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Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3
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| Zeitschriftentitel: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 127B, 2004, 1, S. 11-19 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Yamada, K. Iwayama‐Shigeno, Y. Yoshida, Y. Toyota, T. Itokawa, M. Hattori, E. Shimizu, H. Yoshikawa, T. Yamada, K. Iwayama‐Shigeno, Y. Yoshida, Y. Toyota, T. Itokawa, M. Hattori, E. Shimizu, H. Yoshikawa, T. |
|---|---|
| author |
Yamada, K. Iwayama‐Shigeno, Y. Yoshida, Y. Toyota, T. Itokawa, M. Hattori, E. Shimizu, H. Yoshikawa, T. |
| spellingShingle |
Yamada, K. Iwayama‐Shigeno, Y. Yoshida, Y. Toyota, T. Itokawa, M. Hattori, E. Shimizu, H. Yoshikawa, T. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 Cellular and Molecular Neuroscience Psychiatry and Mental health Genetics (clinical) |
| author_sort |
yamada, k. |
| spelling |
Yamada, K. Iwayama‐Shigeno, Y. Yoshida, Y. Toyota, T. Itokawa, M. Hattori, E. Shimizu, H. Yoshikawa, T. 1552-4841 1552-485X Wiley Cellular and Molecular Neuroscience Psychiatry and Mental health Genetics (clinical) http://dx.doi.org/10.1002/ajmg.b.20166 <jats:title>Abstract</jats:title><jats:p>Family‐based linkage disequilibrium (LD) mapping has been suggested as a powerful and practical alternative to linkage analysis. We have performed a genome‐wide LD survey of susceptibility loci for schizophrenia in a Japanese population. We first typed 119 schizophrenic pedigrees (357 individuals) using 444 microsatellite markers, and analyzed the data using the pedigree disequilibrium test. This analysis revealed 14 markers demonstrating significant transmission distortion. To corroborate these findings, the statistical methods were changed to the extended transmission disequilibrium test (ETDT), using 80 independent complete trios (schizophrenic proband and both parents), with 68 derived from initial pedigrees and 12 newly recruited trios. ETDT supported two markers for continued association, <jats:italic>D11S987</jats:italic> on 11q13.3 (<jats:italic>P</jats:italic> = 0.00009) and <jats:italic>D16S423</jats:italic> on 16p13.3 (<jats:italic>P</jats:italic> = 0.002). We scrutinized the most significant genomic locus on 11q11‐13 by adding 26 new markers for analysis. Results of three‐marker haplotype analysis in the region showed evidence of association with schizophrenia (most significant haplotype <jats:italic>P</jats:italic> = 0.0005, global <jats:italic>P</jats:italic> = 0.022). Although the present study may have missed other potential genomic intervals because of the sparse mapping density, we hope that it has identified promising anchor points for further studies to identify risk‐conferring genes for schizophrenia in the Japanese population. In addition, we provide useful information on genomic LD structures in Japanese populations, which can be used for LD mapping of complex diseases. © 2004 Wiley‐Liss, Inc.</jats:p> Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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| title |
Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_unstemmed |
Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_full |
Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_fullStr |
Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_full_unstemmed |
Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_short |
Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_sort |
family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| topic |
Cellular and Molecular Neuroscience Psychiatry and Mental health Genetics (clinical) |
| url |
http://dx.doi.org/10.1002/ajmg.b.20166 |
| publishDate |
2004 |
| physical |
11-19 |
| description |
<jats:title>Abstract</jats:title><jats:p>Family‐based linkage disequilibrium (LD) mapping has been suggested as a powerful and practical alternative to linkage analysis. We have performed a genome‐wide LD survey of susceptibility loci for schizophrenia in a Japanese population. We first typed 119 schizophrenic pedigrees (357 individuals) using 444 microsatellite markers, and analyzed the data using the pedigree disequilibrium test. This analysis revealed 14 markers demonstrating significant transmission distortion. To corroborate these findings, the statistical methods were changed to the extended transmission disequilibrium test (ETDT), using 80 independent complete trios (schizophrenic proband and both parents), with 68 derived from initial pedigrees and 12 newly recruited trios. ETDT supported two markers for continued association, <jats:italic>D11S987</jats:italic> on 11q13.3 (<jats:italic>P</jats:italic> = 0.00009) and <jats:italic>D16S423</jats:italic> on 16p13.3 (<jats:italic>P</jats:italic> = 0.002). We scrutinized the most significant genomic locus on 11q11‐13 by adding 26 new markers for analysis. Results of three‐marker haplotype analysis in the region showed evidence of association with schizophrenia (most significant haplotype <jats:italic>P</jats:italic> = 0.0005, global <jats:italic>P</jats:italic> = 0.022). Although the present study may have missed other potential genomic intervals because of the sparse mapping density, we hope that it has identified promising anchor points for further studies to identify risk‐conferring genes for schizophrenia in the Japanese population. In addition, we provide useful information on genomic LD structures in Japanese populations, which can be used for LD mapping of complex diseases. © 2004 Wiley‐Liss, Inc.</jats:p> |
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| author | Yamada, K., Iwayama‐Shigeno, Y., Yoshida, Y., Toyota, T., Itokawa, M., Hattori, E., Shimizu, H., Yoshikawa, T. |
| author_facet | Yamada, K., Iwayama‐Shigeno, Y., Yoshida, Y., Toyota, T., Itokawa, M., Hattori, E., Shimizu, H., Yoshikawa, T., Yamada, K., Iwayama‐Shigeno, Y., Yoshida, Y., Toyota, T., Itokawa, M., Hattori, E., Shimizu, H., Yoshikawa, T. |
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| container_title | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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| description | <jats:title>Abstract</jats:title><jats:p>Family‐based linkage disequilibrium (LD) mapping has been suggested as a powerful and practical alternative to linkage analysis. We have performed a genome‐wide LD survey of susceptibility loci for schizophrenia in a Japanese population. We first typed 119 schizophrenic pedigrees (357 individuals) using 444 microsatellite markers, and analyzed the data using the pedigree disequilibrium test. This analysis revealed 14 markers demonstrating significant transmission distortion. To corroborate these findings, the statistical methods were changed to the extended transmission disequilibrium test (ETDT), using 80 independent complete trios (schizophrenic proband and both parents), with 68 derived from initial pedigrees and 12 newly recruited trios. ETDT supported two markers for continued association, <jats:italic>D11S987</jats:italic> on 11q13.3 (<jats:italic>P</jats:italic> = 0.00009) and <jats:italic>D16S423</jats:italic> on 16p13.3 (<jats:italic>P</jats:italic> = 0.002). We scrutinized the most significant genomic locus on 11q11‐13 by adding 26 new markers for analysis. Results of three‐marker haplotype analysis in the region showed evidence of association with schizophrenia (most significant haplotype <jats:italic>P</jats:italic> = 0.0005, global <jats:italic>P</jats:italic> = 0.022). Although the present study may have missed other potential genomic intervals because of the sparse mapping density, we hope that it has identified promising anchor points for further studies to identify risk‐conferring genes for schizophrenia in the Japanese population. In addition, we provide useful information on genomic LD structures in Japanese populations, which can be used for LD mapping of complex diseases. © 2004 Wiley‐Liss, Inc.</jats:p> |
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| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
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| spelling | Yamada, K. Iwayama‐Shigeno, Y. Yoshida, Y. Toyota, T. Itokawa, M. Hattori, E. Shimizu, H. Yoshikawa, T. 1552-4841 1552-485X Wiley Cellular and Molecular Neuroscience Psychiatry and Mental health Genetics (clinical) http://dx.doi.org/10.1002/ajmg.b.20166 <jats:title>Abstract</jats:title><jats:p>Family‐based linkage disequilibrium (LD) mapping has been suggested as a powerful and practical alternative to linkage analysis. We have performed a genome‐wide LD survey of susceptibility loci for schizophrenia in a Japanese population. We first typed 119 schizophrenic pedigrees (357 individuals) using 444 microsatellite markers, and analyzed the data using the pedigree disequilibrium test. This analysis revealed 14 markers demonstrating significant transmission distortion. To corroborate these findings, the statistical methods were changed to the extended transmission disequilibrium test (ETDT), using 80 independent complete trios (schizophrenic proband and both parents), with 68 derived from initial pedigrees and 12 newly recruited trios. ETDT supported two markers for continued association, <jats:italic>D11S987</jats:italic> on 11q13.3 (<jats:italic>P</jats:italic> = 0.00009) and <jats:italic>D16S423</jats:italic> on 16p13.3 (<jats:italic>P</jats:italic> = 0.002). We scrutinized the most significant genomic locus on 11q11‐13 by adding 26 new markers for analysis. Results of three‐marker haplotype analysis in the region showed evidence of association with schizophrenia (most significant haplotype <jats:italic>P</jats:italic> = 0.0005, global <jats:italic>P</jats:italic> = 0.022). Although the present study may have missed other potential genomic intervals because of the sparse mapping density, we hope that it has identified promising anchor points for further studies to identify risk‐conferring genes for schizophrenia in the Japanese population. In addition, we provide useful information on genomic LD structures in Japanese populations, which can be used for LD mapping of complex diseases. © 2004 Wiley‐Liss, Inc.</jats:p> Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
| spellingShingle | Yamada, K., Iwayama‐Shigeno, Y., Yoshida, Y., Toyota, T., Itokawa, M., Hattori, E., Shimizu, H., Yoshikawa, T., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3, Cellular and Molecular Neuroscience, Psychiatry and Mental health, Genetics (clinical) |
| title | Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_full | Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_fullStr | Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_full_unstemmed | Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_short | Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_sort | family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| title_unstemmed | Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
| topic | Cellular and Molecular Neuroscience, Psychiatry and Mental health, Genetics (clinical) |
| url | http://dx.doi.org/10.1002/ajmg.b.20166 |