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In‐Phase Ultra High‐Resolution In Vivo NMR
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| Zeitschriftentitel: | Angewandte Chemie |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Angewandte Chemie, 129, 2017, 22, S. 6421-6425 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Fugariu, Ioana Bermel, Wolfgang Lane, Daniel Soong, Ronald Simpson, Andre J. Fugariu, Ioana Bermel, Wolfgang Lane, Daniel Soong, Ronald Simpson, Andre J. |
|---|---|
| author |
Fugariu, Ioana Bermel, Wolfgang Lane, Daniel Soong, Ronald Simpson, Andre J. |
| spellingShingle |
Fugariu, Ioana Bermel, Wolfgang Lane, Daniel Soong, Ronald Simpson, Andre J. Angewandte Chemie In‐Phase Ultra High‐Resolution In Vivo NMR General Medicine |
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fugariu, ioana |
| spelling |
Fugariu, Ioana Bermel, Wolfgang Lane, Daniel Soong, Ronald Simpson, Andre J. 0044-8249 1521-3757 Wiley General Medicine http://dx.doi.org/10.1002/ange.201701097 <jats:title>Abstract</jats:title><jats:p>Although current NMR techniques allow organisms to be studied in vivo, magnetic susceptibility distortions, which arise from inhomogeneous distributions of chemical moieties, prevent the acquisition of high‐resolution NMR spectra. Intermolecular single quantum coherence (iSQC) is a technique that breaks the sample's spatial isotropy to form long range dipolar couplings, which can be exploited to extract chemical shift information free of perturbations. While this approach holds vast potential, present practical limitations include radiation damping, relaxation losses, and non‐phase sensitive data. Herein, these drawbacks are addressed, and a new technique termed in‐phase iSQC (IP‐iSQC) is introduced. When applied to a living system, high‐resolution NMR spectra, nearly identical to a buffer extract, are obtained. The ability to look inside an organism and extract a high‐resolution metabolic profile is profound and should find applications in fields in which metabolism or in vivo processes are of interest.</jats:p> In‐Phase Ultra High‐Resolution In Vivo NMR Angewandte Chemie |
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Wiley, 2017 |
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| title |
In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_unstemmed |
In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_full |
In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_fullStr |
In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_full_unstemmed |
In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_short |
In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_sort |
in‐phase ultra high‐resolution in vivo nmr |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1002/ange.201701097 |
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2017 |
| physical |
6421-6425 |
| description |
<jats:title>Abstract</jats:title><jats:p>Although current NMR techniques allow organisms to be studied in vivo, magnetic susceptibility distortions, which arise from inhomogeneous distributions of chemical moieties, prevent the acquisition of high‐resolution NMR spectra. Intermolecular single quantum coherence (iSQC) is a technique that breaks the sample's spatial isotropy to form long range dipolar couplings, which can be exploited to extract chemical shift information free of perturbations. While this approach holds vast potential, present practical limitations include radiation damping, relaxation losses, and non‐phase sensitive data. Herein, these drawbacks are addressed, and a new technique termed in‐phase iSQC (IP‐iSQC) is introduced. When applied to a living system, high‐resolution NMR spectra, nearly identical to a buffer extract, are obtained. The ability to look inside an organism and extract a high‐resolution metabolic profile is profound and should find applications in fields in which metabolism or in vivo processes are of interest.</jats:p> |
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| author | Fugariu, Ioana, Bermel, Wolfgang, Lane, Daniel, Soong, Ronald, Simpson, Andre J. |
| author_facet | Fugariu, Ioana, Bermel, Wolfgang, Lane, Daniel, Soong, Ronald, Simpson, Andre J., Fugariu, Ioana, Bermel, Wolfgang, Lane, Daniel, Soong, Ronald, Simpson, Andre J. |
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| description | <jats:title>Abstract</jats:title><jats:p>Although current NMR techniques allow organisms to be studied in vivo, magnetic susceptibility distortions, which arise from inhomogeneous distributions of chemical moieties, prevent the acquisition of high‐resolution NMR spectra. Intermolecular single quantum coherence (iSQC) is a technique that breaks the sample's spatial isotropy to form long range dipolar couplings, which can be exploited to extract chemical shift information free of perturbations. While this approach holds vast potential, present practical limitations include radiation damping, relaxation losses, and non‐phase sensitive data. Herein, these drawbacks are addressed, and a new technique termed in‐phase iSQC (IP‐iSQC) is introduced. When applied to a living system, high‐resolution NMR spectra, nearly identical to a buffer extract, are obtained. The ability to look inside an organism and extract a high‐resolution metabolic profile is profound and should find applications in fields in which metabolism or in vivo processes are of interest.</jats:p> |
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| spelling | Fugariu, Ioana Bermel, Wolfgang Lane, Daniel Soong, Ronald Simpson, Andre J. 0044-8249 1521-3757 Wiley General Medicine http://dx.doi.org/10.1002/ange.201701097 <jats:title>Abstract</jats:title><jats:p>Although current NMR techniques allow organisms to be studied in vivo, magnetic susceptibility distortions, which arise from inhomogeneous distributions of chemical moieties, prevent the acquisition of high‐resolution NMR spectra. Intermolecular single quantum coherence (iSQC) is a technique that breaks the sample's spatial isotropy to form long range dipolar couplings, which can be exploited to extract chemical shift information free of perturbations. While this approach holds vast potential, present practical limitations include radiation damping, relaxation losses, and non‐phase sensitive data. Herein, these drawbacks are addressed, and a new technique termed in‐phase iSQC (IP‐iSQC) is introduced. When applied to a living system, high‐resolution NMR spectra, nearly identical to a buffer extract, are obtained. The ability to look inside an organism and extract a high‐resolution metabolic profile is profound and should find applications in fields in which metabolism or in vivo processes are of interest.</jats:p> In‐Phase Ultra High‐Resolution In Vivo NMR Angewandte Chemie |
| spellingShingle | Fugariu, Ioana, Bermel, Wolfgang, Lane, Daniel, Soong, Ronald, Simpson, Andre J., Angewandte Chemie, In‐Phase Ultra High‐Resolution In Vivo NMR, General Medicine |
| title | In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_full | In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_fullStr | In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_full_unstemmed | In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_short | In‐Phase Ultra High‐Resolution In Vivo NMR |
| title_sort | in‐phase ultra high‐resolution in vivo nmr |
| title_unstemmed | In‐Phase Ultra High‐Resolution In Vivo NMR |
| topic | General Medicine |
| url | http://dx.doi.org/10.1002/ange.201701097 |