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Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles
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| Zeitschriftentitel: | Electroanalysis |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Electroanalysis, 7, 1995, 2, S. 189-193 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Fernández, M. C. Alonso, R. M. Jiménez, R. M. Rodríguez, F. J. Fernández, M. C. Alonso, R. M. Jiménez, R. M. Rodríguez, F. J. |
|---|---|
| author |
Fernández, M. C. Alonso, R. M. Jiménez, R. M. Rodríguez, F. J. |
| spellingShingle |
Fernández, M. C. Alonso, R. M. Jiménez, R. M. Rodríguez, F. J. Electroanalysis Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles Electrochemistry Analytical Chemistry |
| author_sort |
fernández, m. c. |
| spelling |
Fernández, M. C. Alonso, R. M. Jiménez, R. M. Rodríguez, F. J. 1040-0397 1521-4109 Wiley Electrochemistry Analytical Chemistry http://dx.doi.org/10.1002/elan.1140070216 <jats:title>Abstract</jats:title><jats:p>An electroanalytical study of three aminohalogenbenzophenones: 2‐amino‐5‐chlorobenzophenone (MCB), 2‐amino‐2′,5‐dichlorobenzo‐phenone (DCB), and 2‐amino‐5‐bromo‐2′‐fluorobenzophenone (BrFB); metabolites of the psychotropic drugs benzodiazepinooxazoles and benzodiazepines, has been carried out at a glassy carbon electrode using different voltammetric techniques. The compounds studied are electrooxidizable in a hydroalcoholic medium (MeOH:H<jats:sub>2</jats:sub>O, 10 : 90), 0.5 <jats:sc>M</jats:sc> KC1, and a pH range of 1–13. The oxidation processes are irreversible and predominantly diffusion controlled. On the basis of the oxidation process, voltammetric methods have been developed that allow the determination of aminohalogenbenzophenones from 0.2 to 15ppm for MCB and BrFB, and 0.2 to 14ppm for DCB; with a reproducibility in terms of relative standard deviation (RSD) lower than 5.2% for 10 determinations of 10 ppm solutions of MCB, DCB, and BrFB. Detection limits of 200ppb (μg/L) for MCB and DCB, and 100ppb for BrFB were obtained. The voltammetric method developed for DCB has been applied to the indirect determination of Cloxazolam in tablets.</jats:p> Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles Electroanalysis |
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| title |
Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_unstemmed |
Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_full |
Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_fullStr |
Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_full_unstemmed |
Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_short |
Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_sort |
oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| topic |
Electrochemistry Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/elan.1140070216 |
| publishDate |
1995 |
| physical |
189-193 |
| description |
<jats:title>Abstract</jats:title><jats:p>An electroanalytical study of three aminohalogenbenzophenones: 2‐amino‐5‐chlorobenzophenone (MCB), 2‐amino‐2′,5‐dichlorobenzo‐phenone (DCB), and 2‐amino‐5‐bromo‐2′‐fluorobenzophenone (BrFB); metabolites of the psychotropic drugs benzodiazepinooxazoles and benzodiazepines, has been carried out at a glassy carbon electrode using different voltammetric techniques. The compounds studied are electrooxidizable in a hydroalcoholic medium (MeOH:H<jats:sub>2</jats:sub>O, 10 : 90), 0.5 <jats:sc>M</jats:sc> KC1, and a pH range of 1–13. The oxidation processes are irreversible and predominantly diffusion controlled. On the basis of the oxidation process, voltammetric methods have been developed that allow the determination of aminohalogenbenzophenones from 0.2 to 15ppm for MCB and BrFB, and 0.2 to 14ppm for DCB; with a reproducibility in terms of relative standard deviation (RSD) lower than 5.2% for 10 determinations of 10 ppm solutions of MCB, DCB, and BrFB. Detection limits of 200ppb (μg/L) for MCB and DCB, and 100ppb for BrFB were obtained. The voltammetric method developed for DCB has been applied to the indirect determination of Cloxazolam in tablets.</jats:p> |
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| author | Fernández, M. C., Alonso, R. M., Jiménez, R. M., Rodríguez, F. J. |
| author_facet | Fernández, M. C., Alonso, R. M., Jiménez, R. M., Rodríguez, F. J., Fernández, M. C., Alonso, R. M., Jiménez, R. M., Rodríguez, F. J. |
| author_sort | fernández, m. c. |
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| description | <jats:title>Abstract</jats:title><jats:p>An electroanalytical study of three aminohalogenbenzophenones: 2‐amino‐5‐chlorobenzophenone (MCB), 2‐amino‐2′,5‐dichlorobenzo‐phenone (DCB), and 2‐amino‐5‐bromo‐2′‐fluorobenzophenone (BrFB); metabolites of the psychotropic drugs benzodiazepinooxazoles and benzodiazepines, has been carried out at a glassy carbon electrode using different voltammetric techniques. The compounds studied are electrooxidizable in a hydroalcoholic medium (MeOH:H<jats:sub>2</jats:sub>O, 10 : 90), 0.5 <jats:sc>M</jats:sc> KC1, and a pH range of 1–13. The oxidation processes are irreversible and predominantly diffusion controlled. On the basis of the oxidation process, voltammetric methods have been developed that allow the determination of aminohalogenbenzophenones from 0.2 to 15ppm for MCB and BrFB, and 0.2 to 14ppm for DCB; with a reproducibility in terms of relative standard deviation (RSD) lower than 5.2% for 10 determinations of 10 ppm solutions of MCB, DCB, and BrFB. Detection limits of 200ppb (μg/L) for MCB and DCB, and 100ppb for BrFB were obtained. The voltammetric method developed for DCB has been applied to the indirect determination of Cloxazolam in tablets.</jats:p> |
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| imprint | Wiley, 1995 |
| imprint_str_mv | Wiley, 1995 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
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| physical | 189-193 |
| publishDate | 1995 |
| publishDateSort | 1995 |
| publisher | Wiley |
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| series | Electroanalysis |
| source_id | 49 |
| spelling | Fernández, M. C. Alonso, R. M. Jiménez, R. M. Rodríguez, F. J. 1040-0397 1521-4109 Wiley Electrochemistry Analytical Chemistry http://dx.doi.org/10.1002/elan.1140070216 <jats:title>Abstract</jats:title><jats:p>An electroanalytical study of three aminohalogenbenzophenones: 2‐amino‐5‐chlorobenzophenone (MCB), 2‐amino‐2′,5‐dichlorobenzo‐phenone (DCB), and 2‐amino‐5‐bromo‐2′‐fluorobenzophenone (BrFB); metabolites of the psychotropic drugs benzodiazepinooxazoles and benzodiazepines, has been carried out at a glassy carbon electrode using different voltammetric techniques. The compounds studied are electrooxidizable in a hydroalcoholic medium (MeOH:H<jats:sub>2</jats:sub>O, 10 : 90), 0.5 <jats:sc>M</jats:sc> KC1, and a pH range of 1–13. The oxidation processes are irreversible and predominantly diffusion controlled. On the basis of the oxidation process, voltammetric methods have been developed that allow the determination of aminohalogenbenzophenones from 0.2 to 15ppm for MCB and BrFB, and 0.2 to 14ppm for DCB; with a reproducibility in terms of relative standard deviation (RSD) lower than 5.2% for 10 determinations of 10 ppm solutions of MCB, DCB, and BrFB. Detection limits of 200ppb (μg/L) for MCB and DCB, and 100ppb for BrFB were obtained. The voltammetric method developed for DCB has been applied to the indirect determination of Cloxazolam in tablets.</jats:p> Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles Electroanalysis |
| spellingShingle | Fernández, M. C., Alonso, R. M., Jiménez, R. M., Rodríguez, F. J., Electroanalysis, Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles, Electrochemistry, Analytical Chemistry |
| title | Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_full | Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_fullStr | Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_full_unstemmed | Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_short | Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_sort | oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| title_unstemmed | Oxidative behavior of aminohalogenbenzophenones – indirect determination of benzodiazepinooxazoles |
| topic | Electrochemistry, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/elan.1140070216 |