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Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II
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| Zeitschriftentitel: | Archiv der Pharmazie |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Archiv der Pharmazie, 317, 1984, 6, S. 481-487 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Ehresmann, Klaus Zelezny, Otto Eisenbrand, Gerhard Ehresmann, Klaus Zelezny, Otto Eisenbrand, Gerhard |
|---|---|
| author |
Ehresmann, Klaus Zelezny, Otto Eisenbrand, Gerhard |
| spellingShingle |
Ehresmann, Klaus Zelezny, Otto Eisenbrand, Gerhard Archiv der Pharmazie Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II Drug Discovery Pharmaceutical Science |
| author_sort |
ehresmann, klaus |
| spelling |
Ehresmann, Klaus Zelezny, Otto Eisenbrand, Gerhard 0365-6233 1521-4184 Wiley Drug Discovery Pharmaceutical Science http://dx.doi.org/10.1002/ardp.19843170602 <jats:title>Abstract</jats:title><jats:p>Syntheses of <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acid amides and esters as potential antineoplastic substances are reported. <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acids (with the exception of the glycine derivative) were prepared by reaction of 2‐chloroethyl isocyanate with the sodium salt of an amino acid in a heterogenous medium followed by nitrosation with sodium nitrite under acidic conditions. Condensation with amines or alcohols using 1,1‐carbonyldiimidazole led to the amides or esters.</jats:p> Syntheses of Potentially Antineoplastic Amides and Esters of <i>N</i>‐[<i>N</i>'‐(2‐Chloroethyl)‐<i>N</i>'‐nitrosocarbamoyl]amino Acids, II Archiv der Pharmazie |
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10.1002/ardp.19843170602 |
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Online |
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Chemie und Pharmazie |
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Wiley, 1984 |
| imprint_str_mv |
Wiley, 1984 |
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0365-6233 1521-4184 |
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0365-6233 1521-4184 |
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English |
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ehresmann1984synthesesofpotentiallyantineoplasticamidesandestersofnn2chloroethylnnitrosocarbamoylaminoacidsii |
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1984 |
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Archiv der Pharmazie |
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49 |
| title |
Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_unstemmed |
Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_full |
Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_fullStr |
Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_full_unstemmed |
Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_short |
Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_sort |
syntheses of potentially antineoplastic amides and esters of <i>n</i>‐[<i>n</i>'‐(2‐chloroethyl)‐<i>n</i>'‐nitrosocarbamoyl]amino acids, ii |
| topic |
Drug Discovery Pharmaceutical Science |
| url |
http://dx.doi.org/10.1002/ardp.19843170602 |
| publishDate |
1984 |
| physical |
481-487 |
| description |
<jats:title>Abstract</jats:title><jats:p>Syntheses of <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acid amides and esters as potential antineoplastic substances are reported. <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acids (with the exception of the glycine derivative) were prepared by reaction of 2‐chloroethyl isocyanate with the sodium salt of an amino acid in a heterogenous medium followed by nitrosation with sodium nitrite under acidic conditions. Condensation with amines or alcohols using 1,1‐carbonyldiimidazole led to the amides or esters.</jats:p> |
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| author | Ehresmann, Klaus, Zelezny, Otto, Eisenbrand, Gerhard |
| author_facet | Ehresmann, Klaus, Zelezny, Otto, Eisenbrand, Gerhard, Ehresmann, Klaus, Zelezny, Otto, Eisenbrand, Gerhard |
| author_sort | ehresmann, klaus |
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| container_start_page | 481 |
| container_title | Archiv der Pharmazie |
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| description | <jats:title>Abstract</jats:title><jats:p>Syntheses of <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acid amides and esters as potential antineoplastic substances are reported. <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acids (with the exception of the glycine derivative) were prepared by reaction of 2‐chloroethyl isocyanate with the sodium salt of an amino acid in a heterogenous medium followed by nitrosation with sodium nitrite under acidic conditions. Condensation with amines or alcohols using 1,1‐carbonyldiimidazole led to the amides or esters.</jats:p> |
| doi_str_mv | 10.1002/ardp.19843170602 |
| facet_avail | Online |
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| imprint | Wiley, 1984 |
| imprint_str_mv | Wiley, 1984 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0365-6233, 1521-4184 |
| issn_str_mv | 0365-6233, 1521-4184 |
| language | English |
| last_indexed | 2024-03-01T14:59:51.003Z |
| match_str | ehresmann1984synthesesofpotentiallyantineoplasticamidesandestersofnn2chloroethylnnitrosocarbamoylaminoacidsii |
| mega_collection | Wiley (CrossRef) |
| physical | 481-487 |
| publishDate | 1984 |
| publishDateSort | 1984 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Archiv der Pharmazie |
| source_id | 49 |
| spelling | Ehresmann, Klaus Zelezny, Otto Eisenbrand, Gerhard 0365-6233 1521-4184 Wiley Drug Discovery Pharmaceutical Science http://dx.doi.org/10.1002/ardp.19843170602 <jats:title>Abstract</jats:title><jats:p>Syntheses of <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acid amides and esters as potential antineoplastic substances are reported. <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>'‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>'‐nitrosocarbamoyl]amino acids (with the exception of the glycine derivative) were prepared by reaction of 2‐chloroethyl isocyanate with the sodium salt of an amino acid in a heterogenous medium followed by nitrosation with sodium nitrite under acidic conditions. Condensation with amines or alcohols using 1,1‐carbonyldiimidazole led to the amides or esters.</jats:p> Syntheses of Potentially Antineoplastic Amides and Esters of <i>N</i>‐[<i>N</i>'‐(2‐Chloroethyl)‐<i>N</i>'‐nitrosocarbamoyl]amino Acids, II Archiv der Pharmazie |
| spellingShingle | Ehresmann, Klaus, Zelezny, Otto, Eisenbrand, Gerhard, Archiv der Pharmazie, Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II, Drug Discovery, Pharmaceutical Science |
| title | Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_full | Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_fullStr | Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_full_unstemmed | Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_short | Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| title_sort | syntheses of potentially antineoplastic amides and esters of <i>n</i>‐[<i>n</i>'‐(2‐chloroethyl)‐<i>n</i>'‐nitrosocarbamoyl]amino acids, ii |
| title_unstemmed | Syntheses of Potentially Antineoplastic Amides and Esters of N‐[N'‐(2‐Chloroethyl)‐N'‐nitrosocarbamoyl]amino Acids, II |
| topic | Drug Discovery, Pharmaceutical Science |
| url | http://dx.doi.org/10.1002/ardp.19843170602 |