Eintrag weiter verarbeiten
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study
Gespeichert in:
| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | International Journal of Cancer, 139, 2016, 8, S. 1839-1850 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Thomsen, Louise T. Dehlendorff, Christian Junge, Jette Waldstrøm, Marianne Schledermann, Doris Frederiksen, Kirsten Kjaer, Susanne K. Thomsen, Louise T. Dehlendorff, Christian Junge, Jette Waldstrøm, Marianne Schledermann, Doris Frederiksen, Kirsten Kjaer, Susanne K. |
|---|---|
| author |
Thomsen, Louise T. Dehlendorff, Christian Junge, Jette Waldstrøm, Marianne Schledermann, Doris Frederiksen, Kirsten Kjaer, Susanne K. |
| spellingShingle |
Thomsen, Louise T. Dehlendorff, Christian Junge, Jette Waldstrøm, Marianne Schledermann, Doris Frederiksen, Kirsten Kjaer, Susanne K. International Journal of Cancer Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study Cancer Research Oncology |
| author_sort |
thomsen, louise t. |
| spelling |
Thomsen, Louise T. Dehlendorff, Christian Junge, Jette Waldstrøm, Marianne Schledermann, Doris Frederiksen, Kirsten Kjaer, Susanne K. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.30104 <jats:p>In this prospective cohort study, we compared the performance of human papillomavirus (HPV) mRNA and DNA testing of women with atypical squamous cells of undetermined significance (ASC‐US) during cervical cancer screening. Using a nationwide Danish pathology register, we identified women aged 30–65 years with ASC‐US during 2005–2011 who were tested for HPV16/18/31/33/45 mRNA using PreTect HPV‐Proofer (<jats:italic>n</jats:italic> = 3,226) or for high‐risk HPV (hrHPV) DNA using Hybrid Capture 2 (HC2) (<jats:italic>n</jats:italic> = 9,405) or Linear Array HPV‐Genotyping test (LA) (<jats:italic>n</jats:italic> = 1,533). Women with ≥1 subsequent examination in the register (<jats:italic>n</jats:italic> = 13,729) were followed for up to 9.5 years for high‐grade cervical intraepithelial neoplasia (CIN) or cancer. After 3 years' follow‐up, mRNA testing had higher specificity for CIN3 or worse (CIN3+) than HC2 testing (88.1% [95% confidence interval (CI): 86.8–89.6%] <jats:italic>versus</jats:italic> 59.3% [95% CI: 58.1–60.4%]) and higher positive predictive value (PPV) (38.2% [95% CI: 33.8%–43.1%] <jats:italic>versus</jats:italic> 19.5% [95% CI: 17.8–20.9%]). However, the sensitivity of mRNA testing was lower than that of HC2 testing (66.7% [95% CI: 59.3–74.5%] <jats:italic>versus</jats:italic> 97.0% [95% CI: 95.5–98.4%]), and women testing mRNA negative had higher 3‐year risk for CIN3+ than those testing HC2 negative (3.2% [95% CI: 2.2–4.2%] <jats:italic>versus</jats:italic> 0.5% [95% CI: 0.3–0.7%]). Patterns were similar after 18 months and 5 years'; follow‐up; for CIN2+ and cancer as outcomes; across all age groups; and when comparing mRNA testing to hrHPV DNA testing using LA. In conclusion, the HPV16/18/31/33/45 mRNA test is not optimal for ASC‐US triage due to its low sensitivity and the substantial risk for precancer following a negative test.</jats:p> Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study International Journal of Cancer |
| doi_str_mv |
10.1002/ijc.30104 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMzAxMDQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMzAxMDQ |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
Wiley, 2016 |
| imprint_str_mv |
Wiley, 2016 |
| issn |
0020-7136 1097-0215 |
| issn_str_mv |
0020-7136 1097-0215 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
thomsen2016humanpapillomavirusmrnaanddnatestinginwomenwithatypicalsquamouscellsofundeterminedsignificanceaprospectivecohortstudy |
| publishDateSort |
2016 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
International Journal of Cancer |
| source_id |
49 |
| title |
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_unstemmed |
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_full |
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_fullStr |
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_full_unstemmed |
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_short |
Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_sort |
human papillomavirus mrna and dna testing in women with atypical squamous cells of undetermined significance: a prospective cohort study |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.30104 |
| publishDate |
2016 |
| physical |
1839-1850 |
| description |
<jats:p>In this prospective cohort study, we compared the performance of human papillomavirus (HPV) mRNA and DNA testing of women with atypical squamous cells of undetermined significance (ASC‐US) during cervical cancer screening. Using a nationwide Danish pathology register, we identified women aged 30–65 years with ASC‐US during 2005–2011 who were tested for HPV16/18/31/33/45 mRNA using PreTect HPV‐Proofer (<jats:italic>n</jats:italic> = 3,226) or for high‐risk HPV (hrHPV) DNA using Hybrid Capture 2 (HC2) (<jats:italic>n</jats:italic> = 9,405) or Linear Array HPV‐Genotyping test (LA) (<jats:italic>n</jats:italic> = 1,533). Women with ≥1 subsequent examination in the register (<jats:italic>n</jats:italic> = 13,729) were followed for up to 9.5 years for high‐grade cervical intraepithelial neoplasia (CIN) or cancer. After 3 years' follow‐up, mRNA testing had higher specificity for CIN3 or worse (CIN3+) than HC2 testing (88.1% [95% confidence interval (CI): 86.8–89.6%] <jats:italic>versus</jats:italic> 59.3% [95% CI: 58.1–60.4%]) and higher positive predictive value (PPV) (38.2% [95% CI: 33.8%–43.1%] <jats:italic>versus</jats:italic> 19.5% [95% CI: 17.8–20.9%]). However, the sensitivity of mRNA testing was lower than that of HC2 testing (66.7% [95% CI: 59.3–74.5%] <jats:italic>versus</jats:italic> 97.0% [95% CI: 95.5–98.4%]), and women testing mRNA negative had higher 3‐year risk for CIN3+ than those testing HC2 negative (3.2% [95% CI: 2.2–4.2%] <jats:italic>versus</jats:italic> 0.5% [95% CI: 0.3–0.7%]). Patterns were similar after 18 months and 5 years'; follow‐up; for CIN2+ and cancer as outcomes; across all age groups; and when comparing mRNA testing to hrHPV DNA testing using LA. In conclusion, the HPV16/18/31/33/45 mRNA test is not optimal for ASC‐US triage due to its low sensitivity and the substantial risk for precancer following a negative test.</jats:p> |
| container_issue |
8 |
| container_start_page |
1839 |
| container_title |
International Journal of Cancer |
| container_volume |
139 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792335218681577483 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:41:03.988Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Human+papillomavirus+mRNA+and+DNA+testing+in+women+with+atypical+squamous+cells+of+undetermined+significance%3A+A+prospective+cohort+study&rft.date=2016-10-15&genre=article&issn=1097-0215&volume=139&issue=8&spage=1839&epage=1850&pages=1839-1850&jtitle=International+Journal+of+Cancer&atitle=Human+papillomavirus+mRNA+and+DNA+testing+in+women+with+atypical+squamous+cells+of+undetermined+significance%3A+A+prospective+cohort+study&aulast=Kjaer&aufirst=Susanne+K.&rft_id=info%3Adoi%2F10.1002%2Fijc.30104&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792335218681577483 |
| author | Thomsen, Louise T., Dehlendorff, Christian, Junge, Jette, Waldstrøm, Marianne, Schledermann, Doris, Frederiksen, Kirsten, Kjaer, Susanne K. |
| author_facet | Thomsen, Louise T., Dehlendorff, Christian, Junge, Jette, Waldstrøm, Marianne, Schledermann, Doris, Frederiksen, Kirsten, Kjaer, Susanne K., Thomsen, Louise T., Dehlendorff, Christian, Junge, Jette, Waldstrøm, Marianne, Schledermann, Doris, Frederiksen, Kirsten, Kjaer, Susanne K. |
| author_sort | thomsen, louise t. |
| container_issue | 8 |
| container_start_page | 1839 |
| container_title | International Journal of Cancer |
| container_volume | 139 |
| description | <jats:p>In this prospective cohort study, we compared the performance of human papillomavirus (HPV) mRNA and DNA testing of women with atypical squamous cells of undetermined significance (ASC‐US) during cervical cancer screening. Using a nationwide Danish pathology register, we identified women aged 30–65 years with ASC‐US during 2005–2011 who were tested for HPV16/18/31/33/45 mRNA using PreTect HPV‐Proofer (<jats:italic>n</jats:italic> = 3,226) or for high‐risk HPV (hrHPV) DNA using Hybrid Capture 2 (HC2) (<jats:italic>n</jats:italic> = 9,405) or Linear Array HPV‐Genotyping test (LA) (<jats:italic>n</jats:italic> = 1,533). Women with ≥1 subsequent examination in the register (<jats:italic>n</jats:italic> = 13,729) were followed for up to 9.5 years for high‐grade cervical intraepithelial neoplasia (CIN) or cancer. After 3 years' follow‐up, mRNA testing had higher specificity for CIN3 or worse (CIN3+) than HC2 testing (88.1% [95% confidence interval (CI): 86.8–89.6%] <jats:italic>versus</jats:italic> 59.3% [95% CI: 58.1–60.4%]) and higher positive predictive value (PPV) (38.2% [95% CI: 33.8%–43.1%] <jats:italic>versus</jats:italic> 19.5% [95% CI: 17.8–20.9%]). However, the sensitivity of mRNA testing was lower than that of HC2 testing (66.7% [95% CI: 59.3–74.5%] <jats:italic>versus</jats:italic> 97.0% [95% CI: 95.5–98.4%]), and women testing mRNA negative had higher 3‐year risk for CIN3+ than those testing HC2 negative (3.2% [95% CI: 2.2–4.2%] <jats:italic>versus</jats:italic> 0.5% [95% CI: 0.3–0.7%]). Patterns were similar after 18 months and 5 years'; follow‐up; for CIN2+ and cancer as outcomes; across all age groups; and when comparing mRNA testing to hrHPV DNA testing using LA. In conclusion, the HPV16/18/31/33/45 mRNA test is not optimal for ASC‐US triage due to its low sensitivity and the substantial risk for precancer following a negative test.</jats:p> |
| doi_str_mv | 10.1002/ijc.30104 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMzAxMDQ |
| imprint | Wiley, 2016 |
| imprint_str_mv | Wiley, 2016 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 0020-7136, 1097-0215 |
| issn_str_mv | 0020-7136, 1097-0215 |
| language | English |
| last_indexed | 2024-03-01T14:41:03.988Z |
| match_str | thomsen2016humanpapillomavirusmrnaanddnatestinginwomenwithatypicalsquamouscellsofundeterminedsignificanceaprospectivecohortstudy |
| mega_collection | Wiley (CrossRef) |
| physical | 1839-1850 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | International Journal of Cancer |
| source_id | 49 |
| spelling | Thomsen, Louise T. Dehlendorff, Christian Junge, Jette Waldstrøm, Marianne Schledermann, Doris Frederiksen, Kirsten Kjaer, Susanne K. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.30104 <jats:p>In this prospective cohort study, we compared the performance of human papillomavirus (HPV) mRNA and DNA testing of women with atypical squamous cells of undetermined significance (ASC‐US) during cervical cancer screening. Using a nationwide Danish pathology register, we identified women aged 30–65 years with ASC‐US during 2005–2011 who were tested for HPV16/18/31/33/45 mRNA using PreTect HPV‐Proofer (<jats:italic>n</jats:italic> = 3,226) or for high‐risk HPV (hrHPV) DNA using Hybrid Capture 2 (HC2) (<jats:italic>n</jats:italic> = 9,405) or Linear Array HPV‐Genotyping test (LA) (<jats:italic>n</jats:italic> = 1,533). Women with ≥1 subsequent examination in the register (<jats:italic>n</jats:italic> = 13,729) were followed for up to 9.5 years for high‐grade cervical intraepithelial neoplasia (CIN) or cancer. After 3 years' follow‐up, mRNA testing had higher specificity for CIN3 or worse (CIN3+) than HC2 testing (88.1% [95% confidence interval (CI): 86.8–89.6%] <jats:italic>versus</jats:italic> 59.3% [95% CI: 58.1–60.4%]) and higher positive predictive value (PPV) (38.2% [95% CI: 33.8%–43.1%] <jats:italic>versus</jats:italic> 19.5% [95% CI: 17.8–20.9%]). However, the sensitivity of mRNA testing was lower than that of HC2 testing (66.7% [95% CI: 59.3–74.5%] <jats:italic>versus</jats:italic> 97.0% [95% CI: 95.5–98.4%]), and women testing mRNA negative had higher 3‐year risk for CIN3+ than those testing HC2 negative (3.2% [95% CI: 2.2–4.2%] <jats:italic>versus</jats:italic> 0.5% [95% CI: 0.3–0.7%]). Patterns were similar after 18 months and 5 years'; follow‐up; for CIN2+ and cancer as outcomes; across all age groups; and when comparing mRNA testing to hrHPV DNA testing using LA. In conclusion, the HPV16/18/31/33/45 mRNA test is not optimal for ASC‐US triage due to its low sensitivity and the substantial risk for precancer following a negative test.</jats:p> Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study International Journal of Cancer |
| spellingShingle | Thomsen, Louise T., Dehlendorff, Christian, Junge, Jette, Waldstrøm, Marianne, Schledermann, Doris, Frederiksen, Kirsten, Kjaer, Susanne K., International Journal of Cancer, Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study, Cancer Research, Oncology |
| title | Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_full | Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_fullStr | Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_full_unstemmed | Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_short | Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| title_sort | human papillomavirus mrna and dna testing in women with atypical squamous cells of undetermined significance: a prospective cohort study |
| title_unstemmed | Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.30104 |