Eintrag weiter verarbeiten
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition
Gespeichert in:
Zeitschriftentitel: | Advanced Science |
---|---|
Personen und Körperschaften: | , , , , , , , , , , , , , , , , , |
In: | Advanced Science, 7, 2020, 6 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Ju, Yi Cortez‐Jugo, Christina Chen, Jingqu Wang, Ting‐Yi Mitchell, Andrew J. Tsantikos, Evelyn Bertleff‐Zieschang, Nadja Lin, Yu‐Wei Song, Jiaying Cheng, Yizhe Mettu, Srinivas Rahim, Md. Arifur Pan, Shuaijun Yun, Gyeongwon Hibbs, Margaret L. Yeo, Leslie Y. Hagemeyer, Christoph E. Caruso, Frank Ju, Yi Cortez‐Jugo, Christina Chen, Jingqu Wang, Ting‐Yi Mitchell, Andrew J. Tsantikos, Evelyn Bertleff‐Zieschang, Nadja Lin, Yu‐Wei Song, Jiaying Cheng, Yizhe Mettu, Srinivas Rahim, Md. Arifur Pan, Shuaijun Yun, Gyeongwon Hibbs, Margaret L. Yeo, Leslie Y. Hagemeyer, Christoph E. Caruso, Frank |
---|---|
author |
Ju, Yi Cortez‐Jugo, Christina Chen, Jingqu Wang, Ting‐Yi Mitchell, Andrew J. Tsantikos, Evelyn Bertleff‐Zieschang, Nadja Lin, Yu‐Wei Song, Jiaying Cheng, Yizhe Mettu, Srinivas Rahim, Md. Arifur Pan, Shuaijun Yun, Gyeongwon Hibbs, Margaret L. Yeo, Leslie Y. Hagemeyer, Christoph E. Caruso, Frank |
spellingShingle |
Ju, Yi Cortez‐Jugo, Christina Chen, Jingqu Wang, Ting‐Yi Mitchell, Andrew J. Tsantikos, Evelyn Bertleff‐Zieschang, Nadja Lin, Yu‐Wei Song, Jiaying Cheng, Yizhe Mettu, Srinivas Rahim, Md. Arifur Pan, Shuaijun Yun, Gyeongwon Hibbs, Margaret L. Yeo, Leslie Y. Hagemeyer, Christoph E. Caruso, Frank Advanced Science Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) |
author_sort |
ju, yi |
spelling |
Ju, Yi Cortez‐Jugo, Christina Chen, Jingqu Wang, Ting‐Yi Mitchell, Andrew J. Tsantikos, Evelyn Bertleff‐Zieschang, Nadja Lin, Yu‐Wei Song, Jiaying Cheng, Yizhe Mettu, Srinivas Rahim, Md. Arifur Pan, Shuaijun Yun, Gyeongwon Hibbs, Margaret L. Yeo, Leslie Y. Hagemeyer, Christoph E. Caruso, Frank 2198-3844 2198-3844 Wiley General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) http://dx.doi.org/10.1002/advs.201902650 <jats:title>Abstract</jats:title><jats:p>Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but <4% remaining after 30 days without causing lung inflammation or toxicity. Single‐cell analysis from lung digests using mass cytometry shows association primarily with alveolar macrophages, with >90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery.</jats:p> Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition Advanced Science |
doi_str_mv |
10.1002/advs.201902650 |
facet_avail |
Online Free |
finc_class_facet |
Chemie und Pharmazie Biologie Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hZHZzLjIwMTkwMjY1MA |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hZHZzLjIwMTkwMjY1MA |
institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 |
imprint |
Wiley, 2020 |
imprint_str_mv |
Wiley, 2020 |
issn |
2198-3844 |
issn_str_mv |
2198-3844 |
language |
English |
mega_collection |
Wiley (CrossRef) |
match_str |
ju2020engineeringofnebulizedmetalphenoliccapsulesforcontrolledpulmonarydeposition |
publishDateSort |
2020 |
publisher |
Wiley |
recordtype |
ai |
record_format |
ai |
series |
Advanced Science |
source_id |
49 |
title |
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_unstemmed |
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_full |
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_fullStr |
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_full_unstemmed |
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_short |
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_sort |
engineering of nebulized metal–phenolic capsules for controlled pulmonary deposition |
topic |
General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) |
url |
http://dx.doi.org/10.1002/advs.201902650 |
publishDate |
2020 |
physical |
|
description |
<jats:title>Abstract</jats:title><jats:p>Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but <4% remaining after 30 days without causing lung inflammation or toxicity. Single‐cell analysis from lung digests using mass cytometry shows association primarily with alveolar macrophages, with >90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery.</jats:p> |
container_issue |
6 |
container_start_page |
0 |
container_title |
Advanced Science |
container_volume |
7 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792347288033558532 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T17:51:32.092Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Engineering+of+Nebulized+Metal%E2%80%93Phenolic+Capsules+for+Controlled+Pulmonary+Deposition&rft.date=2020-03-01&genre=article&issn=2198-3844&volume=7&issue=6&jtitle=Advanced+Science&atitle=Engineering+of+Nebulized+Metal%E2%80%93Phenolic+Capsules+for+Controlled+Pulmonary+Deposition&aulast=Caruso&aufirst=Frank&rft_id=info%3Adoi%2F10.1002%2Fadvs.201902650&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792347288033558532 |
author | Ju, Yi, Cortez‐Jugo, Christina, Chen, Jingqu, Wang, Ting‐Yi, Mitchell, Andrew J., Tsantikos, Evelyn, Bertleff‐Zieschang, Nadja, Lin, Yu‐Wei, Song, Jiaying, Cheng, Yizhe, Mettu, Srinivas, Rahim, Md. Arifur, Pan, Shuaijun, Yun, Gyeongwon, Hibbs, Margaret L., Yeo, Leslie Y., Hagemeyer, Christoph E., Caruso, Frank |
author_facet | Ju, Yi, Cortez‐Jugo, Christina, Chen, Jingqu, Wang, Ting‐Yi, Mitchell, Andrew J., Tsantikos, Evelyn, Bertleff‐Zieschang, Nadja, Lin, Yu‐Wei, Song, Jiaying, Cheng, Yizhe, Mettu, Srinivas, Rahim, Md. Arifur, Pan, Shuaijun, Yun, Gyeongwon, Hibbs, Margaret L., Yeo, Leslie Y., Hagemeyer, Christoph E., Caruso, Frank, Ju, Yi, Cortez‐Jugo, Christina, Chen, Jingqu, Wang, Ting‐Yi, Mitchell, Andrew J., Tsantikos, Evelyn, Bertleff‐Zieschang, Nadja, Lin, Yu‐Wei, Song, Jiaying, Cheng, Yizhe, Mettu, Srinivas, Rahim, Md. Arifur, Pan, Shuaijun, Yun, Gyeongwon, Hibbs, Margaret L., Yeo, Leslie Y., Hagemeyer, Christoph E., Caruso, Frank |
author_sort | ju, yi |
container_issue | 6 |
container_start_page | 0 |
container_title | Advanced Science |
container_volume | 7 |
description | <jats:title>Abstract</jats:title><jats:p>Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but <4% remaining after 30 days without causing lung inflammation or toxicity. Single‐cell analysis from lung digests using mass cytometry shows association primarily with alveolar macrophages, with >90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery.</jats:p> |
doi_str_mv | 10.1002/advs.201902650 |
facet_avail | Online, Free |
finc_class_facet | Chemie und Pharmazie, Biologie, Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hZHZzLjIwMTkwMjY1MA |
imprint | Wiley, 2020 |
imprint_str_mv | Wiley, 2020 |
institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275 |
issn | 2198-3844 |
issn_str_mv | 2198-3844 |
language | English |
last_indexed | 2024-03-01T17:51:32.092Z |
match_str | ju2020engineeringofnebulizedmetalphenoliccapsulesforcontrolledpulmonarydeposition |
mega_collection | Wiley (CrossRef) |
physical | |
publishDate | 2020 |
publishDateSort | 2020 |
publisher | Wiley |
record_format | ai |
recordtype | ai |
series | Advanced Science |
source_id | 49 |
spelling | Ju, Yi Cortez‐Jugo, Christina Chen, Jingqu Wang, Ting‐Yi Mitchell, Andrew J. Tsantikos, Evelyn Bertleff‐Zieschang, Nadja Lin, Yu‐Wei Song, Jiaying Cheng, Yizhe Mettu, Srinivas Rahim, Md. Arifur Pan, Shuaijun Yun, Gyeongwon Hibbs, Margaret L. Yeo, Leslie Y. Hagemeyer, Christoph E. Caruso, Frank 2198-3844 2198-3844 Wiley General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) http://dx.doi.org/10.1002/advs.201902650 <jats:title>Abstract</jats:title><jats:p>Particle‐based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. The design of particles with enhanced aerodynamic properties can improve lung distribution and deposition, and hence the efficacy of encapsulated inhaled drugs. This study describes the nanoengineering and nebulization of metal–phenolic capsules as pulmonary carriers of small molecule drugs and macromolecular drugs in lung cell lines, a human lung model, and mice. Tuning the aerodynamic diameter by increasing the capsule shell thickness (from ≈100 to 200 nm in increments of ≈50 nm) through repeated film deposition on a sacrificial template allows precise control of capsule deposition in a human lung model, corresponding to a shift from the alveolar region to the bronchi as aerodynamic diameter increases. The capsules are biocompatible and biodegradable, as assessed following intratracheal administration in mice, showing >85% of the capsules in the lung after 20 h, but <4% remaining after 30 days without causing lung inflammation or toxicity. Single‐cell analysis from lung digests using mass cytometry shows association primarily with alveolar macrophages, with >90% of capsules remaining nonassociated with cells. The amenability to nebulization, capacity for loading, tunable aerodynamic properties, high biocompatibility, and biodegradability make these capsules attractive for controlled pulmonary delivery.</jats:p> Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition Advanced Science |
spellingShingle | Ju, Yi, Cortez‐Jugo, Christina, Chen, Jingqu, Wang, Ting‐Yi, Mitchell, Andrew J., Tsantikos, Evelyn, Bertleff‐Zieschang, Nadja, Lin, Yu‐Wei, Song, Jiaying, Cheng, Yizhe, Mettu, Srinivas, Rahim, Md. Arifur, Pan, Shuaijun, Yun, Gyeongwon, Hibbs, Margaret L., Yeo, Leslie Y., Hagemeyer, Christoph E., Caruso, Frank, Advanced Science, Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition, General Physics and Astronomy, General Engineering, Biochemistry, Genetics and Molecular Biology (miscellaneous), General Materials Science, General Chemical Engineering, Medicine (miscellaneous) |
title | Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_full | Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_fullStr | Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_full_unstemmed | Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_short | Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
title_sort | engineering of nebulized metal–phenolic capsules for controlled pulmonary deposition |
title_unstemmed | Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition |
topic | General Physics and Astronomy, General Engineering, Biochemistry, Genetics and Molecular Biology (miscellaneous), General Materials Science, General Chemical Engineering, Medicine (miscellaneous) |
url | http://dx.doi.org/10.1002/advs.201902650 |