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The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Stu...
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| Zeitschriftentitel: | International Journal of Gynecologic Cancer |
|---|---|
| Personen und Körperschaften: | , , |
| In: | International Journal of Gynecologic Cancer, 26, 2016, 8, S. 1510-1514 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
BMJ
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| Schlagwörter: |
| author_facet |
Jiao, Xiao-Bing Hu, Jun Zhu, Li-Rong Jiao, Xiao-Bing Hu, Jun Zhu, Li-Rong |
|---|---|
| author |
Jiao, Xiao-Bing Hu, Jun Zhu, Li-Rong |
| spellingShingle |
Jiao, Xiao-Bing Hu, Jun Zhu, Li-Rong International Journal of Gynecologic Cancer The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies Obstetrics and Gynecology Oncology |
| author_sort |
jiao, xiao-bing |
| spelling |
Jiao, Xiao-Bing Hu, Jun Zhu, Li-Rong 1048-891X 1525-1438 BMJ Obstetrics and Gynecology Oncology http://dx.doi.org/10.1097/igc.0000000000000780 <jats:sec><jats:title>Objective</jats:title><jats:p>The aim of this study was to compare the incidence of ovarian metastasis (OM) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early-stage cervical cancer and evaluate the safety of ovarian preservation in early-stage ADC.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To perform a meta-analysis to compare the incidence of OM between early-stage ADC and SCC, we searched PubMed, EMBASE, and Cochrane for observational studies that compared it with pathological evidence after radical hysterectomy and oophorectomy. Odds ratios with 95% confidence intervals were calculated with a fixed effects model. We also found a few articles evaluating the oncological prognosis of patients with ovarian preservation to perform a systematic review.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 5 studies were included in the meta-analyses. The incidence of OM of patients with early-stage ADC and SCC were 2% and 0.4%, respectively (odds ratio, 5.27; 95% confidence interval, 2.14–13.45). In 1427 patients with ADC or SCC of the cervix FIGO stage (CIS-IIA) who underwent hysterectomy, no ovarian recurrences were observed after unilateral or bilateral ovarian preservation in ADC patients in the follow-up (30–68 months); however, 15 patients with SCC developed pelvic recurrence.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although the incidence of OM was higher in early-stage ADC than SCC according to ovarian pathology, it might be relatively safe to perform ovarian preservation with early-stage ADC because of low ovarian recurrence rate in short-term follow-ups.</jats:p></jats:sec> The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies International Journal of Gynecologic Cancer |
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International Journal of Gynecologic Cancer |
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| title |
The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_unstemmed |
The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full |
The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_fullStr |
The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full_unstemmed |
The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_short |
The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_sort |
the safety of ovarian preservation in early-stage adenocarcinoma compared with squamous cell carcinoma of uterine cervix: a systematic review and meta-analysis of observational studies |
| topic |
Obstetrics and Gynecology Oncology |
| url |
http://dx.doi.org/10.1097/igc.0000000000000780 |
| publishDate |
2016 |
| physical |
1510-1514 |
| description |
<jats:sec><jats:title>Objective</jats:title><jats:p>The aim of this study was to compare the incidence of ovarian metastasis (OM) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early-stage cervical cancer and evaluate the safety of ovarian preservation in early-stage ADC.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To perform a meta-analysis to compare the incidence of OM between early-stage ADC and SCC, we searched PubMed, EMBASE, and Cochrane for observational studies that compared it with pathological evidence after radical hysterectomy and oophorectomy. Odds ratios with 95% confidence intervals were calculated with a fixed effects model. We also found a few articles evaluating the oncological prognosis of patients with ovarian preservation to perform a systematic review.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 5 studies were included in the meta-analyses. The incidence of OM of patients with early-stage ADC and SCC were 2% and 0.4%, respectively (odds ratio, 5.27; 95% confidence interval, 2.14–13.45). In 1427 patients with ADC or SCC of the cervix FIGO stage (CIS-IIA) who underwent hysterectomy, no ovarian recurrences were observed after unilateral or bilateral ovarian preservation in ADC patients in the follow-up (30–68 months); however, 15 patients with SCC developed pelvic recurrence.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although the incidence of OM was higher in early-stage ADC than SCC according to ovarian pathology, it might be relatively safe to perform ovarian preservation with early-stage ADC because of low ovarian recurrence rate in short-term follow-ups.</jats:p></jats:sec> |
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| author | Jiao, Xiao-Bing, Hu, Jun, Zhu, Li-Rong |
| author_facet | Jiao, Xiao-Bing, Hu, Jun, Zhu, Li-Rong, Jiao, Xiao-Bing, Hu, Jun, Zhu, Li-Rong |
| author_sort | jiao, xiao-bing |
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| description | <jats:sec><jats:title>Objective</jats:title><jats:p>The aim of this study was to compare the incidence of ovarian metastasis (OM) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early-stage cervical cancer and evaluate the safety of ovarian preservation in early-stage ADC.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To perform a meta-analysis to compare the incidence of OM between early-stage ADC and SCC, we searched PubMed, EMBASE, and Cochrane for observational studies that compared it with pathological evidence after radical hysterectomy and oophorectomy. Odds ratios with 95% confidence intervals were calculated with a fixed effects model. We also found a few articles evaluating the oncological prognosis of patients with ovarian preservation to perform a systematic review.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 5 studies were included in the meta-analyses. The incidence of OM of patients with early-stage ADC and SCC were 2% and 0.4%, respectively (odds ratio, 5.27; 95% confidence interval, 2.14–13.45). In 1427 patients with ADC or SCC of the cervix FIGO stage (CIS-IIA) who underwent hysterectomy, no ovarian recurrences were observed after unilateral or bilateral ovarian preservation in ADC patients in the follow-up (30–68 months); however, 15 patients with SCC developed pelvic recurrence.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although the incidence of OM was higher in early-stage ADC than SCC according to ovarian pathology, it might be relatively safe to perform ovarian preservation with early-stage ADC because of low ovarian recurrence rate in short-term follow-ups.</jats:p></jats:sec> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-Ch1, DE-L229 |
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| spelling | Jiao, Xiao-Bing Hu, Jun Zhu, Li-Rong 1048-891X 1525-1438 BMJ Obstetrics and Gynecology Oncology http://dx.doi.org/10.1097/igc.0000000000000780 <jats:sec><jats:title>Objective</jats:title><jats:p>The aim of this study was to compare the incidence of ovarian metastasis (OM) in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early-stage cervical cancer and evaluate the safety of ovarian preservation in early-stage ADC.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>To perform a meta-analysis to compare the incidence of OM between early-stage ADC and SCC, we searched PubMed, EMBASE, and Cochrane for observational studies that compared it with pathological evidence after radical hysterectomy and oophorectomy. Odds ratios with 95% confidence intervals were calculated with a fixed effects model. We also found a few articles evaluating the oncological prognosis of patients with ovarian preservation to perform a systematic review.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 5 studies were included in the meta-analyses. The incidence of OM of patients with early-stage ADC and SCC were 2% and 0.4%, respectively (odds ratio, 5.27; 95% confidence interval, 2.14–13.45). In 1427 patients with ADC or SCC of the cervix FIGO stage (CIS-IIA) who underwent hysterectomy, no ovarian recurrences were observed after unilateral or bilateral ovarian preservation in ADC patients in the follow-up (30–68 months); however, 15 patients with SCC developed pelvic recurrence.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although the incidence of OM was higher in early-stage ADC than SCC according to ovarian pathology, it might be relatively safe to perform ovarian preservation with early-stage ADC because of low ovarian recurrence rate in short-term follow-ups.</jats:p></jats:sec> The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies International Journal of Gynecologic Cancer |
| spellingShingle | Jiao, Xiao-Bing, Hu, Jun, Zhu, Li-Rong, International Journal of Gynecologic Cancer, The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies, Obstetrics and Gynecology, Oncology |
| title | The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full | The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_fullStr | The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_full_unstemmed | The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_short | The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| title_sort | the safety of ovarian preservation in early-stage adenocarcinoma compared with squamous cell carcinoma of uterine cervix: a systematic review and meta-analysis of observational studies |
| title_unstemmed | The Safety of Ovarian Preservation in Early-Stage Adenocarcinoma Compared With Squamous Cell Carcinoma of Uterine Cervix: A Systematic Review and Meta-Analysis of Observational Studies |
| topic | Obstetrics and Gynecology, Oncology |
| url | http://dx.doi.org/10.1097/igc.0000000000000780 |