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Differential expression and regulation of olig genes in zebrafish
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| Zeitschriftentitel: | Journal of Comparative Neurology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Comparative Neurology, 515, 2009, 3, S. 378-396 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Tiso, Natascia Filippi, Alida Benato, Francesca Negrisolo, Enrico Modena, Nicola Vaccari, Enrico Driever, Wolfgang Argenton, Francesco Tiso, Natascia Filippi, Alida Benato, Francesca Negrisolo, Enrico Modena, Nicola Vaccari, Enrico Driever, Wolfgang Argenton, Francesco |
|---|---|
| author |
Tiso, Natascia Filippi, Alida Benato, Francesca Negrisolo, Enrico Modena, Nicola Vaccari, Enrico Driever, Wolfgang Argenton, Francesco |
| spellingShingle |
Tiso, Natascia Filippi, Alida Benato, Francesca Negrisolo, Enrico Modena, Nicola Vaccari, Enrico Driever, Wolfgang Argenton, Francesco Journal of Comparative Neurology Differential expression and regulation of olig genes in zebrafish General Neuroscience |
| author_sort |
tiso, natascia |
| spelling |
Tiso, Natascia Filippi, Alida Benato, Francesca Negrisolo, Enrico Modena, Nicola Vaccari, Enrico Driever, Wolfgang Argenton, Francesco 0021-9967 1096-9861 Wiley General Neuroscience http://dx.doi.org/10.1002/cne.22054 <jats:title>Abstract</jats:title><jats:p>The members of the <jats:italic>Olig</jats:italic> gene family encode for basic helix‐loop‐helix (bHLH) transcription factors involved in neural cell type specification. Three <jats:italic>Olig</jats:italic> genes (<jats:italic>Olig1</jats:italic>, <jats:italic>Olig2</jats:italic> and <jats:italic>Olig3</jats:italic>) have been identified in all known vertebrate models and a fourth one in anamniotes (<jats:italic>olig4</jats:italic>). Here we have performed a global analysis of <jats:italic>olig</jats:italic> genes during zebrafish embryonic development and determined which signaling pathways control their induction and regionalization in the CNS. Interestingly, zebrafish <jats:italic>olig3</jats:italic> and <jats:italic>olig4</jats:italic> together establish most of the expression domains corresponding to mouse <jats:italic>Olig3</jats:italic>. According to our data, <jats:italic>olig1</jats:italic> is specifically confined to the oligodendrocyte lineage, whereas the other members display stratified expression in diencephalon, hindbrain, and spinal cord. We observed differential expression of <jats:italic>olig</jats:italic> genes within specific motoneuron and interneuron domains of the spinal cord. <jats:italic>olig2</jats:italic>, <jats:italic>olig3</jats:italic>, and <jats:italic>olig4</jats:italic> expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS. Our findings suggest a role for <jats:italic>olig</jats:italic> genes in CNS patterning as well as in multiple cell fate decisions during neural differentiation. J. Comp. Neurol. 515:378–396, 2009. © 2009 Wiley‐Liss, Inc.</jats:p> Differential expression and regulation of <i>olig</i> genes in zebrafish Journal of Comparative Neurology |
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Wiley, 2009 |
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2009 |
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| title |
Differential expression and regulation of olig genes in zebrafish |
| title_unstemmed |
Differential expression and regulation of olig genes in zebrafish |
| title_full |
Differential expression and regulation of olig genes in zebrafish |
| title_fullStr |
Differential expression and regulation of olig genes in zebrafish |
| title_full_unstemmed |
Differential expression and regulation of olig genes in zebrafish |
| title_short |
Differential expression and regulation of olig genes in zebrafish |
| title_sort |
differential expression and regulation of <i>olig</i> genes in zebrafish |
| topic |
General Neuroscience |
| url |
http://dx.doi.org/10.1002/cne.22054 |
| publishDate |
2009 |
| physical |
378-396 |
| description |
<jats:title>Abstract</jats:title><jats:p>The members of the <jats:italic>Olig</jats:italic> gene family encode for basic helix‐loop‐helix (bHLH) transcription factors involved in neural cell type specification. Three <jats:italic>Olig</jats:italic> genes (<jats:italic>Olig1</jats:italic>, <jats:italic>Olig2</jats:italic> and <jats:italic>Olig3</jats:italic>) have been identified in all known vertebrate models and a fourth one in anamniotes (<jats:italic>olig4</jats:italic>). Here we have performed a global analysis of <jats:italic>olig</jats:italic> genes during zebrafish embryonic development and determined which signaling pathways control their induction and regionalization in the CNS. Interestingly, zebrafish <jats:italic>olig3</jats:italic> and <jats:italic>olig4</jats:italic> together establish most of the expression domains corresponding to mouse <jats:italic>Olig3</jats:italic>. According to our data, <jats:italic>olig1</jats:italic> is specifically confined to the oligodendrocyte lineage, whereas the other members display stratified expression in diencephalon, hindbrain, and spinal cord. We observed differential expression of <jats:italic>olig</jats:italic> genes within specific motoneuron and interneuron domains of the spinal cord. <jats:italic>olig2</jats:italic>, <jats:italic>olig3</jats:italic>, and <jats:italic>olig4</jats:italic> expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS. Our findings suggest a role for <jats:italic>olig</jats:italic> genes in CNS patterning as well as in multiple cell fate decisions during neural differentiation. J. Comp. Neurol. 515:378–396, 2009. © 2009 Wiley‐Liss, Inc.</jats:p> |
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| author | Tiso, Natascia, Filippi, Alida, Benato, Francesca, Negrisolo, Enrico, Modena, Nicola, Vaccari, Enrico, Driever, Wolfgang, Argenton, Francesco |
| author_facet | Tiso, Natascia, Filippi, Alida, Benato, Francesca, Negrisolo, Enrico, Modena, Nicola, Vaccari, Enrico, Driever, Wolfgang, Argenton, Francesco, Tiso, Natascia, Filippi, Alida, Benato, Francesca, Negrisolo, Enrico, Modena, Nicola, Vaccari, Enrico, Driever, Wolfgang, Argenton, Francesco |
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| description | <jats:title>Abstract</jats:title><jats:p>The members of the <jats:italic>Olig</jats:italic> gene family encode for basic helix‐loop‐helix (bHLH) transcription factors involved in neural cell type specification. Three <jats:italic>Olig</jats:italic> genes (<jats:italic>Olig1</jats:italic>, <jats:italic>Olig2</jats:italic> and <jats:italic>Olig3</jats:italic>) have been identified in all known vertebrate models and a fourth one in anamniotes (<jats:italic>olig4</jats:italic>). Here we have performed a global analysis of <jats:italic>olig</jats:italic> genes during zebrafish embryonic development and determined which signaling pathways control their induction and regionalization in the CNS. Interestingly, zebrafish <jats:italic>olig3</jats:italic> and <jats:italic>olig4</jats:italic> together establish most of the expression domains corresponding to mouse <jats:italic>Olig3</jats:italic>. According to our data, <jats:italic>olig1</jats:italic> is specifically confined to the oligodendrocyte lineage, whereas the other members display stratified expression in diencephalon, hindbrain, and spinal cord. We observed differential expression of <jats:italic>olig</jats:italic> genes within specific motoneuron and interneuron domains of the spinal cord. <jats:italic>olig2</jats:italic>, <jats:italic>olig3</jats:italic>, and <jats:italic>olig4</jats:italic> expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS. Our findings suggest a role for <jats:italic>olig</jats:italic> genes in CNS patterning as well as in multiple cell fate decisions during neural differentiation. J. Comp. Neurol. 515:378–396, 2009. © 2009 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Tiso, Natascia Filippi, Alida Benato, Francesca Negrisolo, Enrico Modena, Nicola Vaccari, Enrico Driever, Wolfgang Argenton, Francesco 0021-9967 1096-9861 Wiley General Neuroscience http://dx.doi.org/10.1002/cne.22054 <jats:title>Abstract</jats:title><jats:p>The members of the <jats:italic>Olig</jats:italic> gene family encode for basic helix‐loop‐helix (bHLH) transcription factors involved in neural cell type specification. Three <jats:italic>Olig</jats:italic> genes (<jats:italic>Olig1</jats:italic>, <jats:italic>Olig2</jats:italic> and <jats:italic>Olig3</jats:italic>) have been identified in all known vertebrate models and a fourth one in anamniotes (<jats:italic>olig4</jats:italic>). Here we have performed a global analysis of <jats:italic>olig</jats:italic> genes during zebrafish embryonic development and determined which signaling pathways control their induction and regionalization in the CNS. Interestingly, zebrafish <jats:italic>olig3</jats:italic> and <jats:italic>olig4</jats:italic> together establish most of the expression domains corresponding to mouse <jats:italic>Olig3</jats:italic>. According to our data, <jats:italic>olig1</jats:italic> is specifically confined to the oligodendrocyte lineage, whereas the other members display stratified expression in diencephalon, hindbrain, and spinal cord. We observed differential expression of <jats:italic>olig</jats:italic> genes within specific motoneuron and interneuron domains of the spinal cord. <jats:italic>olig2</jats:italic>, <jats:italic>olig3</jats:italic>, and <jats:italic>olig4</jats:italic> expression appears to be regulated by nodal and FGF signaling during gastrulation and early somitogenesis, by RA signaling in the hindbrain, and by BMP and Hh signals along the dorsoventral axis of the embryonic CNS. Our findings suggest a role for <jats:italic>olig</jats:italic> genes in CNS patterning as well as in multiple cell fate decisions during neural differentiation. J. Comp. Neurol. 515:378–396, 2009. © 2009 Wiley‐Liss, Inc.</jats:p> Differential expression and regulation of <i>olig</i> genes in zebrafish Journal of Comparative Neurology |
| spellingShingle | Tiso, Natascia, Filippi, Alida, Benato, Francesca, Negrisolo, Enrico, Modena, Nicola, Vaccari, Enrico, Driever, Wolfgang, Argenton, Francesco, Journal of Comparative Neurology, Differential expression and regulation of olig genes in zebrafish, General Neuroscience |
| title | Differential expression and regulation of olig genes in zebrafish |
| title_full | Differential expression and regulation of olig genes in zebrafish |
| title_fullStr | Differential expression and regulation of olig genes in zebrafish |
| title_full_unstemmed | Differential expression and regulation of olig genes in zebrafish |
| title_short | Differential expression and regulation of olig genes in zebrafish |
| title_sort | differential expression and regulation of <i>olig</i> genes in zebrafish |
| title_unstemmed | Differential expression and regulation of olig genes in zebrafish |
| topic | General Neuroscience |
| url | http://dx.doi.org/10.1002/cne.22054 |