Eintrag weiter verarbeiten
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers
Gespeichert in:
| Zeitschriftentitel: | Anesthesiology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Anesthesiology, 87, 1997, 6, S. 1348-1358 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Lotsch, Jorn Kobal, Gerd Stockmann, Anne Brune, Kay Geisslinger, Gerd Lotsch, Jorn Kobal, Gerd Stockmann, Anne Brune, Kay Geisslinger, Gerd |
|---|---|
| author |
Lotsch, Jorn Kobal, Gerd Stockmann, Anne Brune, Kay Geisslinger, Gerd |
| spellingShingle |
Lotsch, Jorn Kobal, Gerd Stockmann, Anne Brune, Kay Geisslinger, Gerd Anesthesiology Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers Anesthesiology and Pain Medicine |
| author_sort |
lotsch, jorn |
| spelling |
Lotsch, Jorn Kobal, Gerd Stockmann, Anne Brune, Kay Geisslinger, Gerd 0003-3022 Ovid Technologies (Wolters Kluwer Health) Anesthesiology and Pain Medicine http://dx.doi.org/10.1097/00000542-199712000-00014 <jats:sec> <jats:title>Background</jats:title> <jats:p>The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.</jats:p> </jats:sec> Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers Anesthesiology |
| doi_str_mv |
10.1097/00000542-199712000-00014 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5Ny8wMDAwMDU0Mi0xOTk3MTIwMDAtMDAwMTQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5Ny8wMDAwMDU0Mi0xOTk3MTIwMDAtMDAwMTQ |
| institution |
DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Ovid Technologies (Wolters Kluwer Health), 1997 |
| imprint_str_mv |
Ovid Technologies (Wolters Kluwer Health), 1997 |
| issn |
0003-3022 |
| issn_str_mv |
0003-3022 |
| language |
English |
| mega_collection |
Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| match_str |
lotsch1997lackofanalgesicactivityofmorphine6glucuronideaftershorttermintravenousadministrationinhealthyvolunteers |
| publishDateSort |
1997 |
| publisher |
Ovid Technologies (Wolters Kluwer Health) |
| recordtype |
ai |
| record_format |
ai |
| series |
Anesthesiology |
| source_id |
49 |
| title |
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_unstemmed |
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_full |
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_fullStr |
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_full_unstemmed |
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_short |
Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_sort |
lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers |
| topic |
Anesthesiology and Pain Medicine |
| url |
http://dx.doi.org/10.1097/00000542-199712000-00014 |
| publishDate |
1997 |
| physical |
1348-1358 |
| description |
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.</jats:p>
</jats:sec> |
| container_issue |
6 |
| container_start_page |
1348 |
| container_title |
Anesthesiology |
| container_volume |
87 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339050306207755 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:41:39.302Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Lack+of+Analgesic+Activity+of+Morphine-6-glucuronide+after+Short-term+Intravenous+Administration+in+Healthy+Volunteers&rft.date=1997-12-01&genre=article&issn=0003-3022&volume=87&issue=6&spage=1348&epage=1358&pages=1348-1358&jtitle=Anesthesiology&atitle=Lack+of+Analgesic+Activity+of+Morphine-6-glucuronide+after+Short-term+Intravenous+Administration+in+Healthy+Volunteers&aulast=Geisslinger&aufirst=Gerd&rft_id=info%3Adoi%2F10.1097%2F00000542-199712000-00014&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792339050306207755 |
| author | Lotsch, Jorn, Kobal, Gerd, Stockmann, Anne, Brune, Kay, Geisslinger, Gerd |
| author_facet | Lotsch, Jorn, Kobal, Gerd, Stockmann, Anne, Brune, Kay, Geisslinger, Gerd, Lotsch, Jorn, Kobal, Gerd, Stockmann, Anne, Brune, Kay, Geisslinger, Gerd |
| author_sort | lotsch, jorn |
| container_issue | 6 |
| container_start_page | 1348 |
| container_title | Anesthesiology |
| container_volume | 87 |
| description | <jats:sec> <jats:title>Background</jats:title> <jats:p>The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.</jats:p> </jats:sec> |
| doi_str_mv | 10.1097/00000542-199712000-00014 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5Ny8wMDAwMDU0Mi0xOTk3MTIwMDAtMDAwMTQ |
| imprint | Ovid Technologies (Wolters Kluwer Health), 1997 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 1997 |
| institution | DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1 |
| issn | 0003-3022 |
| issn_str_mv | 0003-3022 |
| language | English |
| last_indexed | 2024-03-01T15:41:39.302Z |
| match_str | lotsch1997lackofanalgesicactivityofmorphine6glucuronideaftershorttermintravenousadministrationinhealthyvolunteers |
| mega_collection | Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| physical | 1348-1358 |
| publishDate | 1997 |
| publishDateSort | 1997 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | ai |
| recordtype | ai |
| series | Anesthesiology |
| source_id | 49 |
| spelling | Lotsch, Jorn Kobal, Gerd Stockmann, Anne Brune, Kay Geisslinger, Gerd 0003-3022 Ovid Technologies (Wolters Kluwer Health) Anesthesiology and Pain Medicine http://dx.doi.org/10.1097/00000542-199712000-00014 <jats:sec> <jats:title>Background</jats:title> <jats:p>The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.</jats:p> </jats:sec> Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers Anesthesiology |
| spellingShingle | Lotsch, Jorn, Kobal, Gerd, Stockmann, Anne, Brune, Kay, Geisslinger, Gerd, Anesthesiology, Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers, Anesthesiology and Pain Medicine |
| title | Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_full | Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_fullStr | Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_full_unstemmed | Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_short | Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| title_sort | lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers |
| title_unstemmed | Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers |
| topic | Anesthesiology and Pain Medicine |
| url | http://dx.doi.org/10.1097/00000542-199712000-00014 |