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Role of T cells in a murine model of Escherichia coli sepsis
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| Zeitschriftentitel: | European Journal of Immunology |
|---|---|
| Personen und Körperschaften: | , |
| In: | European Journal of Immunology, 37, 2007, 11, S. 3101-3110 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
van Schaik, Sandrijn M. Abbas, Abul K. van Schaik, Sandrijn M. Abbas, Abul K. |
|---|---|
| author |
van Schaik, Sandrijn M. Abbas, Abul K. |
| spellingShingle |
van Schaik, Sandrijn M. Abbas, Abul K. European Journal of Immunology Role of T cells in a murine model of Escherichia coli sepsis Immunology Immunology and Allergy |
| author_sort |
van schaik, sandrijn m. |
| spelling |
van Schaik, Sandrijn M. Abbas, Abul K. 0014-2980 1521-4141 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1002/eji.200737295 <jats:title>Abstract</jats:title><jats:p>To study the role of T cells in gram‐negative sepsis, we developed a mouse model in which i.v. injection of <jats:italic>Escherichia coli</jats:italic> results in severe systemic illness, with high mortality rates after day 5. A large proportion of both CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> T cells are activated within 1 day after infection, as evidenced by up‐regulation of CD69 and down‐regulation of CD62L. Even more surprisingly, T cell‐deficient mice exhibit markedly decreased disease severity compared to WT mice, indicating a pathogenic role of T cells. Mice lacking IFN‐γ also show diminished disease, and exhibit reduced T cell activation. Therefore, the pathogenic role of T cells may be mediated by IFN‐γ. Both T cell‐ and IFN‐γ‐deficient mice have reduced serum IL‐6 levels compared to WT mice, suggesting that T cells may stimulate innate immune responses, resulting in enhancement of disease. These data indicate an important role for T cells in a mouse model of <jats:italic>E. coli</jats:italic> sepsis, and reveal an unexpected early and pathogenic T cell response to this bacterial infection.</jats:p> Role of T cells in a murine model of <i>Escherichia coli</i> sepsis European Journal of Immunology |
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| title |
Role of T cells in a murine model of Escherichia coli sepsis |
| title_unstemmed |
Role of T cells in a murine model of Escherichia coli sepsis |
| title_full |
Role of T cells in a murine model of Escherichia coli sepsis |
| title_fullStr |
Role of T cells in a murine model of Escherichia coli sepsis |
| title_full_unstemmed |
Role of T cells in a murine model of Escherichia coli sepsis |
| title_short |
Role of T cells in a murine model of Escherichia coli sepsis |
| title_sort |
role of t cells in a murine model of <i>escherichia coli</i> sepsis |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/eji.200737295 |
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2007 |
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3101-3110 |
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<jats:title>Abstract</jats:title><jats:p>To study the role of T cells in gram‐negative sepsis, we developed a mouse model in which i.v. injection of <jats:italic>Escherichia coli</jats:italic> results in severe systemic illness, with high mortality rates after day 5. A large proportion of both CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> T cells are activated within 1 day after infection, as evidenced by up‐regulation of CD69 and down‐regulation of CD62L. Even more surprisingly, T cell‐deficient mice exhibit markedly decreased disease severity compared to WT mice, indicating a pathogenic role of T cells. Mice lacking IFN‐γ also show diminished disease, and exhibit reduced T cell activation. Therefore, the pathogenic role of T cells may be mediated by IFN‐γ. Both T cell‐ and IFN‐γ‐deficient mice have reduced serum IL‐6 levels compared to WT mice, suggesting that T cells may stimulate innate immune responses, resulting in enhancement of disease. These data indicate an important role for T cells in a mouse model of <jats:italic>E. coli</jats:italic> sepsis, and reveal an unexpected early and pathogenic T cell response to this bacterial infection.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>To study the role of T cells in gram‐negative sepsis, we developed a mouse model in which i.v. injection of <jats:italic>Escherichia coli</jats:italic> results in severe systemic illness, with high mortality rates after day 5. A large proportion of both CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> T cells are activated within 1 day after infection, as evidenced by up‐regulation of CD69 and down‐regulation of CD62L. Even more surprisingly, T cell‐deficient mice exhibit markedly decreased disease severity compared to WT mice, indicating a pathogenic role of T cells. Mice lacking IFN‐γ also show diminished disease, and exhibit reduced T cell activation. Therefore, the pathogenic role of T cells may be mediated by IFN‐γ. Both T cell‐ and IFN‐γ‐deficient mice have reduced serum IL‐6 levels compared to WT mice, suggesting that T cells may stimulate innate immune responses, resulting in enhancement of disease. These data indicate an important role for T cells in a mouse model of <jats:italic>E. coli</jats:italic> sepsis, and reveal an unexpected early and pathogenic T cell response to this bacterial infection.</jats:p> |
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| spelling | van Schaik, Sandrijn M. Abbas, Abul K. 0014-2980 1521-4141 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1002/eji.200737295 <jats:title>Abstract</jats:title><jats:p>To study the role of T cells in gram‐negative sepsis, we developed a mouse model in which i.v. injection of <jats:italic>Escherichia coli</jats:italic> results in severe systemic illness, with high mortality rates after day 5. A large proportion of both CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> T cells are activated within 1 day after infection, as evidenced by up‐regulation of CD69 and down‐regulation of CD62L. Even more surprisingly, T cell‐deficient mice exhibit markedly decreased disease severity compared to WT mice, indicating a pathogenic role of T cells. Mice lacking IFN‐γ also show diminished disease, and exhibit reduced T cell activation. Therefore, the pathogenic role of T cells may be mediated by IFN‐γ. Both T cell‐ and IFN‐γ‐deficient mice have reduced serum IL‐6 levels compared to WT mice, suggesting that T cells may stimulate innate immune responses, resulting in enhancement of disease. These data indicate an important role for T cells in a mouse model of <jats:italic>E. coli</jats:italic> sepsis, and reveal an unexpected early and pathogenic T cell response to this bacterial infection.</jats:p> Role of T cells in a murine model of <i>Escherichia coli</i> sepsis European Journal of Immunology |
| spellingShingle | van Schaik, Sandrijn M., Abbas, Abul K., European Journal of Immunology, Role of T cells in a murine model of Escherichia coli sepsis, Immunology, Immunology and Allergy |
| title | Role of T cells in a murine model of Escherichia coli sepsis |
| title_full | Role of T cells in a murine model of Escherichia coli sepsis |
| title_fullStr | Role of T cells in a murine model of Escherichia coli sepsis |
| title_full_unstemmed | Role of T cells in a murine model of Escherichia coli sepsis |
| title_short | Role of T cells in a murine model of Escherichia coli sepsis |
| title_sort | role of t cells in a murine model of <i>escherichia coli</i> sepsis |
| title_unstemmed | Role of T cells in a murine model of Escherichia coli sepsis |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/eji.200737295 |