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A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss
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| Zeitschriftentitel: | Bulletin of the Korean Chemical Society |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Bulletin of the Korean Chemical Society, 36, 2015, 10, S. 2469-2476 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Lee, Myoung Hee Shon, Young‐Seok Yoon, Kyung‐Sup Lee, Myoung Hee Shon, Young‐Seok Yoon, Kyung‐Sup |
|---|---|
| author |
Lee, Myoung Hee Shon, Young‐Seok Yoon, Kyung‐Sup |
| spellingShingle |
Lee, Myoung Hee Shon, Young‐Seok Yoon, Kyung‐Sup Bulletin of the Korean Chemical Society A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss General Chemistry |
| author_sort |
lee, myoung hee |
| spelling |
Lee, Myoung Hee Shon, Young‐Seok Yoon, Kyung‐Sup 1229-5949 1229-5949 Wiley General Chemistry http://dx.doi.org/10.1002/bkcs.10476 <jats:p>A rapid, sensitive, and selective method involving ultraperformance liquid chromatography‐electrospray ionization tandem mass spectrometry (<jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>) was developed for the qualitative and quantitative analysis of the constituents in a medicinal herbal complex extract (<jats:styled-content style="fixed-case">MHCE</jats:styled-content>). The <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was obtained from 23 herbs traditionally used in oriental medicines that we have been developed as new therapeutic materials to prevent hair loss and enhance hair growth. The chromatographic analysis of the samples of <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was performed on a reversed‐phase <jats:styled-content style="fixed-case">C<jats:sub>18</jats:sub></jats:styled-content> (10 cm × 2.1 mm, flow rate 0.3 <jats:styled-content style="fixed-case">mL</jats:styled-content>/min) column with gradient elution using acetonitrile and water with 0.1% formic acid. Mass spectrometry was performed in the positive <jats:styled-content style="fixed-case">ESI</jats:styled-content> mode. The bioactive compounds were detected by selected reaction monitoring (<jats:styled-content style="fixed-case">SRM</jats:styled-content>) with <jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>. All calibration curves of reference compounds showed good linearity (<jats:italic>r</jats:italic><jats:sup>2</jats:sup> > 0.9964) in the test ranges. The limit of detection and limit of quantification of the method were 0.02 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content> and 0.05 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content>, respectively.</jats:p> A Fast and Efficient <scp>UPLC‐ESI‐MS</scp>/<scp>MS</scp> Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss Bulletin of the Korean Chemical Society |
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10.1002/bkcs.10476 |
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Online |
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Wiley, 2015 |
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Wiley, 2015 |
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1229-5949 |
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2015 |
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Bulletin of the Korean Chemical Society |
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| title |
A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_unstemmed |
A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_full |
A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_fullStr |
A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_full_unstemmed |
A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_short |
A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_sort |
a fast and efficient <scp>uplc‐esi‐ms</scp>/<scp>ms</scp> method for detection, identification, and quantitative analysis of bioactive substances in medicinal herbal extracts of preventing hair loss |
| topic |
General Chemistry |
| url |
http://dx.doi.org/10.1002/bkcs.10476 |
| publishDate |
2015 |
| physical |
2469-2476 |
| description |
<jats:p>A rapid, sensitive, and selective method involving ultraperformance liquid chromatography‐electrospray ionization tandem mass spectrometry (<jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>) was developed for the qualitative and quantitative analysis of the constituents in a medicinal herbal complex extract (<jats:styled-content style="fixed-case">MHCE</jats:styled-content>). The <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was obtained from 23 herbs traditionally used in oriental medicines that we have been developed as new therapeutic materials to prevent hair loss and enhance hair growth. The chromatographic analysis of the samples of <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was performed on a reversed‐phase <jats:styled-content style="fixed-case">C<jats:sub>18</jats:sub></jats:styled-content> (10 cm × 2.1 mm, flow rate 0.3 <jats:styled-content style="fixed-case">mL</jats:styled-content>/min) column with gradient elution using acetonitrile and water with 0.1% formic acid. Mass spectrometry was performed in the positive <jats:styled-content style="fixed-case">ESI</jats:styled-content> mode. The bioactive compounds were detected by selected reaction monitoring (<jats:styled-content style="fixed-case">SRM</jats:styled-content>) with <jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>. All calibration curves of reference compounds showed good linearity (<jats:italic>r</jats:italic><jats:sup>2</jats:sup> > 0.9964) in the test ranges. The limit of detection and limit of quantification of the method were 0.02 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content> and 0.05 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content>, respectively.</jats:p> |
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| author | Lee, Myoung Hee, Shon, Young‐Seok, Yoon, Kyung‐Sup |
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| description | <jats:p>A rapid, sensitive, and selective method involving ultraperformance liquid chromatography‐electrospray ionization tandem mass spectrometry (<jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>) was developed for the qualitative and quantitative analysis of the constituents in a medicinal herbal complex extract (<jats:styled-content style="fixed-case">MHCE</jats:styled-content>). The <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was obtained from 23 herbs traditionally used in oriental medicines that we have been developed as new therapeutic materials to prevent hair loss and enhance hair growth. The chromatographic analysis of the samples of <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was performed on a reversed‐phase <jats:styled-content style="fixed-case">C<jats:sub>18</jats:sub></jats:styled-content> (10 cm × 2.1 mm, flow rate 0.3 <jats:styled-content style="fixed-case">mL</jats:styled-content>/min) column with gradient elution using acetonitrile and water with 0.1% formic acid. Mass spectrometry was performed in the positive <jats:styled-content style="fixed-case">ESI</jats:styled-content> mode. The bioactive compounds were detected by selected reaction monitoring (<jats:styled-content style="fixed-case">SRM</jats:styled-content>) with <jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>. All calibration curves of reference compounds showed good linearity (<jats:italic>r</jats:italic><jats:sup>2</jats:sup> > 0.9964) in the test ranges. The limit of detection and limit of quantification of the method were 0.02 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content> and 0.05 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content>, respectively.</jats:p> |
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| imprint | Wiley, 2015 |
| imprint_str_mv | Wiley, 2015 |
| institution | DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| issn_str_mv | 1229-5949 |
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| mega_collection | Wiley (CrossRef) |
| physical | 2469-2476 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Bulletin of the Korean Chemical Society |
| source_id | 49 |
| spelling | Lee, Myoung Hee Shon, Young‐Seok Yoon, Kyung‐Sup 1229-5949 1229-5949 Wiley General Chemistry http://dx.doi.org/10.1002/bkcs.10476 <jats:p>A rapid, sensitive, and selective method involving ultraperformance liquid chromatography‐electrospray ionization tandem mass spectrometry (<jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>) was developed for the qualitative and quantitative analysis of the constituents in a medicinal herbal complex extract (<jats:styled-content style="fixed-case">MHCE</jats:styled-content>). The <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was obtained from 23 herbs traditionally used in oriental medicines that we have been developed as new therapeutic materials to prevent hair loss and enhance hair growth. The chromatographic analysis of the samples of <jats:styled-content style="fixed-case">MHCE</jats:styled-content> was performed on a reversed‐phase <jats:styled-content style="fixed-case">C<jats:sub>18</jats:sub></jats:styled-content> (10 cm × 2.1 mm, flow rate 0.3 <jats:styled-content style="fixed-case">mL</jats:styled-content>/min) column with gradient elution using acetonitrile and water with 0.1% formic acid. Mass spectrometry was performed in the positive <jats:styled-content style="fixed-case">ESI</jats:styled-content> mode. The bioactive compounds were detected by selected reaction monitoring (<jats:styled-content style="fixed-case">SRM</jats:styled-content>) with <jats:styled-content style="fixed-case">UPLC‐ESI‐MS</jats:styled-content>/<jats:styled-content style="fixed-case">MS</jats:styled-content>. All calibration curves of reference compounds showed good linearity (<jats:italic>r</jats:italic><jats:sup>2</jats:sup> > 0.9964) in the test ranges. The limit of detection and limit of quantification of the method were 0.02 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content> and 0.05 ng/<jats:styled-content style="fixed-case">mL</jats:styled-content>, respectively.</jats:p> A Fast and Efficient <scp>UPLC‐ESI‐MS</scp>/<scp>MS</scp> Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss Bulletin of the Korean Chemical Society |
| spellingShingle | Lee, Myoung Hee, Shon, Young‐Seok, Yoon, Kyung‐Sup, Bulletin of the Korean Chemical Society, A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss, General Chemistry |
| title | A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_full | A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_fullStr | A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_full_unstemmed | A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_short | A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| title_sort | a fast and efficient <scp>uplc‐esi‐ms</scp>/<scp>ms</scp> method for detection, identification, and quantitative analysis of bioactive substances in medicinal herbal extracts of preventing hair loss |
| title_unstemmed | A Fast and Efficient UPLC‐ESI‐MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss |
| topic | General Chemistry |
| url | http://dx.doi.org/10.1002/bkcs.10476 |