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The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis: A Meta-analysis

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Zeitschriftentitel: Medicine
Personen und Körperschaften: Xu, Gui-Ping, Chen, Wei-Xian, Xie, Wen-Yue, Wu, Li-Fang
In: Medicine, 97, 2018, 51, S. e13829
Format: E-Article
Sprache: Englisch
veröffentlicht:
Ovid Technologies (Wolters Kluwer Health)
Schlagwörter:
General Medicine
author_facet Xu, Gui-Ping
Chen, Wei-Xian
Xie, Wen-Yue
Wu, Li-Fang
Xu, Gui-Ping
Chen, Wei-Xian
Xie, Wen-Yue
Wu, Li-Fang
author Xu, Gui-Ping
Chen, Wei-Xian
Xie, Wen-Yue
Wu, Li-Fang
spellingShingle Xu, Gui-Ping
Chen, Wei-Xian
Xie, Wen-Yue
Wu, Li-Fang
Medicine
The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
General Medicine
author_sort xu, gui-ping
spelling Xu, Gui-Ping Chen, Wei-Xian Xie, Wen-Yue Wu, Li-Fang 0025-7974 1536-5964 Ovid Technologies (Wolters Kluwer Health) General Medicine http://dx.doi.org/10.1097/md.0000000000013829 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Objective:</jats:title> <jats:p>Insulin-like growth factor 1 (<jats:italic toggle="yes">IGF1</jats:italic>) gene three prime untranslated region (3’-UTR) polymorphisms have been reported to be associated with cancer risk. However, the conclusions of the relevant studies are not consistent. The present meta-analysis evaluates the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Articles regarding the relationship between <jats:italic toggle="yes">IGF1</jats:italic> rs5742714, rs6214, and rs6220 polymorphisms and cancer risk were selected by searching the PubMed, Embase, and Web of Science databases before April 30, 2018. Altogether, we obtained 34 case-controlled studies from 20 articles, including 21,568 cases and 31,199 controls. The strength of associations was quantified using odds ratios (ORs) and the corresponding 95% confidence intervals (CIs).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>In the present meta-analysis, no significant associations were detected between rs5742714, rs6214, and rs6220 and overall cancer risk. Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88–1.00, <jats:italic toggle="yes">P</jats:italic> = .044; GA vs GG: OR, 0.88, 95% CI, 0.80–0.97, <jats:italic toggle="yes">P</jats:italic> = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81–0.97, <jats:italic toggle="yes">P</jats:italic> = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53–0.87, <jats:italic toggle="yes">P</jats:italic> = .003). Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02–1.48, <jats:italic toggle="yes">P</jats:italic> = .031). In addition, rs6220 was found to increase overall cancer risk among Caucasians under the allele model (G vs A: OR, 1.06, 95% CI, 1.00–1.13, <jats:italic toggle="yes">P</jats:italic> = .043).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>In this meta-analysis, we investigated and reviewed the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies. Further studies are needed to draw more precise conclusions in the future.</jats:p> </jats:sec> A Meta-analysis The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis Medicine
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title_sub A Meta-analysis
title The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_unstemmed The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_full The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_fullStr The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_full_unstemmed The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_short The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_sort the association between igf1 gene 3’-utr polymorphisms and cancer risk : a meta-analysis
topic General Medicine
url http://dx.doi.org/10.1097/md.0000000000013829
publishDate 2018
physical e13829
description <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Objective:</jats:title> <jats:p>Insulin-like growth factor 1 (<jats:italic toggle="yes">IGF1</jats:italic>) gene three prime untranslated region (3’-UTR) polymorphisms have been reported to be associated with cancer risk. However, the conclusions of the relevant studies are not consistent. The present meta-analysis evaluates the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Articles regarding the relationship between <jats:italic toggle="yes">IGF1</jats:italic> rs5742714, rs6214, and rs6220 polymorphisms and cancer risk were selected by searching the PubMed, Embase, and Web of Science databases before April 30, 2018. Altogether, we obtained 34 case-controlled studies from 20 articles, including 21,568 cases and 31,199 controls. The strength of associations was quantified using odds ratios (ORs) and the corresponding 95% confidence intervals (CIs).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>In the present meta-analysis, no significant associations were detected between rs5742714, rs6214, and rs6220 and overall cancer risk. Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88–1.00, <jats:italic toggle="yes">P</jats:italic> = .044; GA vs GG: OR, 0.88, 95% CI, 0.80–0.97, <jats:italic toggle="yes">P</jats:italic> = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81–0.97, <jats:italic toggle="yes">P</jats:italic> = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53–0.87, <jats:italic toggle="yes">P</jats:italic> = .003). Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02–1.48, <jats:italic toggle="yes">P</jats:italic> = .031). In addition, rs6220 was found to increase overall cancer risk among Caucasians under the allele model (G vs A: OR, 1.06, 95% CI, 1.00–1.13, <jats:italic toggle="yes">P</jats:italic> = .043).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>In this meta-analysis, we investigated and reviewed the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies. Further studies are needed to draw more precise conclusions in the future.</jats:p> </jats:sec>
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author Xu, Gui-Ping, Chen, Wei-Xian, Xie, Wen-Yue, Wu, Li-Fang
author_facet Xu, Gui-Ping, Chen, Wei-Xian, Xie, Wen-Yue, Wu, Li-Fang, Xu, Gui-Ping, Chen, Wei-Xian, Xie, Wen-Yue, Wu, Li-Fang
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description <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Objective:</jats:title> <jats:p>Insulin-like growth factor 1 (<jats:italic toggle="yes">IGF1</jats:italic>) gene three prime untranslated region (3’-UTR) polymorphisms have been reported to be associated with cancer risk. However, the conclusions of the relevant studies are not consistent. The present meta-analysis evaluates the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Articles regarding the relationship between <jats:italic toggle="yes">IGF1</jats:italic> rs5742714, rs6214, and rs6220 polymorphisms and cancer risk were selected by searching the PubMed, Embase, and Web of Science databases before April 30, 2018. Altogether, we obtained 34 case-controlled studies from 20 articles, including 21,568 cases and 31,199 controls. The strength of associations was quantified using odds ratios (ORs) and the corresponding 95% confidence intervals (CIs).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>In the present meta-analysis, no significant associations were detected between rs5742714, rs6214, and rs6220 and overall cancer risk. Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88–1.00, <jats:italic toggle="yes">P</jats:italic> = .044; GA vs GG: OR, 0.88, 95% CI, 0.80–0.97, <jats:italic toggle="yes">P</jats:italic> = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81–0.97, <jats:italic toggle="yes">P</jats:italic> = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53–0.87, <jats:italic toggle="yes">P</jats:italic> = .003). Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02–1.48, <jats:italic toggle="yes">P</jats:italic> = .031). In addition, rs6220 was found to increase overall cancer risk among Caucasians under the allele model (G vs A: OR, 1.06, 95% CI, 1.00–1.13, <jats:italic toggle="yes">P</jats:italic> = .043).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>In this meta-analysis, we investigated and reviewed the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies. Further studies are needed to draw more precise conclusions in the future.</jats:p> </jats:sec>
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spelling Xu, Gui-Ping Chen, Wei-Xian Xie, Wen-Yue Wu, Li-Fang 0025-7974 1536-5964 Ovid Technologies (Wolters Kluwer Health) General Medicine http://dx.doi.org/10.1097/md.0000000000013829 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Objective:</jats:title> <jats:p>Insulin-like growth factor 1 (<jats:italic toggle="yes">IGF1</jats:italic>) gene three prime untranslated region (3’-UTR) polymorphisms have been reported to be associated with cancer risk. However, the conclusions of the relevant studies are not consistent. The present meta-analysis evaluates the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Articles regarding the relationship between <jats:italic toggle="yes">IGF1</jats:italic> rs5742714, rs6214, and rs6220 polymorphisms and cancer risk were selected by searching the PubMed, Embase, and Web of Science databases before April 30, 2018. Altogether, we obtained 34 case-controlled studies from 20 articles, including 21,568 cases and 31,199 controls. The strength of associations was quantified using odds ratios (ORs) and the corresponding 95% confidence intervals (CIs).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>In the present meta-analysis, no significant associations were detected between rs5742714, rs6214, and rs6220 and overall cancer risk. Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88–1.00, <jats:italic toggle="yes">P</jats:italic> = .044; GA vs GG: OR, 0.88, 95% CI, 0.80–0.97, <jats:italic toggle="yes">P</jats:italic> = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81–0.97, <jats:italic toggle="yes">P</jats:italic> = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53–0.87, <jats:italic toggle="yes">P</jats:italic> = .003). Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02–1.48, <jats:italic toggle="yes">P</jats:italic> = .031). In addition, rs6220 was found to increase overall cancer risk among Caucasians under the allele model (G vs A: OR, 1.06, 95% CI, 1.00–1.13, <jats:italic toggle="yes">P</jats:italic> = .043).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>In this meta-analysis, we investigated and reviewed the relationship between <jats:italic toggle="yes">IGF1</jats:italic> gene 3’-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies. Further studies are needed to draw more precise conclusions in the future.</jats:p> </jats:sec> A Meta-analysis The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis Medicine
spellingShingle Xu, Gui-Ping, Chen, Wei-Xian, Xie, Wen-Yue, Wu, Li-Fang, Medicine, The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis, General Medicine
title The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_full The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_fullStr The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_full_unstemmed The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_short The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
title_sort the association between igf1 gene 3’-utr polymorphisms and cancer risk : a meta-analysis
title_sub A Meta-analysis
title_unstemmed The association between IGF1 Gene 3’-UTR polymorphisms and cancer risk : A Meta-analysis
topic General Medicine
url http://dx.doi.org/10.1097/md.0000000000013829