Eintrag weiter verarbeiten
Online-Ressource

Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel: Cancer
Personen und Körperschaften: Jin, Guangfu, Huang, Jinlin, Hu, Zhibin, Dai, Juncheng, Tang, Rong, Chen, Yijiang, Xu, Lin, Huang, Xinen, Shu, Yongqian, Shen, Hongbing
In: Cancer, 116, 2010, 24, S. 5700-5709
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Cancer Research
Oncology
author_facet Jin, Guangfu
Huang, Jinlin
Hu, Zhibin
Dai, Juncheng
Tang, Rong
Chen, Yijiang
Xu, Lin
Huang, Xinen
Shu, Yongqian
Shen, Hongbing
Jin, Guangfu
Huang, Jinlin
Hu, Zhibin
Dai, Juncheng
Tang, Rong
Chen, Yijiang
Xu, Lin
Huang, Xinen
Shu, Yongqian
Shen, Hongbing
author Jin, Guangfu
Huang, Jinlin
Hu, Zhibin
Dai, Juncheng
Tang, Rong
Chen, Yijiang
Xu, Lin
Huang, Xinen
Shu, Yongqian
Shen, Hongbing
spellingShingle Jin, Guangfu
Huang, Jinlin
Hu, Zhibin
Dai, Juncheng
Tang, Rong
Chen, Yijiang
Xu, Lin
Huang, Xinen
Shu, Yongqian
Shen, Hongbing
Cancer
Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
Cancer Research
Oncology
author_sort jin, guangfu
spelling Jin, Guangfu Huang, Jinlin Hu, Zhibin Dai, Juncheng Tang, Rong Chen, Yijiang Xu, Lin Huang, Xinen Shu, Yongqian Shen, Hongbing 0008-543X 1097-0142 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/cncr.25301 <jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND:</jats:title><jats:p>One‐carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one‐carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized that polymorphisms in one‐carbon metabolism‐related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC).</jats:p></jats:sec><jats:sec><jats:title>METHODS:</jats:title><jats:p>The authors screened 57 potentially functional single nucleotide polymorphisms (SNPs) from 11 candidate genes involved in one‐carbon metabolism and genotyped them in a cohort of 568 NSCLC patients by using Illumina Golden Gate platform. The Kaplan‐Meier method with log‐rank test and Cox proportional hazards model were used for survival analyses.</jats:p></jats:sec><jats:sec><jats:title>RESULTS:</jats:title><jats:p>Variant alleles were significantly associated with favorable survivals of NSCLC for <jats:italic>MTR</jats:italic> rs3768160 A&gt;G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62‐0.98), <jats:italic>MTRR</jats:italic> rs2966952 G&gt;A (allelic HR, 0.84; 95% CI, 0.71‐0.99) and <jats:italic>DHFR</jats:italic> rs1650697 G&gt;A (allelic HR, 0.83; 95% CI, 0.70‐0.99) and with unfavorable prognosis for <jats:italic>MTHFD1</jats:italic> rs1950902 G&gt;A with borderline significance (allelic HR, 1.18; 95% CI, 0.99‐1.40). In addition, the combined genotypes of these four SNPs showed a locus‐dosage effect on NSCLC survival (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 6.9 × 10<jats:sup>−5</jats:sup>). In the final multivariate Cox regression model, combined genotypes based on 3 categories may be an independent prognostic factor for NSCLC with adjusted trend HR of 0.78 (95% CI, 0.66‐0.92).</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION:</jats:title><jats:p>Genetic variants in one‐carbon metabolism pathway may be candidate biomarkers for NSCLC prognosis. Cancer 2010. © 2010 American Cancer Society.</jats:p></jats:sec> Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population Cancer
doi_str_mv 10.1002/cncr.25301
facet_avail Online
Free
finc_class_facet Medizin
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9jbmNyLjI1MzAx
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9jbmNyLjI1MzAx
institution DE-D275
DE-Bn3
DE-Brt1
DE-Zwi2
DE-D161
DE-Gla1
DE-Zi4
DE-15
DE-Pl11
DE-Rs1
DE-105
DE-14
DE-Ch1
DE-L229
imprint Wiley, 2010
imprint_str_mv Wiley, 2010
issn 0008-543X
1097-0142
issn_str_mv 0008-543X
1097-0142
language English
mega_collection Wiley (CrossRef)
match_str jin2010geneticvariantsinonecarbonmetabolismrelatedgenescontributetonsclcprognosisinachinesepopulation
publishDateSort 2010
publisher Wiley
recordtype ai
record_format ai
series Cancer
source_id 49
title Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_unstemmed Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_full Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_fullStr Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_full_unstemmed Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_short Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_sort genetic variants in one‐carbon metabolism‐related genes contribute to nsclc prognosis in a chinese population
topic Cancer Research
Oncology
url http://dx.doi.org/10.1002/cncr.25301
publishDate 2010
physical 5700-5709
description <jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND:</jats:title><jats:p>One‐carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one‐carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized that polymorphisms in one‐carbon metabolism‐related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC).</jats:p></jats:sec><jats:sec><jats:title>METHODS:</jats:title><jats:p>The authors screened 57 potentially functional single nucleotide polymorphisms (SNPs) from 11 candidate genes involved in one‐carbon metabolism and genotyped them in a cohort of 568 NSCLC patients by using Illumina Golden Gate platform. The Kaplan‐Meier method with log‐rank test and Cox proportional hazards model were used for survival analyses.</jats:p></jats:sec><jats:sec><jats:title>RESULTS:</jats:title><jats:p>Variant alleles were significantly associated with favorable survivals of NSCLC for <jats:italic>MTR</jats:italic> rs3768160 A&gt;G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62‐0.98), <jats:italic>MTRR</jats:italic> rs2966952 G&gt;A (allelic HR, 0.84; 95% CI, 0.71‐0.99) and <jats:italic>DHFR</jats:italic> rs1650697 G&gt;A (allelic HR, 0.83; 95% CI, 0.70‐0.99) and with unfavorable prognosis for <jats:italic>MTHFD1</jats:italic> rs1950902 G&gt;A with borderline significance (allelic HR, 1.18; 95% CI, 0.99‐1.40). In addition, the combined genotypes of these four SNPs showed a locus‐dosage effect on NSCLC survival (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 6.9 × 10<jats:sup>−5</jats:sup>). In the final multivariate Cox regression model, combined genotypes based on 3 categories may be an independent prognostic factor for NSCLC with adjusted trend HR of 0.78 (95% CI, 0.66‐0.92).</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION:</jats:title><jats:p>Genetic variants in one‐carbon metabolism pathway may be candidate biomarkers for NSCLC prognosis. Cancer 2010. © 2010 American Cancer Society.</jats:p></jats:sec>
container_issue 24
container_start_page 5700
container_title Cancer
container_volume 116
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792339158728966148
geogr_code not assigned
last_indexed 2024-03-01T15:43:41.831Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Genetic+variants+in+one%E2%80%90carbon+metabolism%E2%80%90related+genes+contribute+to+NSCLC+prognosis+in+a+Chinese+population&rft.date=2010-12-15&genre=article&issn=1097-0142&volume=116&issue=24&spage=5700&epage=5709&pages=5700-5709&jtitle=Cancer&atitle=Genetic+variants+in+one%E2%80%90carbon+metabolism%E2%80%90related+genes+contribute+to+NSCLC+prognosis+in+a+Chinese+population&aulast=Shen&aufirst=Hongbing&rft_id=info%3Adoi%2F10.1002%2Fcncr.25301&rft.language%5B0%5D=eng
SOLR
_version_ 1792339158728966148
author Jin, Guangfu, Huang, Jinlin, Hu, Zhibin, Dai, Juncheng, Tang, Rong, Chen, Yijiang, Xu, Lin, Huang, Xinen, Shu, Yongqian, Shen, Hongbing
author_facet Jin, Guangfu, Huang, Jinlin, Hu, Zhibin, Dai, Juncheng, Tang, Rong, Chen, Yijiang, Xu, Lin, Huang, Xinen, Shu, Yongqian, Shen, Hongbing, Jin, Guangfu, Huang, Jinlin, Hu, Zhibin, Dai, Juncheng, Tang, Rong, Chen, Yijiang, Xu, Lin, Huang, Xinen, Shu, Yongqian, Shen, Hongbing
author_sort jin, guangfu
container_issue 24
container_start_page 5700
container_title Cancer
container_volume 116
description <jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND:</jats:title><jats:p>One‐carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one‐carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized that polymorphisms in one‐carbon metabolism‐related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC).</jats:p></jats:sec><jats:sec><jats:title>METHODS:</jats:title><jats:p>The authors screened 57 potentially functional single nucleotide polymorphisms (SNPs) from 11 candidate genes involved in one‐carbon metabolism and genotyped them in a cohort of 568 NSCLC patients by using Illumina Golden Gate platform. The Kaplan‐Meier method with log‐rank test and Cox proportional hazards model were used for survival analyses.</jats:p></jats:sec><jats:sec><jats:title>RESULTS:</jats:title><jats:p>Variant alleles were significantly associated with favorable survivals of NSCLC for <jats:italic>MTR</jats:italic> rs3768160 A&gt;G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62‐0.98), <jats:italic>MTRR</jats:italic> rs2966952 G&gt;A (allelic HR, 0.84; 95% CI, 0.71‐0.99) and <jats:italic>DHFR</jats:italic> rs1650697 G&gt;A (allelic HR, 0.83; 95% CI, 0.70‐0.99) and with unfavorable prognosis for <jats:italic>MTHFD1</jats:italic> rs1950902 G&gt;A with borderline significance (allelic HR, 1.18; 95% CI, 0.99‐1.40). In addition, the combined genotypes of these four SNPs showed a locus‐dosage effect on NSCLC survival (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 6.9 × 10<jats:sup>−5</jats:sup>). In the final multivariate Cox regression model, combined genotypes based on 3 categories may be an independent prognostic factor for NSCLC with adjusted trend HR of 0.78 (95% CI, 0.66‐0.92).</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION:</jats:title><jats:p>Genetic variants in one‐carbon metabolism pathway may be candidate biomarkers for NSCLC prognosis. Cancer 2010. © 2010 American Cancer Society.</jats:p></jats:sec>
doi_str_mv 10.1002/cncr.25301
facet_avail Online, Free
finc_class_facet Medizin
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9jbmNyLjI1MzAx
imprint Wiley, 2010
imprint_str_mv Wiley, 2010
institution DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229
issn 0008-543X, 1097-0142
issn_str_mv 0008-543X, 1097-0142
language English
last_indexed 2024-03-01T15:43:41.831Z
match_str jin2010geneticvariantsinonecarbonmetabolismrelatedgenescontributetonsclcprognosisinachinesepopulation
mega_collection Wiley (CrossRef)
physical 5700-5709
publishDate 2010
publishDateSort 2010
publisher Wiley
record_format ai
recordtype ai
series Cancer
source_id 49
spelling Jin, Guangfu Huang, Jinlin Hu, Zhibin Dai, Juncheng Tang, Rong Chen, Yijiang Xu, Lin Huang, Xinen Shu, Yongqian Shen, Hongbing 0008-543X 1097-0142 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/cncr.25301 <jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND:</jats:title><jats:p>One‐carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one‐carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized that polymorphisms in one‐carbon metabolism‐related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC).</jats:p></jats:sec><jats:sec><jats:title>METHODS:</jats:title><jats:p>The authors screened 57 potentially functional single nucleotide polymorphisms (SNPs) from 11 candidate genes involved in one‐carbon metabolism and genotyped them in a cohort of 568 NSCLC patients by using Illumina Golden Gate platform. The Kaplan‐Meier method with log‐rank test and Cox proportional hazards model were used for survival analyses.</jats:p></jats:sec><jats:sec><jats:title>RESULTS:</jats:title><jats:p>Variant alleles were significantly associated with favorable survivals of NSCLC for <jats:italic>MTR</jats:italic> rs3768160 A&gt;G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62‐0.98), <jats:italic>MTRR</jats:italic> rs2966952 G&gt;A (allelic HR, 0.84; 95% CI, 0.71‐0.99) and <jats:italic>DHFR</jats:italic> rs1650697 G&gt;A (allelic HR, 0.83; 95% CI, 0.70‐0.99) and with unfavorable prognosis for <jats:italic>MTHFD1</jats:italic> rs1950902 G&gt;A with borderline significance (allelic HR, 1.18; 95% CI, 0.99‐1.40). In addition, the combined genotypes of these four SNPs showed a locus‐dosage effect on NSCLC survival (<jats:italic>P</jats:italic><jats:sub>trend</jats:sub> = 6.9 × 10<jats:sup>−5</jats:sup>). In the final multivariate Cox regression model, combined genotypes based on 3 categories may be an independent prognostic factor for NSCLC with adjusted trend HR of 0.78 (95% CI, 0.66‐0.92).</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION:</jats:title><jats:p>Genetic variants in one‐carbon metabolism pathway may be candidate biomarkers for NSCLC prognosis. Cancer 2010. © 2010 American Cancer Society.</jats:p></jats:sec> Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population Cancer
spellingShingle Jin, Guangfu, Huang, Jinlin, Hu, Zhibin, Dai, Juncheng, Tang, Rong, Chen, Yijiang, Xu, Lin, Huang, Xinen, Shu, Yongqian, Shen, Hongbing, Cancer, Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population, Cancer Research, Oncology
title Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_full Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_fullStr Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_full_unstemmed Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_short Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
title_sort genetic variants in one‐carbon metabolism‐related genes contribute to nsclc prognosis in a chinese population
title_unstemmed Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
topic Cancer Research, Oncology
url http://dx.doi.org/10.1002/cncr.25301