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Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | International Journal of Cancer, 138, 2016, 7, S. 1670-1679 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Butt, Julia Romero‐Hernández, Beatriz Pérez‐Gómez, Beatriz Willhauck‐Fleckenstein, Martina Holzinger, Dana Martin, Vicente Moreno, Victor Linares, Cristina Dierssen‐Sotos, Trinidad Barricarte, Aurelio Tardón, Adonina Altzibar, Jone M. Moreno‐Osset, Eduardo Franco, Francisco Requena, Rocío Olmedo Huerta, José María Michel, Angelika Waterboer, Tim Castaño‐Vinyals, Gemma Kogevinas, Manolis Pollán, Marina Boleij, Annemarie de Sanjosé, Silvia del Campo, Rosa Tjalsma, Harold Aragonés, Nuria Pawlita, Michael Butt, Julia Romero‐Hernández, Beatriz Pérez‐Gómez, Beatriz Willhauck‐Fleckenstein, Martina Holzinger, Dana Martin, Vicente Moreno, Victor Linares, Cristina Dierssen‐Sotos, Trinidad Barricarte, Aurelio Tardón, Adonina Altzibar, Jone M. Moreno‐Osset, Eduardo Franco, Francisco Requena, Rocío Olmedo Huerta, José María Michel, Angelika Waterboer, Tim Castaño‐Vinyals, Gemma Kogevinas, Manolis Pollán, Marina Boleij, Annemarie de Sanjosé, Silvia del Campo, Rosa Tjalsma, Harold Aragonés, Nuria Pawlita, Michael |
|---|---|
| author |
Butt, Julia Romero‐Hernández, Beatriz Pérez‐Gómez, Beatriz Willhauck‐Fleckenstein, Martina Holzinger, Dana Martin, Vicente Moreno, Victor Linares, Cristina Dierssen‐Sotos, Trinidad Barricarte, Aurelio Tardón, Adonina Altzibar, Jone M. Moreno‐Osset, Eduardo Franco, Francisco Requena, Rocío Olmedo Huerta, José María Michel, Angelika Waterboer, Tim Castaño‐Vinyals, Gemma Kogevinas, Manolis Pollán, Marina Boleij, Annemarie de Sanjosé, Silvia del Campo, Rosa Tjalsma, Harold Aragonés, Nuria Pawlita, Michael |
| spellingShingle |
Butt, Julia Romero‐Hernández, Beatriz Pérez‐Gómez, Beatriz Willhauck‐Fleckenstein, Martina Holzinger, Dana Martin, Vicente Moreno, Victor Linares, Cristina Dierssen‐Sotos, Trinidad Barricarte, Aurelio Tardón, Adonina Altzibar, Jone M. Moreno‐Osset, Eduardo Franco, Francisco Requena, Rocío Olmedo Huerta, José María Michel, Angelika Waterboer, Tim Castaño‐Vinyals, Gemma Kogevinas, Manolis Pollán, Marina Boleij, Annemarie de Sanjosé, Silvia del Campo, Rosa Tjalsma, Harold Aragonés, Nuria Pawlita, Michael International Journal of Cancer Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence Cancer Research Oncology |
| author_sort |
butt, julia |
| spelling |
Butt, Julia Romero‐Hernández, Beatriz Pérez‐Gómez, Beatriz Willhauck‐Fleckenstein, Martina Holzinger, Dana Martin, Vicente Moreno, Victor Linares, Cristina Dierssen‐Sotos, Trinidad Barricarte, Aurelio Tardón, Adonina Altzibar, Jone M. Moreno‐Osset, Eduardo Franco, Francisco Requena, Rocío Olmedo Huerta, José María Michel, Angelika Waterboer, Tim Castaño‐Vinyals, Gemma Kogevinas, Manolis Pollán, Marina Boleij, Annemarie de Sanjosé, Silvia del Campo, Rosa Tjalsma, Harold Aragonés, Nuria Pawlita, Michael 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.29914 <jats:p>The colonic opportunist <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG) is potentially associated with colorectal cancer (CRC). Large‐scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population‐based multicase–control project (MCC‐Spain). MCC‐Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity‐purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease‐specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09–2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09–2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00–2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04–3.56) and for double‐positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49–8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.</jats:p> Association of <scp><i>S</i></scp><i>treptococcus gallolyticus</i> subspecies <i>gallolyticus</i> with colorectal cancer: Serological evidence International Journal of Cancer |
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| title |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_unstemmed |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_full |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_fullStr |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_full_unstemmed |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_short |
Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_sort |
association of <scp><i>s</i></scp><i>treptococcus gallolyticus</i> subspecies <i>gallolyticus</i> with colorectal cancer: serological evidence |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.29914 |
| publishDate |
2016 |
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1670-1679 |
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<jats:p>The colonic opportunist <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG) is potentially associated with colorectal cancer (CRC). Large‐scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population‐based multicase–control project (MCC‐Spain). MCC‐Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity‐purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease‐specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09–2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09–2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00–2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04–3.56) and for double‐positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49–8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.</jats:p> |
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| author | Butt, Julia, Romero‐Hernández, Beatriz, Pérez‐Gómez, Beatriz, Willhauck‐Fleckenstein, Martina, Holzinger, Dana, Martin, Vicente, Moreno, Victor, Linares, Cristina, Dierssen‐Sotos, Trinidad, Barricarte, Aurelio, Tardón, Adonina, Altzibar, Jone M., Moreno‐Osset, Eduardo, Franco, Francisco, Requena, Rocío Olmedo, Huerta, José María, Michel, Angelika, Waterboer, Tim, Castaño‐Vinyals, Gemma, Kogevinas, Manolis, Pollán, Marina, Boleij, Annemarie, de Sanjosé, Silvia, del Campo, Rosa, Tjalsma, Harold, Aragonés, Nuria, Pawlita, Michael |
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| description | <jats:p>The colonic opportunist <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG) is potentially associated with colorectal cancer (CRC). Large‐scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population‐based multicase–control project (MCC‐Spain). MCC‐Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity‐purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease‐specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09–2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09–2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00–2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04–3.56) and for double‐positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49–8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.</jats:p> |
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| spelling | Butt, Julia Romero‐Hernández, Beatriz Pérez‐Gómez, Beatriz Willhauck‐Fleckenstein, Martina Holzinger, Dana Martin, Vicente Moreno, Victor Linares, Cristina Dierssen‐Sotos, Trinidad Barricarte, Aurelio Tardón, Adonina Altzibar, Jone M. Moreno‐Osset, Eduardo Franco, Francisco Requena, Rocío Olmedo Huerta, José María Michel, Angelika Waterboer, Tim Castaño‐Vinyals, Gemma Kogevinas, Manolis Pollán, Marina Boleij, Annemarie de Sanjosé, Silvia del Campo, Rosa Tjalsma, Harold Aragonés, Nuria Pawlita, Michael 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.29914 <jats:p>The colonic opportunist <jats:italic>Streptococcus gallolyticus</jats:italic> subspecies <jats:italic>gallolyticus</jats:italic> (SGG) is potentially associated with colorectal cancer (CRC). Large‐scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population‐based multicase–control project (MCC‐Spain). MCC‐Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity‐purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease‐specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09–2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09–2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00–2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04–3.56) and for double‐positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49–8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.</jats:p> Association of <scp><i>S</i></scp><i>treptococcus gallolyticus</i> subspecies <i>gallolyticus</i> with colorectal cancer: Serological evidence International Journal of Cancer |
| spellingShingle | Butt, Julia, Romero‐Hernández, Beatriz, Pérez‐Gómez, Beatriz, Willhauck‐Fleckenstein, Martina, Holzinger, Dana, Martin, Vicente, Moreno, Victor, Linares, Cristina, Dierssen‐Sotos, Trinidad, Barricarte, Aurelio, Tardón, Adonina, Altzibar, Jone M., Moreno‐Osset, Eduardo, Franco, Francisco, Requena, Rocío Olmedo, Huerta, José María, Michel, Angelika, Waterboer, Tim, Castaño‐Vinyals, Gemma, Kogevinas, Manolis, Pollán, Marina, Boleij, Annemarie, de Sanjosé, Silvia, del Campo, Rosa, Tjalsma, Harold, Aragonés, Nuria, Pawlita, Michael, International Journal of Cancer, Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence, Cancer Research, Oncology |
| title | Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_full | Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_fullStr | Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_full_unstemmed | Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_short | Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| title_sort | association of <scp><i>s</i></scp><i>treptococcus gallolyticus</i> subspecies <i>gallolyticus</i> with colorectal cancer: serological evidence |
| title_unstemmed | Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.29914 |