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Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | FEBS Letters, 594, 2020, 3, S. 452-465 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Geng, Shuang Wang, Jing Zhang, Xiannian Zhang, Jia‐jia Wu, Fan Pang, Yuhong Zhong, Yuping Wang, Jianbin Wang, Wenming Lyu, Xiaoqing Huang, Yanyi Jing, Hongmei Geng, Shuang Wang, Jing Zhang, Xiannian Zhang, Jia‐jia Wu, Fan Pang, Yuhong Zhong, Yuping Wang, Jianbin Wang, Wenming Lyu, Xiaoqing Huang, Yanyi Jing, Hongmei |
|---|---|
| author |
Geng, Shuang Wang, Jing Zhang, Xiannian Zhang, Jia‐jia Wu, Fan Pang, Yuhong Zhong, Yuping Wang, Jianbin Wang, Wenming Lyu, Xiaoqing Huang, Yanyi Jing, Hongmei |
| spellingShingle |
Geng, Shuang Wang, Jing Zhang, Xiannian Zhang, Jia‐jia Wu, Fan Pang, Yuhong Zhong, Yuping Wang, Jianbin Wang, Wenming Lyu, Xiaoqing Huang, Yanyi Jing, Hongmei FEBS Letters Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
geng, shuang |
| spelling |
Geng, Shuang Wang, Jing Zhang, Xiannian Zhang, Jia‐jia Wu, Fan Pang, Yuhong Zhong, Yuping Wang, Jianbin Wang, Wenming Lyu, Xiaoqing Huang, Yanyi Jing, Hongmei 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1002/1873-3468.13623 <jats:p>In this study, we aimed to determine the mechanisms underlying the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood. We found that clonal circulating plasma cells (cPCs) are more frequently detected by flow cytometry in extramedullary plasmacytoma (EMP) patients and worsen their prognosis. It is technically much easier to collect single cPCs using FACS than it is to perform EMP biopsy. Therefore, combining EMP imaging with cPC detection may be a promising strategy for prognostic stratification. Here, using single‐cell transcriptome analysis, we found that the chemokine CXCL12, a key molecule involved in CXCR4‐dependent cell retention in the bone marrow, is abnormally upregulated in cPCs and might initially enable cPCs to evade bone marrow retention and translocate into the bloodstream.</jats:p> Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis FEBS Letters |
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10.1002/1873-3468.13623 |
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| title |
Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_unstemmed |
Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_full |
Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_fullStr |
Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_full_unstemmed |
Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_short |
Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_sort |
single‐cell rna sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1002/1873-3468.13623 |
| publishDate |
2020 |
| physical |
452-465 |
| description |
<jats:p>In this study, we aimed to determine the mechanisms underlying the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood. We found that clonal circulating plasma cells (cPCs) are more frequently detected by flow cytometry in extramedullary plasmacytoma (EMP) patients and worsen their prognosis. It is technically much easier to collect single cPCs using FACS than it is to perform EMP biopsy. Therefore, combining EMP imaging with cPC detection may be a promising strategy for prognostic stratification. Here, using single‐cell transcriptome analysis, we found that the chemokine CXCL12, a key molecule involved in CXCR4‐dependent cell retention in the bone marrow, is abnormally upregulated in cPCs and might initially enable cPCs to evade bone marrow retention and translocate into the bloodstream.</jats:p> |
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| author | Geng, Shuang, Wang, Jing, Zhang, Xiannian, Zhang, Jia‐jia, Wu, Fan, Pang, Yuhong, Zhong, Yuping, Wang, Jianbin, Wang, Wenming, Lyu, Xiaoqing, Huang, Yanyi, Jing, Hongmei |
| author_facet | Geng, Shuang, Wang, Jing, Zhang, Xiannian, Zhang, Jia‐jia, Wu, Fan, Pang, Yuhong, Zhong, Yuping, Wang, Jianbin, Wang, Wenming, Lyu, Xiaoqing, Huang, Yanyi, Jing, Hongmei, Geng, Shuang, Wang, Jing, Zhang, Xiannian, Zhang, Jia‐jia, Wu, Fan, Pang, Yuhong, Zhong, Yuping, Wang, Jianbin, Wang, Wenming, Lyu, Xiaoqing, Huang, Yanyi, Jing, Hongmei |
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| description | <jats:p>In this study, we aimed to determine the mechanisms underlying the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood. We found that clonal circulating plasma cells (cPCs) are more frequently detected by flow cytometry in extramedullary plasmacytoma (EMP) patients and worsen their prognosis. It is technically much easier to collect single cPCs using FACS than it is to perform EMP biopsy. Therefore, combining EMP imaging with cPC detection may be a promising strategy for prognostic stratification. Here, using single‐cell transcriptome analysis, we found that the chemokine CXCL12, a key molecule involved in CXCR4‐dependent cell retention in the bone marrow, is abnormally upregulated in cPCs and might initially enable cPCs to evade bone marrow retention and translocate into the bloodstream.</jats:p> |
| doi_str_mv | 10.1002/1873-3468.13623 |
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| imprint | Wiley, 2020 |
| imprint_str_mv | Wiley, 2020 |
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| physical | 452-465 |
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| publishDateSort | 2020 |
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| source_id | 49 |
| spelling | Geng, Shuang Wang, Jing Zhang, Xiannian Zhang, Jia‐jia Wu, Fan Pang, Yuhong Zhong, Yuping Wang, Jianbin Wang, Wenming Lyu, Xiaoqing Huang, Yanyi Jing, Hongmei 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1002/1873-3468.13623 <jats:p>In this study, we aimed to determine the mechanisms underlying the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood. We found that clonal circulating plasma cells (cPCs) are more frequently detected by flow cytometry in extramedullary plasmacytoma (EMP) patients and worsen their prognosis. It is technically much easier to collect single cPCs using FACS than it is to perform EMP biopsy. Therefore, combining EMP imaging with cPC detection may be a promising strategy for prognostic stratification. Here, using single‐cell transcriptome analysis, we found that the chemokine CXCL12, a key molecule involved in CXCR4‐dependent cell retention in the bone marrow, is abnormally upregulated in cPCs and might initially enable cPCs to evade bone marrow retention and translocate into the bloodstream.</jats:p> Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis FEBS Letters |
| spellingShingle | Geng, Shuang, Wang, Jing, Zhang, Xiannian, Zhang, Jia‐jia, Wu, Fan, Pang, Yuhong, Zhong, Yuping, Wang, Jianbin, Wang, Wenming, Lyu, Xiaoqing, Huang, Yanyi, Jing, Hongmei, FEBS Letters, Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_full | Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_fullStr | Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_full_unstemmed | Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_short | Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_sort | single‐cell rna sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| title_unstemmed | Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1002/1873-3468.13623 |