Eintrag weiter verarbeiten
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gespeichert in:
| Zeitschriftentitel: | Arthritis & Rheumatism |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Arthritis & Rheumatism, 46, 2002, 5, S. 1333-1343 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Gracely, Richard H. Petzke, Frank Wolf, Julie M. Clauw, Daniel J. Gracely, Richard H. Petzke, Frank Wolf, Julie M. Clauw, Daniel J. |
|---|---|
| author |
Gracely, Richard H. Petzke, Frank Wolf, Julie M. Clauw, Daniel J. |
| spellingShingle |
Gracely, Richard H. Petzke, Frank Wolf, Julie M. Clauw, Daniel J. Arthritis & Rheumatism Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| author_sort |
gracely, richard h. |
| spelling |
Gracely, Richard H. Petzke, Frank Wolf, Julie M. Clauw, Daniel J. 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.10225 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To use functional magnetic resonance imaging (fMRI) to evaluate the pattern of cerebral activation during the application of painful pressure and determine whether this pattern is augmented in patients with fibromyalgia (FM) compared with controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Pressure was applied to the left thumbnail beds of 16 right‐handed patients with FM and 16 right‐handed matched controls. Each FM patient underwent fMRI while moderately painful pressure was being applied. The functional activation patterns in FM patients were compared with those in controls, who were tested under 2 conditions: the “stimulus pressure control” condition, during which they received an amount of pressure similar to that delivered to patients, and the “subjective pain control” condition, during which the intensity of stimulation was increased to deliver a subjective level of pain similar to that experienced by patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Stimulation with adequate pressure to cause similar pain in both groups resulted in 19 regions of increased regional cerebral blood flow in healthy controls and 12 significant regions in patients. Increased fMRI signal occurred in 7 regions common to both groups, and decreased signal was observed in 1 common region. In contrast, stimulation of controls with the same amount of pressure that caused pain in patients resulted in only 2 regions of increased signal, neither of which coincided with a region of activation in patients. Statistical comparison of the patient and control groups receiving similar stimulus pressures revealed 13 regions of greater activation in the patient group. In contrast, similar stimulus pressures produced only 1 region of greater activation in the control group.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The fact that comparable subjectively painful conditions resulted in activation patterns that were similar in patients and controls, whereas similar pressures resulted in no common regions of activation and greater effects in patients, supports the hypothesis that FM is characterized by cortical or subcortical augmentation of pain processing.</jats:p></jats:sec> Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia Arthritis & Rheumatism |
| doi_str_mv |
10.1002/art.10225 |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hcnQuMTAyMjU |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hcnQuMTAyMjU |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 |
| imprint |
Wiley, 2002 |
| imprint_str_mv |
Wiley, 2002 |
| issn |
0004-3591 1529-0131 |
| issn_str_mv |
0004-3591 1529-0131 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
gracely2002functionalmagneticresonanceimagingevidenceofaugmentedpainprocessinginfibromyalgia |
| publishDateSort |
2002 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Arthritis & Rheumatism |
| source_id |
49 |
| title |
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_unstemmed |
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_full |
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_fullStr |
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_full_unstemmed |
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_short |
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_sort |
functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| topic |
Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/art.10225 |
| publishDate |
2002 |
| physical |
1333-1343 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To use functional magnetic resonance imaging (fMRI) to evaluate the pattern of cerebral activation during the application of painful pressure and determine whether this pattern is augmented in patients with fibromyalgia (FM) compared with controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Pressure was applied to the left thumbnail beds of 16 right‐handed patients with FM and 16 right‐handed matched controls. Each FM patient underwent fMRI while moderately painful pressure was being applied. The functional activation patterns in FM patients were compared with those in controls, who were tested under 2 conditions: the “stimulus pressure control” condition, during which they received an amount of pressure similar to that delivered to patients, and the “subjective pain control” condition, during which the intensity of stimulation was increased to deliver a subjective level of pain similar to that experienced by patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Stimulation with adequate pressure to cause similar pain in both groups resulted in 19 regions of increased regional cerebral blood flow in healthy controls and 12 significant regions in patients. Increased fMRI signal occurred in 7 regions common to both groups, and decreased signal was observed in 1 common region. In contrast, stimulation of controls with the same amount of pressure that caused pain in patients resulted in only 2 regions of increased signal, neither of which coincided with a region of activation in patients. Statistical comparison of the patient and control groups receiving similar stimulus pressures revealed 13 regions of greater activation in the patient group. In contrast, similar stimulus pressures produced only 1 region of greater activation in the control group.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The fact that comparable subjectively painful conditions resulted in activation patterns that were similar in patients and controls, whereas similar pressures resulted in no common regions of activation and greater effects in patients, supports the hypothesis that FM is characterized by cortical or subcortical augmentation of pain processing.</jats:p></jats:sec> |
| container_issue |
5 |
| container_start_page |
1333 |
| container_title |
Arthritis & Rheumatism |
| container_volume |
46 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348118033891328 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:06:05.094Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Functional+magnetic+resonance+imaging+evidence+of+augmented+pain+processing+in+fibromyalgia&rft.date=2002-05-01&genre=article&issn=1529-0131&volume=46&issue=5&spage=1333&epage=1343&pages=1333-1343&jtitle=Arthritis+%26+Rheumatism&atitle=Functional+magnetic+resonance+imaging+evidence+of+augmented+pain+processing+in+fibromyalgia&aulast=Clauw&aufirst=Daniel+J.&rft_id=info%3Adoi%2F10.1002%2Fart.10225&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348118033891328 |
| author | Gracely, Richard H., Petzke, Frank, Wolf, Julie M., Clauw, Daniel J. |
| author_facet | Gracely, Richard H., Petzke, Frank, Wolf, Julie M., Clauw, Daniel J., Gracely, Richard H., Petzke, Frank, Wolf, Julie M., Clauw, Daniel J. |
| author_sort | gracely, richard h. |
| container_issue | 5 |
| container_start_page | 1333 |
| container_title | Arthritis & Rheumatism |
| container_volume | 46 |
| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To use functional magnetic resonance imaging (fMRI) to evaluate the pattern of cerebral activation during the application of painful pressure and determine whether this pattern is augmented in patients with fibromyalgia (FM) compared with controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Pressure was applied to the left thumbnail beds of 16 right‐handed patients with FM and 16 right‐handed matched controls. Each FM patient underwent fMRI while moderately painful pressure was being applied. The functional activation patterns in FM patients were compared with those in controls, who were tested under 2 conditions: the “stimulus pressure control” condition, during which they received an amount of pressure similar to that delivered to patients, and the “subjective pain control” condition, during which the intensity of stimulation was increased to deliver a subjective level of pain similar to that experienced by patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Stimulation with adequate pressure to cause similar pain in both groups resulted in 19 regions of increased regional cerebral blood flow in healthy controls and 12 significant regions in patients. Increased fMRI signal occurred in 7 regions common to both groups, and decreased signal was observed in 1 common region. In contrast, stimulation of controls with the same amount of pressure that caused pain in patients resulted in only 2 regions of increased signal, neither of which coincided with a region of activation in patients. Statistical comparison of the patient and control groups receiving similar stimulus pressures revealed 13 regions of greater activation in the patient group. In contrast, similar stimulus pressures produced only 1 region of greater activation in the control group.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The fact that comparable subjectively painful conditions resulted in activation patterns that were similar in patients and controls, whereas similar pressures resulted in no common regions of activation and greater effects in patients, supports the hypothesis that FM is characterized by cortical or subcortical augmentation of pain processing.</jats:p></jats:sec> |
| doi_str_mv | 10.1002/art.10225 |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hcnQuMTAyMjU |
| imprint | Wiley, 2002 |
| imprint_str_mv | Wiley, 2002 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1 |
| issn | 0004-3591, 1529-0131 |
| issn_str_mv | 0004-3591, 1529-0131 |
| language | English |
| last_indexed | 2024-03-01T18:06:05.094Z |
| match_str | gracely2002functionalmagneticresonanceimagingevidenceofaugmentedpainprocessinginfibromyalgia |
| mega_collection | Wiley (CrossRef) |
| physical | 1333-1343 |
| publishDate | 2002 |
| publishDateSort | 2002 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Arthritis & Rheumatism |
| source_id | 49 |
| spelling | Gracely, Richard H. Petzke, Frank Wolf, Julie M. Clauw, Daniel J. 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.10225 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To use functional magnetic resonance imaging (fMRI) to evaluate the pattern of cerebral activation during the application of painful pressure and determine whether this pattern is augmented in patients with fibromyalgia (FM) compared with controls.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Pressure was applied to the left thumbnail beds of 16 right‐handed patients with FM and 16 right‐handed matched controls. Each FM patient underwent fMRI while moderately painful pressure was being applied. The functional activation patterns in FM patients were compared with those in controls, who were tested under 2 conditions: the “stimulus pressure control” condition, during which they received an amount of pressure similar to that delivered to patients, and the “subjective pain control” condition, during which the intensity of stimulation was increased to deliver a subjective level of pain similar to that experienced by patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Stimulation with adequate pressure to cause similar pain in both groups resulted in 19 regions of increased regional cerebral blood flow in healthy controls and 12 significant regions in patients. Increased fMRI signal occurred in 7 regions common to both groups, and decreased signal was observed in 1 common region. In contrast, stimulation of controls with the same amount of pressure that caused pain in patients resulted in only 2 regions of increased signal, neither of which coincided with a region of activation in patients. Statistical comparison of the patient and control groups receiving similar stimulus pressures revealed 13 regions of greater activation in the patient group. In contrast, similar stimulus pressures produced only 1 region of greater activation in the control group.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The fact that comparable subjectively painful conditions resulted in activation patterns that were similar in patients and controls, whereas similar pressures resulted in no common regions of activation and greater effects in patients, supports the hypothesis that FM is characterized by cortical or subcortical augmentation of pain processing.</jats:p></jats:sec> Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia Arthritis & Rheumatism |
| spellingShingle | Gracely, Richard H., Petzke, Frank, Wolf, Julie M., Clauw, Daniel J., Arthritis & Rheumatism, Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia, Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| title | Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_full | Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_fullStr | Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_full_unstemmed | Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_short | Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_sort | functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| title_unstemmed | Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia |
| topic | Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/art.10225 |