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Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | International Journal of Cancer, 136, 2015, 5, S. 1149-1161 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Hughes, David J. Fedirko, Veronika Jenab, Mazda Schomburg, Lutz Méplan, Catherine Freisling, Heinz Bueno‐de‐Mesquita, H.B(as) Hybsier, Sandra Becker, Niels‐Peter Czuban, Magdalena Tjønneland, Anne Outzen, Malene Boutron‐Ruault, Marie‐Christine Racine, Antoine Bastide, Nadia Kühn, Tilman Kaaks, Rudolf Trichopoulos, Dimitrios Trichopoulou, Antonia Lagiou, Pagona Panico, Salvatore Peeters, Petra H Weiderpass, Elisabete Skeie, Guri Dagrun, Engeset Chirlaque, Maria‐Dolores Sánchez, Maria‐Jose Ardanaz, Eva Ljuslinder, Ingrid Wennberg, Maria Bradbury, Kathryn E Vineis, Paolo Naccarati, Alessio Palli, Domenico Boeing, Heiner Overvad, Kim Dorronsoro, Miren Jakszyn, Paula Cross, Amanda J. Quirós, Jose Ramón Stepien, Magdalena Kong, So Yeon Duarte‐Salles, Talita Riboli, Elio Hesketh, John E. Hughes, David J. Fedirko, Veronika Jenab, Mazda Schomburg, Lutz Méplan, Catherine Freisling, Heinz Bueno‐de‐Mesquita, H.B(as) Hybsier, Sandra Becker, Niels‐Peter Czuban, Magdalena Tjønneland, Anne Outzen, Malene Boutron‐Ruault, Marie‐Christine Racine, Antoine Bastide, Nadia Kühn, Tilman Kaaks, Rudolf Trichopoulos, Dimitrios Trichopoulou, Antonia Lagiou, Pagona Panico, Salvatore Peeters, Petra H Weiderpass, Elisabete Skeie, Guri Dagrun, Engeset Chirlaque, Maria‐Dolores Sánchez, Maria‐Jose Ardanaz, Eva Ljuslinder, Ingrid Wennberg, Maria Bradbury, Kathryn E Vineis, Paolo Naccarati, Alessio Palli, Domenico Boeing, Heiner Overvad, Kim Dorronsoro, Miren Jakszyn, Paula Cross, Amanda J. Quirós, Jose Ramón Stepien, Magdalena Kong, So Yeon Duarte‐Salles, Talita Riboli, Elio Hesketh, John E. |
|---|---|
| author |
Hughes, David J. Fedirko, Veronika Jenab, Mazda Schomburg, Lutz Méplan, Catherine Freisling, Heinz Bueno‐de‐Mesquita, H.B(as) Hybsier, Sandra Becker, Niels‐Peter Czuban, Magdalena Tjønneland, Anne Outzen, Malene Boutron‐Ruault, Marie‐Christine Racine, Antoine Bastide, Nadia Kühn, Tilman Kaaks, Rudolf Trichopoulos, Dimitrios Trichopoulou, Antonia Lagiou, Pagona Panico, Salvatore Peeters, Petra H Weiderpass, Elisabete Skeie, Guri Dagrun, Engeset Chirlaque, Maria‐Dolores Sánchez, Maria‐Jose Ardanaz, Eva Ljuslinder, Ingrid Wennberg, Maria Bradbury, Kathryn E Vineis, Paolo Naccarati, Alessio Palli, Domenico Boeing, Heiner Overvad, Kim Dorronsoro, Miren Jakszyn, Paula Cross, Amanda J. Quirós, Jose Ramón Stepien, Magdalena Kong, So Yeon Duarte‐Salles, Talita Riboli, Elio Hesketh, John E. |
| spellingShingle |
Hughes, David J. Fedirko, Veronika Jenab, Mazda Schomburg, Lutz Méplan, Catherine Freisling, Heinz Bueno‐de‐Mesquita, H.B(as) Hybsier, Sandra Becker, Niels‐Peter Czuban, Magdalena Tjønneland, Anne Outzen, Malene Boutron‐Ruault, Marie‐Christine Racine, Antoine Bastide, Nadia Kühn, Tilman Kaaks, Rudolf Trichopoulos, Dimitrios Trichopoulou, Antonia Lagiou, Pagona Panico, Salvatore Peeters, Petra H Weiderpass, Elisabete Skeie, Guri Dagrun, Engeset Chirlaque, Maria‐Dolores Sánchez, Maria‐Jose Ardanaz, Eva Ljuslinder, Ingrid Wennberg, Maria Bradbury, Kathryn E Vineis, Paolo Naccarati, Alessio Palli, Domenico Boeing, Heiner Overvad, Kim Dorronsoro, Miren Jakszyn, Paula Cross, Amanda J. Quirós, Jose Ramón Stepien, Magdalena Kong, So Yeon Duarte‐Salles, Talita Riboli, Elio Hesketh, John E. International Journal of Cancer Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort Cancer Research Oncology |
| author_sort |
hughes, david j. |
| spelling |
Hughes, David J. Fedirko, Veronika Jenab, Mazda Schomburg, Lutz Méplan, Catherine Freisling, Heinz Bueno‐de‐Mesquita, H.B(as) Hybsier, Sandra Becker, Niels‐Peter Czuban, Magdalena Tjønneland, Anne Outzen, Malene Boutron‐Ruault, Marie‐Christine Racine, Antoine Bastide, Nadia Kühn, Tilman Kaaks, Rudolf Trichopoulos, Dimitrios Trichopoulou, Antonia Lagiou, Pagona Panico, Salvatore Peeters, Petra H Weiderpass, Elisabete Skeie, Guri Dagrun, Engeset Chirlaque, Maria‐Dolores Sánchez, Maria‐Jose Ardanaz, Eva Ljuslinder, Ingrid Wennberg, Maria Bradbury, Kathryn E Vineis, Paolo Naccarati, Alessio Palli, Domenico Boeing, Heiner Overvad, Kim Dorronsoro, Miren Jakszyn, Paula Cross, Amanda J. Quirós, Jose Ramón Stepien, Magdalena Kong, So Yeon Duarte‐Salles, Talita Riboli, Elio Hesketh, John E. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.29071 <jats:p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case–control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X‐ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non‐significant lower CRC risk (IRR = 0.92, 95% CI: 0.82–1.03 per 25 μg/L increase). However, sub‐group analyses by sex showed a statistically significant association for women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70–0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82–0.98) with the association more apparent in women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.004; IRR = 0.82, 95% CI: 0.72–0.94 per 0.806 mg/L increase) than men (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.485; IRR = 0.98, 95% CI: 0.86–1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</jats:p> Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort International Journal of Cancer |
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| title |
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_unstemmed |
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_full |
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_fullStr |
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_full_unstemmed |
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_short |
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_sort |
selenium status is associated with colorectal cancer risk in the european prospective investigation of cancer and nutrition cohort |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.29071 |
| publishDate |
2015 |
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1149-1161 |
| description |
<jats:p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case–control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X‐ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non‐significant lower CRC risk (IRR = 0.92, 95% CI: 0.82–1.03 per 25 μg/L increase). However, sub‐group analyses by sex showed a statistically significant association for women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70–0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82–0.98) with the association more apparent in women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.004; IRR = 0.82, 95% CI: 0.72–0.94 per 0.806 mg/L increase) than men (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.485; IRR = 0.98, 95% CI: 0.86–1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</jats:p> |
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| author | Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Méplan, Catherine, Freisling, Heinz, Bueno‐de‐Mesquita, H.B(as), Hybsier, Sandra, Becker, Niels‐Peter, Czuban, Magdalena, Tjønneland, Anne, Outzen, Malene, Boutron‐Ruault, Marie‐Christine, Racine, Antoine, Bastide, Nadia, Kühn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H, Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria‐Dolores, Sánchez, Maria‐Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E, Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quirós, Jose Ramón, Stepien, Magdalena, Kong, So Yeon, Duarte‐Salles, Talita, Riboli, Elio, Hesketh, John E. |
| author_facet | Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Méplan, Catherine, Freisling, Heinz, Bueno‐de‐Mesquita, H.B(as), Hybsier, Sandra, Becker, Niels‐Peter, Czuban, Magdalena, Tjønneland, Anne, Outzen, Malene, Boutron‐Ruault, Marie‐Christine, Racine, Antoine, Bastide, Nadia, Kühn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H, Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria‐Dolores, Sánchez, Maria‐Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E, Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quirós, Jose Ramón, Stepien, Magdalena, Kong, So Yeon, Duarte‐Salles, Talita, Riboli, Elio, Hesketh, John E., Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Méplan, Catherine, Freisling, Heinz, Bueno‐de‐Mesquita, H.B(as), Hybsier, Sandra, Becker, Niels‐Peter, Czuban, Magdalena, Tjønneland, Anne, Outzen, Malene, Boutron‐Ruault, Marie‐Christine, Racine, Antoine, Bastide, Nadia, Kühn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H, Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria‐Dolores, Sánchez, Maria‐Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E, Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quirós, Jose Ramón, Stepien, Magdalena, Kong, So Yeon, Duarte‐Salles, Talita, Riboli, Elio, Hesketh, John E. |
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| description | <jats:p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case–control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X‐ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non‐significant lower CRC risk (IRR = 0.92, 95% CI: 0.82–1.03 per 25 μg/L increase). However, sub‐group analyses by sex showed a statistically significant association for women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70–0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82–0.98) with the association more apparent in women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.004; IRR = 0.82, 95% CI: 0.72–0.94 per 0.806 mg/L increase) than men (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.485; IRR = 0.98, 95% CI: 0.86–1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</jats:p> |
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| spelling | Hughes, David J. Fedirko, Veronika Jenab, Mazda Schomburg, Lutz Méplan, Catherine Freisling, Heinz Bueno‐de‐Mesquita, H.B(as) Hybsier, Sandra Becker, Niels‐Peter Czuban, Magdalena Tjønneland, Anne Outzen, Malene Boutron‐Ruault, Marie‐Christine Racine, Antoine Bastide, Nadia Kühn, Tilman Kaaks, Rudolf Trichopoulos, Dimitrios Trichopoulou, Antonia Lagiou, Pagona Panico, Salvatore Peeters, Petra H Weiderpass, Elisabete Skeie, Guri Dagrun, Engeset Chirlaque, Maria‐Dolores Sánchez, Maria‐Jose Ardanaz, Eva Ljuslinder, Ingrid Wennberg, Maria Bradbury, Kathryn E Vineis, Paolo Naccarati, Alessio Palli, Domenico Boeing, Heiner Overvad, Kim Dorronsoro, Miren Jakszyn, Paula Cross, Amanda J. Quirós, Jose Ramón Stepien, Magdalena Kong, So Yeon Duarte‐Salles, Talita Riboli, Elio Hesketh, John E. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.29071 <jats:p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case–control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X‐ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non‐significant lower CRC risk (IRR = 0.92, 95% CI: 0.82–1.03 per 25 μg/L increase). However, sub‐group analyses by sex showed a statistically significant association for women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70–0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82–0.98) with the association more apparent in women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.004; IRR = 0.82, 95% CI: 0.72–0.94 per 0.806 mg/L increase) than men (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.485; IRR = 0.98, 95% CI: 0.86–1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</jats:p> Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort International Journal of Cancer |
| spellingShingle | Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Méplan, Catherine, Freisling, Heinz, Bueno‐de‐Mesquita, H.B(as), Hybsier, Sandra, Becker, Niels‐Peter, Czuban, Magdalena, Tjønneland, Anne, Outzen, Malene, Boutron‐Ruault, Marie‐Christine, Racine, Antoine, Bastide, Nadia, Kühn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H, Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria‐Dolores, Sánchez, Maria‐Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E, Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quirós, Jose Ramón, Stepien, Magdalena, Kong, So Yeon, Duarte‐Salles, Talita, Riboli, Elio, Hesketh, John E., International Journal of Cancer, Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort, Cancer Research, Oncology |
| title | Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_full | Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_fullStr | Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_full_unstemmed | Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_short | Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| title_sort | selenium status is associated with colorectal cancer risk in the european prospective investigation of cancer and nutrition cohort |
| title_unstemmed | Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.29071 |