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Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function
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| Zeitschriftentitel: | Journal of Clinical Gastroenterology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Journal of Clinical Gastroenterology, 51, 2017, 7, S. 619-625 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Azpiroz, Fernando Molne, Laura Mendez, Sara Nieto, Adoración Manichanh, Chaysavanh Mego, Marianela Accarino, Anna Santos, Javier Sailer, Manuela Theis, Stephan Guarner, Francisco Azpiroz, Fernando Molne, Laura Mendez, Sara Nieto, Adoración Manichanh, Chaysavanh Mego, Marianela Accarino, Anna Santos, Javier Sailer, Manuela Theis, Stephan Guarner, Francisco |
|---|---|
| author |
Azpiroz, Fernando Molne, Laura Mendez, Sara Nieto, Adoración Manichanh, Chaysavanh Mego, Marianela Accarino, Anna Santos, Javier Sailer, Manuela Theis, Stephan Guarner, Francisco |
| spellingShingle |
Azpiroz, Fernando Molne, Laura Mendez, Sara Nieto, Adoración Manichanh, Chaysavanh Mego, Marianela Accarino, Anna Santos, Javier Sailer, Manuela Theis, Stephan Guarner, Francisco Journal of Clinical Gastroenterology Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function Gastroenterology |
| author_sort |
azpiroz, fernando |
| spelling |
Azpiroz, Fernando Molne, Laura Mendez, Sara Nieto, Adoración Manichanh, Chaysavanh Mego, Marianela Accarino, Anna Santos, Javier Sailer, Manuela Theis, Stephan Guarner, Francisco 0192-0790 Ovid Technologies (Wolters Kluwer Health) Gastroenterology http://dx.doi.org/10.1097/mcg.0000000000000723 <jats:sec> <jats:title>Goal:</jats:title> <jats:p>To determine the effect of a prebiotic chicory-derived inulin-type fructan on the tolerance of intestinal gas.</jats:p> </jats:sec> <jats:sec> <jats:title>Background:</jats:title> <jats:p>Subjects with gas-related complaints exhibit impaired handling of intestinal gas loads and we hypothesized that inulin would have a beneficial effect.</jats:p> </jats:sec> <jats:sec> <jats:title>Study:</jats:title> <jats:p>Placebo-controlled, parallel, randomized, double-blind trial. Subjects with abdominal symptoms and reduced tolerance of intestinal gas (selected by a pretest) received either inulin (8 g/d, n=18) or maltodextrin as a placebo (8 g/d, n=18) for 4 weeks. A gas challenge test (4 h jejunal gas infusion at 12 mL/min while measuring abdominal symptoms and gas retention for 3 h) was performed before and at the end of the intervention phase. Gastrointestinal symptoms and bowel habits (using daily questionnaires for 1 wk) and fecal bifidobacteria counts were measured before and at the end of the intervention.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Inulin decreased gas retention during the gas challenge test (by 22%; <jats:italic toggle="yes">P</jats:italic>=0.035 <jats:italic toggle="yes">vs.</jats:italic> baseline), while the placebo did not, but the intergroup difference was not statistically significant (<jats:italic toggle="yes">P</jats:italic>=0.343). Inulin and placebo reduced the perception of abdominal sensations in the gas challenge test to a similar extent (by 52% and 43%, respectively). Participants reported moderate gastrointestinal symptoms and normal bowel habits during baseline examination, and these findings remained unchanged in both groups during the intervention. Inulin led to a higher relative abundance of bifidobacteria counts (<jats:italic toggle="yes">P</jats:italic>=0.01 vs. placebo).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A daily dose of inulin that promotes bifidobacteria growth and may improve gut function, is well tolerated by subjects with gastrointestinal complaints.</jats:p> </jats:sec> Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function Journal of Clinical Gastroenterology |
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Ovid Technologies (Wolters Kluwer Health), 2017 |
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Ovid Technologies (Wolters Kluwer Health), 2017 |
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2017 |
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Ovid Technologies (Wolters Kluwer Health) |
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Journal of Clinical Gastroenterology |
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| title |
Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_unstemmed |
Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_full |
Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_fullStr |
Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_full_unstemmed |
Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_short |
Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_sort |
effect of chicory-derived inulin on abdominal sensations and bowel motor function |
| topic |
Gastroenterology |
| url |
http://dx.doi.org/10.1097/mcg.0000000000000723 |
| publishDate |
2017 |
| physical |
619-625 |
| description |
<jats:sec>
<jats:title>Goal:</jats:title>
<jats:p>To determine the effect of a prebiotic chicory-derived inulin-type fructan on the tolerance of intestinal gas.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Background:</jats:title>
<jats:p>Subjects with gas-related complaints exhibit impaired handling of intestinal gas loads and we hypothesized that inulin would have a beneficial effect.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Study:</jats:title>
<jats:p>Placebo-controlled, parallel, randomized, double-blind trial. Subjects with abdominal symptoms and reduced tolerance of intestinal gas (selected by a pretest) received either inulin (8 g/d, n=18) or maltodextrin as a placebo (8 g/d, n=18) for 4 weeks. A gas challenge test (4 h jejunal gas infusion at 12 mL/min while measuring abdominal symptoms and gas retention for 3 h) was performed before and at the end of the intervention phase. Gastrointestinal symptoms and bowel habits (using daily questionnaires for 1 wk) and fecal bifidobacteria counts were measured before and at the end of the intervention.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>Inulin decreased gas retention during the gas challenge test (by 22%; <jats:italic toggle="yes">P</jats:italic>=0.035 <jats:italic toggle="yes">vs.</jats:italic> baseline), while the placebo did not, but the intergroup difference was not statistically significant (<jats:italic toggle="yes">P</jats:italic>=0.343). Inulin and placebo reduced the perception of abdominal sensations in the gas challenge test to a similar extent (by 52% and 43%, respectively). Participants reported moderate gastrointestinal symptoms and normal bowel habits during baseline examination, and these findings remained unchanged in both groups during the intervention. Inulin led to a higher relative abundance of bifidobacteria counts (<jats:italic toggle="yes">P</jats:italic>=0.01 vs. placebo).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions:</jats:title>
<jats:p>A daily dose of inulin that promotes bifidobacteria growth and may improve gut function, is well tolerated by subjects with gastrointestinal complaints.</jats:p>
</jats:sec> |
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| author | Azpiroz, Fernando, Molne, Laura, Mendez, Sara, Nieto, Adoración, Manichanh, Chaysavanh, Mego, Marianela, Accarino, Anna, Santos, Javier, Sailer, Manuela, Theis, Stephan, Guarner, Francisco |
| author_facet | Azpiroz, Fernando, Molne, Laura, Mendez, Sara, Nieto, Adoración, Manichanh, Chaysavanh, Mego, Marianela, Accarino, Anna, Santos, Javier, Sailer, Manuela, Theis, Stephan, Guarner, Francisco, Azpiroz, Fernando, Molne, Laura, Mendez, Sara, Nieto, Adoración, Manichanh, Chaysavanh, Mego, Marianela, Accarino, Anna, Santos, Javier, Sailer, Manuela, Theis, Stephan, Guarner, Francisco |
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| description | <jats:sec> <jats:title>Goal:</jats:title> <jats:p>To determine the effect of a prebiotic chicory-derived inulin-type fructan on the tolerance of intestinal gas.</jats:p> </jats:sec> <jats:sec> <jats:title>Background:</jats:title> <jats:p>Subjects with gas-related complaints exhibit impaired handling of intestinal gas loads and we hypothesized that inulin would have a beneficial effect.</jats:p> </jats:sec> <jats:sec> <jats:title>Study:</jats:title> <jats:p>Placebo-controlled, parallel, randomized, double-blind trial. Subjects with abdominal symptoms and reduced tolerance of intestinal gas (selected by a pretest) received either inulin (8 g/d, n=18) or maltodextrin as a placebo (8 g/d, n=18) for 4 weeks. A gas challenge test (4 h jejunal gas infusion at 12 mL/min while measuring abdominal symptoms and gas retention for 3 h) was performed before and at the end of the intervention phase. Gastrointestinal symptoms and bowel habits (using daily questionnaires for 1 wk) and fecal bifidobacteria counts were measured before and at the end of the intervention.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Inulin decreased gas retention during the gas challenge test (by 22%; <jats:italic toggle="yes">P</jats:italic>=0.035 <jats:italic toggle="yes">vs.</jats:italic> baseline), while the placebo did not, but the intergroup difference was not statistically significant (<jats:italic toggle="yes">P</jats:italic>=0.343). Inulin and placebo reduced the perception of abdominal sensations in the gas challenge test to a similar extent (by 52% and 43%, respectively). Participants reported moderate gastrointestinal symptoms and normal bowel habits during baseline examination, and these findings remained unchanged in both groups during the intervention. Inulin led to a higher relative abundance of bifidobacteria counts (<jats:italic toggle="yes">P</jats:italic>=0.01 vs. placebo).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A daily dose of inulin that promotes bifidobacteria growth and may improve gut function, is well tolerated by subjects with gastrointestinal complaints.</jats:p> </jats:sec> |
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| spelling | Azpiroz, Fernando Molne, Laura Mendez, Sara Nieto, Adoración Manichanh, Chaysavanh Mego, Marianela Accarino, Anna Santos, Javier Sailer, Manuela Theis, Stephan Guarner, Francisco 0192-0790 Ovid Technologies (Wolters Kluwer Health) Gastroenterology http://dx.doi.org/10.1097/mcg.0000000000000723 <jats:sec> <jats:title>Goal:</jats:title> <jats:p>To determine the effect of a prebiotic chicory-derived inulin-type fructan on the tolerance of intestinal gas.</jats:p> </jats:sec> <jats:sec> <jats:title>Background:</jats:title> <jats:p>Subjects with gas-related complaints exhibit impaired handling of intestinal gas loads and we hypothesized that inulin would have a beneficial effect.</jats:p> </jats:sec> <jats:sec> <jats:title>Study:</jats:title> <jats:p>Placebo-controlled, parallel, randomized, double-blind trial. Subjects with abdominal symptoms and reduced tolerance of intestinal gas (selected by a pretest) received either inulin (8 g/d, n=18) or maltodextrin as a placebo (8 g/d, n=18) for 4 weeks. A gas challenge test (4 h jejunal gas infusion at 12 mL/min while measuring abdominal symptoms and gas retention for 3 h) was performed before and at the end of the intervention phase. Gastrointestinal symptoms and bowel habits (using daily questionnaires for 1 wk) and fecal bifidobacteria counts were measured before and at the end of the intervention.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Inulin decreased gas retention during the gas challenge test (by 22%; <jats:italic toggle="yes">P</jats:italic>=0.035 <jats:italic toggle="yes">vs.</jats:italic> baseline), while the placebo did not, but the intergroup difference was not statistically significant (<jats:italic toggle="yes">P</jats:italic>=0.343). Inulin and placebo reduced the perception of abdominal sensations in the gas challenge test to a similar extent (by 52% and 43%, respectively). Participants reported moderate gastrointestinal symptoms and normal bowel habits during baseline examination, and these findings remained unchanged in both groups during the intervention. Inulin led to a higher relative abundance of bifidobacteria counts (<jats:italic toggle="yes">P</jats:italic>=0.01 vs. placebo).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>A daily dose of inulin that promotes bifidobacteria growth and may improve gut function, is well tolerated by subjects with gastrointestinal complaints.</jats:p> </jats:sec> Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function Journal of Clinical Gastroenterology |
| spellingShingle | Azpiroz, Fernando, Molne, Laura, Mendez, Sara, Nieto, Adoración, Manichanh, Chaysavanh, Mego, Marianela, Accarino, Anna, Santos, Javier, Sailer, Manuela, Theis, Stephan, Guarner, Francisco, Journal of Clinical Gastroenterology, Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function, Gastroenterology |
| title | Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_full | Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_fullStr | Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_full_unstemmed | Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_short | Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| title_sort | effect of chicory-derived inulin on abdominal sensations and bowel motor function |
| title_unstemmed | Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function |
| topic | Gastroenterology |
| url | http://dx.doi.org/10.1097/mcg.0000000000000723 |