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Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects
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Zeitschriftentitel: | ELECTROPHORESIS |
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Personen und Körperschaften: | , |
In: | ELECTROPHORESIS, 34, 2013, 13, S. 1852-1862 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
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Schlagwörter: |
author_facet |
Jabbar, Abdul Gasser, Robin B. Jabbar, Abdul Gasser, Robin B. |
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author |
Jabbar, Abdul Gasser, Robin B. |
spellingShingle |
Jabbar, Abdul Gasser, Robin B. ELECTROPHORESIS Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects Clinical Biochemistry Biochemistry Analytical Chemistry |
author_sort |
jabbar, abdul |
spelling |
Jabbar, Abdul Gasser, Robin B. 0173-0835 1522-2683 Wiley Clinical Biochemistry Biochemistry Analytical Chemistry http://dx.doi.org/10.1002/elps.201300078 <jats:p>Adult tapeworms of the genus <jats:italic>Echinococcus</jats:italic> (family Taeniidae) occur in the small intestines of carnivorous definitive hosts and are transmitted to particular intermediate mammalian hosts, in which they develop as fluid‐filled larvae (cysts) in internal organs (usually lung and liver), causing the disease echinococcosis. <jats:italic>Echinococcus</jats:italic> species are of major medical importance and also cause losses to the meat and livestock industries, mainly due to the condemnation of infected offal. Decisions regarding the treatment and control of echinococcosis rely on the accurate identification of species and population variants (strains). Conventional, phenetic methods for specific identification have some significant limitations. Despite advances in the development of molecular tools, there has been limited application of mutation scanning methods to species of <jats:italic>Echinococcus</jats:italic>. Here, we briefly review key genetic markers used for the identification of <jats:italic>Echinococcus</jats:italic> species and techniques for the analysis of genetic variation within and among populations, and the diagnosis of echinococcosis. We also discuss the benefits of utilizing mutation scanning approaches to elucidate the population genetics and epidemiology of <jats:italic>Echinococcus</jats:italic> species. These benefits are likely to become more evident following the complete characterization of the genomes of <jats:italic>E. granulosus</jats:italic> and <jats:italic>E. multilocularis</jats:italic>.</jats:p> Mutation scanning analysis of genetic variation within and among <i>Echinococcus</i> species: Implications and future prospects ELECTROPHORESIS |
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10.1002/elps.201300078 |
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title |
Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_unstemmed |
Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_full |
Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_fullStr |
Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_full_unstemmed |
Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_short |
Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_sort |
mutation scanning analysis of genetic variation within and among <i>echinococcus</i> species: implications and future prospects |
topic |
Clinical Biochemistry Biochemistry Analytical Chemistry |
url |
http://dx.doi.org/10.1002/elps.201300078 |
publishDate |
2013 |
physical |
1852-1862 |
description |
<jats:p>Adult tapeworms of the genus <jats:italic>Echinococcus</jats:italic> (family Taeniidae) occur in the small intestines of carnivorous definitive hosts and are transmitted to particular intermediate mammalian hosts, in which they develop as fluid‐filled larvae (cysts) in internal organs (usually lung and liver), causing the disease echinococcosis. <jats:italic>Echinococcus</jats:italic> species are of major medical importance and also cause losses to the meat and livestock industries, mainly due to the condemnation of infected offal. Decisions regarding the treatment and control of echinococcosis rely on the accurate identification of species and population variants (strains). Conventional, phenetic methods for specific identification have some significant limitations. Despite advances in the development of molecular tools, there has been limited application of mutation scanning methods to species of <jats:italic>Echinococcus</jats:italic>. Here, we briefly review key genetic markers used for the identification of <jats:italic>Echinococcus</jats:italic> species and techniques for the analysis of genetic variation within and among populations, and the diagnosis of echinococcosis. We also discuss the benefits of utilizing mutation scanning approaches to elucidate the population genetics and epidemiology of <jats:italic>Echinococcus</jats:italic> species. These benefits are likely to become more evident following the complete characterization of the genomes of <jats:italic>E. granulosus</jats:italic> and <jats:italic>E. multilocularis</jats:italic>.</jats:p> |
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description | <jats:p>Adult tapeworms of the genus <jats:italic>Echinococcus</jats:italic> (family Taeniidae) occur in the small intestines of carnivorous definitive hosts and are transmitted to particular intermediate mammalian hosts, in which they develop as fluid‐filled larvae (cysts) in internal organs (usually lung and liver), causing the disease echinococcosis. <jats:italic>Echinococcus</jats:italic> species are of major medical importance and also cause losses to the meat and livestock industries, mainly due to the condemnation of infected offal. Decisions regarding the treatment and control of echinococcosis rely on the accurate identification of species and population variants (strains). Conventional, phenetic methods for specific identification have some significant limitations. Despite advances in the development of molecular tools, there has been limited application of mutation scanning methods to species of <jats:italic>Echinococcus</jats:italic>. Here, we briefly review key genetic markers used for the identification of <jats:italic>Echinococcus</jats:italic> species and techniques for the analysis of genetic variation within and among populations, and the diagnosis of echinococcosis. We also discuss the benefits of utilizing mutation scanning approaches to elucidate the population genetics and epidemiology of <jats:italic>Echinococcus</jats:italic> species. These benefits are likely to become more evident following the complete characterization of the genomes of <jats:italic>E. granulosus</jats:italic> and <jats:italic>E. multilocularis</jats:italic>.</jats:p> |
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spelling | Jabbar, Abdul Gasser, Robin B. 0173-0835 1522-2683 Wiley Clinical Biochemistry Biochemistry Analytical Chemistry http://dx.doi.org/10.1002/elps.201300078 <jats:p>Adult tapeworms of the genus <jats:italic>Echinococcus</jats:italic> (family Taeniidae) occur in the small intestines of carnivorous definitive hosts and are transmitted to particular intermediate mammalian hosts, in which they develop as fluid‐filled larvae (cysts) in internal organs (usually lung and liver), causing the disease echinococcosis. <jats:italic>Echinococcus</jats:italic> species are of major medical importance and also cause losses to the meat and livestock industries, mainly due to the condemnation of infected offal. Decisions regarding the treatment and control of echinococcosis rely on the accurate identification of species and population variants (strains). Conventional, phenetic methods for specific identification have some significant limitations. Despite advances in the development of molecular tools, there has been limited application of mutation scanning methods to species of <jats:italic>Echinococcus</jats:italic>. Here, we briefly review key genetic markers used for the identification of <jats:italic>Echinococcus</jats:italic> species and techniques for the analysis of genetic variation within and among populations, and the diagnosis of echinococcosis. We also discuss the benefits of utilizing mutation scanning approaches to elucidate the population genetics and epidemiology of <jats:italic>Echinococcus</jats:italic> species. These benefits are likely to become more evident following the complete characterization of the genomes of <jats:italic>E. granulosus</jats:italic> and <jats:italic>E. multilocularis</jats:italic>.</jats:p> Mutation scanning analysis of genetic variation within and among <i>Echinococcus</i> species: Implications and future prospects ELECTROPHORESIS |
spellingShingle | Jabbar, Abdul, Gasser, Robin B., ELECTROPHORESIS, Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects, Clinical Biochemistry, Biochemistry, Analytical Chemistry |
title | Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_full | Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_fullStr | Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_full_unstemmed | Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_short | Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
title_sort | mutation scanning analysis of genetic variation within and among <i>echinococcus</i> species: implications and future prospects |
title_unstemmed | Mutation scanning analysis of genetic variation within and among Echinococcus species: Implications and future prospects |
topic | Clinical Biochemistry, Biochemistry, Analytical Chemistry |
url | http://dx.doi.org/10.1002/elps.201300078 |