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ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans
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| Zeitschriftentitel: | Royal Society Open Science |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Royal Society Open Science, 7, 2020, 1, S. 190775 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Royal Society
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| Schlagwörter: |
| author_facet |
Camacho-Mejorado, Rafael Gómez, Rocío Torres-Sánchez, Luisa E. Alhelí Hernández-Tobías, Esther Noris, Gino Santana, Carla Magaña, Jonathan J. Orozco, Lorena de la Peña-Díaz, Aurora de la Luz Arenas-Sordo, María Meraz-Ríos, Marco Antonio Majluf-Cruz, Abraham Camacho-Mejorado, Rafael Gómez, Rocío Torres-Sánchez, Luisa E. Alhelí Hernández-Tobías, Esther Noris, Gino Santana, Carla Magaña, Jonathan J. Orozco, Lorena de la Peña-Díaz, Aurora de la Luz Arenas-Sordo, María Meraz-Ríos, Marco Antonio Majluf-Cruz, Abraham |
|---|---|
| author |
Camacho-Mejorado, Rafael Gómez, Rocío Torres-Sánchez, Luisa E. Alhelí Hernández-Tobías, Esther Noris, Gino Santana, Carla Magaña, Jonathan J. Orozco, Lorena de la Peña-Díaz, Aurora de la Luz Arenas-Sordo, María Meraz-Ríos, Marco Antonio Majluf-Cruz, Abraham |
| spellingShingle |
Camacho-Mejorado, Rafael Gómez, Rocío Torres-Sánchez, Luisa E. Alhelí Hernández-Tobías, Esther Noris, Gino Santana, Carla Magaña, Jonathan J. Orozco, Lorena de la Peña-Díaz, Aurora de la Luz Arenas-Sordo, María Meraz-Ríos, Marco Antonio Majluf-Cruz, Abraham Royal Society Open Science ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans Multidisciplinary |
| author_sort |
camacho-mejorado, rafael |
| spelling |
Camacho-Mejorado, Rafael Gómez, Rocío Torres-Sánchez, Luisa E. Alhelí Hernández-Tobías, Esther Noris, Gino Santana, Carla Magaña, Jonathan J. Orozco, Lorena de la Peña-Díaz, Aurora de la Luz Arenas-Sordo, María Meraz-Ríos, Marco Antonio Majluf-Cruz, Abraham 2054-5703 The Royal Society Multidisciplinary http://dx.doi.org/10.1098/rsos.190775 <jats:p>Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (<jats:italic>n</jats:italic>= 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included.<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.</jats:p> <i>ALOX5</i>,<i>LPA</i>,<i>MMP9</i>and<i>TPO</i>gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans Royal Society Open Science |
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| title |
ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_unstemmed |
ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_full |
ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_fullStr |
ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_full_unstemmed |
ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_short |
ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_sort |
<i>alox5</i>,<i>lpa</i>,<i>mmp9</i>and<i>tpo</i>gene polymorphisms increase atherothrombosis susceptibility in middle-aged mexicans |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1098/rsos.190775 |
| publishDate |
2020 |
| physical |
190775 |
| description |
<jats:p>Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (<jats:italic>n</jats:italic>= 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included.<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.</jats:p> |
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| author | Camacho-Mejorado, Rafael, Gómez, Rocío, Torres-Sánchez, Luisa E., Alhelí Hernández-Tobías, Esther, Noris, Gino, Santana, Carla, Magaña, Jonathan J., Orozco, Lorena, de la Peña-Díaz, Aurora, de la Luz Arenas-Sordo, María, Meraz-Ríos, Marco Antonio, Majluf-Cruz, Abraham |
| author_facet | Camacho-Mejorado, Rafael, Gómez, Rocío, Torres-Sánchez, Luisa E., Alhelí Hernández-Tobías, Esther, Noris, Gino, Santana, Carla, Magaña, Jonathan J., Orozco, Lorena, de la Peña-Díaz, Aurora, de la Luz Arenas-Sordo, María, Meraz-Ríos, Marco Antonio, Majluf-Cruz, Abraham, Camacho-Mejorado, Rafael, Gómez, Rocío, Torres-Sánchez, Luisa E., Alhelí Hernández-Tobías, Esther, Noris, Gino, Santana, Carla, Magaña, Jonathan J., Orozco, Lorena, de la Peña-Díaz, Aurora, de la Luz Arenas-Sordo, María, Meraz-Ríos, Marco Antonio, Majluf-Cruz, Abraham |
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| description | <jats:p>Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (<jats:italic>n</jats:italic>= 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included.<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Camacho-Mejorado, Rafael Gómez, Rocío Torres-Sánchez, Luisa E. Alhelí Hernández-Tobías, Esther Noris, Gino Santana, Carla Magaña, Jonathan J. Orozco, Lorena de la Peña-Díaz, Aurora de la Luz Arenas-Sordo, María Meraz-Ríos, Marco Antonio Majluf-Cruz, Abraham 2054-5703 The Royal Society Multidisciplinary http://dx.doi.org/10.1098/rsos.190775 <jats:p>Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (<jats:italic>n</jats:italic>= 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included.<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of<jats:italic>ALOX5</jats:italic>,<jats:italic>LPA</jats:italic>,<jats:italic>MMP9</jats:italic>and<jats:italic>TPO</jats:italic>polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.</jats:p> <i>ALOX5</i>,<i>LPA</i>,<i>MMP9</i>and<i>TPO</i>gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans Royal Society Open Science |
| spellingShingle | Camacho-Mejorado, Rafael, Gómez, Rocío, Torres-Sánchez, Luisa E., Alhelí Hernández-Tobías, Esther, Noris, Gino, Santana, Carla, Magaña, Jonathan J., Orozco, Lorena, de la Peña-Díaz, Aurora, de la Luz Arenas-Sordo, María, Meraz-Ríos, Marco Antonio, Majluf-Cruz, Abraham, Royal Society Open Science, ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans, Multidisciplinary |
| title | ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_full | ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_fullStr | ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_full_unstemmed | ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_short | ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| title_sort | <i>alox5</i>,<i>lpa</i>,<i>mmp9</i>and<i>tpo</i>gene polymorphisms increase atherothrombosis susceptibility in middle-aged mexicans |
| title_unstemmed | ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1098/rsos.190775 |