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Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients
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| Zeitschriftentitel: | Arthritis Care & Research |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Arthritis Care & Research, 55, 2006, 1, S. 131-137 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Blockmans, Daniël Ceuninck, Liesbet de Vanderschueren, Steven Knockaert, Daniël Mortelmans, Luc Bobbaers, Herman Blockmans, Daniël Ceuninck, Liesbet de Vanderschueren, Steven Knockaert, Daniël Mortelmans, Luc Bobbaers, Herman |
|---|---|
| author |
Blockmans, Daniël Ceuninck, Liesbet de Vanderschueren, Steven Knockaert, Daniël Mortelmans, Luc Bobbaers, Herman |
| spellingShingle |
Blockmans, Daniël Ceuninck, Liesbet de Vanderschueren, Steven Knockaert, Daniël Mortelmans, Luc Bobbaers, Herman Arthritis Care & Research Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients Rheumatology |
| author_sort |
blockmans, daniël |
| spelling |
Blockmans, Daniël Ceuninck, Liesbet de Vanderschueren, Steven Knockaert, Daniël Mortelmans, Luc Bobbaers, Herman 0893-7524 1529-0123 Wiley Rheumatology http://dx.doi.org/10.1002/art.21699 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study fluorodeoxyglucose (FDG) uptake in the different vascular beds and in the large joints of patients with giant cell arteritis (GCA) at diagnosis, during steroid treatment, and at relapse.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>All consecutive patients admitted to our department with a diagnosis of GCA underwent FDG–positron emission tomography (PET) scan before treatment with methylprednisolone was started. PET scans were repeated at 3 and 6 months, if the initial PET scans showed vascular FDG uptake. PET scans were scored at 7 different vascular areas and a total vascular score (TVS) was calculated, ranging from 0 to 21.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 35 patients entered the study. At diagnosis, vascular FDG uptake was noted in 29 patients (83%), especially in the subclavian arteries (74%), but also in the aorta (>50%) and up to the femoral arteries (37%). TVS decreased from a mean ± SD score of 7.9 ± 5.5 at baseline to 2.4 ± 3.5 on repeat PET scan at 3 months (<jats:italic>P</jats:italic> < 0.0005), but did not further decrease at 6 months. The patients who relapsed had similar earlier decreases of TVS compared with those who did not relapse. FDG uptake in the shoulders at diagnosis correlated significantly with the presence of polymyalgia rheumatica (<jats:italic>P</jats:italic> = 0.005).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>FDG uptake in the large vessels is a sensitive marker for GCA, which can involve the larger thoracic, abdominal, and peripheral arteries. Polymyalgia rheumatica symptoms in patients with GCA correlate with (peri)synovitis of the shoulders. Relapses of GCA cannot be predicted by results of former PET scintigraphies.</jats:p></jats:sec> Repetitive <sup>18</sup>F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients Arthritis Care & Research |
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10.1002/art.21699 |
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Medizin |
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Wiley, 2006 |
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Wiley, 2006 |
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Arthritis Care & Research |
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| title |
Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_unstemmed |
Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_full |
Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_fullStr |
Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_full_unstemmed |
Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_short |
Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_sort |
repetitive <sup>18</sup>f‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients |
| topic |
Rheumatology |
| url |
http://dx.doi.org/10.1002/art.21699 |
| publishDate |
2006 |
| physical |
131-137 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study fluorodeoxyglucose (FDG) uptake in the different vascular beds and in the large joints of patients with giant cell arteritis (GCA) at diagnosis, during steroid treatment, and at relapse.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>All consecutive patients admitted to our department with a diagnosis of GCA underwent FDG–positron emission tomography (PET) scan before treatment with methylprednisolone was started. PET scans were repeated at 3 and 6 months, if the initial PET scans showed vascular FDG uptake. PET scans were scored at 7 different vascular areas and a total vascular score (TVS) was calculated, ranging from 0 to 21.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 35 patients entered the study. At diagnosis, vascular FDG uptake was noted in 29 patients (83%), especially in the subclavian arteries (74%), but also in the aorta (>50%) and up to the femoral arteries (37%). TVS decreased from a mean ± SD score of 7.9 ± 5.5 at baseline to 2.4 ± 3.5 on repeat PET scan at 3 months (<jats:italic>P</jats:italic> < 0.0005), but did not further decrease at 6 months. The patients who relapsed had similar earlier decreases of TVS compared with those who did not relapse. FDG uptake in the shoulders at diagnosis correlated significantly with the presence of polymyalgia rheumatica (<jats:italic>P</jats:italic> = 0.005).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>FDG uptake in the large vessels is a sensitive marker for GCA, which can involve the larger thoracic, abdominal, and peripheral arteries. Polymyalgia rheumatica symptoms in patients with GCA correlate with (peri)synovitis of the shoulders. Relapses of GCA cannot be predicted by results of former PET scintigraphies.</jats:p></jats:sec> |
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| author | Blockmans, Daniël, Ceuninck, Liesbet de, Vanderschueren, Steven, Knockaert, Daniël, Mortelmans, Luc, Bobbaers, Herman |
| author_facet | Blockmans, Daniël, Ceuninck, Liesbet de, Vanderschueren, Steven, Knockaert, Daniël, Mortelmans, Luc, Bobbaers, Herman, Blockmans, Daniël, Ceuninck, Liesbet de, Vanderschueren, Steven, Knockaert, Daniël, Mortelmans, Luc, Bobbaers, Herman |
| author_sort | blockmans, daniël |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study fluorodeoxyglucose (FDG) uptake in the different vascular beds and in the large joints of patients with giant cell arteritis (GCA) at diagnosis, during steroid treatment, and at relapse.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>All consecutive patients admitted to our department with a diagnosis of GCA underwent FDG–positron emission tomography (PET) scan before treatment with methylprednisolone was started. PET scans were repeated at 3 and 6 months, if the initial PET scans showed vascular FDG uptake. PET scans were scored at 7 different vascular areas and a total vascular score (TVS) was calculated, ranging from 0 to 21.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 35 patients entered the study. At diagnosis, vascular FDG uptake was noted in 29 patients (83%), especially in the subclavian arteries (74%), but also in the aorta (>50%) and up to the femoral arteries (37%). TVS decreased from a mean ± SD score of 7.9 ± 5.5 at baseline to 2.4 ± 3.5 on repeat PET scan at 3 months (<jats:italic>P</jats:italic> < 0.0005), but did not further decrease at 6 months. The patients who relapsed had similar earlier decreases of TVS compared with those who did not relapse. FDG uptake in the shoulders at diagnosis correlated significantly with the presence of polymyalgia rheumatica (<jats:italic>P</jats:italic> = 0.005).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>FDG uptake in the large vessels is a sensitive marker for GCA, which can involve the larger thoracic, abdominal, and peripheral arteries. Polymyalgia rheumatica symptoms in patients with GCA correlate with (peri)synovitis of the shoulders. Relapses of GCA cannot be predicted by results of former PET scintigraphies.</jats:p></jats:sec> |
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| imprint | Wiley, 2006 |
| imprint_str_mv | Wiley, 2006 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| language | English |
| last_indexed | 2024-03-01T17:55:22.562Z |
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| spelling | Blockmans, Daniël Ceuninck, Liesbet de Vanderschueren, Steven Knockaert, Daniël Mortelmans, Luc Bobbaers, Herman 0893-7524 1529-0123 Wiley Rheumatology http://dx.doi.org/10.1002/art.21699 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study fluorodeoxyglucose (FDG) uptake in the different vascular beds and in the large joints of patients with giant cell arteritis (GCA) at diagnosis, during steroid treatment, and at relapse.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>All consecutive patients admitted to our department with a diagnosis of GCA underwent FDG–positron emission tomography (PET) scan before treatment with methylprednisolone was started. PET scans were repeated at 3 and 6 months, if the initial PET scans showed vascular FDG uptake. PET scans were scored at 7 different vascular areas and a total vascular score (TVS) was calculated, ranging from 0 to 21.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 35 patients entered the study. At diagnosis, vascular FDG uptake was noted in 29 patients (83%), especially in the subclavian arteries (74%), but also in the aorta (>50%) and up to the femoral arteries (37%). TVS decreased from a mean ± SD score of 7.9 ± 5.5 at baseline to 2.4 ± 3.5 on repeat PET scan at 3 months (<jats:italic>P</jats:italic> < 0.0005), but did not further decrease at 6 months. The patients who relapsed had similar earlier decreases of TVS compared with those who did not relapse. FDG uptake in the shoulders at diagnosis correlated significantly with the presence of polymyalgia rheumatica (<jats:italic>P</jats:italic> = 0.005).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>FDG uptake in the large vessels is a sensitive marker for GCA, which can involve the larger thoracic, abdominal, and peripheral arteries. Polymyalgia rheumatica symptoms in patients with GCA correlate with (peri)synovitis of the shoulders. Relapses of GCA cannot be predicted by results of former PET scintigraphies.</jats:p></jats:sec> Repetitive <sup>18</sup>F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients Arthritis Care & Research |
| spellingShingle | Blockmans, Daniël, Ceuninck, Liesbet de, Vanderschueren, Steven, Knockaert, Daniël, Mortelmans, Luc, Bobbaers, Herman, Arthritis Care & Research, Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients, Rheumatology |
| title | Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_full | Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_fullStr | Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_full_unstemmed | Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_short | Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| title_sort | repetitive <sup>18</sup>f‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients |
| title_unstemmed | Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients |
| topic | Rheumatology |
| url | http://dx.doi.org/10.1002/art.21699 |