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Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice
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| Zeitschriftentitel: | Environmental Toxicology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Environmental Toxicology, 35, 2020, 1, S. 97-107 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei Kuang, Haibin Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei Kuang, Haibin |
|---|---|
| author |
Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei Kuang, Haibin |
| spellingShingle |
Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei Kuang, Haibin Environmental Toxicology Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice Health, Toxicology and Mutagenesis Management, Monitoring, Policy and Law Toxicology General Medicine |
| author_sort |
yang, bei |
| spelling |
Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei Kuang, Haibin 1520-4081 1522-7278 Wiley Health, Toxicology and Mutagenesis Management, Monitoring, Policy and Law Toxicology General Medicine http://dx.doi.org/10.1002/tox.22846 <jats:title>Abstract</jats:title><jats:p>Tri‐ortho‐cresyl phosphate (TOCP) has been widely used as plasticizers, and reported causing reproductive toxicity in mammals. However, little is known about the toxic effect on the placenta. In this study, dams were orally administered different doses of TOCP to explore the effect of TOCP on placental development. Results showed that TOCP exposure significantly reduced numbers of implanted embryo, caused atrophy and collapse of ectoplacental cone, and decreased total areas of placenta and numbers of PCNA‐positive cells. Expression levels of placental development genes were prominently downregulated in the TOCP‐treated groups. Moreover, TOCP administration induced placental apoptosis and autophagy by upregulating P53, Bax, Beclin‐1, ratio of LC3 II/LC3 I and Atg5 and downregulating Bcl‐2 protein. In addition, TOCP exposure markedly inhibited activities of catalase and superoxide dismutase and increased the production of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and malondialdehyde. Collectively, these findings suggest that apoptosis, autophagy and oxidative stress may be involved in the TOCP‐induced reproductive toxicity.</jats:p> Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice Environmental Toxicology |
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10.1002/tox.22846 |
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Wiley, 2020 |
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Wiley, 2020 |
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| title |
Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_unstemmed |
Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_full |
Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_fullStr |
Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_full_unstemmed |
Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_short |
Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_sort |
tri‐ortho‐cresyl phosphate (tocp)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| topic |
Health, Toxicology and Mutagenesis Management, Monitoring, Policy and Law Toxicology General Medicine |
| url |
http://dx.doi.org/10.1002/tox.22846 |
| publishDate |
2020 |
| physical |
97-107 |
| description |
<jats:title>Abstract</jats:title><jats:p>Tri‐ortho‐cresyl phosphate (TOCP) has been widely used as plasticizers, and reported causing reproductive toxicity in mammals. However, little is known about the toxic effect on the placenta. In this study, dams were orally administered different doses of TOCP to explore the effect of TOCP on placental development. Results showed that TOCP exposure significantly reduced numbers of implanted embryo, caused atrophy and collapse of ectoplacental cone, and decreased total areas of placenta and numbers of PCNA‐positive cells. Expression levels of placental development genes were prominently downregulated in the TOCP‐treated groups. Moreover, TOCP administration induced placental apoptosis and autophagy by upregulating P53, Bax, Beclin‐1, ratio of LC3 II/LC3 I and Atg5 and downregulating Bcl‐2 protein. In addition, TOCP exposure markedly inhibited activities of catalase and superoxide dismutase and increased the production of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and malondialdehyde. Collectively, these findings suggest that apoptosis, autophagy and oxidative stress may be involved in the TOCP‐induced reproductive toxicity.</jats:p> |
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| author | Yang, Bei, Wang, Xinlu, Ma, Yilin, Yan, Lei, Ren, Yuan, Yu, Dainan, Qiao, Bo, Shen, Xin, Liu, Hui, Zhang, Dalei, Kuang, Haibin |
| author_facet | Yang, Bei, Wang, Xinlu, Ma, Yilin, Yan, Lei, Ren, Yuan, Yu, Dainan, Qiao, Bo, Shen, Xin, Liu, Hui, Zhang, Dalei, Kuang, Haibin, Yang, Bei, Wang, Xinlu, Ma, Yilin, Yan, Lei, Ren, Yuan, Yu, Dainan, Qiao, Bo, Shen, Xin, Liu, Hui, Zhang, Dalei, Kuang, Haibin |
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| description | <jats:title>Abstract</jats:title><jats:p>Tri‐ortho‐cresyl phosphate (TOCP) has been widely used as plasticizers, and reported causing reproductive toxicity in mammals. However, little is known about the toxic effect on the placenta. In this study, dams were orally administered different doses of TOCP to explore the effect of TOCP on placental development. Results showed that TOCP exposure significantly reduced numbers of implanted embryo, caused atrophy and collapse of ectoplacental cone, and decreased total areas of placenta and numbers of PCNA‐positive cells. Expression levels of placental development genes were prominently downregulated in the TOCP‐treated groups. Moreover, TOCP administration induced placental apoptosis and autophagy by upregulating P53, Bax, Beclin‐1, ratio of LC3 II/LC3 I and Atg5 and downregulating Bcl‐2 protein. In addition, TOCP exposure markedly inhibited activities of catalase and superoxide dismutase and increased the production of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and malondialdehyde. Collectively, these findings suggest that apoptosis, autophagy and oxidative stress may be involved in the TOCP‐induced reproductive toxicity.</jats:p> |
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| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
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| language | English |
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| spelling | Yang, Bei Wang, Xinlu Ma, Yilin Yan, Lei Ren, Yuan Yu, Dainan Qiao, Bo Shen, Xin Liu, Hui Zhang, Dalei Kuang, Haibin 1520-4081 1522-7278 Wiley Health, Toxicology and Mutagenesis Management, Monitoring, Policy and Law Toxicology General Medicine http://dx.doi.org/10.1002/tox.22846 <jats:title>Abstract</jats:title><jats:p>Tri‐ortho‐cresyl phosphate (TOCP) has been widely used as plasticizers, and reported causing reproductive toxicity in mammals. However, little is known about the toxic effect on the placenta. In this study, dams were orally administered different doses of TOCP to explore the effect of TOCP on placental development. Results showed that TOCP exposure significantly reduced numbers of implanted embryo, caused atrophy and collapse of ectoplacental cone, and decreased total areas of placenta and numbers of PCNA‐positive cells. Expression levels of placental development genes were prominently downregulated in the TOCP‐treated groups. Moreover, TOCP administration induced placental apoptosis and autophagy by upregulating P53, Bax, Beclin‐1, ratio of LC3 II/LC3 I and Atg5 and downregulating Bcl‐2 protein. In addition, TOCP exposure markedly inhibited activities of catalase and superoxide dismutase and increased the production of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and malondialdehyde. Collectively, these findings suggest that apoptosis, autophagy and oxidative stress may be involved in the TOCP‐induced reproductive toxicity.</jats:p> Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice Environmental Toxicology |
| spellingShingle | Yang, Bei, Wang, Xinlu, Ma, Yilin, Yan, Lei, Ren, Yuan, Yu, Dainan, Qiao, Bo, Shen, Xin, Liu, Hui, Zhang, Dalei, Kuang, Haibin, Environmental Toxicology, Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice, Health, Toxicology and Mutagenesis, Management, Monitoring, Policy and Law, Toxicology, General Medicine |
| title | Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_full | Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_fullStr | Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_full_unstemmed | Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_short | Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_sort | tri‐ortho‐cresyl phosphate (tocp)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| title_unstemmed | Tri‐ortho‐cresyl phosphate (TOCP)‐induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice |
| topic | Health, Toxicology and Mutagenesis, Management, Monitoring, Policy and Law, Toxicology, General Medicine |
| url | http://dx.doi.org/10.1002/tox.22846 |