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| author_facet |
Schmidt, Norbert Brune, Kay Williams, Kenneth M. Geisslinger, Gerd Schmidt, Norbert Brune, Kay Williams, Kenneth M. Geisslinger, Gerd |
|---|---|
| author |
Schmidt, Norbert Brune, Kay Williams, Kenneth M. Geisslinger, Gerd |
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Schmidt, Norbert Brune, Kay Williams, Kenneth M. Geisslinger, Gerd Chirality Stereoselective pharmacokinetics of methadone in beagle dogs Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry |
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schmidt, norbert |
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Schmidt, Norbert Brune, Kay Williams, Kenneth M. Geisslinger, Gerd 0899-0042 1520-636X Wiley Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry http://dx.doi.org/10.1002/chir.530060608 <jats:title>Abstract</jats:title><jats:p>The pharmacokinetics of methadone were studied in beagle dogs (<jats:italic>n</jats:italic> = 4) following intravenous administration of the racemate (0.5 mg/kg) and of the individual (R)‐(0.25 mg/kg) and (S)‐enantiomers (0.25 mg/kg) using a stereospecific HPLC assay. There was no significant difference between the pharmacokinetic parameters of (R)‐methadone and (S)‐methadone following administration of the individual enantiomers. Stereoselective differences were evident following administration of the racemate (<jats:italic>P</jats:italic> values for differences in AUC and CL were 0.001 and 0.046, respectively) and the clearance of the (S)‐enantiomer was increased when administered as part of the racemate (316 ± 81 vs 487 ± 128 ml/min, <jats:italic>P</jats:italic> = 0.04). The data suggest that stereoselective disposition including potential enantiomer–enantiomer interactions should be considered in pharmacokinetic–pharmacodynamic studies of (R,S)‐methadone. © 1994 Wiley‐Liss, Inc.</jats:p> Stereoselective pharmacokinetics of methadone in beagle dogs Chirality |
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10.1002/chir.530060608 |
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| title |
Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_unstemmed |
Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_full |
Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_fullStr |
Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_full_unstemmed |
Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_short |
Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_sort |
stereoselective pharmacokinetics of methadone in beagle dogs |
| topic |
Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/chir.530060608 |
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1994 |
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492-495 |
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<jats:title>Abstract</jats:title><jats:p>The pharmacokinetics of methadone were studied in beagle dogs (<jats:italic>n</jats:italic> = 4) following intravenous administration of the racemate (0.5 mg/kg) and of the individual (R)‐(0.25 mg/kg) and (S)‐enantiomers (0.25 mg/kg) using a stereospecific HPLC assay. There was no significant difference between the pharmacokinetic parameters of (R)‐methadone and (S)‐methadone following administration of the individual enantiomers. Stereoselective differences were evident following administration of the racemate (<jats:italic>P</jats:italic> values for differences in AUC and CL were 0.001 and 0.046, respectively) and the clearance of the (S)‐enantiomer was increased when administered as part of the racemate (316 ± 81 vs 487 ± 128 ml/min, <jats:italic>P</jats:italic> = 0.04). The data suggest that stereoselective disposition including potential enantiomer–enantiomer interactions should be considered in pharmacokinetic–pharmacodynamic studies of (R,S)‐methadone. © 1994 Wiley‐Liss, Inc.</jats:p> |
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| author | Schmidt, Norbert, Brune, Kay, Williams, Kenneth M., Geisslinger, Gerd |
| author_facet | Schmidt, Norbert, Brune, Kay, Williams, Kenneth M., Geisslinger, Gerd, Schmidt, Norbert, Brune, Kay, Williams, Kenneth M., Geisslinger, Gerd |
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| description | <jats:title>Abstract</jats:title><jats:p>The pharmacokinetics of methadone were studied in beagle dogs (<jats:italic>n</jats:italic> = 4) following intravenous administration of the racemate (0.5 mg/kg) and of the individual (R)‐(0.25 mg/kg) and (S)‐enantiomers (0.25 mg/kg) using a stereospecific HPLC assay. There was no significant difference between the pharmacokinetic parameters of (R)‐methadone and (S)‐methadone following administration of the individual enantiomers. Stereoselective differences were evident following administration of the racemate (<jats:italic>P</jats:italic> values for differences in AUC and CL were 0.001 and 0.046, respectively) and the clearance of the (S)‐enantiomer was increased when administered as part of the racemate (316 ± 81 vs 487 ± 128 ml/min, <jats:italic>P</jats:italic> = 0.04). The data suggest that stereoselective disposition including potential enantiomer–enantiomer interactions should be considered in pharmacokinetic–pharmacodynamic studies of (R,S)‐methadone. © 1994 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Schmidt, Norbert Brune, Kay Williams, Kenneth M. Geisslinger, Gerd 0899-0042 1520-636X Wiley Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry http://dx.doi.org/10.1002/chir.530060608 <jats:title>Abstract</jats:title><jats:p>The pharmacokinetics of methadone were studied in beagle dogs (<jats:italic>n</jats:italic> = 4) following intravenous administration of the racemate (0.5 mg/kg) and of the individual (R)‐(0.25 mg/kg) and (S)‐enantiomers (0.25 mg/kg) using a stereospecific HPLC assay. There was no significant difference between the pharmacokinetic parameters of (R)‐methadone and (S)‐methadone following administration of the individual enantiomers. Stereoselective differences were evident following administration of the racemate (<jats:italic>P</jats:italic> values for differences in AUC and CL were 0.001 and 0.046, respectively) and the clearance of the (S)‐enantiomer was increased when administered as part of the racemate (316 ± 81 vs 487 ± 128 ml/min, <jats:italic>P</jats:italic> = 0.04). The data suggest that stereoselective disposition including potential enantiomer–enantiomer interactions should be considered in pharmacokinetic–pharmacodynamic studies of (R,S)‐methadone. © 1994 Wiley‐Liss, Inc.</jats:p> Stereoselective pharmacokinetics of methadone in beagle dogs Chirality |
| spellingShingle | Schmidt, Norbert, Brune, Kay, Williams, Kenneth M., Geisslinger, Gerd, Chirality, Stereoselective pharmacokinetics of methadone in beagle dogs, Organic Chemistry, Spectroscopy, Drug Discovery, Pharmacology, Catalysis, Analytical Chemistry |
| title | Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_full | Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_fullStr | Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_full_unstemmed | Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_short | Stereoselective pharmacokinetics of methadone in beagle dogs |
| title_sort | stereoselective pharmacokinetics of methadone in beagle dogs |
| title_unstemmed | Stereoselective pharmacokinetics of methadone in beagle dogs |
| topic | Organic Chemistry, Spectroscopy, Drug Discovery, Pharmacology, Catalysis, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/chir.530060608 |