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Systems vaccinology: a promise for the young and the poor
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| Zeitschriftentitel: | Philosophical Transactions of the Royal Society B: Biological Sciences |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Philosophical Transactions of the Royal Society B: Biological Sciences, 370, 2015, 1671, S. 20140340 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Royal Society
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| Schlagwörter: |
| author_facet |
Amenyogbe, Nelly Levy, Ofer Kollmann, Tobias R. Amenyogbe, Nelly Levy, Ofer Kollmann, Tobias R. |
|---|---|
| author |
Amenyogbe, Nelly Levy, Ofer Kollmann, Tobias R. |
| spellingShingle |
Amenyogbe, Nelly Levy, Ofer Kollmann, Tobias R. Philosophical Transactions of the Royal Society B: Biological Sciences Systems vaccinology: a promise for the young and the poor General Agricultural and Biological Sciences General Biochemistry, Genetics and Molecular Biology |
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amenyogbe, nelly |
| spelling |
Amenyogbe, Nelly Levy, Ofer Kollmann, Tobias R. 0962-8436 1471-2970 The Royal Society General Agricultural and Biological Sciences General Biochemistry, Genetics and Molecular Biology http://dx.doi.org/10.1098/rstb.2014.0340 <jats:p>As a child, the risk of suffering and dying from infection is higher the younger you are; and higher, the less developed a region you are born in. Childhood vaccination programmes have greatly reduced mortality around the world, but least so for the very young among the very poor of the world. This appears partly owing to suboptimal vaccine effectiveness. Unfortunately, although most vaccines are administered to the newborn and very young infant (less than or equal to two months), we know the least about their host response to vaccination. We thus currently lack the knowledge to guide efforts aimed at improving vaccine effectiveness in this vulnerable population. Systems vaccinology, the study of molecular networks activated by immunization, has begun to provide unprecedented insights into mechanisms leading to vaccine-induced protection from infection or disease. However, all published reports of systems vaccinology have focused on either adults or at most children and older infants, not those most in need, i.e. newborns and very young infants. Given that the tools of systems vaccinology work perfectly well with very small sample volumes, it is time we deliver the promise that systems vaccinology holds for those most in need of vaccine-mediated protection from infection.</jats:p> Systems vaccinology: a promise for the young and the poor Philosophical Transactions of the Royal Society B: Biological Sciences |
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systems vaccinology: a promise for the young and the poor |
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General Agricultural and Biological Sciences General Biochemistry, Genetics and Molecular Biology |
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<jats:p>As a child, the risk of suffering and dying from infection is higher the younger you are; and higher, the less developed a region you are born in. Childhood vaccination programmes have greatly reduced mortality around the world, but least so for the very young among the very poor of the world. This appears partly owing to suboptimal vaccine effectiveness. Unfortunately, although most vaccines are administered to the newborn and very young infant (less than or equal to two months), we know the least about their host response to vaccination. We thus currently lack the knowledge to guide efforts aimed at improving vaccine effectiveness in this vulnerable population. Systems vaccinology, the study of molecular networks activated by immunization, has begun to provide unprecedented insights into mechanisms leading to vaccine-induced protection from infection or disease. However, all published reports of systems vaccinology have focused on either adults or at most children and older infants, not those most in need, i.e. newborns and very young infants. Given that the tools of systems vaccinology work perfectly well with very small sample volumes, it is time we deliver the promise that systems vaccinology holds for those most in need of vaccine-mediated protection from infection.</jats:p> |
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| description | <jats:p>As a child, the risk of suffering and dying from infection is higher the younger you are; and higher, the less developed a region you are born in. Childhood vaccination programmes have greatly reduced mortality around the world, but least so for the very young among the very poor of the world. This appears partly owing to suboptimal vaccine effectiveness. Unfortunately, although most vaccines are administered to the newborn and very young infant (less than or equal to two months), we know the least about their host response to vaccination. We thus currently lack the knowledge to guide efforts aimed at improving vaccine effectiveness in this vulnerable population. Systems vaccinology, the study of molecular networks activated by immunization, has begun to provide unprecedented insights into mechanisms leading to vaccine-induced protection from infection or disease. However, all published reports of systems vaccinology have focused on either adults or at most children and older infants, not those most in need, i.e. newborns and very young infants. Given that the tools of systems vaccinology work perfectly well with very small sample volumes, it is time we deliver the promise that systems vaccinology holds for those most in need of vaccine-mediated protection from infection.</jats:p> |
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| spelling | Amenyogbe, Nelly Levy, Ofer Kollmann, Tobias R. 0962-8436 1471-2970 The Royal Society General Agricultural and Biological Sciences General Biochemistry, Genetics and Molecular Biology http://dx.doi.org/10.1098/rstb.2014.0340 <jats:p>As a child, the risk of suffering and dying from infection is higher the younger you are; and higher, the less developed a region you are born in. Childhood vaccination programmes have greatly reduced mortality around the world, but least so for the very young among the very poor of the world. This appears partly owing to suboptimal vaccine effectiveness. Unfortunately, although most vaccines are administered to the newborn and very young infant (less than or equal to two months), we know the least about their host response to vaccination. We thus currently lack the knowledge to guide efforts aimed at improving vaccine effectiveness in this vulnerable population. Systems vaccinology, the study of molecular networks activated by immunization, has begun to provide unprecedented insights into mechanisms leading to vaccine-induced protection from infection or disease. However, all published reports of systems vaccinology have focused on either adults or at most children and older infants, not those most in need, i.e. newborns and very young infants. Given that the tools of systems vaccinology work perfectly well with very small sample volumes, it is time we deliver the promise that systems vaccinology holds for those most in need of vaccine-mediated protection from infection.</jats:p> Systems vaccinology: a promise for the young and the poor Philosophical Transactions of the Royal Society B: Biological Sciences |
| spellingShingle | Amenyogbe, Nelly, Levy, Ofer, Kollmann, Tobias R., Philosophical Transactions of the Royal Society B: Biological Sciences, Systems vaccinology: a promise for the young and the poor, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology |
| title | Systems vaccinology: a promise for the young and the poor |
| title_full | Systems vaccinology: a promise for the young and the poor |
| title_fullStr | Systems vaccinology: a promise for the young and the poor |
| title_full_unstemmed | Systems vaccinology: a promise for the young and the poor |
| title_short | Systems vaccinology: a promise for the young and the poor |
| title_sort | systems vaccinology: a promise for the young and the poor |
| title_unstemmed | Systems vaccinology: a promise for the young and the poor |
| topic | General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology |
| url | http://dx.doi.org/10.1098/rstb.2014.0340 |