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Association of STAT4 with rheumatoid arthritis: A replication study in three European populations
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| Zeitschriftentitel: | Arthritis & Rheumatism |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , |
| In: | Arthritis & Rheumatism, 58, 2008, 7, S. 1974-1980 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Orozco, Gisela Alizadeh, Behrooz Z. Delgado‐Vega, Angélica M. González‐Gay, Miguel Á. Balsa, Alejandro Pascual‐Salcedo, Dora Fernández‐Gutierrez, Benjamín González‐Escribano, María F. Petersson, Ingemar F. van Riel, Piet L. C. M. Barrera, Pilar Coenen, Marieke J. H. Radstake, Timothy R. D. J. van Leeuwen, Miek A. Wijmenga, Cisca Koeleman, Bobby P. C. Alarcón‐Riquelme, Marta Martín, Javier Orozco, Gisela Alizadeh, Behrooz Z. Delgado‐Vega, Angélica M. González‐Gay, Miguel Á. Balsa, Alejandro Pascual‐Salcedo, Dora Fernández‐Gutierrez, Benjamín González‐Escribano, María F. Petersson, Ingemar F. van Riel, Piet L. C. M. Barrera, Pilar Coenen, Marieke J. H. Radstake, Timothy R. D. J. van Leeuwen, Miek A. Wijmenga, Cisca Koeleman, Bobby P. C. Alarcón‐Riquelme, Marta Martín, Javier |
|---|---|
| author |
Orozco, Gisela Alizadeh, Behrooz Z. Delgado‐Vega, Angélica M. González‐Gay, Miguel Á. Balsa, Alejandro Pascual‐Salcedo, Dora Fernández‐Gutierrez, Benjamín González‐Escribano, María F. Petersson, Ingemar F. van Riel, Piet L. C. M. Barrera, Pilar Coenen, Marieke J. H. Radstake, Timothy R. D. J. van Leeuwen, Miek A. Wijmenga, Cisca Koeleman, Bobby P. C. Alarcón‐Riquelme, Marta Martín, Javier |
| spellingShingle |
Orozco, Gisela Alizadeh, Behrooz Z. Delgado‐Vega, Angélica M. González‐Gay, Miguel Á. Balsa, Alejandro Pascual‐Salcedo, Dora Fernández‐Gutierrez, Benjamín González‐Escribano, María F. Petersson, Ingemar F. van Riel, Piet L. C. M. Barrera, Pilar Coenen, Marieke J. H. Radstake, Timothy R. D. J. van Leeuwen, Miek A. Wijmenga, Cisca Koeleman, Bobby P. C. Alarcón‐Riquelme, Marta Martín, Javier Arthritis & Rheumatism Association of STAT4 with rheumatoid arthritis: A replication study in three European populations Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| author_sort |
orozco, gisela |
| spelling |
Orozco, Gisela Alizadeh, Behrooz Z. Delgado‐Vega, Angélica M. González‐Gay, Miguel Á. Balsa, Alejandro Pascual‐Salcedo, Dora Fernández‐Gutierrez, Benjamín González‐Escribano, María F. Petersson, Ingemar F. van Riel, Piet L. C. M. Barrera, Pilar Coenen, Marieke J. H. Radstake, Timothy R. D. J. van Leeuwen, Miek A. Wijmenga, Cisca Koeleman, Bobby P. C. Alarcón‐Riquelme, Marta Martín, Javier 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.23549 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>This study was undertaken to investigate the previously reported association of the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the <jats:italic>STAT4</jats:italic> single‐nucleotide polymorphism rs7574865 using a TaqMan 5′‐allele discrimination assay. The chi‐square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; <jats:italic>P</jats:italic> = 0.001, OR 1.26 [95% CI 1.09–1.45]). This association was confirmed in both the Swedish population (<jats:italic>P</jats:italic> = 0.03, OR 1.35 [95% CI 1.03–1.77]) and the Dutch population (<jats:italic>P</jats:italic> = 0.03, OR 1.45 [95% CI 1.21–1.73]). The overall <jats:italic>P</jats:italic> value for all 3 populations was 9.79 × 10<jats:sup>−6</jats:sup> (OR 1.25 [95% CI 1.13–1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti–cyclic citrullinated peptide autoantibodies was observed. A meta‐analysis of all published <jats:italic>STAT4</jats:italic> associations revealed an OR of 1.25 (95% CI 1.19–1.33) (<jats:italic>P</jats:italic> = 1 × 10<jats:sup>−5</jats:sup>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings indicate an association between the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data.</jats:p></jats:sec> Association of <i>STAT4</i> with rheumatoid arthritis: A replication study in three European populations Arthritis & Rheumatism |
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10.1002/art.23549 |
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Chemie und Pharmazie Medizin |
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Wiley, 2008 |
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Wiley, 2008 |
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2008 |
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Wiley |
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ai |
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ai |
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Arthritis & Rheumatism |
| source_id |
49 |
| title |
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_unstemmed |
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_full |
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_fullStr |
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_full_unstemmed |
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_short |
Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_sort |
association of <i>stat4</i> with rheumatoid arthritis: a replication study in three european populations |
| topic |
Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/art.23549 |
| publishDate |
2008 |
| physical |
1974-1980 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>This study was undertaken to investigate the previously reported association of the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the <jats:italic>STAT4</jats:italic> single‐nucleotide polymorphism rs7574865 using a TaqMan 5′‐allele discrimination assay. The chi‐square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; <jats:italic>P</jats:italic> = 0.001, OR 1.26 [95% CI 1.09–1.45]). This association was confirmed in both the Swedish population (<jats:italic>P</jats:italic> = 0.03, OR 1.35 [95% CI 1.03–1.77]) and the Dutch population (<jats:italic>P</jats:italic> = 0.03, OR 1.45 [95% CI 1.21–1.73]). The overall <jats:italic>P</jats:italic> value for all 3 populations was 9.79 × 10<jats:sup>−6</jats:sup> (OR 1.25 [95% CI 1.13–1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti–cyclic citrullinated peptide autoantibodies was observed. A meta‐analysis of all published <jats:italic>STAT4</jats:italic> associations revealed an OR of 1.25 (95% CI 1.19–1.33) (<jats:italic>P</jats:italic> = 1 × 10<jats:sup>−5</jats:sup>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings indicate an association between the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data.</jats:p></jats:sec> |
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| author | Orozco, Gisela, Alizadeh, Behrooz Z., Delgado‐Vega, Angélica M., González‐Gay, Miguel Á., Balsa, Alejandro, Pascual‐Salcedo, Dora, Fernández‐Gutierrez, Benjamín, González‐Escribano, María F., Petersson, Ingemar F., van Riel, Piet L. C. M., Barrera, Pilar, Coenen, Marieke J. H., Radstake, Timothy R. D. J., van Leeuwen, Miek A., Wijmenga, Cisca, Koeleman, Bobby P. C., Alarcón‐Riquelme, Marta, Martín, Javier |
| author_facet | Orozco, Gisela, Alizadeh, Behrooz Z., Delgado‐Vega, Angélica M., González‐Gay, Miguel Á., Balsa, Alejandro, Pascual‐Salcedo, Dora, Fernández‐Gutierrez, Benjamín, González‐Escribano, María F., Petersson, Ingemar F., van Riel, Piet L. C. M., Barrera, Pilar, Coenen, Marieke J. H., Radstake, Timothy R. D. J., van Leeuwen, Miek A., Wijmenga, Cisca, Koeleman, Bobby P. C., Alarcón‐Riquelme, Marta, Martín, Javier, Orozco, Gisela, Alizadeh, Behrooz Z., Delgado‐Vega, Angélica M., González‐Gay, Miguel Á., Balsa, Alejandro, Pascual‐Salcedo, Dora, Fernández‐Gutierrez, Benjamín, González‐Escribano, María F., Petersson, Ingemar F., van Riel, Piet L. C. M., Barrera, Pilar, Coenen, Marieke J. H., Radstake, Timothy R. D. J., van Leeuwen, Miek A., Wijmenga, Cisca, Koeleman, Bobby P. C., Alarcón‐Riquelme, Marta, Martín, Javier |
| author_sort | orozco, gisela |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>This study was undertaken to investigate the previously reported association of the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the <jats:italic>STAT4</jats:italic> single‐nucleotide polymorphism rs7574865 using a TaqMan 5′‐allele discrimination assay. The chi‐square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; <jats:italic>P</jats:italic> = 0.001, OR 1.26 [95% CI 1.09–1.45]). This association was confirmed in both the Swedish population (<jats:italic>P</jats:italic> = 0.03, OR 1.35 [95% CI 1.03–1.77]) and the Dutch population (<jats:italic>P</jats:italic> = 0.03, OR 1.45 [95% CI 1.21–1.73]). The overall <jats:italic>P</jats:italic> value for all 3 populations was 9.79 × 10<jats:sup>−6</jats:sup> (OR 1.25 [95% CI 1.13–1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti–cyclic citrullinated peptide autoantibodies was observed. A meta‐analysis of all published <jats:italic>STAT4</jats:italic> associations revealed an OR of 1.25 (95% CI 1.19–1.33) (<jats:italic>P</jats:italic> = 1 × 10<jats:sup>−5</jats:sup>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings indicate an association between the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data.</jats:p></jats:sec> |
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| spelling | Orozco, Gisela Alizadeh, Behrooz Z. Delgado‐Vega, Angélica M. González‐Gay, Miguel Á. Balsa, Alejandro Pascual‐Salcedo, Dora Fernández‐Gutierrez, Benjamín González‐Escribano, María F. Petersson, Ingemar F. van Riel, Piet L. C. M. Barrera, Pilar Coenen, Marieke J. H. Radstake, Timothy R. D. J. van Leeuwen, Miek A. Wijmenga, Cisca Koeleman, Bobby P. C. Alarcón‐Riquelme, Marta Martín, Javier 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.23549 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>This study was undertaken to investigate the previously reported association of the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the <jats:italic>STAT4</jats:italic> single‐nucleotide polymorphism rs7574865 using a TaqMan 5′‐allele discrimination assay. The chi‐square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; <jats:italic>P</jats:italic> = 0.001, OR 1.26 [95% CI 1.09–1.45]). This association was confirmed in both the Swedish population (<jats:italic>P</jats:italic> = 0.03, OR 1.35 [95% CI 1.03–1.77]) and the Dutch population (<jats:italic>P</jats:italic> = 0.03, OR 1.45 [95% CI 1.21–1.73]). The overall <jats:italic>P</jats:italic> value for all 3 populations was 9.79 × 10<jats:sup>−6</jats:sup> (OR 1.25 [95% CI 1.13–1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti–cyclic citrullinated peptide autoantibodies was observed. A meta‐analysis of all published <jats:italic>STAT4</jats:italic> associations revealed an OR of 1.25 (95% CI 1.19–1.33) (<jats:italic>P</jats:italic> = 1 × 10<jats:sup>−5</jats:sup>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings indicate an association between the <jats:italic>STAT4</jats:italic> polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data.</jats:p></jats:sec> Association of <i>STAT4</i> with rheumatoid arthritis: A replication study in three European populations Arthritis & Rheumatism |
| spellingShingle | Orozco, Gisela, Alizadeh, Behrooz Z., Delgado‐Vega, Angélica M., González‐Gay, Miguel Á., Balsa, Alejandro, Pascual‐Salcedo, Dora, Fernández‐Gutierrez, Benjamín, González‐Escribano, María F., Petersson, Ingemar F., van Riel, Piet L. C. M., Barrera, Pilar, Coenen, Marieke J. H., Radstake, Timothy R. D. J., van Leeuwen, Miek A., Wijmenga, Cisca, Koeleman, Bobby P. C., Alarcón‐Riquelme, Marta, Martín, Javier, Arthritis & Rheumatism, Association of STAT4 with rheumatoid arthritis: A replication study in three European populations, Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| title | Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_full | Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_fullStr | Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_full_unstemmed | Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_short | Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| title_sort | association of <i>stat4</i> with rheumatoid arthritis: a replication study in three european populations |
| title_unstemmed | Association of STAT4 with rheumatoid arthritis: A replication study in three European populations |
| topic | Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/art.23549 |