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Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC)
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| Zeitschriftentitel: | Journal of Cellular Biochemistry |
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| Personen und Körperschaften: | , , , , , , , , , , , , , , , |
| In: | Journal of Cellular Biochemistry, 121, 2020, 3, S. 2571-2581 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Liu, Shiyi Li, Saijiao Wang, Yanqing Wang, Feiyan Zhang, Li Xian, Shu Yang, Dongyong Yuan, Mengqin Dai, Fangfang Zhao, Xin Liu, Yuping Jin, Yumeng Zeng, Zihang Mahgoub, Omer Kamal Ahmed Zhou, Chenliang Cheng, Yanxiang Liu, Shiyi Li, Saijiao Wang, Yanqing Wang, Feiyan Zhang, Li Xian, Shu Yang, Dongyong Yuan, Mengqin Dai, Fangfang Zhao, Xin Liu, Yuping Jin, Yumeng Zeng, Zihang Mahgoub, Omer Kamal Ahmed Zhou, Chenliang Cheng, Yanxiang |
|---|---|
| author |
Liu, Shiyi Li, Saijiao Wang, Yanqing Wang, Feiyan Zhang, Li Xian, Shu Yang, Dongyong Yuan, Mengqin Dai, Fangfang Zhao, Xin Liu, Yuping Jin, Yumeng Zeng, Zihang Mahgoub, Omer Kamal Ahmed Zhou, Chenliang Cheng, Yanxiang |
| spellingShingle |
Liu, Shiyi Li, Saijiao Wang, Yanqing Wang, Feiyan Zhang, Li Xian, Shu Yang, Dongyong Yuan, Mengqin Dai, Fangfang Zhao, Xin Liu, Yuping Jin, Yumeng Zeng, Zihang Mahgoub, Omer Kamal Ahmed Zhou, Chenliang Cheng, Yanxiang Journal of Cellular Biochemistry Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) Cell Biology Molecular Biology Biochemistry |
| author_sort |
liu, shiyi |
| spelling |
Liu, Shiyi Li, Saijiao Wang, Yanqing Wang, Feiyan Zhang, Li Xian, Shu Yang, Dongyong Yuan, Mengqin Dai, Fangfang Zhao, Xin Liu, Yuping Jin, Yumeng Zeng, Zihang Mahgoub, Omer Kamal Ahmed Zhou, Chenliang Cheng, Yanxiang 0730-2312 1097-4644 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1002/jcb.29479 <jats:title>Abstract</jats:title><jats:p>In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the “Estimation of STromal and Immune cells in MAlignant Tumours using Expression data” algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.</jats:p> Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) Journal of Cellular Biochemistry |
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| title |
Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_unstemmed |
Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_full |
Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_fullStr |
Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_full_unstemmed |
Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_short |
Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_sort |
prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccrcc) |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1002/jcb.29479 |
| publishDate |
2020 |
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2571-2581 |
| description |
<jats:title>Abstract</jats:title><jats:p>In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the “Estimation of STromal and Immune cells in MAlignant Tumours using Expression data” algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.</jats:p> |
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| author | Liu, Shiyi, Li, Saijiao, Wang, Yanqing, Wang, Feiyan, Zhang, Li, Xian, Shu, Yang, Dongyong, Yuan, Mengqin, Dai, Fangfang, Zhao, Xin, Liu, Yuping, Jin, Yumeng, Zeng, Zihang, Mahgoub, Omer Kamal Ahmed, Zhou, Chenliang, Cheng, Yanxiang |
| author_facet | Liu, Shiyi, Li, Saijiao, Wang, Yanqing, Wang, Feiyan, Zhang, Li, Xian, Shu, Yang, Dongyong, Yuan, Mengqin, Dai, Fangfang, Zhao, Xin, Liu, Yuping, Jin, Yumeng, Zeng, Zihang, Mahgoub, Omer Kamal Ahmed, Zhou, Chenliang, Cheng, Yanxiang, Liu, Shiyi, Li, Saijiao, Wang, Yanqing, Wang, Feiyan, Zhang, Li, Xian, Shu, Yang, Dongyong, Yuan, Mengqin, Dai, Fangfang, Zhao, Xin, Liu, Yuping, Jin, Yumeng, Zeng, Zihang, Mahgoub, Omer Kamal Ahmed, Zhou, Chenliang, Cheng, Yanxiang |
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| description | <jats:title>Abstract</jats:title><jats:p>In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the “Estimation of STromal and Immune cells in MAlignant Tumours using Expression data” algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.</jats:p> |
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| spelling | Liu, Shiyi Li, Saijiao Wang, Yanqing Wang, Feiyan Zhang, Li Xian, Shu Yang, Dongyong Yuan, Mengqin Dai, Fangfang Zhao, Xin Liu, Yuping Jin, Yumeng Zeng, Zihang Mahgoub, Omer Kamal Ahmed Zhou, Chenliang Cheng, Yanxiang 0730-2312 1097-4644 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1002/jcb.29479 <jats:title>Abstract</jats:title><jats:p>In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the “Estimation of STromal and Immune cells in MAlignant Tumours using Expression data” algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.</jats:p> Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) Journal of Cellular Biochemistry |
| spellingShingle | Liu, Shiyi, Li, Saijiao, Wang, Yanqing, Wang, Feiyan, Zhang, Li, Xian, Shu, Yang, Dongyong, Yuan, Mengqin, Dai, Fangfang, Zhao, Xin, Liu, Yuping, Jin, Yumeng, Zeng, Zihang, Mahgoub, Omer Kamal Ahmed, Zhou, Chenliang, Cheng, Yanxiang, Journal of Cellular Biochemistry, Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC), Cell Biology, Molecular Biology, Biochemistry |
| title | Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_full | Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_fullStr | Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_full_unstemmed | Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_short | Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| title_sort | prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccrcc) |
| title_unstemmed | Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC) |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1002/jcb.29479 |