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Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | International Journal of Cancer, 131, 2012, 8, S. 1863-1873 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Luo, Weiren Fang, Weiyi Li, Siyi Yao, Kaitai Luo, Weiren Fang, Weiyi Li, Siyi Yao, Kaitai |
|---|---|
| author |
Luo, Weiren Fang, Weiyi Li, Siyi Yao, Kaitai |
| spellingShingle |
Luo, Weiren Fang, Weiyi Li, Siyi Yao, Kaitai International Journal of Cancer Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma Cancer Research Oncology |
| author_sort |
luo, weiren |
| spelling |
Luo, Weiren Fang, Weiyi Li, Siyi Yao, Kaitai 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.27467 <jats:title>Abstract</jats:title><jats:p>Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E‐cadherin, β‐catenin is essential for the progression of various human cancers. Our study aimed to investigate the aberrant localization E‐cadherin, β‐catenin and vimentin, and their prognostic significance in 122 nasopharyngeal carcinoma (NPC) patients by immunohistochemistry and immunofluorescence. Our results showed that both membranous and cytoplasmic localization of E‐cadherin staining were associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000 and 0.005, respectively) and clinical stage (<jats:italic>p</jats:italic> = 0.000 and 0.007, respectively). High cytoplasmic β‐catenin correlated significantly with larger tumor size (<jats:italic>p</jats:italic> = 0.020), lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.036). However, no significant difference was observed between membranous β‐catenin and clinicopathologic features (<jats:italic>p</jats:italic> ≥ 0.05). High nuclear vimentin expression correlated significantly with positive lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Multivariate analysis showed that nuclear vimentin and cytoplasmic E‐cadherin were independent prognostic factors (<jats:italic>p</jats:italic> = 0.016 and 0.001, respectively), as well as M classification (<jats:italic>p</jats:italic> = 0.001). More importantly, patients with high coexpression of nuclear vimentin and cytoplasmic E‐cadherin had shorter survival time (<jats:italic>p</jats:italic> = 0.000). Furthermore, high coexpression of these two proteins was closely associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Our studies provide convincing evidence that EMT may play an important role in the biological progression of NPC, and nuclear vimentin and cytoplasmic E‐cadherin might have independent prognostic value in NPC patients and serve as novel targets for prognostic therapeutics.</jats:p> Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma International Journal of Cancer |
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Wiley, 2012 |
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Wiley, 2012 |
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2012 |
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International Journal of Cancer |
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| title |
Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_unstemmed |
Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_full |
Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_fullStr |
Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_full_unstemmed |
Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_short |
Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_sort |
aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.27467 |
| publishDate |
2012 |
| physical |
1863-1873 |
| description |
<jats:title>Abstract</jats:title><jats:p>Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E‐cadherin, β‐catenin is essential for the progression of various human cancers. Our study aimed to investigate the aberrant localization E‐cadherin, β‐catenin and vimentin, and their prognostic significance in 122 nasopharyngeal carcinoma (NPC) patients by immunohistochemistry and immunofluorescence. Our results showed that both membranous and cytoplasmic localization of E‐cadherin staining were associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000 and 0.005, respectively) and clinical stage (<jats:italic>p</jats:italic> = 0.000 and 0.007, respectively). High cytoplasmic β‐catenin correlated significantly with larger tumor size (<jats:italic>p</jats:italic> = 0.020), lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.036). However, no significant difference was observed between membranous β‐catenin and clinicopathologic features (<jats:italic>p</jats:italic> ≥ 0.05). High nuclear vimentin expression correlated significantly with positive lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Multivariate analysis showed that nuclear vimentin and cytoplasmic E‐cadherin were independent prognostic factors (<jats:italic>p</jats:italic> = 0.016 and 0.001, respectively), as well as M classification (<jats:italic>p</jats:italic> = 0.001). More importantly, patients with high coexpression of nuclear vimentin and cytoplasmic E‐cadherin had shorter survival time (<jats:italic>p</jats:italic> = 0.000). Furthermore, high coexpression of these two proteins was closely associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Our studies provide convincing evidence that EMT may play an important role in the biological progression of NPC, and nuclear vimentin and cytoplasmic E‐cadherin might have independent prognostic value in NPC patients and serve as novel targets for prognostic therapeutics.</jats:p> |
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| author | Luo, Weiren, Fang, Weiyi, Li, Siyi, Yao, Kaitai |
| author_facet | Luo, Weiren, Fang, Weiyi, Li, Siyi, Yao, Kaitai, Luo, Weiren, Fang, Weiyi, Li, Siyi, Yao, Kaitai |
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| description | <jats:title>Abstract</jats:title><jats:p>Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E‐cadherin, β‐catenin is essential for the progression of various human cancers. Our study aimed to investigate the aberrant localization E‐cadherin, β‐catenin and vimentin, and their prognostic significance in 122 nasopharyngeal carcinoma (NPC) patients by immunohistochemistry and immunofluorescence. Our results showed that both membranous and cytoplasmic localization of E‐cadherin staining were associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000 and 0.005, respectively) and clinical stage (<jats:italic>p</jats:italic> = 0.000 and 0.007, respectively). High cytoplasmic β‐catenin correlated significantly with larger tumor size (<jats:italic>p</jats:italic> = 0.020), lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.036). However, no significant difference was observed between membranous β‐catenin and clinicopathologic features (<jats:italic>p</jats:italic> ≥ 0.05). High nuclear vimentin expression correlated significantly with positive lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Multivariate analysis showed that nuclear vimentin and cytoplasmic E‐cadherin were independent prognostic factors (<jats:italic>p</jats:italic> = 0.016 and 0.001, respectively), as well as M classification (<jats:italic>p</jats:italic> = 0.001). More importantly, patients with high coexpression of nuclear vimentin and cytoplasmic E‐cadherin had shorter survival time (<jats:italic>p</jats:italic> = 0.000). Furthermore, high coexpression of these two proteins was closely associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Our studies provide convincing evidence that EMT may play an important role in the biological progression of NPC, and nuclear vimentin and cytoplasmic E‐cadherin might have independent prognostic value in NPC patients and serve as novel targets for prognostic therapeutics.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Luo, Weiren Fang, Weiyi Li, Siyi Yao, Kaitai 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.27467 <jats:title>Abstract</jats:title><jats:p>Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E‐cadherin, β‐catenin is essential for the progression of various human cancers. Our study aimed to investigate the aberrant localization E‐cadherin, β‐catenin and vimentin, and their prognostic significance in 122 nasopharyngeal carcinoma (NPC) patients by immunohistochemistry and immunofluorescence. Our results showed that both membranous and cytoplasmic localization of E‐cadherin staining were associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000 and 0.005, respectively) and clinical stage (<jats:italic>p</jats:italic> = 0.000 and 0.007, respectively). High cytoplasmic β‐catenin correlated significantly with larger tumor size (<jats:italic>p</jats:italic> = 0.020), lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.036). However, no significant difference was observed between membranous β‐catenin and clinicopathologic features (<jats:italic>p</jats:italic> ≥ 0.05). High nuclear vimentin expression correlated significantly with positive lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Multivariate analysis showed that nuclear vimentin and cytoplasmic E‐cadherin were independent prognostic factors (<jats:italic>p</jats:italic> = 0.016 and 0.001, respectively), as well as M classification (<jats:italic>p</jats:italic> = 0.001). More importantly, patients with high coexpression of nuclear vimentin and cytoplasmic E‐cadherin had shorter survival time (<jats:italic>p</jats:italic> = 0.000). Furthermore, high coexpression of these two proteins was closely associated with lymph node metastasis (<jats:italic>p</jats:italic> = 0.000) and advanced clinical stage (<jats:italic>p</jats:italic> = 0.000). Our studies provide convincing evidence that EMT may play an important role in the biological progression of NPC, and nuclear vimentin and cytoplasmic E‐cadherin might have independent prognostic value in NPC patients and serve as novel targets for prognostic therapeutics.</jats:p> Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma International Journal of Cancer |
| spellingShingle | Luo, Weiren, Fang, Weiyi, Li, Siyi, Yao, Kaitai, International Journal of Cancer, Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma, Cancer Research, Oncology |
| title | Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_full | Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_fullStr | Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_full_unstemmed | Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_short | Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_sort | aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| title_unstemmed | Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.27467 |