Eintrag weiter verarbeiten
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish
Gespeichert in:
| Zeitschriftentitel: | Developmental Dynamics |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Developmental Dynamics, 243, 2014, 10, S. 1338-1351 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Yao, Di Zhao, Feng Wu, Ying Wang, Jialiang Dong, Wei Zhao, Jue Zhu, Zuoyan Liu, Dong Yao, Di Zhao, Feng Wu, Ying Wang, Jialiang Dong, Wei Zhao, Jue Zhu, Zuoyan Liu, Dong |
|---|---|
| author |
Yao, Di Zhao, Feng Wu, Ying Wang, Jialiang Dong, Wei Zhao, Jue Zhu, Zuoyan Liu, Dong |
| spellingShingle |
Yao, Di Zhao, Feng Wu, Ying Wang, Jialiang Dong, Wei Zhao, Jue Zhu, Zuoyan Liu, Dong Developmental Dynamics Dissecting the differentiation process of the preplacodal ectoderm in zebrafish Developmental Biology |
| author_sort |
yao, di |
| spelling |
Yao, Di Zhao, Feng Wu, Ying Wang, Jialiang Dong, Wei Zhao, Jue Zhu, Zuoyan Liu, Dong 1058-8388 1097-0177 Wiley Developmental Biology http://dx.doi.org/10.1002/dvdy.24160 <jats:p><jats:styled-content>Background:</jats:styled-content> The preplacodal region (PPR) is a region of specialized ectoderm at the border of neural and nonneural ectoderm (NNE). Coordinated Bmp, Fgf, and Wnt signals are known to drive PPR development; however, the underlying mechanism is unknown. <jats:styled-content>Results:</jats:styled-content> We identified key components involved in PPR differentiation. The mesoderm/marginal Wnts at the early gastrula stage trigger differentiation by allowing the adjacent NNE border cells to start adopting caudal PPR fates; otherwise, the development of caudal PPR identity is hindered due to the persistent presence of <jats:italic>gata3</jats:italic> mRNA. The caudal PPR fate dominates when <jats:italic>foxi1</jats:italic> expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) reduces the otic‐epibranchial placodal domain. When the Gata3 level is manipulated at the fertilized egg stage or near 6 hpf, the lens is always affected. In establishing PPR polarity, both Gata3 and Foxi1 inhibit Bmp signaling, whereas Foxi1 inhibits, but Gata3 enhances, Fgf sensitivity of the PPR cells. <jats:styled-content>Conclusions:</jats:styled-content> Our study reveals that in zebrafish, (1) the PPR at the shield stage may enter a developmental state when the PPR cells preferentially adopt a particular placodal fate and (2) a network of genetically linked factors, including Wnt/beta‐catenin, Fgfr, Bmp, Gata3, and Foxi1, direct the process of PPR differentiation. <jats:italic>Developmental Dynamics 243:1338–1351, 2014</jats:italic>. © 2014 Wiley Periodicals, Inc.</jats:p> Dissecting the differentiation process of the preplacodal ectoderm in zebrafish Developmental Dynamics |
| doi_str_mv |
10.1002/dvdy.24160 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9kdmR5LjI0MTYw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9kdmR5LjI0MTYw |
| institution |
DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 |
| imprint |
Wiley, 2014 |
| imprint_str_mv |
Wiley, 2014 |
| issn |
1058-8388 1097-0177 |
| issn_str_mv |
1058-8388 1097-0177 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
yao2014dissectingthedifferentiationprocessofthepreplacodalectoderminzebrafish |
| publishDateSort |
2014 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Developmental Dynamics |
| source_id |
49 |
| title |
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_unstemmed |
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_full |
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_fullStr |
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_full_unstemmed |
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_short |
Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_sort |
dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| topic |
Developmental Biology |
| url |
http://dx.doi.org/10.1002/dvdy.24160 |
| publishDate |
2014 |
| physical |
1338-1351 |
| description |
<jats:p><jats:styled-content>Background:</jats:styled-content> The preplacodal region (PPR) is a region of specialized ectoderm at the border of neural and nonneural ectoderm (NNE). Coordinated Bmp, Fgf, and Wnt signals are known to drive PPR development; however, the underlying mechanism is unknown. <jats:styled-content>Results:</jats:styled-content> We identified key components involved in PPR differentiation. The mesoderm/marginal Wnts at the early gastrula stage trigger differentiation by allowing the adjacent NNE border cells to start adopting caudal PPR fates; otherwise, the development of caudal PPR identity is hindered due to the persistent presence of <jats:italic>gata3</jats:italic> mRNA. The caudal PPR fate dominates when <jats:italic>foxi1</jats:italic> expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) reduces the otic‐epibranchial placodal domain. When the Gata3 level is manipulated at the fertilized egg stage or near 6 hpf, the lens is always affected. In establishing PPR polarity, both Gata3 and Foxi1 inhibit Bmp signaling, whereas Foxi1 inhibits, but Gata3 enhances, Fgf sensitivity of the PPR cells. <jats:styled-content>Conclusions:</jats:styled-content> Our study reveals that in zebrafish, (1) the PPR at the shield stage may enter a developmental state when the PPR cells preferentially adopt a particular placodal fate and (2) a network of genetically linked factors, including Wnt/beta‐catenin, Fgfr, Bmp, Gata3, and Foxi1, direct the process of PPR differentiation. <jats:italic>Developmental Dynamics 243:1338–1351, 2014</jats:italic>. © 2014 Wiley Periodicals, Inc.</jats:p> |
| container_issue |
10 |
| container_start_page |
1338 |
| container_title |
Developmental Dynamics |
| container_volume |
243 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337271380246531 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:13:16.101Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Dissecting+the+differentiation+process+of+the+preplacodal+ectoderm+in+zebrafish&rft.date=2014-10-01&genre=article&issn=1097-0177&volume=243&issue=10&spage=1338&epage=1351&pages=1338-1351&jtitle=Developmental+Dynamics&atitle=Dissecting+the+differentiation+process+of+the+preplacodal+ectoderm+in+zebrafish&aulast=Liu&aufirst=Dong&rft_id=info%3Adoi%2F10.1002%2Fdvdy.24160&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337271380246531 |
| author | Yao, Di, Zhao, Feng, Wu, Ying, Wang, Jialiang, Dong, Wei, Zhao, Jue, Zhu, Zuoyan, Liu, Dong |
| author_facet | Yao, Di, Zhao, Feng, Wu, Ying, Wang, Jialiang, Dong, Wei, Zhao, Jue, Zhu, Zuoyan, Liu, Dong, Yao, Di, Zhao, Feng, Wu, Ying, Wang, Jialiang, Dong, Wei, Zhao, Jue, Zhu, Zuoyan, Liu, Dong |
| author_sort | yao, di |
| container_issue | 10 |
| container_start_page | 1338 |
| container_title | Developmental Dynamics |
| container_volume | 243 |
| description | <jats:p><jats:styled-content>Background:</jats:styled-content> The preplacodal region (PPR) is a region of specialized ectoderm at the border of neural and nonneural ectoderm (NNE). Coordinated Bmp, Fgf, and Wnt signals are known to drive PPR development; however, the underlying mechanism is unknown. <jats:styled-content>Results:</jats:styled-content> We identified key components involved in PPR differentiation. The mesoderm/marginal Wnts at the early gastrula stage trigger differentiation by allowing the adjacent NNE border cells to start adopting caudal PPR fates; otherwise, the development of caudal PPR identity is hindered due to the persistent presence of <jats:italic>gata3</jats:italic> mRNA. The caudal PPR fate dominates when <jats:italic>foxi1</jats:italic> expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) reduces the otic‐epibranchial placodal domain. When the Gata3 level is manipulated at the fertilized egg stage or near 6 hpf, the lens is always affected. In establishing PPR polarity, both Gata3 and Foxi1 inhibit Bmp signaling, whereas Foxi1 inhibits, but Gata3 enhances, Fgf sensitivity of the PPR cells. <jats:styled-content>Conclusions:</jats:styled-content> Our study reveals that in zebrafish, (1) the PPR at the shield stage may enter a developmental state when the PPR cells preferentially adopt a particular placodal fate and (2) a network of genetically linked factors, including Wnt/beta‐catenin, Fgfr, Bmp, Gata3, and Foxi1, direct the process of PPR differentiation. <jats:italic>Developmental Dynamics 243:1338–1351, 2014</jats:italic>. © 2014 Wiley Periodicals, Inc.</jats:p> |
| doi_str_mv | 10.1002/dvdy.24160 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9kdmR5LjI0MTYw |
| imprint | Wiley, 2014 |
| imprint_str_mv | Wiley, 2014 |
| institution | DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
| issn | 1058-8388, 1097-0177 |
| issn_str_mv | 1058-8388, 1097-0177 |
| language | English |
| last_indexed | 2024-03-01T15:13:16.101Z |
| match_str | yao2014dissectingthedifferentiationprocessofthepreplacodalectoderminzebrafish |
| mega_collection | Wiley (CrossRef) |
| physical | 1338-1351 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Developmental Dynamics |
| source_id | 49 |
| spelling | Yao, Di Zhao, Feng Wu, Ying Wang, Jialiang Dong, Wei Zhao, Jue Zhu, Zuoyan Liu, Dong 1058-8388 1097-0177 Wiley Developmental Biology http://dx.doi.org/10.1002/dvdy.24160 <jats:p><jats:styled-content>Background:</jats:styled-content> The preplacodal region (PPR) is a region of specialized ectoderm at the border of neural and nonneural ectoderm (NNE). Coordinated Bmp, Fgf, and Wnt signals are known to drive PPR development; however, the underlying mechanism is unknown. <jats:styled-content>Results:</jats:styled-content> We identified key components involved in PPR differentiation. The mesoderm/marginal Wnts at the early gastrula stage trigger differentiation by allowing the adjacent NNE border cells to start adopting caudal PPR fates; otherwise, the development of caudal PPR identity is hindered due to the persistent presence of <jats:italic>gata3</jats:italic> mRNA. The caudal PPR fate dominates when <jats:italic>foxi1</jats:italic> expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) reduces the otic‐epibranchial placodal domain. When the Gata3 level is manipulated at the fertilized egg stage or near 6 hpf, the lens is always affected. In establishing PPR polarity, both Gata3 and Foxi1 inhibit Bmp signaling, whereas Foxi1 inhibits, but Gata3 enhances, Fgf sensitivity of the PPR cells. <jats:styled-content>Conclusions:</jats:styled-content> Our study reveals that in zebrafish, (1) the PPR at the shield stage may enter a developmental state when the PPR cells preferentially adopt a particular placodal fate and (2) a network of genetically linked factors, including Wnt/beta‐catenin, Fgfr, Bmp, Gata3, and Foxi1, direct the process of PPR differentiation. <jats:italic>Developmental Dynamics 243:1338–1351, 2014</jats:italic>. © 2014 Wiley Periodicals, Inc.</jats:p> Dissecting the differentiation process of the preplacodal ectoderm in zebrafish Developmental Dynamics |
| spellingShingle | Yao, Di, Zhao, Feng, Wu, Ying, Wang, Jialiang, Dong, Wei, Zhao, Jue, Zhu, Zuoyan, Liu, Dong, Developmental Dynamics, Dissecting the differentiation process of the preplacodal ectoderm in zebrafish, Developmental Biology |
| title | Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_full | Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_fullStr | Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_full_unstemmed | Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_short | Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_sort | dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| title_unstemmed | Dissecting the differentiation process of the preplacodal ectoderm in zebrafish |
| topic | Developmental Biology |
| url | http://dx.doi.org/10.1002/dvdy.24160 |