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Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid
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| Zeitschriftentitel: | Arthritis & Rheumatism |
|---|---|
| Personen und Körperschaften: | , |
| In: | Arthritis & Rheumatism, 31, 1988, 8, S. 1046-1051 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Vitti, Gerard Hamilton, John A. Vitti, Gerard Hamilton, John A. |
|---|---|
| author |
Vitti, Gerard Hamilton, John A. |
| spellingShingle |
Vitti, Gerard Hamilton, John A. Arthritis & Rheumatism Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| author_sort |
vitti, gerard |
| spelling |
Vitti, Gerard Hamilton, John A. 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.1780310817 <jats:title>Abstract</jats:title><jats:p>Previous studies have shown that mononuclear cell–conditioned medium (MCCM), interleukin‐1 (IL‐1), and all‐<jats:italic>trans</jats:italic>‐retinoic acid rapidly stimulate, while glucocorticoids lower, the urokinase‐type plasminogen activator (u‐PA) activity of human synovial fibroblastlike cells. It is now reported that MCCM, recombinant human IL‐1α (rHuIL‐1α), rHuIL‐1β, and all‐<jats:italic>trans</jats:italic>‐retinoic acid elevate the u‐PA messenger RNA (mRNA) levels to a steady‐state value within 2 hours, while dexamethasone (10<jats:sup>−7</jats:sup><jats:italic>M</jats:italic>) inhibits this increase. For both situations, when the u‐PA activity is either stimulated or reduced, the changes in the u‐PA mRNA levels parallel the changes in the u‐PA activity, and it is suggested that modulation of gene transcription plays an important role.</jats:p> Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid Arthritis & Rheumatism |
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10.1002/art.1780310817 |
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Wiley, 1988 |
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Wiley, 1988 |
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| title |
Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_unstemmed |
Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_full |
Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_fullStr |
Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_full_unstemmed |
Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_short |
Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_sort |
modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| topic |
Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/art.1780310817 |
| publishDate |
1988 |
| physical |
1046-1051 |
| description |
<jats:title>Abstract</jats:title><jats:p>Previous studies have shown that mononuclear cell–conditioned medium (MCCM), interleukin‐1 (IL‐1), and all‐<jats:italic>trans</jats:italic>‐retinoic acid rapidly stimulate, while glucocorticoids lower, the urokinase‐type plasminogen activator (u‐PA) activity of human synovial fibroblastlike cells. It is now reported that MCCM, recombinant human IL‐1α (rHuIL‐1α), rHuIL‐1β, and all‐<jats:italic>trans</jats:italic>‐retinoic acid elevate the u‐PA messenger RNA (mRNA) levels to a steady‐state value within 2 hours, while dexamethasone (10<jats:sup>−7</jats:sup><jats:italic>M</jats:italic>) inhibits this increase. For both situations, when the u‐PA activity is either stimulated or reduced, the changes in the u‐PA mRNA levels parallel the changes in the u‐PA activity, and it is suggested that modulation of gene transcription plays an important role.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>Previous studies have shown that mononuclear cell–conditioned medium (MCCM), interleukin‐1 (IL‐1), and all‐<jats:italic>trans</jats:italic>‐retinoic acid rapidly stimulate, while glucocorticoids lower, the urokinase‐type plasminogen activator (u‐PA) activity of human synovial fibroblastlike cells. It is now reported that MCCM, recombinant human IL‐1α (rHuIL‐1α), rHuIL‐1β, and all‐<jats:italic>trans</jats:italic>‐retinoic acid elevate the u‐PA messenger RNA (mRNA) levels to a steady‐state value within 2 hours, while dexamethasone (10<jats:sup>−7</jats:sup><jats:italic>M</jats:italic>) inhibits this increase. For both situations, when the u‐PA activity is either stimulated or reduced, the changes in the u‐PA mRNA levels parallel the changes in the u‐PA activity, and it is suggested that modulation of gene transcription plays an important role.</jats:p> |
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| imprint | Wiley, 1988 |
| imprint_str_mv | Wiley, 1988 |
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| spelling | Vitti, Gerard Hamilton, John A. 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.1780310817 <jats:title>Abstract</jats:title><jats:p>Previous studies have shown that mononuclear cell–conditioned medium (MCCM), interleukin‐1 (IL‐1), and all‐<jats:italic>trans</jats:italic>‐retinoic acid rapidly stimulate, while glucocorticoids lower, the urokinase‐type plasminogen activator (u‐PA) activity of human synovial fibroblastlike cells. It is now reported that MCCM, recombinant human IL‐1α (rHuIL‐1α), rHuIL‐1β, and all‐<jats:italic>trans</jats:italic>‐retinoic acid elevate the u‐PA messenger RNA (mRNA) levels to a steady‐state value within 2 hours, while dexamethasone (10<jats:sup>−7</jats:sup><jats:italic>M</jats:italic>) inhibits this increase. For both situations, when the u‐PA activity is either stimulated or reduced, the changes in the u‐PA mRNA levels parallel the changes in the u‐PA activity, and it is suggested that modulation of gene transcription plays an important role.</jats:p> Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid Arthritis & Rheumatism |
| spellingShingle | Vitti, Gerard, Hamilton, John A., Arthritis & Rheumatism, Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid, Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| title | Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_full | Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_fullStr | Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_full_unstemmed | Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_short | Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_sort | modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| title_unstemmed | Modulation of urokinase‐type plasminogen activator messenger rna levels in human synovial fibroblasts by interleukin‐1, retinoic acid, and a glucocorticoid |
| topic | Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/art.1780310817 |