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Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
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| Zeitschriftentitel: | Arthritis & Rheumatism |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , |
| In: | Arthritis & Rheumatism, 60, 2009, 9, S. 2558-2564 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Suarez‐Gestal, Marian Calaza, Manuel Dieguez‐Gonzalez, Rebeca Perez‐Pampin, Eva Pablos, Jose Luis Navarro, Federico Narvaez, Javier Marenco, Jose Luis Herrero‐Beaumont, Gabriel Fernandez‐Gutierrez, Benjamin Lamas, Jose Ramon de la Serna, Arturo Rodriguez Ortiz, Ana Maria Carreño, Luis Cañete, Juan D. Caliz, Rafael Blanco, Francisco J. Balsa, Alejandro Gomez‐Reino, Juan J. Gonzalez, Antonio Suarez‐Gestal, Marian Calaza, Manuel Dieguez‐Gonzalez, Rebeca Perez‐Pampin, Eva Pablos, Jose Luis Navarro, Federico Narvaez, Javier Marenco, Jose Luis Herrero‐Beaumont, Gabriel Fernandez‐Gutierrez, Benjamin Lamas, Jose Ramon de la Serna, Arturo Rodriguez Ortiz, Ana Maria Carreño, Luis Cañete, Juan D. Caliz, Rafael Blanco, Francisco J. Balsa, Alejandro Gomez‐Reino, Juan J. Gonzalez, Antonio |
|---|---|
| author |
Suarez‐Gestal, Marian Calaza, Manuel Dieguez‐Gonzalez, Rebeca Perez‐Pampin, Eva Pablos, Jose Luis Navarro, Federico Narvaez, Javier Marenco, Jose Luis Herrero‐Beaumont, Gabriel Fernandez‐Gutierrez, Benjamin Lamas, Jose Ramon de la Serna, Arturo Rodriguez Ortiz, Ana Maria Carreño, Luis Cañete, Juan D. Caliz, Rafael Blanco, Francisco J. Balsa, Alejandro Gomez‐Reino, Juan J. Gonzalez, Antonio |
| spellingShingle |
Suarez‐Gestal, Marian Calaza, Manuel Dieguez‐Gonzalez, Rebeca Perez‐Pampin, Eva Pablos, Jose Luis Navarro, Federico Narvaez, Javier Marenco, Jose Luis Herrero‐Beaumont, Gabriel Fernandez‐Gutierrez, Benjamin Lamas, Jose Ramon de la Serna, Arturo Rodriguez Ortiz, Ana Maria Carreño, Luis Cañete, Juan D. Caliz, Rafael Blanco, Francisco J. Balsa, Alejandro Gomez‐Reino, Juan J. Gonzalez, Antonio Arthritis & Rheumatism Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| author_sort |
suarez‐gestal, marian |
| spelling |
Suarez‐Gestal, Marian Calaza, Manuel Dieguez‐Gonzalez, Rebeca Perez‐Pampin, Eva Pablos, Jose Luis Navarro, Federico Narvaez, Javier Marenco, Jose Luis Herrero‐Beaumont, Gabriel Fernandez‐Gutierrez, Benjamin Lamas, Jose Ramon de la Serna, Arturo Rodriguez Ortiz, Ana Maria Carreño, Luis Cañete, Juan D. Caliz, Rafael Blanco, Francisco J. Balsa, Alejandro Gomez‐Reino, Juan J. Gonzalez, Antonio 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.24748 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as <jats:italic>HLA</jats:italic>, <jats:italic>PTPN22</jats:italic>, <jats:italic>STAT4</jats:italic>, and <jats:italic>6q23</jats:italic>. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A characteristic single‐nucleotide polymorphism (SNP) in each of 9 genetic factors, <jats:italic>ITGAM</jats:italic> (rs1143679), <jats:italic>C8orf13–BLK</jats:italic> (rs13277113), <jats:italic>TYK2</jats:italic> (rs2304256), <jats:italic>1q25.1</jats:italic> (rs10798269), <jats:italic>PXK</jats:italic> (rs6445975), <jats:italic>KIAA1542</jats:italic> (rs4963128), <jats:italic>MECP2</jats:italic> (rs17435), <jats:italic>BANK1</jats:italic> (rs17266594), and <jats:italic>LY9</jats:italic> (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in <jats:italic>STAT4</jats:italic> was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti–cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta‐analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the <jats:italic>C8orf13–BLK</jats:italic> locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; <jats:italic>P</jats:italic> = 0.003).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.</jats:p></jats:sec> Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors Arthritis & Rheumatism |
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Chemie und Pharmazie Medizin |
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2009 |
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Wiley |
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Arthritis & Rheumatism |
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49 |
| title |
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_unstemmed |
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_full |
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_fullStr |
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_full_unstemmed |
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_short |
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_sort |
rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| topic |
Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/art.24748 |
| publishDate |
2009 |
| physical |
2558-2564 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as <jats:italic>HLA</jats:italic>, <jats:italic>PTPN22</jats:italic>, <jats:italic>STAT4</jats:italic>, and <jats:italic>6q23</jats:italic>. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A characteristic single‐nucleotide polymorphism (SNP) in each of 9 genetic factors, <jats:italic>ITGAM</jats:italic> (rs1143679), <jats:italic>C8orf13–BLK</jats:italic> (rs13277113), <jats:italic>TYK2</jats:italic> (rs2304256), <jats:italic>1q25.1</jats:italic> (rs10798269), <jats:italic>PXK</jats:italic> (rs6445975), <jats:italic>KIAA1542</jats:italic> (rs4963128), <jats:italic>MECP2</jats:italic> (rs17435), <jats:italic>BANK1</jats:italic> (rs17266594), and <jats:italic>LY9</jats:italic> (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in <jats:italic>STAT4</jats:italic> was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti–cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta‐analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the <jats:italic>C8orf13–BLK</jats:italic> locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; <jats:italic>P</jats:italic> = 0.003).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.</jats:p></jats:sec> |
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| author | Suarez‐Gestal, Marian, Calaza, Manuel, Dieguez‐Gonzalez, Rebeca, Perez‐Pampin, Eva, Pablos, Jose Luis, Navarro, Federico, Narvaez, Javier, Marenco, Jose Luis, Herrero‐Beaumont, Gabriel, Fernandez‐Gutierrez, Benjamin, Lamas, Jose Ramon, de la Serna, Arturo Rodriguez, Ortiz, Ana Maria, Carreño, Luis, Cañete, Juan D., Caliz, Rafael, Blanco, Francisco J., Balsa, Alejandro, Gomez‐Reino, Juan J., Gonzalez, Antonio |
| author_facet | Suarez‐Gestal, Marian, Calaza, Manuel, Dieguez‐Gonzalez, Rebeca, Perez‐Pampin, Eva, Pablos, Jose Luis, Navarro, Federico, Narvaez, Javier, Marenco, Jose Luis, Herrero‐Beaumont, Gabriel, Fernandez‐Gutierrez, Benjamin, Lamas, Jose Ramon, de la Serna, Arturo Rodriguez, Ortiz, Ana Maria, Carreño, Luis, Cañete, Juan D., Caliz, Rafael, Blanco, Francisco J., Balsa, Alejandro, Gomez‐Reino, Juan J., Gonzalez, Antonio, Suarez‐Gestal, Marian, Calaza, Manuel, Dieguez‐Gonzalez, Rebeca, Perez‐Pampin, Eva, Pablos, Jose Luis, Navarro, Federico, Narvaez, Javier, Marenco, Jose Luis, Herrero‐Beaumont, Gabriel, Fernandez‐Gutierrez, Benjamin, Lamas, Jose Ramon, de la Serna, Arturo Rodriguez, Ortiz, Ana Maria, Carreño, Luis, Cañete, Juan D., Caliz, Rafael, Blanco, Francisco J., Balsa, Alejandro, Gomez‐Reino, Juan J., Gonzalez, Antonio |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as <jats:italic>HLA</jats:italic>, <jats:italic>PTPN22</jats:italic>, <jats:italic>STAT4</jats:italic>, and <jats:italic>6q23</jats:italic>. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A characteristic single‐nucleotide polymorphism (SNP) in each of 9 genetic factors, <jats:italic>ITGAM</jats:italic> (rs1143679), <jats:italic>C8orf13–BLK</jats:italic> (rs13277113), <jats:italic>TYK2</jats:italic> (rs2304256), <jats:italic>1q25.1</jats:italic> (rs10798269), <jats:italic>PXK</jats:italic> (rs6445975), <jats:italic>KIAA1542</jats:italic> (rs4963128), <jats:italic>MECP2</jats:italic> (rs17435), <jats:italic>BANK1</jats:italic> (rs17266594), and <jats:italic>LY9</jats:italic> (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in <jats:italic>STAT4</jats:italic> was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti–cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta‐analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the <jats:italic>C8orf13–BLK</jats:italic> locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; <jats:italic>P</jats:italic> = 0.003).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.</jats:p></jats:sec> |
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| spelling | Suarez‐Gestal, Marian Calaza, Manuel Dieguez‐Gonzalez, Rebeca Perez‐Pampin, Eva Pablos, Jose Luis Navarro, Federico Narvaez, Javier Marenco, Jose Luis Herrero‐Beaumont, Gabriel Fernandez‐Gutierrez, Benjamin Lamas, Jose Ramon de la Serna, Arturo Rodriguez Ortiz, Ana Maria Carreño, Luis Cañete, Juan D. Caliz, Rafael Blanco, Francisco J. Balsa, Alejandro Gomez‐Reino, Juan J. Gonzalez, Antonio 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.24748 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as <jats:italic>HLA</jats:italic>, <jats:italic>PTPN22</jats:italic>, <jats:italic>STAT4</jats:italic>, and <jats:italic>6q23</jats:italic>. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A characteristic single‐nucleotide polymorphism (SNP) in each of 9 genetic factors, <jats:italic>ITGAM</jats:italic> (rs1143679), <jats:italic>C8orf13–BLK</jats:italic> (rs13277113), <jats:italic>TYK2</jats:italic> (rs2304256), <jats:italic>1q25.1</jats:italic> (rs10798269), <jats:italic>PXK</jats:italic> (rs6445975), <jats:italic>KIAA1542</jats:italic> (rs4963128), <jats:italic>MECP2</jats:italic> (rs17435), <jats:italic>BANK1</jats:italic> (rs17266594), and <jats:italic>LY9</jats:italic> (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in <jats:italic>STAT4</jats:italic> was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti–cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta‐analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the <jats:italic>C8orf13–BLK</jats:italic> locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; <jats:italic>P</jats:italic> = 0.003).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.</jats:p></jats:sec> Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors Arthritis & Rheumatism |
| spellingShingle | Suarez‐Gestal, Marian, Calaza, Manuel, Dieguez‐Gonzalez, Rebeca, Perez‐Pampin, Eva, Pablos, Jose Luis, Navarro, Federico, Narvaez, Javier, Marenco, Jose Luis, Herrero‐Beaumont, Gabriel, Fernandez‐Gutierrez, Benjamin, Lamas, Jose Ramon, de la Serna, Arturo Rodriguez, Ortiz, Ana Maria, Carreño, Luis, Cañete, Juan D., Caliz, Rafael, Blanco, Francisco J., Balsa, Alejandro, Gomez‐Reino, Juan J., Gonzalez, Antonio, Arthritis & Rheumatism, Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors, Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| title | Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_full | Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_fullStr | Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_full_unstemmed | Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_short | Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_sort | rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| title_unstemmed | Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors |
| topic | Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/art.24748 |