with the risk of asthma in children.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A missense <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 (odds ratio (<jats:styled-content style="fixed-case">OR</jats:styled-content>) = 2.185, 95% confidence interval (<jats:styled-content style="fixed-case">CI</jats:styled-content>) = 1.561‐2.252, <jats:italic>P</jats:italic>‐value = 8.69468E‐19) of the interleukin‐7 gene is associated with the risk of children asthma.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study reveals that <jats:styled-content style="fixed-case">SNP</jats:styled-content> rs766736182 of interleukin‐7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma.</jats:p></jats:sec> Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children Journal of Clinical Laboratory Analysis |
| spellingShingle | Cao, Junhua, Tian, Lijun, Li, Zhenguang, Zhang, Chonglin, Ji, Qiang, Zhang, Chuanling, Qian, Tong, Journal of Clinical Laboratory Analysis, Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children, Microbiology (medical), Biochemistry (medical), Medical Laboratory Technology, Clinical Biochemistry, Public Health, Environmental and Occupational Health, Hematology, Immunology and Allergy |
| title | Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_full | Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_fullStr | Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_full_unstemmed | Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_short | Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_sort | interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| title_unstemmed | Interleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children |
| topic | Microbiology (medical), Biochemistry (medical), Medical Laboratory Technology, Clinical Biochemistry, Public Health, Environmental and Occupational Health, Hematology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/jcla.22675 |