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Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , |
| In: | International Journal of Cancer, 109, 2004, 6, S. 855-866 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Wesley, Umadevi V. Tiwari, Shakuntala Houghton, Alan N. Wesley, Umadevi V. Tiwari, Shakuntala Houghton, Alan N. |
|---|---|
| author |
Wesley, Umadevi V. Tiwari, Shakuntala Houghton, Alan N. |
| spellingShingle |
Wesley, Umadevi V. Tiwari, Shakuntala Houghton, Alan N. International Journal of Cancer Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells Cancer Research Oncology |
| author_sort |
wesley, umadevi v. |
| spelling |
Wesley, Umadevi V. Tiwari, Shakuntala Houghton, Alan N. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.20091 <jats:title>Abstract</jats:title><jats:p>Lung cancer is the leading cause of cancer death. Lung cancers produce a variety of mitogenic growth factors that stimulate tumor cell proliferation and migration. The cell surface protease, dipeptidyl peptidase IV (DPPIV), is involved in diverse biologic functions, including peptide‐mediated cellular growth and differentiation. DPPIV is expressed in various normal tissues, including lung tissue, and its expression is lost in many types of human cancers. DPPIV expression and its enzymatic activity are detected in normal bronchial and alveolar epithelium but different histologic subtypes of lung carcinomas lose DPPIV expression. To investigate the role of DPPIV in lung carcinoma, we examined the expression of DPPIV at both mRNA and protein levels in non small cell lung cancer (NSCLC) cell lines and normal human bronchial epithelial cells. DPPIV expression was detectable in normal lung epithelial cells, but was absent or markedly reduced in all NSCLC cell lines at both mRNA and protein levels. Restoration of DPPIV expression in NSCLC cells resulted in profound morphologic changes, inhibition of cell proliferation, anchorage‐independent growth, <jats:italic>in vitro</jats:italic> cell migration and tumorigenicity in nude mice. DPPIV reexpression also correlated with increased p21 expression, leading to induction of apoptosis and cell cycle arrest in G1 stage. These effects were accompanied by increased expression of cell surface proteins, fibroblast‐activating protein (Fapα) and CD44 that are associated with suppression of tumor growth and metastasis. Thus, DPPIV functions as a tumor suppressor, and its downregulation may contribute to the loss of growth control in NSCLC cells. © 2004 Wiley‐Liss, Inc.</jats:p> Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells International Journal of Cancer |
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Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_unstemmed |
Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_full |
Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_fullStr |
Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_full_unstemmed |
Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_short |
Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_sort |
role for dipeptidyl peptidase iv in tumor suppression of human non small cell lung carcinoma cells |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.20091 |
| publishDate |
2004 |
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855-866 |
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<jats:title>Abstract</jats:title><jats:p>Lung cancer is the leading cause of cancer death. Lung cancers produce a variety of mitogenic growth factors that stimulate tumor cell proliferation and migration. The cell surface protease, dipeptidyl peptidase IV (DPPIV), is involved in diverse biologic functions, including peptide‐mediated cellular growth and differentiation. DPPIV is expressed in various normal tissues, including lung tissue, and its expression is lost in many types of human cancers. DPPIV expression and its enzymatic activity are detected in normal bronchial and alveolar epithelium but different histologic subtypes of lung carcinomas lose DPPIV expression. To investigate the role of DPPIV in lung carcinoma, we examined the expression of DPPIV at both mRNA and protein levels in non small cell lung cancer (NSCLC) cell lines and normal human bronchial epithelial cells. DPPIV expression was detectable in normal lung epithelial cells, but was absent or markedly reduced in all NSCLC cell lines at both mRNA and protein levels. Restoration of DPPIV expression in NSCLC cells resulted in profound morphologic changes, inhibition of cell proliferation, anchorage‐independent growth, <jats:italic>in vitro</jats:italic> cell migration and tumorigenicity in nude mice. DPPIV reexpression also correlated with increased p21 expression, leading to induction of apoptosis and cell cycle arrest in G1 stage. These effects were accompanied by increased expression of cell surface proteins, fibroblast‐activating protein (Fapα) and CD44 that are associated with suppression of tumor growth and metastasis. Thus, DPPIV functions as a tumor suppressor, and its downregulation may contribute to the loss of growth control in NSCLC cells. © 2004 Wiley‐Liss, Inc.</jats:p> |
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| author | Wesley, Umadevi V., Tiwari, Shakuntala, Houghton, Alan N. |
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| description | <jats:title>Abstract</jats:title><jats:p>Lung cancer is the leading cause of cancer death. Lung cancers produce a variety of mitogenic growth factors that stimulate tumor cell proliferation and migration. The cell surface protease, dipeptidyl peptidase IV (DPPIV), is involved in diverse biologic functions, including peptide‐mediated cellular growth and differentiation. DPPIV is expressed in various normal tissues, including lung tissue, and its expression is lost in many types of human cancers. DPPIV expression and its enzymatic activity are detected in normal bronchial and alveolar epithelium but different histologic subtypes of lung carcinomas lose DPPIV expression. To investigate the role of DPPIV in lung carcinoma, we examined the expression of DPPIV at both mRNA and protein levels in non small cell lung cancer (NSCLC) cell lines and normal human bronchial epithelial cells. DPPIV expression was detectable in normal lung epithelial cells, but was absent or markedly reduced in all NSCLC cell lines at both mRNA and protein levels. Restoration of DPPIV expression in NSCLC cells resulted in profound morphologic changes, inhibition of cell proliferation, anchorage‐independent growth, <jats:italic>in vitro</jats:italic> cell migration and tumorigenicity in nude mice. DPPIV reexpression also correlated with increased p21 expression, leading to induction of apoptosis and cell cycle arrest in G1 stage. These effects were accompanied by increased expression of cell surface proteins, fibroblast‐activating protein (Fapα) and CD44 that are associated with suppression of tumor growth and metastasis. Thus, DPPIV functions as a tumor suppressor, and its downregulation may contribute to the loss of growth control in NSCLC cells. © 2004 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Wesley, Umadevi V. Tiwari, Shakuntala Houghton, Alan N. 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.20091 <jats:title>Abstract</jats:title><jats:p>Lung cancer is the leading cause of cancer death. Lung cancers produce a variety of mitogenic growth factors that stimulate tumor cell proliferation and migration. The cell surface protease, dipeptidyl peptidase IV (DPPIV), is involved in diverse biologic functions, including peptide‐mediated cellular growth and differentiation. DPPIV is expressed in various normal tissues, including lung tissue, and its expression is lost in many types of human cancers. DPPIV expression and its enzymatic activity are detected in normal bronchial and alveolar epithelium but different histologic subtypes of lung carcinomas lose DPPIV expression. To investigate the role of DPPIV in lung carcinoma, we examined the expression of DPPIV at both mRNA and protein levels in non small cell lung cancer (NSCLC) cell lines and normal human bronchial epithelial cells. DPPIV expression was detectable in normal lung epithelial cells, but was absent or markedly reduced in all NSCLC cell lines at both mRNA and protein levels. Restoration of DPPIV expression in NSCLC cells resulted in profound morphologic changes, inhibition of cell proliferation, anchorage‐independent growth, <jats:italic>in vitro</jats:italic> cell migration and tumorigenicity in nude mice. DPPIV reexpression also correlated with increased p21 expression, leading to induction of apoptosis and cell cycle arrest in G1 stage. These effects were accompanied by increased expression of cell surface proteins, fibroblast‐activating protein (Fapα) and CD44 that are associated with suppression of tumor growth and metastasis. Thus, DPPIV functions as a tumor suppressor, and its downregulation may contribute to the loss of growth control in NSCLC cells. © 2004 Wiley‐Liss, Inc.</jats:p> Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells International Journal of Cancer |
| spellingShingle | Wesley, Umadevi V., Tiwari, Shakuntala, Houghton, Alan N., International Journal of Cancer, Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells, Cancer Research, Oncology |
| title | Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_full | Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_fullStr | Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_full_unstemmed | Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_short | Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| title_sort | role for dipeptidyl peptidase iv in tumor suppression of human non small cell lung carcinoma cells |
| title_unstemmed | Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.20091 |