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New insight into the control of peptic ulcer by targeting the histamine H2 receptor
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| Zeitschriftentitel: | Journal of Cellular Biochemistry |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Cellular Biochemistry, 119, 2018, 2, S. 2003-2011 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Singh, Vijai Gohil, Nisarg Ramírez‐García, Robert Singh, Vijai Gohil, Nisarg Ramírez‐García, Robert |
|---|---|
| author |
Singh, Vijai Gohil, Nisarg Ramírez‐García, Robert |
| spellingShingle |
Singh, Vijai Gohil, Nisarg Ramírez‐García, Robert Journal of Cellular Biochemistry New insight into the control of peptic ulcer by targeting the histamine H2 receptor Cell Biology Molecular Biology Biochemistry |
| author_sort |
singh, vijai |
| spelling |
Singh, Vijai Gohil, Nisarg Ramírez‐García, Robert 0730-2312 1097-4644 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1002/jcb.26361 <jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H<jats:sub>2</jats:sub> receptor (H<jats:sub>2</jats:sub>R). Recently, a number of H<jats:sub>2</jats:sub>R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H<jats:sub>2</jats:sub>R by homology modeling using the 3‐D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot. We used this 3‐D model for screening of highly potent drugs using molecular docking. We found cimetidine, cimetex, and famotidine as the most potent drugs based on the binding affinity of drug‐protein interactions. We also generated a cellular network for H<jats:sub>2</jats:sub>R that could be useful for better understanding of cellular mechanism and drug targets. These findings provide a new insight into the development of suitable, specific, and effective anti‐ulcer drugs for a most effective treatment of ulcerous diseases.</jats:p></jats:sec> New insight into the control of peptic ulcer by targeting the histamine H<sub>2</sub> receptor Journal of Cellular Biochemistry |
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New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_unstemmed |
New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_full |
New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
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New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
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New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_short |
New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_sort |
new insight into the control of peptic ulcer by targeting the histamine h<sub>2</sub> receptor |
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Cell Biology Molecular Biology Biochemistry |
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http://dx.doi.org/10.1002/jcb.26361 |
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2018 |
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2003-2011 |
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<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H<jats:sub>2</jats:sub> receptor (H<jats:sub>2</jats:sub>R). Recently, a number of H<jats:sub>2</jats:sub>R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H<jats:sub>2</jats:sub>R by homology modeling using the 3‐D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot. We used this 3‐D model for screening of highly potent drugs using molecular docking. We found cimetidine, cimetex, and famotidine as the most potent drugs based on the binding affinity of drug‐protein interactions. We also generated a cellular network for H<jats:sub>2</jats:sub>R that could be useful for better understanding of cellular mechanism and drug targets. These findings provide a new insight into the development of suitable, specific, and effective anti‐ulcer drugs for a most effective treatment of ulcerous diseases.</jats:p></jats:sec> |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H<jats:sub>2</jats:sub> receptor (H<jats:sub>2</jats:sub>R). Recently, a number of H<jats:sub>2</jats:sub>R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H<jats:sub>2</jats:sub>R by homology modeling using the 3‐D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot. We used this 3‐D model for screening of highly potent drugs using molecular docking. We found cimetidine, cimetex, and famotidine as the most potent drugs based on the binding affinity of drug‐protein interactions. We also generated a cellular network for H<jats:sub>2</jats:sub>R that could be useful for better understanding of cellular mechanism and drug targets. These findings provide a new insight into the development of suitable, specific, and effective anti‐ulcer drugs for a most effective treatment of ulcerous diseases.</jats:p></jats:sec> |
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| spelling | Singh, Vijai Gohil, Nisarg Ramírez‐García, Robert 0730-2312 1097-4644 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1002/jcb.26361 <jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H<jats:sub>2</jats:sub> receptor (H<jats:sub>2</jats:sub>R). Recently, a number of H<jats:sub>2</jats:sub>R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H<jats:sub>2</jats:sub>R by homology modeling using the 3‐D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot. We used this 3‐D model for screening of highly potent drugs using molecular docking. We found cimetidine, cimetex, and famotidine as the most potent drugs based on the binding affinity of drug‐protein interactions. We also generated a cellular network for H<jats:sub>2</jats:sub>R that could be useful for better understanding of cellular mechanism and drug targets. These findings provide a new insight into the development of suitable, specific, and effective anti‐ulcer drugs for a most effective treatment of ulcerous diseases.</jats:p></jats:sec> New insight into the control of peptic ulcer by targeting the histamine H<sub>2</sub> receptor Journal of Cellular Biochemistry |
| spellingShingle | Singh, Vijai, Gohil, Nisarg, Ramírez‐García, Robert, Journal of Cellular Biochemistry, New insight into the control of peptic ulcer by targeting the histamine H2 receptor, Cell Biology, Molecular Biology, Biochemistry |
| title | New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_full | New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_fullStr | New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_full_unstemmed | New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_short | New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| title_sort | new insight into the control of peptic ulcer by targeting the histamine h<sub>2</sub> receptor |
| title_unstemmed | New insight into the control of peptic ulcer by targeting the histamine H2 receptor |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1002/jcb.26361 |