Eintrag weiter verarbeiten
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure
Gespeichert in:
| Zeitschriftentitel: | Advanced Science |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , |
| In: | Advanced Science, 6, 2019, 18 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Li, Xiaobo Sun, Hao Li, Bin Zhang, Xinwei Cui, Jian Yun, Jun Yang, Yiping Zhang, Li'e Meng, Qingtao Wu, Shenshen Duan, Junchao Yang, Hongbao Wu, Jiong Sun, Zhiwei Zou, Yunfeng Chen, Rui Li, Xiaobo Sun, Hao Li, Bin Zhang, Xinwei Cui, Jian Yun, Jun Yang, Yiping Zhang, Li'e Meng, Qingtao Wu, Shenshen Duan, Junchao Yang, Hongbao Wu, Jiong Sun, Zhiwei Zou, Yunfeng Chen, Rui |
|---|---|
| author |
Li, Xiaobo Sun, Hao Li, Bin Zhang, Xinwei Cui, Jian Yun, Jun Yang, Yiping Zhang, Li'e Meng, Qingtao Wu, Shenshen Duan, Junchao Yang, Hongbao Wu, Jiong Sun, Zhiwei Zou, Yunfeng Chen, Rui |
| spellingShingle |
Li, Xiaobo Sun, Hao Li, Bin Zhang, Xinwei Cui, Jian Yun, Jun Yang, Yiping Zhang, Li'e Meng, Qingtao Wu, Shenshen Duan, Junchao Yang, Hongbao Wu, Jiong Sun, Zhiwei Zou, Yunfeng Chen, Rui Advanced Science Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) |
| author_sort |
li, xiaobo |
| spelling |
Li, Xiaobo Sun, Hao Li, Bin Zhang, Xinwei Cui, Jian Yun, Jun Yang, Yiping Zhang, Li'e Meng, Qingtao Wu, Shenshen Duan, Junchao Yang, Hongbao Wu, Jiong Sun, Zhiwei Zou, Yunfeng Chen, Rui 2198-3844 2198-3844 Wiley General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) http://dx.doi.org/10.1002/advs.201900972 <jats:title>Abstract</jats:title><jats:p>Diesel exhaust particles (DEPs) are common airborne ultrafine particles (UFPs); however, few studies have examined their effects on the gastrointestinal tract. To investigate the interaction of gut microbiota and DEPs‐induced colonic injury, adult C57BL/6 mice are kept in whole‐body inhalation chambers and exposed to filtered room air (FRA) or DEPs (300 µg m<jats:sup>−3</jats:sup>) 1 h per day for 28 consecutive days. DEPs exposure results in colon epithelial injury with inflammatory cell infiltration and mucus depletion. Abundance of <jats:italic>Lactobacillus</jats:italic> in murine feces is transiently increased following 7‐day DEPs exposure and then decreased until the end of 28‐day exposure. A reduction of the colonic mucus layer thickness is observed in mice receiving gut microbiota from DEPs‐exposed mice. Mechanistically, RNA‐sequencing suggests disruption of the nitrogen metabolism pathway in DEPs‐exposed NCM460 cells. Upregulation of carbonic anhydrase 9 (CA9) expression levels is observed in epithelia following DEPs exposure both in vivo and in vitro. Oral administration of probiotics protects the mice against DEPS‐induced colon epithelial injury. The results strongly suggest the involvement of gut microbiota in response to DEPs exposure and subsequently epithelial injury in vivo. Supplementation with probiotic may be a potential way to protect against UFPs‐induced colon epithelial injury.</jats:p> Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure Advanced Science |
| doi_str_mv |
10.1002/advs.201900972 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hZHZzLjIwMTkwMDk3Mg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hZHZzLjIwMTkwMDk3Mg |
| institution |
DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
Wiley, 2019 |
| imprint_str_mv |
Wiley, 2019 |
| issn |
2198-3844 |
| issn_str_mv |
2198-3844 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
li2019probioticsamelioratecolonepithelialinjuryinducedbyambientultrafineparticlesexposure |
| publishDateSort |
2019 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Advanced Science |
| source_id |
49 |
| title |
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_unstemmed |
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_full |
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_fullStr |
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_full_unstemmed |
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_short |
Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_sort |
probiotics ameliorate colon epithelial injury induced by ambient ultrafine particles exposure |
| topic |
General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) |
| url |
http://dx.doi.org/10.1002/advs.201900972 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title><jats:p>Diesel exhaust particles (DEPs) are common airborne ultrafine particles (UFPs); however, few studies have examined their effects on the gastrointestinal tract. To investigate the interaction of gut microbiota and DEPs‐induced colonic injury, adult C57BL/6 mice are kept in whole‐body inhalation chambers and exposed to filtered room air (FRA) or DEPs (300 µg m<jats:sup>−3</jats:sup>) 1 h per day for 28 consecutive days. DEPs exposure results in colon epithelial injury with inflammatory cell infiltration and mucus depletion. Abundance of <jats:italic>Lactobacillus</jats:italic> in murine feces is transiently increased following 7‐day DEPs exposure and then decreased until the end of 28‐day exposure. A reduction of the colonic mucus layer thickness is observed in mice receiving gut microbiota from DEPs‐exposed mice. Mechanistically, RNA‐sequencing suggests disruption of the nitrogen metabolism pathway in DEPs‐exposed NCM460 cells. Upregulation of carbonic anhydrase 9 (CA9) expression levels is observed in epithelia following DEPs exposure both in vivo and in vitro. Oral administration of probiotics protects the mice against DEPS‐induced colon epithelial injury. The results strongly suggest the involvement of gut microbiota in response to DEPs exposure and subsequently epithelial injury in vivo. Supplementation with probiotic may be a potential way to protect against UFPs‐induced colon epithelial injury.</jats:p> |
| container_issue |
18 |
| container_start_page |
0 |
| container_title |
Advanced Science |
| container_volume |
6 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792341850269417478 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:26:28.163Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Probiotics+Ameliorate+Colon+Epithelial+Injury+Induced+by+Ambient+Ultrafine+Particles+Exposure&rft.date=2019-09-01&genre=article&issn=2198-3844&volume=6&issue=18&jtitle=Advanced+Science&atitle=Probiotics+Ameliorate+Colon+Epithelial+Injury+Induced+by+Ambient+Ultrafine+Particles+Exposure&aulast=Chen&aufirst=Rui&rft_id=info%3Adoi%2F10.1002%2Fadvs.201900972&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792341850269417478 |
| author | Li, Xiaobo, Sun, Hao, Li, Bin, Zhang, Xinwei, Cui, Jian, Yun, Jun, Yang, Yiping, Zhang, Li'e, Meng, Qingtao, Wu, Shenshen, Duan, Junchao, Yang, Hongbao, Wu, Jiong, Sun, Zhiwei, Zou, Yunfeng, Chen, Rui |
| author_facet | Li, Xiaobo, Sun, Hao, Li, Bin, Zhang, Xinwei, Cui, Jian, Yun, Jun, Yang, Yiping, Zhang, Li'e, Meng, Qingtao, Wu, Shenshen, Duan, Junchao, Yang, Hongbao, Wu, Jiong, Sun, Zhiwei, Zou, Yunfeng, Chen, Rui, Li, Xiaobo, Sun, Hao, Li, Bin, Zhang, Xinwei, Cui, Jian, Yun, Jun, Yang, Yiping, Zhang, Li'e, Meng, Qingtao, Wu, Shenshen, Duan, Junchao, Yang, Hongbao, Wu, Jiong, Sun, Zhiwei, Zou, Yunfeng, Chen, Rui |
| author_sort | li, xiaobo |
| container_issue | 18 |
| container_start_page | 0 |
| container_title | Advanced Science |
| container_volume | 6 |
| description | <jats:title>Abstract</jats:title><jats:p>Diesel exhaust particles (DEPs) are common airborne ultrafine particles (UFPs); however, few studies have examined their effects on the gastrointestinal tract. To investigate the interaction of gut microbiota and DEPs‐induced colonic injury, adult C57BL/6 mice are kept in whole‐body inhalation chambers and exposed to filtered room air (FRA) or DEPs (300 µg m<jats:sup>−3</jats:sup>) 1 h per day for 28 consecutive days. DEPs exposure results in colon epithelial injury with inflammatory cell infiltration and mucus depletion. Abundance of <jats:italic>Lactobacillus</jats:italic> in murine feces is transiently increased following 7‐day DEPs exposure and then decreased until the end of 28‐day exposure. A reduction of the colonic mucus layer thickness is observed in mice receiving gut microbiota from DEPs‐exposed mice. Mechanistically, RNA‐sequencing suggests disruption of the nitrogen metabolism pathway in DEPs‐exposed NCM460 cells. Upregulation of carbonic anhydrase 9 (CA9) expression levels is observed in epithelia following DEPs exposure both in vivo and in vitro. Oral administration of probiotics protects the mice against DEPS‐induced colon epithelial injury. The results strongly suggest the involvement of gut microbiota in response to DEPs exposure and subsequently epithelial injury in vivo. Supplementation with probiotic may be a potential way to protect against UFPs‐induced colon epithelial injury.</jats:p> |
| doi_str_mv | 10.1002/advs.201900972 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hZHZzLjIwMTkwMDk3Mg |
| imprint | Wiley, 2019 |
| imprint_str_mv | Wiley, 2019 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 2198-3844 |
| issn_str_mv | 2198-3844 |
| language | English |
| last_indexed | 2024-03-01T16:26:28.163Z |
| match_str | li2019probioticsamelioratecolonepithelialinjuryinducedbyambientultrafineparticlesexposure |
| mega_collection | Wiley (CrossRef) |
| physical | |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Advanced Science |
| source_id | 49 |
| spelling | Li, Xiaobo Sun, Hao Li, Bin Zhang, Xinwei Cui, Jian Yun, Jun Yang, Yiping Zhang, Li'e Meng, Qingtao Wu, Shenshen Duan, Junchao Yang, Hongbao Wu, Jiong Sun, Zhiwei Zou, Yunfeng Chen, Rui 2198-3844 2198-3844 Wiley General Physics and Astronomy General Engineering Biochemistry, Genetics and Molecular Biology (miscellaneous) General Materials Science General Chemical Engineering Medicine (miscellaneous) http://dx.doi.org/10.1002/advs.201900972 <jats:title>Abstract</jats:title><jats:p>Diesel exhaust particles (DEPs) are common airborne ultrafine particles (UFPs); however, few studies have examined their effects on the gastrointestinal tract. To investigate the interaction of gut microbiota and DEPs‐induced colonic injury, adult C57BL/6 mice are kept in whole‐body inhalation chambers and exposed to filtered room air (FRA) or DEPs (300 µg m<jats:sup>−3</jats:sup>) 1 h per day for 28 consecutive days. DEPs exposure results in colon epithelial injury with inflammatory cell infiltration and mucus depletion. Abundance of <jats:italic>Lactobacillus</jats:italic> in murine feces is transiently increased following 7‐day DEPs exposure and then decreased until the end of 28‐day exposure. A reduction of the colonic mucus layer thickness is observed in mice receiving gut microbiota from DEPs‐exposed mice. Mechanistically, RNA‐sequencing suggests disruption of the nitrogen metabolism pathway in DEPs‐exposed NCM460 cells. Upregulation of carbonic anhydrase 9 (CA9) expression levels is observed in epithelia following DEPs exposure both in vivo and in vitro. Oral administration of probiotics protects the mice against DEPS‐induced colon epithelial injury. The results strongly suggest the involvement of gut microbiota in response to DEPs exposure and subsequently epithelial injury in vivo. Supplementation with probiotic may be a potential way to protect against UFPs‐induced colon epithelial injury.</jats:p> Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure Advanced Science |
| spellingShingle | Li, Xiaobo, Sun, Hao, Li, Bin, Zhang, Xinwei, Cui, Jian, Yun, Jun, Yang, Yiping, Zhang, Li'e, Meng, Qingtao, Wu, Shenshen, Duan, Junchao, Yang, Hongbao, Wu, Jiong, Sun, Zhiwei, Zou, Yunfeng, Chen, Rui, Advanced Science, Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure, General Physics and Astronomy, General Engineering, Biochemistry, Genetics and Molecular Biology (miscellaneous), General Materials Science, General Chemical Engineering, Medicine (miscellaneous) |
| title | Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_full | Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_fullStr | Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_full_unstemmed | Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_short | Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| title_sort | probiotics ameliorate colon epithelial injury induced by ambient ultrafine particles exposure |
| title_unstemmed | Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure |
| topic | General Physics and Astronomy, General Engineering, Biochemistry, Genetics and Molecular Biology (miscellaneous), General Materials Science, General Chemical Engineering, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1002/advs.201900972 |