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Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients
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| Zeitschriftentitel: | Hematological Oncology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Hematological Oncology, 38, 2020, 3, S. 301-308 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Hosry, Jeff Miranda, Roberto N. Samaniego, Felipe Angelidakis, Georgios Torres, Harrys A. Hosry, Jeff Miranda, Roberto N. Samaniego, Felipe Angelidakis, Georgios Torres, Harrys A. |
|---|---|
| author |
Hosry, Jeff Miranda, Roberto N. Samaniego, Felipe Angelidakis, Georgios Torres, Harrys A. |
| spellingShingle |
Hosry, Jeff Miranda, Roberto N. Samaniego, Felipe Angelidakis, Georgios Torres, Harrys A. Hematological Oncology Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients Cancer Research Oncology Hematology General Medicine |
| author_sort |
hosry, jeff |
| spelling |
Hosry, Jeff Miranda, Roberto N. Samaniego, Felipe Angelidakis, Georgios Torres, Harrys A. 0278-0232 1099-1069 Wiley Cancer Research Oncology Hematology General Medicine http://dx.doi.org/10.1002/hon.2731 <jats:title>Abstract</jats:title><jats:p>Follicular lymphoma (FL) is the most common subtype of indolent non‐Hodgkin lymphoma. It has been hypothesized that chronic hepatitis C virus (HCV) infection stimulates <jats:italic>IGH‐BCL2</jats:italic> clone proliferation, leading to development of FL. Furthermore, regression of FL after antiviral treatment without chemotherapy has been reported in HCV‐infected patients. To clarify the relationship between HCV and FL, we compared the prevalence of <jats:italic>IGH‐BCL2</jats:italic> translocation and other clinicopathologic characteristics between HCV‐infected and HCV‐uninfected FL patients and determined the impact of HCV eradication on the oncologic outcomes of HCV‐infected FL patients. The study included HCV‐infected patients (cases) with FL seen at our institution during 2004‐2018. Cases were matched with HCV‐uninfected FL patients (controls) according to year of lymphoma diagnosis, sex, and hepatitis B serology. We studied 19 cases and 57 controls. More cases than controls had splenic involvement of FL (26% vs 5%, <jats:italic>P</jats:italic> = 0.02), higher histologic grade (grade 3 in 56% vs 24%, <jats:italic>P</jats:italic> = 0.01), absent or weak CD10 expression (42% vs 11%, <jats:italic>P</jats:italic> = 0.005), and absent BCL2 expression (33% vs 4%, <jats:italic>P</jats:italic> = 0.004). Compared to controls, cases had a lower rate of detection of <jats:italic>IGH‐BCL2</jats:italic> translocation (31% vs 68%, <jats:italic>P</jats:italic> = 0.02). Finally, cases with a sustained virologic response (virologic cure of HCV) had a better 10‐year overall survival rate than did cases not treated with antivirals or controls (<jats:italic>P</jats:italic> = 0.001). In conclusion, HCV‐infected patients with FL have unique clinicopathologic characteristics including improved overall survival with HCV eradication. The pathogenesis of FL in HCV‐infected patients seems unrelated to antiapoptotic effect of <jats:italic>IGH‐BCL2</jats:italic> rearrangement.</jats:p> Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients Hematological Oncology |
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| title |
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_unstemmed |
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_full |
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_fullStr |
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_full_unstemmed |
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_short |
Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_sort |
clinicopathologic characteristics of follicular lymphoma in hepatitis c virus‐infected patients |
| topic |
Cancer Research Oncology Hematology General Medicine |
| url |
http://dx.doi.org/10.1002/hon.2731 |
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2020 |
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301-308 |
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<jats:title>Abstract</jats:title><jats:p>Follicular lymphoma (FL) is the most common subtype of indolent non‐Hodgkin lymphoma. It has been hypothesized that chronic hepatitis C virus (HCV) infection stimulates <jats:italic>IGH‐BCL2</jats:italic> clone proliferation, leading to development of FL. Furthermore, regression of FL after antiviral treatment without chemotherapy has been reported in HCV‐infected patients. To clarify the relationship between HCV and FL, we compared the prevalence of <jats:italic>IGH‐BCL2</jats:italic> translocation and other clinicopathologic characteristics between HCV‐infected and HCV‐uninfected FL patients and determined the impact of HCV eradication on the oncologic outcomes of HCV‐infected FL patients. The study included HCV‐infected patients (cases) with FL seen at our institution during 2004‐2018. Cases were matched with HCV‐uninfected FL patients (controls) according to year of lymphoma diagnosis, sex, and hepatitis B serology. We studied 19 cases and 57 controls. More cases than controls had splenic involvement of FL (26% vs 5%, <jats:italic>P</jats:italic> = 0.02), higher histologic grade (grade 3 in 56% vs 24%, <jats:italic>P</jats:italic> = 0.01), absent or weak CD10 expression (42% vs 11%, <jats:italic>P</jats:italic> = 0.005), and absent BCL2 expression (33% vs 4%, <jats:italic>P</jats:italic> = 0.004). Compared to controls, cases had a lower rate of detection of <jats:italic>IGH‐BCL2</jats:italic> translocation (31% vs 68%, <jats:italic>P</jats:italic> = 0.02). Finally, cases with a sustained virologic response (virologic cure of HCV) had a better 10‐year overall survival rate than did cases not treated with antivirals or controls (<jats:italic>P</jats:italic> = 0.001). In conclusion, HCV‐infected patients with FL have unique clinicopathologic characteristics including improved overall survival with HCV eradication. The pathogenesis of FL in HCV‐infected patients seems unrelated to antiapoptotic effect of <jats:italic>IGH‐BCL2</jats:italic> rearrangement.</jats:p> |
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| author | Hosry, Jeff, Miranda, Roberto N., Samaniego, Felipe, Angelidakis, Georgios, Torres, Harrys A. |
| author_facet | Hosry, Jeff, Miranda, Roberto N., Samaniego, Felipe, Angelidakis, Georgios, Torres, Harrys A., Hosry, Jeff, Miranda, Roberto N., Samaniego, Felipe, Angelidakis, Georgios, Torres, Harrys A. |
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| description | <jats:title>Abstract</jats:title><jats:p>Follicular lymphoma (FL) is the most common subtype of indolent non‐Hodgkin lymphoma. It has been hypothesized that chronic hepatitis C virus (HCV) infection stimulates <jats:italic>IGH‐BCL2</jats:italic> clone proliferation, leading to development of FL. Furthermore, regression of FL after antiviral treatment without chemotherapy has been reported in HCV‐infected patients. To clarify the relationship between HCV and FL, we compared the prevalence of <jats:italic>IGH‐BCL2</jats:italic> translocation and other clinicopathologic characteristics between HCV‐infected and HCV‐uninfected FL patients and determined the impact of HCV eradication on the oncologic outcomes of HCV‐infected FL patients. The study included HCV‐infected patients (cases) with FL seen at our institution during 2004‐2018. Cases were matched with HCV‐uninfected FL patients (controls) according to year of lymphoma diagnosis, sex, and hepatitis B serology. We studied 19 cases and 57 controls. More cases than controls had splenic involvement of FL (26% vs 5%, <jats:italic>P</jats:italic> = 0.02), higher histologic grade (grade 3 in 56% vs 24%, <jats:italic>P</jats:italic> = 0.01), absent or weak CD10 expression (42% vs 11%, <jats:italic>P</jats:italic> = 0.005), and absent BCL2 expression (33% vs 4%, <jats:italic>P</jats:italic> = 0.004). Compared to controls, cases had a lower rate of detection of <jats:italic>IGH‐BCL2</jats:italic> translocation (31% vs 68%, <jats:italic>P</jats:italic> = 0.02). Finally, cases with a sustained virologic response (virologic cure of HCV) had a better 10‐year overall survival rate than did cases not treated with antivirals or controls (<jats:italic>P</jats:italic> = 0.001). In conclusion, HCV‐infected patients with FL have unique clinicopathologic characteristics including improved overall survival with HCV eradication. The pathogenesis of FL in HCV‐infected patients seems unrelated to antiapoptotic effect of <jats:italic>IGH‐BCL2</jats:italic> rearrangement.</jats:p> |
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| spelling | Hosry, Jeff Miranda, Roberto N. Samaniego, Felipe Angelidakis, Georgios Torres, Harrys A. 0278-0232 1099-1069 Wiley Cancer Research Oncology Hematology General Medicine http://dx.doi.org/10.1002/hon.2731 <jats:title>Abstract</jats:title><jats:p>Follicular lymphoma (FL) is the most common subtype of indolent non‐Hodgkin lymphoma. It has been hypothesized that chronic hepatitis C virus (HCV) infection stimulates <jats:italic>IGH‐BCL2</jats:italic> clone proliferation, leading to development of FL. Furthermore, regression of FL after antiviral treatment without chemotherapy has been reported in HCV‐infected patients. To clarify the relationship between HCV and FL, we compared the prevalence of <jats:italic>IGH‐BCL2</jats:italic> translocation and other clinicopathologic characteristics between HCV‐infected and HCV‐uninfected FL patients and determined the impact of HCV eradication on the oncologic outcomes of HCV‐infected FL patients. The study included HCV‐infected patients (cases) with FL seen at our institution during 2004‐2018. Cases were matched with HCV‐uninfected FL patients (controls) according to year of lymphoma diagnosis, sex, and hepatitis B serology. We studied 19 cases and 57 controls. More cases than controls had splenic involvement of FL (26% vs 5%, <jats:italic>P</jats:italic> = 0.02), higher histologic grade (grade 3 in 56% vs 24%, <jats:italic>P</jats:italic> = 0.01), absent or weak CD10 expression (42% vs 11%, <jats:italic>P</jats:italic> = 0.005), and absent BCL2 expression (33% vs 4%, <jats:italic>P</jats:italic> = 0.004). Compared to controls, cases had a lower rate of detection of <jats:italic>IGH‐BCL2</jats:italic> translocation (31% vs 68%, <jats:italic>P</jats:italic> = 0.02). Finally, cases with a sustained virologic response (virologic cure of HCV) had a better 10‐year overall survival rate than did cases not treated with antivirals or controls (<jats:italic>P</jats:italic> = 0.001). In conclusion, HCV‐infected patients with FL have unique clinicopathologic characteristics including improved overall survival with HCV eradication. The pathogenesis of FL in HCV‐infected patients seems unrelated to antiapoptotic effect of <jats:italic>IGH‐BCL2</jats:italic> rearrangement.</jats:p> Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients Hematological Oncology |
| spellingShingle | Hosry, Jeff, Miranda, Roberto N., Samaniego, Felipe, Angelidakis, Georgios, Torres, Harrys A., Hematological Oncology, Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients, Cancer Research, Oncology, Hematology, General Medicine |
| title | Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_full | Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_fullStr | Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_full_unstemmed | Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_short | Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| title_sort | clinicopathologic characteristics of follicular lymphoma in hepatitis c virus‐infected patients |
| title_unstemmed | Clinicopathologic characteristics of follicular lymphoma in hepatitis C virus‐infected patients |
| topic | Cancer Research, Oncology, Hematology, General Medicine |
| url | http://dx.doi.org/10.1002/hon.2731 |