Eintrag weiter verarbeiten
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population
Gespeichert in:
| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | International Journal of Cancer, 118, 2006, 5, S. 1275-1278 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Hu, Zhibin Ma, Hongxia Lu, Daru Qian, Ji Zhou, Jiannong Chen, Yijiang Xu, Lin Wang, Xinru Wei, Qingyi Shen, Hongbing Hu, Zhibin Ma, Hongxia Lu, Daru Qian, Ji Zhou, Jiannong Chen, Yijiang Xu, Lin Wang, Xinru Wei, Qingyi Shen, Hongbing |
|---|---|
| author |
Hu, Zhibin Ma, Hongxia Lu, Daru Qian, Ji Zhou, Jiannong Chen, Yijiang Xu, Lin Wang, Xinru Wei, Qingyi Shen, Hongbing |
| spellingShingle |
Hu, Zhibin Ma, Hongxia Lu, Daru Qian, Ji Zhou, Jiannong Chen, Yijiang Xu, Lin Wang, Xinru Wei, Qingyi Shen, Hongbing International Journal of Cancer Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population Cancer Research Oncology |
| author_sort |
hu, zhibin |
| spelling |
Hu, Zhibin Ma, Hongxia Lu, Daru Qian, Ji Zhou, Jiannong Chen, Yijiang Xu, Lin Wang, Xinru Wei, Qingyi Shen, Hongbing 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.21463 <jats:title>Abstract</jats:title><jats:p>Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/deletion polymorphism in the constitutive promoter) were identified, and recently the T/G substitution (SNP309) has been demonstrated to alter the levels of <jats:italic>MDM2</jats:italic> gene products. In this molecular epidemiological study with 717 incident lung cancer cases and 1,083 cancer‐free controls, we genotyped these 2 promoter polymorphisms of <jats:italic>MDM2</jats:italic> and evaluated their associations with risk of lung cancer. We found that there were no significant associations between <jats:italic>MDM2</jats:italic> SNP309 variant genotypes and lung cancer risk (adjusted OR = 1.20, 95% CI = 0.95–1.53 for TG and adjusted OR = 1.12, 95% CI = 0.85–1.48 for GG, respectively). Similarly, we did not find evidence for any association between risk of lung cancer and <jats:italic>MDM2</jats:italic> insertion/deletion polymorphism. The findings suggest that these two <jats:italic>MDM2</jats:italic> promoter polymorphisms may not play a major role in lung cancer susceptibility in this Chinese population. © 2005 Wiley‐Liss, Inc.</jats:p> Genetic variants in the <i>MDM2</i> promoter and lung cancer risk in a Chinese population International Journal of Cancer |
| doi_str_mv |
10.1002/ijc.21463 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMjE0NjM |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMjE0NjM |
| institution |
DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 |
| imprint |
Wiley, 2006 |
| imprint_str_mv |
Wiley, 2006 |
| issn |
1097-0215 0020-7136 |
| issn_str_mv |
1097-0215 0020-7136 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
hu2006geneticvariantsinthemdm2promoterandlungcancerriskinachinesepopulation |
| publishDateSort |
2006 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
International Journal of Cancer |
| source_id |
49 |
| title |
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_unstemmed |
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_full |
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_fullStr |
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_full_unstemmed |
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_short |
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_sort |
genetic variants in the <i>mdm2</i> promoter and lung cancer risk in a chinese population |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.21463 |
| publishDate |
2006 |
| physical |
1275-1278 |
| description |
<jats:title>Abstract</jats:title><jats:p>Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/deletion polymorphism in the constitutive promoter) were identified, and recently the T/G substitution (SNP309) has been demonstrated to alter the levels of <jats:italic>MDM2</jats:italic> gene products. In this molecular epidemiological study with 717 incident lung cancer cases and 1,083 cancer‐free controls, we genotyped these 2 promoter polymorphisms of <jats:italic>MDM2</jats:italic> and evaluated their associations with risk of lung cancer. We found that there were no significant associations between <jats:italic>MDM2</jats:italic> SNP309 variant genotypes and lung cancer risk (adjusted OR = 1.20, 95% CI = 0.95–1.53 for TG and adjusted OR = 1.12, 95% CI = 0.85–1.48 for GG, respectively). Similarly, we did not find evidence for any association between risk of lung cancer and <jats:italic>MDM2</jats:italic> insertion/deletion polymorphism. The findings suggest that these two <jats:italic>MDM2</jats:italic> promoter polymorphisms may not play a major role in lung cancer susceptibility in this Chinese population. © 2005 Wiley‐Liss, Inc.</jats:p> |
| container_issue |
5 |
| container_start_page |
1275 |
| container_title |
International Journal of Cancer |
| container_volume |
118 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337404101656579 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:15:06.412Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Genetic+variants+in+the+MDM2+promoter+and+lung+cancer+risk+in+a+Chinese+population&rft.date=2006-03-01&genre=article&issn=1097-0215&volume=118&issue=5&spage=1275&epage=1278&pages=1275-1278&jtitle=International+Journal+of+Cancer&atitle=Genetic+variants+in+the+%3Ci%3EMDM2%3C%2Fi%3E+promoter+and+lung+cancer+risk+in+a+Chinese+population&aulast=Shen&aufirst=Hongbing&rft_id=info%3Adoi%2F10.1002%2Fijc.21463&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337404101656579 |
| author | Hu, Zhibin, Ma, Hongxia, Lu, Daru, Qian, Ji, Zhou, Jiannong, Chen, Yijiang, Xu, Lin, Wang, Xinru, Wei, Qingyi, Shen, Hongbing |
| author_facet | Hu, Zhibin, Ma, Hongxia, Lu, Daru, Qian, Ji, Zhou, Jiannong, Chen, Yijiang, Xu, Lin, Wang, Xinru, Wei, Qingyi, Shen, Hongbing, Hu, Zhibin, Ma, Hongxia, Lu, Daru, Qian, Ji, Zhou, Jiannong, Chen, Yijiang, Xu, Lin, Wang, Xinru, Wei, Qingyi, Shen, Hongbing |
| author_sort | hu, zhibin |
| container_issue | 5 |
| container_start_page | 1275 |
| container_title | International Journal of Cancer |
| container_volume | 118 |
| description | <jats:title>Abstract</jats:title><jats:p>Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/deletion polymorphism in the constitutive promoter) were identified, and recently the T/G substitution (SNP309) has been demonstrated to alter the levels of <jats:italic>MDM2</jats:italic> gene products. In this molecular epidemiological study with 717 incident lung cancer cases and 1,083 cancer‐free controls, we genotyped these 2 promoter polymorphisms of <jats:italic>MDM2</jats:italic> and evaluated their associations with risk of lung cancer. We found that there were no significant associations between <jats:italic>MDM2</jats:italic> SNP309 variant genotypes and lung cancer risk (adjusted OR = 1.20, 95% CI = 0.95–1.53 for TG and adjusted OR = 1.12, 95% CI = 0.85–1.48 for GG, respectively). Similarly, we did not find evidence for any association between risk of lung cancer and <jats:italic>MDM2</jats:italic> insertion/deletion polymorphism. The findings suggest that these two <jats:italic>MDM2</jats:italic> promoter polymorphisms may not play a major role in lung cancer susceptibility in this Chinese population. © 2005 Wiley‐Liss, Inc.</jats:p> |
| doi_str_mv | 10.1002/ijc.21463 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMjE0NjM |
| imprint | Wiley, 2006 |
| imprint_str_mv | Wiley, 2006 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
| issn | 1097-0215, 0020-7136 |
| issn_str_mv | 1097-0215, 0020-7136 |
| language | English |
| last_indexed | 2024-03-01T15:15:06.412Z |
| match_str | hu2006geneticvariantsinthemdm2promoterandlungcancerriskinachinesepopulation |
| mega_collection | Wiley (CrossRef) |
| physical | 1275-1278 |
| publishDate | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | International Journal of Cancer |
| source_id | 49 |
| spelling | Hu, Zhibin Ma, Hongxia Lu, Daru Qian, Ji Zhou, Jiannong Chen, Yijiang Xu, Lin Wang, Xinru Wei, Qingyi Shen, Hongbing 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.21463 <jats:title>Abstract</jats:title><jats:p>Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/deletion polymorphism in the constitutive promoter) were identified, and recently the T/G substitution (SNP309) has been demonstrated to alter the levels of <jats:italic>MDM2</jats:italic> gene products. In this molecular epidemiological study with 717 incident lung cancer cases and 1,083 cancer‐free controls, we genotyped these 2 promoter polymorphisms of <jats:italic>MDM2</jats:italic> and evaluated their associations with risk of lung cancer. We found that there were no significant associations between <jats:italic>MDM2</jats:italic> SNP309 variant genotypes and lung cancer risk (adjusted OR = 1.20, 95% CI = 0.95–1.53 for TG and adjusted OR = 1.12, 95% CI = 0.85–1.48 for GG, respectively). Similarly, we did not find evidence for any association between risk of lung cancer and <jats:italic>MDM2</jats:italic> insertion/deletion polymorphism. The findings suggest that these two <jats:italic>MDM2</jats:italic> promoter polymorphisms may not play a major role in lung cancer susceptibility in this Chinese population. © 2005 Wiley‐Liss, Inc.</jats:p> Genetic variants in the <i>MDM2</i> promoter and lung cancer risk in a Chinese population International Journal of Cancer |
| spellingShingle | Hu, Zhibin, Ma, Hongxia, Lu, Daru, Qian, Ji, Zhou, Jiannong, Chen, Yijiang, Xu, Lin, Wang, Xinru, Wei, Qingyi, Shen, Hongbing, International Journal of Cancer, Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population, Cancer Research, Oncology |
| title | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_full | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_fullStr | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_full_unstemmed | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_short | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| title_sort | genetic variants in the <i>mdm2</i> promoter and lung cancer risk in a chinese population |
| title_unstemmed | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.21463 |