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Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis
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| Zeitschriftentitel: | Teratology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Teratology, 7, 1973, 3, S. 219-225 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Ritter, E. J. Scott, W. J. Wilson, J. G. Ritter, E. J. Scott, W. J. Wilson, J. G. |
|---|---|
| author |
Ritter, E. J. Scott, W. J. Wilson, J. G. |
| spellingShingle |
Ritter, E. J. Scott, W. J. Wilson, J. G. Teratology Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis Health, Toxicology and Mutagenesis Developmental Biology Toxicology Embryology |
| author_sort |
ritter, e. j. |
| spelling |
Ritter, E. J. Scott, W. J. Wilson, J. G. 0040-3709 1096-9926 Wiley Health, Toxicology and Mutagenesis Developmental Biology Toxicology Embryology http://dx.doi.org/10.1002/tera.1420070302 <jats:title>Abstract</jats:title><jats:p>Cytosine arabinoside palmitate (ara‐CP) is a sustained‐action form of the DNA‐synthesis‐inhibitor cytosine arabinoside (ara‐C). When given at day 12 of rat gestation ara‐CP caused moderate but prolonged depression of DNA synthesis, killed embryonic cells after 2–3 days, and led to severe limb and other defects and extreme growth retardation. The results were compared with those obtained in earlier studies with hydroxyurea and with ara‐C, both of which also caused depression of DNA synthesis, cell death, and limb defects, but at different times in relation to treatment. There was a relation between the time of maximal cell death in the limbs after treatment and the specific limb malformations seen at day 20. The relation of cell death to teratogenesis seen with these chemical agents is similar to that previously reported for X irradiation.</jats:p> Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis Teratology |
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10.1002/tera.1420070302 |
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Wiley, 1973 |
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Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_unstemmed |
Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_full |
Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_fullStr |
Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_full_unstemmed |
Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_short |
Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_sort |
relationship of temporal patterns of cell death and development to malformations in the rat limb. possible mechanisms of teratogenesis with inhibitors of dna synthesis |
| topic |
Health, Toxicology and Mutagenesis Developmental Biology Toxicology Embryology |
| url |
http://dx.doi.org/10.1002/tera.1420070302 |
| publishDate |
1973 |
| physical |
219-225 |
| description |
<jats:title>Abstract</jats:title><jats:p>Cytosine arabinoside palmitate (ara‐CP) is a sustained‐action form of the DNA‐synthesis‐inhibitor cytosine arabinoside (ara‐C). When given at day 12 of rat gestation ara‐CP caused moderate but prolonged depression of DNA synthesis, killed embryonic cells after 2–3 days, and led to severe limb and other defects and extreme growth retardation. The results were compared with those obtained in earlier studies with hydroxyurea and with ara‐C, both of which also caused depression of DNA synthesis, cell death, and limb defects, but at different times in relation to treatment. There was a relation between the time of maximal cell death in the limbs after treatment and the specific limb malformations seen at day 20. The relation of cell death to teratogenesis seen with these chemical agents is similar to that previously reported for X irradiation.</jats:p> |
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| author | Ritter, E. J., Scott, W. J., Wilson, J. G. |
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| description | <jats:title>Abstract</jats:title><jats:p>Cytosine arabinoside palmitate (ara‐CP) is a sustained‐action form of the DNA‐synthesis‐inhibitor cytosine arabinoside (ara‐C). When given at day 12 of rat gestation ara‐CP caused moderate but prolonged depression of DNA synthesis, killed embryonic cells after 2–3 days, and led to severe limb and other defects and extreme growth retardation. The results were compared with those obtained in earlier studies with hydroxyurea and with ara‐C, both of which also caused depression of DNA synthesis, cell death, and limb defects, but at different times in relation to treatment. There was a relation between the time of maximal cell death in the limbs after treatment and the specific limb malformations seen at day 20. The relation of cell death to teratogenesis seen with these chemical agents is similar to that previously reported for X irradiation.</jats:p> |
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| imprint | Wiley, 1973 |
| imprint_str_mv | Wiley, 1973 |
| institution | DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| source_id | 49 |
| spelling | Ritter, E. J. Scott, W. J. Wilson, J. G. 0040-3709 1096-9926 Wiley Health, Toxicology and Mutagenesis Developmental Biology Toxicology Embryology http://dx.doi.org/10.1002/tera.1420070302 <jats:title>Abstract</jats:title><jats:p>Cytosine arabinoside palmitate (ara‐CP) is a sustained‐action form of the DNA‐synthesis‐inhibitor cytosine arabinoside (ara‐C). When given at day 12 of rat gestation ara‐CP caused moderate but prolonged depression of DNA synthesis, killed embryonic cells after 2–3 days, and led to severe limb and other defects and extreme growth retardation. The results were compared with those obtained in earlier studies with hydroxyurea and with ara‐C, both of which also caused depression of DNA synthesis, cell death, and limb defects, but at different times in relation to treatment. There was a relation between the time of maximal cell death in the limbs after treatment and the specific limb malformations seen at day 20. The relation of cell death to teratogenesis seen with these chemical agents is similar to that previously reported for X irradiation.</jats:p> Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis Teratology |
| spellingShingle | Ritter, E. J., Scott, W. J., Wilson, J. G., Teratology, Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis, Health, Toxicology and Mutagenesis, Developmental Biology, Toxicology, Embryology |
| title | Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_full | Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_fullStr | Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_full_unstemmed | Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_short | Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| title_sort | relationship of temporal patterns of cell death and development to malformations in the rat limb. possible mechanisms of teratogenesis with inhibitors of dna synthesis |
| title_unstemmed | Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis |
| topic | Health, Toxicology and Mutagenesis, Developmental Biology, Toxicology, Embryology |
| url | http://dx.doi.org/10.1002/tera.1420070302 |