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Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis

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Bibliographische Detailangaben
Zeitschriftentitel: Advanced Materials Technologies
Personen und Körperschaften: Nelson, Arif Z., Xie, Jiaxun, Khan, Saif A., Doyle, Patrick S.
In: Advanced Materials Technologies, 6, 2021, 4
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Industrial and Manufacturing Engineering
Mechanics of Materials
General Materials Science
author_facet Nelson, Arif Z.
Xie, Jiaxun
Khan, Saif A.
Doyle, Patrick S.
Nelson, Arif Z.
Xie, Jiaxun
Khan, Saif A.
Doyle, Patrick S.
author Nelson, Arif Z.
Xie, Jiaxun
Khan, Saif A.
Doyle, Patrick S.
spellingShingle Nelson, Arif Z.
Xie, Jiaxun
Khan, Saif A.
Doyle, Patrick S.
Advanced Materials Technologies
Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
Industrial and Manufacturing Engineering
Mechanics of Materials
General Materials Science
author_sort nelson, arif z.
spelling Nelson, Arif Z. Xie, Jiaxun Khan, Saif A. Doyle, Patrick S. 2365-709X 2365-709X Wiley Industrial and Manufacturing Engineering Mechanics of Materials General Materials Science http://dx.doi.org/10.1002/admt.202001245 <jats:title>Abstract</jats:title><jats:p>Embedded droplet printing is a recent mode of generating and processing droplets within yield‐stress fluids. This technique has shown promise for performing sensitive processes like pharmaceutical crystallization, as well as chemical synthesis and biological experimentation due to the unique ability to process droplets that are quiescently suspended. Despite improving on conventional microfluidic technologies in numerous ways, current embedded droplet printing methods are limited to batch processes, severely hampering their overall utility. A new platform that enables continuous production of embedded droplets is presented and characterized. This platform expands the capabilities of embedded droplet printing and allows for its application to areas of continuous materials discovery, screening, and manufacturing. Here, the platform is used for the rapid production of pharmaceutical particles that are highly spherical and uniform, key targets for flowability, and ultimately manufacturability of pharmaceutical drug products. The presented platform achieves a maximum throughput of over 100 g per day, enabling characterization of the superior powder flow properties. The available operating space of this platform is demonstrated for an antisolvent crystallization process with an anti‐malarial drug. This understanding provides design guidelines for how similar platforms may be engineered for precise, rapid, customized, and distributed manufacturing of drug particles with superior flowability.</jats:p> Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis Advanced Materials Technologies
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title Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_unstemmed Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_full Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_fullStr Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_full_unstemmed Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_short Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_sort continuous embedded droplet printing in yield‐stress fluids for pharmaceutical drug particle synthesis
topic Industrial and Manufacturing Engineering
Mechanics of Materials
General Materials Science
url http://dx.doi.org/10.1002/admt.202001245
publishDate 2021
physical
description <jats:title>Abstract</jats:title><jats:p>Embedded droplet printing is a recent mode of generating and processing droplets within yield‐stress fluids. This technique has shown promise for performing sensitive processes like pharmaceutical crystallization, as well as chemical synthesis and biological experimentation due to the unique ability to process droplets that are quiescently suspended. Despite improving on conventional microfluidic technologies in numerous ways, current embedded droplet printing methods are limited to batch processes, severely hampering their overall utility. A new platform that enables continuous production of embedded droplets is presented and characterized. This platform expands the capabilities of embedded droplet printing and allows for its application to areas of continuous materials discovery, screening, and manufacturing. Here, the platform is used for the rapid production of pharmaceutical particles that are highly spherical and uniform, key targets for flowability, and ultimately manufacturability of pharmaceutical drug products. The presented platform achieves a maximum throughput of over 100 g per day, enabling characterization of the superior powder flow properties. The available operating space of this platform is demonstrated for an antisolvent crystallization process with an anti‐malarial drug. This understanding provides design guidelines for how similar platforms may be engineered for precise, rapid, customized, and distributed manufacturing of drug particles with superior flowability.</jats:p>
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author Nelson, Arif Z., Xie, Jiaxun, Khan, Saif A., Doyle, Patrick S.
author_facet Nelson, Arif Z., Xie, Jiaxun, Khan, Saif A., Doyle, Patrick S., Nelson, Arif Z., Xie, Jiaxun, Khan, Saif A., Doyle, Patrick S.
author_sort nelson, arif z.
container_issue 4
container_start_page 0
container_title Advanced Materials Technologies
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description <jats:title>Abstract</jats:title><jats:p>Embedded droplet printing is a recent mode of generating and processing droplets within yield‐stress fluids. This technique has shown promise for performing sensitive processes like pharmaceutical crystallization, as well as chemical synthesis and biological experimentation due to the unique ability to process droplets that are quiescently suspended. Despite improving on conventional microfluidic technologies in numerous ways, current embedded droplet printing methods are limited to batch processes, severely hampering their overall utility. A new platform that enables continuous production of embedded droplets is presented and characterized. This platform expands the capabilities of embedded droplet printing and allows for its application to areas of continuous materials discovery, screening, and manufacturing. Here, the platform is used for the rapid production of pharmaceutical particles that are highly spherical and uniform, key targets for flowability, and ultimately manufacturability of pharmaceutical drug products. The presented platform achieves a maximum throughput of over 100 g per day, enabling characterization of the superior powder flow properties. The available operating space of this platform is demonstrated for an antisolvent crystallization process with an anti‐malarial drug. This understanding provides design guidelines for how similar platforms may be engineered for precise, rapid, customized, and distributed manufacturing of drug particles with superior flowability.</jats:p>
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spelling Nelson, Arif Z. Xie, Jiaxun Khan, Saif A. Doyle, Patrick S. 2365-709X 2365-709X Wiley Industrial and Manufacturing Engineering Mechanics of Materials General Materials Science http://dx.doi.org/10.1002/admt.202001245 <jats:title>Abstract</jats:title><jats:p>Embedded droplet printing is a recent mode of generating and processing droplets within yield‐stress fluids. This technique has shown promise for performing sensitive processes like pharmaceutical crystallization, as well as chemical synthesis and biological experimentation due to the unique ability to process droplets that are quiescently suspended. Despite improving on conventional microfluidic technologies in numerous ways, current embedded droplet printing methods are limited to batch processes, severely hampering their overall utility. A new platform that enables continuous production of embedded droplets is presented and characterized. This platform expands the capabilities of embedded droplet printing and allows for its application to areas of continuous materials discovery, screening, and manufacturing. Here, the platform is used for the rapid production of pharmaceutical particles that are highly spherical and uniform, key targets for flowability, and ultimately manufacturability of pharmaceutical drug products. The presented platform achieves a maximum throughput of over 100 g per day, enabling characterization of the superior powder flow properties. The available operating space of this platform is demonstrated for an antisolvent crystallization process with an anti‐malarial drug. This understanding provides design guidelines for how similar platforms may be engineered for precise, rapid, customized, and distributed manufacturing of drug particles with superior flowability.</jats:p> Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis Advanced Materials Technologies
spellingShingle Nelson, Arif Z., Xie, Jiaxun, Khan, Saif A., Doyle, Patrick S., Advanced Materials Technologies, Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis, Industrial and Manufacturing Engineering, Mechanics of Materials, General Materials Science
title Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_full Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_fullStr Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_full_unstemmed Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_short Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
title_sort continuous embedded droplet printing in yield‐stress fluids for pharmaceutical drug particle synthesis
title_unstemmed Continuous Embedded Droplet Printing in Yield‐Stress Fluids for Pharmaceutical Drug Particle Synthesis
topic Industrial and Manufacturing Engineering, Mechanics of Materials, General Materials Science
url http://dx.doi.org/10.1002/admt.202001245