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Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | International Journal of Cancer, 143, 2018, 2, S. 245-252 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. |
|---|---|
| author |
Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. |
| spellingShingle |
Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. International Journal of Cancer Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer Cancer Research Oncology |
| author_sort |
butt, julia |
| spelling |
Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.31283 <jats:p>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.</jats:p> Prospective evaluation of antibody response to <i>Streptococcus gallolyticus</i> and risk of colorectal cancer International Journal of Cancer |
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| title |
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_unstemmed |
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_full |
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_fullStr |
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_full_unstemmed |
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_short |
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_sort |
prospective evaluation of antibody response to <i>streptococcus gallolyticus</i> and risk of colorectal cancer |
| topic |
Cancer Research Oncology |
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http://dx.doi.org/10.1002/ijc.31283 |
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2018 |
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<jats:p>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.</jats:p> |
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| author | Butt, Julia, Jenab, Mazda, Willhauck‐Fleckenstein, Martina, Michel, Angelika, Pawlita, Michael, Kyrø, Cecilie, Tjønneland, Anne, Boutron‐Ruault, Marie‐Christine, Carbonnel, Franck, Severi, Gianluca, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, la Vecchia, Carlo, Karakatsani, Anna, Panico, Salvatore, Tumino, Rosario, Agnoli, Claudia, Palli, Domenico, Sacerdote, Carlotta, Bueno‐de‐Mesquita, H. B(as), Weiderpass, Elisabete, Sánchez, Maria‐José, Bonet Bonet, Catalina, Huerta, José María, Ardanaz, Eva, Bradbury, Kathryn, Gunter, Marc, Murphy, Neil, Freisling, Heinz, Riboli, Elio, Tsilidis, Kostas, Aune, Dagfinn, Waterboer, Tim, Hughes, David J. |
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| description | <jats:p>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.</jats:p> |
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| spelling | Butt, Julia Jenab, Mazda Willhauck‐Fleckenstein, Martina Michel, Angelika Pawlita, Michael Kyrø, Cecilie Tjønneland, Anne Boutron‐Ruault, Marie‐Christine Carbonnel, Franck Severi, Gianluca Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia la Vecchia, Carlo Karakatsani, Anna Panico, Salvatore Tumino, Rosario Agnoli, Claudia Palli, Domenico Sacerdote, Carlotta Bueno‐de‐Mesquita, H. B(as) Weiderpass, Elisabete Sánchez, Maria‐José Bonet Bonet, Catalina Huerta, José María Ardanaz, Eva Bradbury, Kathryn Gunter, Marc Murphy, Neil Freisling, Heinz Riboli, Elio Tsilidis, Kostas Aune, Dagfinn Waterboer, Tim Hughes, David J. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.31283 <jats:p>The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG). However, it is unclear whether the association is also present pre‐diagnostically. We assessed the association of antibody responses to SGG proteins in pre‐diagnostic serum samples with CRC risk in a case–control study nested within a prospective cohort. Pre‐diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04–1.77). Positivity for two or more proteins of a previously identified SGG 6‐marker panel with greater CRC‐specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44–3.27). In this prospective nested case–control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.</jats:p> Prospective evaluation of antibody response to <i>Streptococcus gallolyticus</i> and risk of colorectal cancer International Journal of Cancer |
| spellingShingle | Butt, Julia, Jenab, Mazda, Willhauck‐Fleckenstein, Martina, Michel, Angelika, Pawlita, Michael, Kyrø, Cecilie, Tjønneland, Anne, Boutron‐Ruault, Marie‐Christine, Carbonnel, Franck, Severi, Gianluca, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, la Vecchia, Carlo, Karakatsani, Anna, Panico, Salvatore, Tumino, Rosario, Agnoli, Claudia, Palli, Domenico, Sacerdote, Carlotta, Bueno‐de‐Mesquita, H. B(as), Weiderpass, Elisabete, Sánchez, Maria‐José, Bonet Bonet, Catalina, Huerta, José María, Ardanaz, Eva, Bradbury, Kathryn, Gunter, Marc, Murphy, Neil, Freisling, Heinz, Riboli, Elio, Tsilidis, Kostas, Aune, Dagfinn, Waterboer, Tim, Hughes, David J., International Journal of Cancer, Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer, Cancer Research, Oncology |
| title | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_full | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_fullStr | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_full_unstemmed | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_short | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| title_sort | prospective evaluation of antibody response to <i>streptococcus gallolyticus</i> and risk of colorectal cancer |
| title_unstemmed | Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.31283 |