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Spred2 expression during mouse development
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| Zeitschriftentitel: | Developmental Dynamics |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Developmental Dynamics, 239, 2010, 11, S. 3072-3085 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Tuduce, Ioana Laura Schuh, Kai Bundschu, Karin Tuduce, Ioana Laura Schuh, Kai Bundschu, Karin |
|---|---|
| author |
Tuduce, Ioana Laura Schuh, Kai Bundschu, Karin |
| spellingShingle |
Tuduce, Ioana Laura Schuh, Kai Bundschu, Karin Developmental Dynamics Spred2 expression during mouse development Developmental Biology |
| author_sort |
tuduce, ioana laura |
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Tuduce, Ioana Laura Schuh, Kai Bundschu, Karin 1058-8388 1097-0177 Wiley Developmental Biology http://dx.doi.org/10.1002/dvdy.22432 <jats:title>Abstract</jats:title><jats:p>SPREDs (Sprouty‐related proteins with Ena/Vasodilator‐stimulated phosphoprotein homology‐1 domain) are known membrane‐associated modulators of receptor tyrosine kinases by inhibiting the mitogen‐activated protein kinase (MAPK) signaling pathway. Although <jats:italic>Spred2</jats:italic><jats:sup>−/−</jats:sup> mice exhibit dwarfism and increase of early haematopoiesis, the precise expression and role of SPRED2 in mouse development remains unknown. Here, we demonstrate a detailed <jats:italic>Spred2</jats:italic> expression pattern during mouse development using X‐Gal stainings from samples of a gene‐trapped <jats:italic>Spred2</jats:italic> mouse line. In early stages, <jats:italic>Spred2</jats:italic> was highly expressed in ectodermal and mesodermal tissues, and later on in developing neural tissue, heart, lung, intestine, urogenital tract, and limbs. Strikingly, we observed that <jats:italic>Spred2</jats:italic> was mainly expressed at leading edges of further outgrowing structures and in folds of newly forming grooves. Therefore, SPRED2 is likely involved in the regulation of dynamic developmental processes. These new data provide valuable information for further studies regarding the still enigmatic physiological SPRED functions during mouse development. Developmental Dynamics 239:3072–3085, 2010. © 2010 Wiley‐Liss, Inc.</jats:p> <i>Spred2</i> expression during mouse development Developmental Dynamics |
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Spred2 expression during mouse development |
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Spred2 expression during mouse development |
| title_full |
Spred2 expression during mouse development |
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Spred2 expression during mouse development |
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Spred2 expression during mouse development |
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Spred2 expression during mouse development |
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<i>spred2</i> expression during mouse development |
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Developmental Biology |
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http://dx.doi.org/10.1002/dvdy.22432 |
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2010 |
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3072-3085 |
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<jats:title>Abstract</jats:title><jats:p>SPREDs (Sprouty‐related proteins with Ena/Vasodilator‐stimulated phosphoprotein homology‐1 domain) are known membrane‐associated modulators of receptor tyrosine kinases by inhibiting the mitogen‐activated protein kinase (MAPK) signaling pathway. Although <jats:italic>Spred2</jats:italic><jats:sup>−/−</jats:sup> mice exhibit dwarfism and increase of early haematopoiesis, the precise expression and role of SPRED2 in mouse development remains unknown. Here, we demonstrate a detailed <jats:italic>Spred2</jats:italic> expression pattern during mouse development using X‐Gal stainings from samples of a gene‐trapped <jats:italic>Spred2</jats:italic> mouse line. In early stages, <jats:italic>Spred2</jats:italic> was highly expressed in ectodermal and mesodermal tissues, and later on in developing neural tissue, heart, lung, intestine, urogenital tract, and limbs. Strikingly, we observed that <jats:italic>Spred2</jats:italic> was mainly expressed at leading edges of further outgrowing structures and in folds of newly forming grooves. Therefore, SPRED2 is likely involved in the regulation of dynamic developmental processes. These new data provide valuable information for further studies regarding the still enigmatic physiological SPRED functions during mouse development. Developmental Dynamics 239:3072–3085, 2010. © 2010 Wiley‐Liss, Inc.</jats:p> |
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| author | Tuduce, Ioana Laura, Schuh, Kai, Bundschu, Karin |
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| description | <jats:title>Abstract</jats:title><jats:p>SPREDs (Sprouty‐related proteins with Ena/Vasodilator‐stimulated phosphoprotein homology‐1 domain) are known membrane‐associated modulators of receptor tyrosine kinases by inhibiting the mitogen‐activated protein kinase (MAPK) signaling pathway. Although <jats:italic>Spred2</jats:italic><jats:sup>−/−</jats:sup> mice exhibit dwarfism and increase of early haematopoiesis, the precise expression and role of SPRED2 in mouse development remains unknown. Here, we demonstrate a detailed <jats:italic>Spred2</jats:italic> expression pattern during mouse development using X‐Gal stainings from samples of a gene‐trapped <jats:italic>Spred2</jats:italic> mouse line. In early stages, <jats:italic>Spred2</jats:italic> was highly expressed in ectodermal and mesodermal tissues, and later on in developing neural tissue, heart, lung, intestine, urogenital tract, and limbs. Strikingly, we observed that <jats:italic>Spred2</jats:italic> was mainly expressed at leading edges of further outgrowing structures and in folds of newly forming grooves. Therefore, SPRED2 is likely involved in the regulation of dynamic developmental processes. These new data provide valuable information for further studies regarding the still enigmatic physiological SPRED functions during mouse development. Developmental Dynamics 239:3072–3085, 2010. © 2010 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Tuduce, Ioana Laura Schuh, Kai Bundschu, Karin 1058-8388 1097-0177 Wiley Developmental Biology http://dx.doi.org/10.1002/dvdy.22432 <jats:title>Abstract</jats:title><jats:p>SPREDs (Sprouty‐related proteins with Ena/Vasodilator‐stimulated phosphoprotein homology‐1 domain) are known membrane‐associated modulators of receptor tyrosine kinases by inhibiting the mitogen‐activated protein kinase (MAPK) signaling pathway. Although <jats:italic>Spred2</jats:italic><jats:sup>−/−</jats:sup> mice exhibit dwarfism and increase of early haematopoiesis, the precise expression and role of SPRED2 in mouse development remains unknown. Here, we demonstrate a detailed <jats:italic>Spred2</jats:italic> expression pattern during mouse development using X‐Gal stainings from samples of a gene‐trapped <jats:italic>Spred2</jats:italic> mouse line. In early stages, <jats:italic>Spred2</jats:italic> was highly expressed in ectodermal and mesodermal tissues, and later on in developing neural tissue, heart, lung, intestine, urogenital tract, and limbs. Strikingly, we observed that <jats:italic>Spred2</jats:italic> was mainly expressed at leading edges of further outgrowing structures and in folds of newly forming grooves. Therefore, SPRED2 is likely involved in the regulation of dynamic developmental processes. These new data provide valuable information for further studies regarding the still enigmatic physiological SPRED functions during mouse development. Developmental Dynamics 239:3072–3085, 2010. © 2010 Wiley‐Liss, Inc.</jats:p> <i>Spred2</i> expression during mouse development Developmental Dynamics |
| spellingShingle | Tuduce, Ioana Laura, Schuh, Kai, Bundschu, Karin, Developmental Dynamics, Spred2 expression during mouse development, Developmental Biology |
| title | Spred2 expression during mouse development |
| title_full | Spred2 expression during mouse development |
| title_fullStr | Spred2 expression during mouse development |
| title_full_unstemmed | Spred2 expression during mouse development |
| title_short | Spred2 expression during mouse development |
| title_sort | <i>spred2</i> expression during mouse development |
| title_unstemmed | Spred2 expression during mouse development |
| topic | Developmental Biology |
| url | http://dx.doi.org/10.1002/dvdy.22432 |