Eintrag weiter verarbeiten
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients
Gespeichert in:
| Zeitschriftentitel: | Human Psychopharmacology: Clinical and Experimental |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Human Psychopharmacology: Clinical and Experimental, 26, 2011, 6, S. 404-411 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Specka, Michael Bonnet, Udo Heilmann, Martin Schifano, Fabrizio Scherbaum, Norbert Specka, Michael Bonnet, Udo Heilmann, Martin Schifano, Fabrizio Scherbaum, Norbert |
|---|---|
| author |
Specka, Michael Bonnet, Udo Heilmann, Martin Schifano, Fabrizio Scherbaum, Norbert |
| spellingShingle |
Specka, Michael Bonnet, Udo Heilmann, Martin Schifano, Fabrizio Scherbaum, Norbert Human Psychopharmacology: Clinical and Experimental Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients Pharmacology (medical) Psychiatry and Mental health Neurology (clinical) Neurology |
| author_sort |
specka, michael |
| spelling |
Specka, Michael Bonnet, Udo Heilmann, Martin Schifano, Fabrizio Scherbaum, Norbert 0885-6222 1099-1077 Wiley Pharmacology (medical) Psychiatry and Mental health Neurology (clinical) Neurology http://dx.doi.org/10.1002/hup.1222 <jats:sec><jats:title>Objective</jats:title><jats:p>Cross‐sectional studies show that considerable proportions of opiate dependents in methadone maintenance treatment (MMT) consume benzodiazepines (BZD). The longitudinal patterns of BZD use over time were described here.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>After admission to MMT, patients from two outpatient MMT clinics (<jats:italic>n</jats:italic> = 345) were observed for up to 2 years whilst in treatment. The use of BZD, cannabis, opiates and cocaine was assessed by urine sampling carried out twice a month.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the whole sample, the mean BZD‐positive urine specimen rate was 0.36 during the first 3 months. Rates slightly decreased during the first year and remained stable afterwards (last observation carried forward). For study completers (<jats:italic>n</jats:italic> = 152), the rate decreased over time, from 0.31 (first 3‐month period) to 0.19 (last period; <jats:italic>p</jats:italic> < 0.001). According to a longitudinal cluster analysis, 26% of all patients showed a pattern of constantly high BZD‐positivity rates, mostly in combination with other substances. Inpatient detoxifications from BZD (carried out in 18% of cases) did not have a sustained effect on levels of BZD use.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>BZD consumption in MMT is often part of a polydrug consumption pattern and is associated with poorer treatment retention. It is necessary to further investigate the reasons for BZD use in MMT patients and to develop effective interventions to reduce levels of BZD consumption. Copyright © 2011 John Wiley & Sons, Ltd.</jats:p></jats:sec> Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients Human Psychopharmacology: Clinical and Experimental |
| doi_str_mv |
10.1002/hup.1222 |
| facet_avail |
Online |
| finc_class_facet |
Chemie und Pharmazie Medizin Psychologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9odXAuMTIyMg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9odXAuMTIyMg |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Wiley, 2011 |
| imprint_str_mv |
Wiley, 2011 |
| issn |
0885-6222 1099-1077 |
| issn_str_mv |
0885-6222 1099-1077 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
specka2011longitudinalpatternsofbenzodiazepineconsumptioninagermancohortofmethadonemaintenancetreatmentpatients |
| publishDateSort |
2011 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Human Psychopharmacology: Clinical and Experimental |
| source_id |
49 |
| title |
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_unstemmed |
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_full |
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_fullStr |
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_full_unstemmed |
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_short |
Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_sort |
longitudinal patterns of benzodiazepine consumption in a german cohort of methadone maintenance treatment patients |
| topic |
Pharmacology (medical) Psychiatry and Mental health Neurology (clinical) Neurology |
| url |
http://dx.doi.org/10.1002/hup.1222 |
| publishDate |
2011 |
| physical |
404-411 |
| description |
<jats:sec><jats:title>Objective</jats:title><jats:p>Cross‐sectional studies show that considerable proportions of opiate dependents in methadone maintenance treatment (MMT) consume benzodiazepines (BZD). The longitudinal patterns of BZD use over time were described here.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>After admission to MMT, patients from two outpatient MMT clinics (<jats:italic>n</jats:italic> = 345) were observed for up to 2 years whilst in treatment. The use of BZD, cannabis, opiates and cocaine was assessed by urine sampling carried out twice a month.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the whole sample, the mean BZD‐positive urine specimen rate was 0.36 during the first 3 months. Rates slightly decreased during the first year and remained stable afterwards (last observation carried forward). For study completers (<jats:italic>n</jats:italic> = 152), the rate decreased over time, from 0.31 (first 3‐month period) to 0.19 (last period; <jats:italic>p</jats:italic> < 0.001). According to a longitudinal cluster analysis, 26% of all patients showed a pattern of constantly high BZD‐positivity rates, mostly in combination with other substances. Inpatient detoxifications from BZD (carried out in 18% of cases) did not have a sustained effect on levels of BZD use.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>BZD consumption in MMT is often part of a polydrug consumption pattern and is associated with poorer treatment retention. It is necessary to further investigate the reasons for BZD use in MMT patients and to develop effective interventions to reduce levels of BZD consumption. Copyright © 2011 John Wiley & Sons, Ltd.</jats:p></jats:sec> |
| container_issue |
6 |
| container_start_page |
404 |
| container_title |
Human Psychopharmacology: Clinical and Experimental |
| container_volume |
26 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339296846348294 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:45:24.128Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Longitudinal+patterns+of+benzodiazepine+consumption+in+a+German+cohort+of+methadone+maintenance+treatment+patients&rft.date=2011-08-01&genre=article&issn=1099-1077&volume=26&issue=6&spage=404&epage=411&pages=404-411&jtitle=Human+Psychopharmacology%3A+Clinical+and+Experimental&atitle=Longitudinal+patterns+of+benzodiazepine+consumption+in+a+German+cohort+of+methadone+maintenance+treatment+patients&aulast=Scherbaum&aufirst=Norbert&rft_id=info%3Adoi%2F10.1002%2Fhup.1222&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792339296846348294 |
| author | Specka, Michael, Bonnet, Udo, Heilmann, Martin, Schifano, Fabrizio, Scherbaum, Norbert |
| author_facet | Specka, Michael, Bonnet, Udo, Heilmann, Martin, Schifano, Fabrizio, Scherbaum, Norbert, Specka, Michael, Bonnet, Udo, Heilmann, Martin, Schifano, Fabrizio, Scherbaum, Norbert |
| author_sort | specka, michael |
| container_issue | 6 |
| container_start_page | 404 |
| container_title | Human Psychopharmacology: Clinical and Experimental |
| container_volume | 26 |
| description | <jats:sec><jats:title>Objective</jats:title><jats:p>Cross‐sectional studies show that considerable proportions of opiate dependents in methadone maintenance treatment (MMT) consume benzodiazepines (BZD). The longitudinal patterns of BZD use over time were described here.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>After admission to MMT, patients from two outpatient MMT clinics (<jats:italic>n</jats:italic> = 345) were observed for up to 2 years whilst in treatment. The use of BZD, cannabis, opiates and cocaine was assessed by urine sampling carried out twice a month.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the whole sample, the mean BZD‐positive urine specimen rate was 0.36 during the first 3 months. Rates slightly decreased during the first year and remained stable afterwards (last observation carried forward). For study completers (<jats:italic>n</jats:italic> = 152), the rate decreased over time, from 0.31 (first 3‐month period) to 0.19 (last period; <jats:italic>p</jats:italic> < 0.001). According to a longitudinal cluster analysis, 26% of all patients showed a pattern of constantly high BZD‐positivity rates, mostly in combination with other substances. Inpatient detoxifications from BZD (carried out in 18% of cases) did not have a sustained effect on levels of BZD use.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>BZD consumption in MMT is often part of a polydrug consumption pattern and is associated with poorer treatment retention. It is necessary to further investigate the reasons for BZD use in MMT patients and to develop effective interventions to reduce levels of BZD consumption. Copyright © 2011 John Wiley & Sons, Ltd.</jats:p></jats:sec> |
| doi_str_mv | 10.1002/hup.1222 |
| facet_avail | Online |
| finc_class_facet | Chemie und Pharmazie, Medizin, Psychologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9odXAuMTIyMg |
| imprint | Wiley, 2011 |
| imprint_str_mv | Wiley, 2011 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0885-6222, 1099-1077 |
| issn_str_mv | 0885-6222, 1099-1077 |
| language | English |
| last_indexed | 2024-03-01T15:45:24.128Z |
| match_str | specka2011longitudinalpatternsofbenzodiazepineconsumptioninagermancohortofmethadonemaintenancetreatmentpatients |
| mega_collection | Wiley (CrossRef) |
| physical | 404-411 |
| publishDate | 2011 |
| publishDateSort | 2011 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Human Psychopharmacology: Clinical and Experimental |
| source_id | 49 |
| spelling | Specka, Michael Bonnet, Udo Heilmann, Martin Schifano, Fabrizio Scherbaum, Norbert 0885-6222 1099-1077 Wiley Pharmacology (medical) Psychiatry and Mental health Neurology (clinical) Neurology http://dx.doi.org/10.1002/hup.1222 <jats:sec><jats:title>Objective</jats:title><jats:p>Cross‐sectional studies show that considerable proportions of opiate dependents in methadone maintenance treatment (MMT) consume benzodiazepines (BZD). The longitudinal patterns of BZD use over time were described here.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>After admission to MMT, patients from two outpatient MMT clinics (<jats:italic>n</jats:italic> = 345) were observed for up to 2 years whilst in treatment. The use of BZD, cannabis, opiates and cocaine was assessed by urine sampling carried out twice a month.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the whole sample, the mean BZD‐positive urine specimen rate was 0.36 during the first 3 months. Rates slightly decreased during the first year and remained stable afterwards (last observation carried forward). For study completers (<jats:italic>n</jats:italic> = 152), the rate decreased over time, from 0.31 (first 3‐month period) to 0.19 (last period; <jats:italic>p</jats:italic> < 0.001). According to a longitudinal cluster analysis, 26% of all patients showed a pattern of constantly high BZD‐positivity rates, mostly in combination with other substances. Inpatient detoxifications from BZD (carried out in 18% of cases) did not have a sustained effect on levels of BZD use.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>BZD consumption in MMT is often part of a polydrug consumption pattern and is associated with poorer treatment retention. It is necessary to further investigate the reasons for BZD use in MMT patients and to develop effective interventions to reduce levels of BZD consumption. Copyright © 2011 John Wiley & Sons, Ltd.</jats:p></jats:sec> Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients Human Psychopharmacology: Clinical and Experimental |
| spellingShingle | Specka, Michael, Bonnet, Udo, Heilmann, Martin, Schifano, Fabrizio, Scherbaum, Norbert, Human Psychopharmacology: Clinical and Experimental, Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients, Pharmacology (medical), Psychiatry and Mental health, Neurology (clinical), Neurology |
| title | Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_full | Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_fullStr | Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_full_unstemmed | Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_short | Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| title_sort | longitudinal patterns of benzodiazepine consumption in a german cohort of methadone maintenance treatment patients |
| title_unstemmed | Longitudinal patterns of benzodiazepine consumption in a German cohort of methadone maintenance treatment patients |
| topic | Pharmacology (medical), Psychiatry and Mental health, Neurology (clinical), Neurology |
| url | http://dx.doi.org/10.1002/hup.1222 |