Eintrag weiter verarbeiten
Glycosilated nucleolin as marker for human gliomas
Gespeichert in:
Zeitschriftentitel: | Journal of Cellular Biochemistry |
---|---|
Personen und Körperschaften: | , , , , , , , , , , , |
In: | Journal of Cellular Biochemistry, 113, 2012, 2, S. 571-579 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Galzio, R. Rosati, F. Benedetti, E. Cristiano, L. Aldi, S. Mei, S. D'Angelo, B. Gentile, R. Laurenti, G. Cifone, M.G. Giordano, A. Cimini, A. Galzio, R. Rosati, F. Benedetti, E. Cristiano, L. Aldi, S. Mei, S. D'Angelo, B. Gentile, R. Laurenti, G. Cifone, M.G. Giordano, A. Cimini, A. |
---|---|
author |
Galzio, R. Rosati, F. Benedetti, E. Cristiano, L. Aldi, S. Mei, S. D'Angelo, B. Gentile, R. Laurenti, G. Cifone, M.G. Giordano, A. Cimini, A. |
spellingShingle |
Galzio, R. Rosati, F. Benedetti, E. Cristiano, L. Aldi, S. Mei, S. D'Angelo, B. Gentile, R. Laurenti, G. Cifone, M.G. Giordano, A. Cimini, A. Journal of Cellular Biochemistry Glycosilated nucleolin as marker for human gliomas Cell Biology Molecular Biology Biochemistry |
author_sort |
galzio, r. |
spelling |
Galzio, R. Rosati, F. Benedetti, E. Cristiano, L. Aldi, S. Mei, S. D'Angelo, B. Gentile, R. Laurenti, G. Cifone, M.G. Giordano, A. Cimini, A. 0730-2312 1097-4644 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1002/jcb.23381 <jats:title>Abstract</jats:title><jats:p>Nucleolin is a multifunctional DNA and RNA binding protein involved in regulation of gene transcription, chromatin remodeling, RNA metabolism, and ribosomal RNA synthesis. Nucleolin seems to be over‐expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by RNA polymerase I and II, rRNA processing, mRNA stabilization, cytokinesis, and apoptosis. Although nucleolin is localized predominantly in the nucleolus, it has also been shown to be localized in a phosphorylated/glycolsilated form on the cell surface of different cells. Numerous articles dealing with surface nucleolin targeting for tumor therapy have been recently published. However, at present, no extensive informations are so far available for the presence of nucleolin in human gliomas. In the present work we investigated on the presence and localization of nucleolin in glioma on glioma specimens at different grade of malignancy and on primary glioma cell cultures derived by surgical resection, trying to correlate the presence of glycosilated membrane nucleolin with the malignancy grade. To this purpose an antibody produced by us against gp273 protein, demonstrated to recognized the glycosilated surface nucleolin, has been used. The results obtained demonstrate that surface nucleolin increase with the malignancy grade thus suggesting that it may constitute a histopathological marker for glioma grading and a possible tool for targeted therapy. J. Cell. Biochem. 113: 571–579, 2012. © 2011 Wiley Periodicals, Inc.</jats:p> Glycosilated nucleolin as marker for human gliomas Journal of Cellular Biochemistry |
doi_str_mv |
10.1002/jcb.23381 |
facet_avail |
Online |
finc_class_facet |
Biologie Chemie und Pharmazie |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9qY2IuMjMzODE |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9qY2IuMjMzODE |
institution |
DE-Bn3 DE-Brt1 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 |
imprint |
Wiley, 2012 |
imprint_str_mv |
Wiley, 2012 |
issn |
0730-2312 1097-4644 |
issn_str_mv |
0730-2312 1097-4644 |
language |
English |
mega_collection |
Wiley (CrossRef) |
match_str |
galzio2012glycosilatednucleolinasmarkerforhumangliomas |
publishDateSort |
2012 |
publisher |
Wiley |
recordtype |
ai |
record_format |
ai |
series |
Journal of Cellular Biochemistry |
source_id |
49 |
title |
Glycosilated nucleolin as marker for human gliomas |
title_unstemmed |
Glycosilated nucleolin as marker for human gliomas |
title_full |
Glycosilated nucleolin as marker for human gliomas |
title_fullStr |
Glycosilated nucleolin as marker for human gliomas |
title_full_unstemmed |
Glycosilated nucleolin as marker for human gliomas |
title_short |
Glycosilated nucleolin as marker for human gliomas |
title_sort |
glycosilated nucleolin as marker for human gliomas |
topic |
Cell Biology Molecular Biology Biochemistry |
url |
http://dx.doi.org/10.1002/jcb.23381 |
publishDate |
2012 |
physical |
571-579 |
description |
<jats:title>Abstract</jats:title><jats:p>Nucleolin is a multifunctional DNA and RNA binding protein involved in regulation of gene transcription, chromatin remodeling, RNA metabolism, and ribosomal RNA synthesis. Nucleolin seems to be over‐expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by RNA polymerase I and II, rRNA processing, mRNA stabilization, cytokinesis, and apoptosis. Although nucleolin is localized predominantly in the nucleolus, it has also been shown to be localized in a phosphorylated/glycolsilated form on the cell surface of different cells. Numerous articles dealing with surface nucleolin targeting for tumor therapy have been recently published. However, at present, no extensive informations are so far available for the presence of nucleolin in human gliomas. In the present work we investigated on the presence and localization of nucleolin in glioma on glioma specimens at different grade of malignancy and on primary glioma cell cultures derived by surgical resection, trying to correlate the presence of glycosilated membrane nucleolin with the malignancy grade. To this purpose an antibody produced by us against gp273 protein, demonstrated to recognized the glycosilated surface nucleolin, has been used. The results obtained demonstrate that surface nucleolin increase with the malignancy grade thus suggesting that it may constitute a histopathological marker for glioma grading and a possible tool for targeted therapy. J. Cell. Biochem. 113: 571–579, 2012. © 2011 Wiley Periodicals, Inc.</jats:p> |
container_issue |
2 |
container_start_page |
571 |
container_title |
Journal of Cellular Biochemistry |
container_volume |
113 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792344997236834312 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T17:16:27.5Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Glycosilated+nucleolin+as+marker+for+human+gliomas&rft.date=2012-02-01&genre=article&issn=1097-4644&volume=113&issue=2&spage=571&epage=579&pages=571-579&jtitle=Journal+of+Cellular+Biochemistry&atitle=Glycosilated+nucleolin+as+marker+for+human+gliomas&aulast=Cimini&aufirst=A.&rft_id=info%3Adoi%2F10.1002%2Fjcb.23381&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792344997236834312 |
author | Galzio, R., Rosati, F., Benedetti, E., Cristiano, L., Aldi, S., Mei, S., D'Angelo, B., Gentile, R., Laurenti, G., Cifone, M.G., Giordano, A., Cimini, A. |
author_facet | Galzio, R., Rosati, F., Benedetti, E., Cristiano, L., Aldi, S., Mei, S., D'Angelo, B., Gentile, R., Laurenti, G., Cifone, M.G., Giordano, A., Cimini, A., Galzio, R., Rosati, F., Benedetti, E., Cristiano, L., Aldi, S., Mei, S., D'Angelo, B., Gentile, R., Laurenti, G., Cifone, M.G., Giordano, A., Cimini, A. |
author_sort | galzio, r. |
container_issue | 2 |
container_start_page | 571 |
container_title | Journal of Cellular Biochemistry |
container_volume | 113 |
description | <jats:title>Abstract</jats:title><jats:p>Nucleolin is a multifunctional DNA and RNA binding protein involved in regulation of gene transcription, chromatin remodeling, RNA metabolism, and ribosomal RNA synthesis. Nucleolin seems to be over‐expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by RNA polymerase I and II, rRNA processing, mRNA stabilization, cytokinesis, and apoptosis. Although nucleolin is localized predominantly in the nucleolus, it has also been shown to be localized in a phosphorylated/glycolsilated form on the cell surface of different cells. Numerous articles dealing with surface nucleolin targeting for tumor therapy have been recently published. However, at present, no extensive informations are so far available for the presence of nucleolin in human gliomas. In the present work we investigated on the presence and localization of nucleolin in glioma on glioma specimens at different grade of malignancy and on primary glioma cell cultures derived by surgical resection, trying to correlate the presence of glycosilated membrane nucleolin with the malignancy grade. To this purpose an antibody produced by us against gp273 protein, demonstrated to recognized the glycosilated surface nucleolin, has been used. The results obtained demonstrate that surface nucleolin increase with the malignancy grade thus suggesting that it may constitute a histopathological marker for glioma grading and a possible tool for targeted therapy. J. Cell. Biochem. 113: 571–579, 2012. © 2011 Wiley Periodicals, Inc.</jats:p> |
doi_str_mv | 10.1002/jcb.23381 |
facet_avail | Online |
finc_class_facet | Biologie, Chemie und Pharmazie |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9qY2IuMjMzODE |
imprint | Wiley, 2012 |
imprint_str_mv | Wiley, 2012 |
institution | DE-Bn3, DE-Brt1, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275 |
issn | 0730-2312, 1097-4644 |
issn_str_mv | 0730-2312, 1097-4644 |
language | English |
last_indexed | 2024-03-01T17:16:27.5Z |
match_str | galzio2012glycosilatednucleolinasmarkerforhumangliomas |
mega_collection | Wiley (CrossRef) |
physical | 571-579 |
publishDate | 2012 |
publishDateSort | 2012 |
publisher | Wiley |
record_format | ai |
recordtype | ai |
series | Journal of Cellular Biochemistry |
source_id | 49 |
spelling | Galzio, R. Rosati, F. Benedetti, E. Cristiano, L. Aldi, S. Mei, S. D'Angelo, B. Gentile, R. Laurenti, G. Cifone, M.G. Giordano, A. Cimini, A. 0730-2312 1097-4644 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1002/jcb.23381 <jats:title>Abstract</jats:title><jats:p>Nucleolin is a multifunctional DNA and RNA binding protein involved in regulation of gene transcription, chromatin remodeling, RNA metabolism, and ribosomal RNA synthesis. Nucleolin seems to be over‐expressed in highly proliferative cells and is involved in many aspect of gene expression: DNA recombination and replication, RNA transcription by RNA polymerase I and II, rRNA processing, mRNA stabilization, cytokinesis, and apoptosis. Although nucleolin is localized predominantly in the nucleolus, it has also been shown to be localized in a phosphorylated/glycolsilated form on the cell surface of different cells. Numerous articles dealing with surface nucleolin targeting for tumor therapy have been recently published. However, at present, no extensive informations are so far available for the presence of nucleolin in human gliomas. In the present work we investigated on the presence and localization of nucleolin in glioma on glioma specimens at different grade of malignancy and on primary glioma cell cultures derived by surgical resection, trying to correlate the presence of glycosilated membrane nucleolin with the malignancy grade. To this purpose an antibody produced by us against gp273 protein, demonstrated to recognized the glycosilated surface nucleolin, has been used. The results obtained demonstrate that surface nucleolin increase with the malignancy grade thus suggesting that it may constitute a histopathological marker for glioma grading and a possible tool for targeted therapy. J. Cell. Biochem. 113: 571–579, 2012. © 2011 Wiley Periodicals, Inc.</jats:p> Glycosilated nucleolin as marker for human gliomas Journal of Cellular Biochemistry |
spellingShingle | Galzio, R., Rosati, F., Benedetti, E., Cristiano, L., Aldi, S., Mei, S., D'Angelo, B., Gentile, R., Laurenti, G., Cifone, M.G., Giordano, A., Cimini, A., Journal of Cellular Biochemistry, Glycosilated nucleolin as marker for human gliomas, Cell Biology, Molecular Biology, Biochemistry |
title | Glycosilated nucleolin as marker for human gliomas |
title_full | Glycosilated nucleolin as marker for human gliomas |
title_fullStr | Glycosilated nucleolin as marker for human gliomas |
title_full_unstemmed | Glycosilated nucleolin as marker for human gliomas |
title_short | Glycosilated nucleolin as marker for human gliomas |
title_sort | glycosilated nucleolin as marker for human gliomas |
title_unstemmed | Glycosilated nucleolin as marker for human gliomas |
topic | Cell Biology, Molecular Biology, Biochemistry |
url | http://dx.doi.org/10.1002/jcb.23381 |