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(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats
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| Zeitschriftentitel: | Chirality |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Chirality, 17, 2005, 5, S. 239-244 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Xu, Lin Liu, Shao‐Lin Zhang, Jun‐Tian Xu, Lin Liu, Shao‐Lin Zhang, Jun‐Tian |
|---|---|
| author |
Xu, Lin Liu, Shao‐Lin Zhang, Jun‐Tian |
| spellingShingle |
Xu, Lin Liu, Shao‐Lin Zhang, Jun‐Tian Chirality (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry |
| author_sort |
xu, lin |
| spelling |
Xu, Lin Liu, Shao‐Lin Zhang, Jun‐Tian 0899-0042 1520-636X Wiley Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry http://dx.doi.org/10.1002/chir.20150 <jats:title>Abstract</jats:title><jats:p>The effect of clausenamide on synaptic transmission in the dentate gyrus of rats in vivo and its possible mechanism of action were investigated in this study. Four of 16 enantiomers showed potentiating effects on basal synaptic transmission in anesthetized animals. By comparing one pair of enantiomers, (−)‐clausenamide and (+)‐clausenamide, we can report three primary findings: (1) (−)‐clausenamide potentiated synaptic transmission in both anesthetized and freely moving animals while (+)‐clausenamide showed no or little effect; (2) (−)‐clausenamide increased the magnitude of long‐term potentiation (LTP) induced by high‐frequency stimulation (HFS) in anesthetized animals whereas (+)‐clausenamide had no effect; (3) voltage‐dependent calcium channels (VDCCs) calcineurin and calpain are involved in (−)‐clausenamide‐induced potentiation of synaptic transmission. Because hippocampal LTP is thought to reflect a cellular mechanism involved in learning and memory, our findings may provide the pharmacological basis for understanding the nootropic mechanisms of (−)‐clausenamide, which is the first chiral nootropic agent developed in China. <jats:italic>Chirality 17:239–244, 2005. </jats:italic>© 2005 Wiley‐Liss, Inc.</jats:p> (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats Chirality |
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10.1002/chir.20150 |
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(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_unstemmed |
(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_full |
(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_fullStr |
(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_full_unstemmed |
(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_short |
(−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_sort |
(−)‐clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| topic |
Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/chir.20150 |
| publishDate |
2005 |
| physical |
239-244 |
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<jats:title>Abstract</jats:title><jats:p>The effect of clausenamide on synaptic transmission in the dentate gyrus of rats in vivo and its possible mechanism of action were investigated in this study. Four of 16 enantiomers showed potentiating effects on basal synaptic transmission in anesthetized animals. By comparing one pair of enantiomers, (−)‐clausenamide and (+)‐clausenamide, we can report three primary findings: (1) (−)‐clausenamide potentiated synaptic transmission in both anesthetized and freely moving animals while (+)‐clausenamide showed no or little effect; (2) (−)‐clausenamide increased the magnitude of long‐term potentiation (LTP) induced by high‐frequency stimulation (HFS) in anesthetized animals whereas (+)‐clausenamide had no effect; (3) voltage‐dependent calcium channels (VDCCs) calcineurin and calpain are involved in (−)‐clausenamide‐induced potentiation of synaptic transmission. Because hippocampal LTP is thought to reflect a cellular mechanism involved in learning and memory, our findings may provide the pharmacological basis for understanding the nootropic mechanisms of (−)‐clausenamide, which is the first chiral nootropic agent developed in China. <jats:italic>Chirality 17:239–244, 2005. </jats:italic>© 2005 Wiley‐Liss, Inc.</jats:p> |
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| author | Xu, Lin, Liu, Shao‐Lin, Zhang, Jun‐Tian |
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| description | <jats:title>Abstract</jats:title><jats:p>The effect of clausenamide on synaptic transmission in the dentate gyrus of rats in vivo and its possible mechanism of action were investigated in this study. Four of 16 enantiomers showed potentiating effects on basal synaptic transmission in anesthetized animals. By comparing one pair of enantiomers, (−)‐clausenamide and (+)‐clausenamide, we can report three primary findings: (1) (−)‐clausenamide potentiated synaptic transmission in both anesthetized and freely moving animals while (+)‐clausenamide showed no or little effect; (2) (−)‐clausenamide increased the magnitude of long‐term potentiation (LTP) induced by high‐frequency stimulation (HFS) in anesthetized animals whereas (+)‐clausenamide had no effect; (3) voltage‐dependent calcium channels (VDCCs) calcineurin and calpain are involved in (−)‐clausenamide‐induced potentiation of synaptic transmission. Because hippocampal LTP is thought to reflect a cellular mechanism involved in learning and memory, our findings may provide the pharmacological basis for understanding the nootropic mechanisms of (−)‐clausenamide, which is the first chiral nootropic agent developed in China. <jats:italic>Chirality 17:239–244, 2005. </jats:italic>© 2005 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Xu, Lin Liu, Shao‐Lin Zhang, Jun‐Tian 0899-0042 1520-636X Wiley Organic Chemistry Spectroscopy Drug Discovery Pharmacology Catalysis Analytical Chemistry http://dx.doi.org/10.1002/chir.20150 <jats:title>Abstract</jats:title><jats:p>The effect of clausenamide on synaptic transmission in the dentate gyrus of rats in vivo and its possible mechanism of action were investigated in this study. Four of 16 enantiomers showed potentiating effects on basal synaptic transmission in anesthetized animals. By comparing one pair of enantiomers, (−)‐clausenamide and (+)‐clausenamide, we can report three primary findings: (1) (−)‐clausenamide potentiated synaptic transmission in both anesthetized and freely moving animals while (+)‐clausenamide showed no or little effect; (2) (−)‐clausenamide increased the magnitude of long‐term potentiation (LTP) induced by high‐frequency stimulation (HFS) in anesthetized animals whereas (+)‐clausenamide had no effect; (3) voltage‐dependent calcium channels (VDCCs) calcineurin and calpain are involved in (−)‐clausenamide‐induced potentiation of synaptic transmission. Because hippocampal LTP is thought to reflect a cellular mechanism involved in learning and memory, our findings may provide the pharmacological basis for understanding the nootropic mechanisms of (−)‐clausenamide, which is the first chiral nootropic agent developed in China. <jats:italic>Chirality 17:239–244, 2005. </jats:italic>© 2005 Wiley‐Liss, Inc.</jats:p> (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats Chirality |
| spellingShingle | Xu, Lin, Liu, Shao‐Lin, Zhang, Jun‐Tian, Chirality, (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats, Organic Chemistry, Spectroscopy, Drug Discovery, Pharmacology, Catalysis, Analytical Chemistry |
| title | (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_full | (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_fullStr | (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_full_unstemmed | (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_short | (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_sort | (−)‐clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| title_unstemmed | (−)‐Clausenamide potentiates synaptic transmission in the dentate gyrus of rats |
| topic | Organic Chemistry, Spectroscopy, Drug Discovery, Pharmacology, Catalysis, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/chir.20150 |