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Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases
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| Zeitschriftentitel: | Open Forum Infectious Diseases |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Open Forum Infectious Diseases, 6, 2019, 5 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Zhang, Peiling Zeng, Chen Cheng, Jiali Zhou, Jing Gu, Jia Mao, Xia Zhang, Wei Cao, Yang Luo, Hui Xu, Bin Li, Qinlu Xiao, Min Zhou, Jianfeng Zhang, Peiling Zeng, Chen Cheng, Jiali Zhou, Jing Gu, Jia Mao, Xia Zhang, Wei Cao, Yang Luo, Hui Xu, Bin Li, Qinlu Xiao, Min Zhou, Jianfeng |
|---|---|
| author |
Zhang, Peiling Zeng, Chen Cheng, Jiali Zhou, Jing Gu, Jia Mao, Xia Zhang, Wei Cao, Yang Luo, Hui Xu, Bin Li, Qinlu Xiao, Min Zhou, Jianfeng |
| spellingShingle |
Zhang, Peiling Zeng, Chen Cheng, Jiali Zhou, Jing Gu, Jia Mao, Xia Zhang, Wei Cao, Yang Luo, Hui Xu, Bin Li, Qinlu Xiao, Min Zhou, Jianfeng Open Forum Infectious Diseases Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases Infectious Diseases Oncology |
| author_sort |
zhang, peiling |
| spelling |
Zhang, Peiling Zeng, Chen Cheng, Jiali Zhou, Jing Gu, Jia Mao, Xia Zhang, Wei Cao, Yang Luo, Hui Xu, Bin Li, Qinlu Xiao, Min Zhou, Jianfeng 2328-8957 Oxford University Press (OUP) Infectious Diseases Oncology http://dx.doi.org/10.1093/ofid/ofz171 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>High loads of Epstein-Barr virus (EBV) in peripheral blood mononuclear cells (PBMCs) can be indicative of a broad spectrum of diseases, ranging from asymptomatic infection to fatal cancers.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We retrospectively investigated the EBV-infected cell types in PBMCs among 291 patients. Based on EBV-infected cell types, the clinical features and prognoses of 93 patients with EBV-associated (EBV+) T/natural killer (NK)–cell lymphoproliferative diseases (LPDs) T/NK-LPDs) were investigated over a 5-year period.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Although B-cell-type infection was found in immunocompromised patients and patients with asymptomatic high EBV carriage, infectious mononucleosis, EBV+ B-cell LPDs and B-cell lymphomas, T-cell, NK-cell or multiple-cell-type infection in immunocompetent hosts were highly suggestive of EBV+ T/NK-LPDs, EBV+ T/NK-cell lymphomas, and aggressive NK-cell leukemia. Patients with non–B-cell infection had a poorer prognosis than those with B-cell-type infection. In our cohort, 79.6% of patients with EBV+ T/NK-LPDs were &gt;18 years old, and NK cells were identified as EBV-infected cell type in 54.8%. Nearly half of patients with EBV+ T/NK-LPDs had genetic defects associated with immunodeficiency. However, hemophagocytic lymphohistiocytosis, and not genetic defects, was the only parameter correlated with poor prognosis of EBV+ T/NK-LPDs.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Determination of EBV-infected cell types among PBMCs is a valuable tool for the differential diagnosis of EBV+ hematological diseases.</jats:p> <jats:p>In this study, determination of Epstein-Barr virus-infected cell types in peripheral blood mononuclear cells of 291 patients with high Epstein-Barr virus loads were retrospectively investigated, which indicate it is a valuable tool for Epstein-Barr virus-associated hematological diseases.</jats:p> </jats:sec> Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases Open Forum Infectious Diseases |
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Oxford University Press (OUP), 2019 |
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Oxford University Press (OUP), 2019 |
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| title |
Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_unstemmed |
Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_full |
Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_fullStr |
Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_full_unstemmed |
Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_short |
Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_sort |
determination of epstein-barr virus–infected lymphocyte cell types in peripheral blood mononuclear cells as a valuable diagnostic tool in hematological diseases |
| topic |
Infectious Diseases Oncology |
| url |
http://dx.doi.org/10.1093/ofid/ofz171 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>High loads of Epstein-Barr virus (EBV) in peripheral blood mononuclear cells (PBMCs) can be indicative of a broad spectrum of diseases, ranging from asymptomatic infection to fatal cancers.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We retrospectively investigated the EBV-infected cell types in PBMCs among 291 patients. Based on EBV-infected cell types, the clinical features and prognoses of 93 patients with EBV-associated (EBV+) T/natural killer (NK)–cell lymphoproliferative diseases (LPDs) T/NK-LPDs) were investigated over a 5-year period.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Although B-cell-type infection was found in immunocompromised patients and patients with asymptomatic high EBV carriage, infectious mononucleosis, EBV+ B-cell LPDs and B-cell lymphomas, T-cell, NK-cell or multiple-cell-type infection in immunocompetent hosts were highly suggestive of EBV+ T/NK-LPDs, EBV+ T/NK-cell lymphomas, and aggressive NK-cell leukemia. Patients with non–B-cell infection had a poorer prognosis than those with B-cell-type infection. In our cohort, 79.6% of patients with EBV+ T/NK-LPDs were &gt;18 years old, and NK cells were identified as EBV-infected cell type in 54.8%. Nearly half of patients with EBV+ T/NK-LPDs had genetic defects associated with immunodeficiency. However, hemophagocytic lymphohistiocytosis, and not genetic defects, was the only parameter correlated with poor prognosis of EBV+ T/NK-LPDs.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>Determination of EBV-infected cell types among PBMCs is a valuable tool for the differential diagnosis of EBV+ hematological diseases.</jats:p>
<jats:p>In this study, determination of Epstein-Barr virus-infected cell types in peripheral blood mononuclear cells of 291 patients with high Epstein-Barr virus loads were retrospectively investigated, which indicate it is a valuable tool for Epstein-Barr virus-associated hematological diseases.</jats:p>
</jats:sec> |
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| author | Zhang, Peiling, Zeng, Chen, Cheng, Jiali, Zhou, Jing, Gu, Jia, Mao, Xia, Zhang, Wei, Cao, Yang, Luo, Hui, Xu, Bin, Li, Qinlu, Xiao, Min, Zhou, Jianfeng |
| author_facet | Zhang, Peiling, Zeng, Chen, Cheng, Jiali, Zhou, Jing, Gu, Jia, Mao, Xia, Zhang, Wei, Cao, Yang, Luo, Hui, Xu, Bin, Li, Qinlu, Xiao, Min, Zhou, Jianfeng, Zhang, Peiling, Zeng, Chen, Cheng, Jiali, Zhou, Jing, Gu, Jia, Mao, Xia, Zhang, Wei, Cao, Yang, Luo, Hui, Xu, Bin, Li, Qinlu, Xiao, Min, Zhou, Jianfeng |
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| description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>High loads of Epstein-Barr virus (EBV) in peripheral blood mononuclear cells (PBMCs) can be indicative of a broad spectrum of diseases, ranging from asymptomatic infection to fatal cancers.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We retrospectively investigated the EBV-infected cell types in PBMCs among 291 patients. Based on EBV-infected cell types, the clinical features and prognoses of 93 patients with EBV-associated (EBV+) T/natural killer (NK)–cell lymphoproliferative diseases (LPDs) T/NK-LPDs) were investigated over a 5-year period.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Although B-cell-type infection was found in immunocompromised patients and patients with asymptomatic high EBV carriage, infectious mononucleosis, EBV+ B-cell LPDs and B-cell lymphomas, T-cell, NK-cell or multiple-cell-type infection in immunocompetent hosts were highly suggestive of EBV+ T/NK-LPDs, EBV+ T/NK-cell lymphomas, and aggressive NK-cell leukemia. Patients with non–B-cell infection had a poorer prognosis than those with B-cell-type infection. In our cohort, 79.6% of patients with EBV+ T/NK-LPDs were &gt;18 years old, and NK cells were identified as EBV-infected cell type in 54.8%. Nearly half of patients with EBV+ T/NK-LPDs had genetic defects associated with immunodeficiency. However, hemophagocytic lymphohistiocytosis, and not genetic defects, was the only parameter correlated with poor prognosis of EBV+ T/NK-LPDs.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Determination of EBV-infected cell types among PBMCs is a valuable tool for the differential diagnosis of EBV+ hematological diseases.</jats:p> <jats:p>In this study, determination of Epstein-Barr virus-infected cell types in peripheral blood mononuclear cells of 291 patients with high Epstein-Barr virus loads were retrospectively investigated, which indicate it is a valuable tool for Epstein-Barr virus-associated hematological diseases.</jats:p> </jats:sec> |
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| imprint | Oxford University Press (OUP), 2019 |
| imprint_str_mv | Oxford University Press (OUP), 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Zhang, Peiling Zeng, Chen Cheng, Jiali Zhou, Jing Gu, Jia Mao, Xia Zhang, Wei Cao, Yang Luo, Hui Xu, Bin Li, Qinlu Xiao, Min Zhou, Jianfeng 2328-8957 Oxford University Press (OUP) Infectious Diseases Oncology http://dx.doi.org/10.1093/ofid/ofz171 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>High loads of Epstein-Barr virus (EBV) in peripheral blood mononuclear cells (PBMCs) can be indicative of a broad spectrum of diseases, ranging from asymptomatic infection to fatal cancers.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We retrospectively investigated the EBV-infected cell types in PBMCs among 291 patients. Based on EBV-infected cell types, the clinical features and prognoses of 93 patients with EBV-associated (EBV+) T/natural killer (NK)–cell lymphoproliferative diseases (LPDs) T/NK-LPDs) were investigated over a 5-year period.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Although B-cell-type infection was found in immunocompromised patients and patients with asymptomatic high EBV carriage, infectious mononucleosis, EBV+ B-cell LPDs and B-cell lymphomas, T-cell, NK-cell or multiple-cell-type infection in immunocompetent hosts were highly suggestive of EBV+ T/NK-LPDs, EBV+ T/NK-cell lymphomas, and aggressive NK-cell leukemia. Patients with non–B-cell infection had a poorer prognosis than those with B-cell-type infection. In our cohort, 79.6% of patients with EBV+ T/NK-LPDs were &gt;18 years old, and NK cells were identified as EBV-infected cell type in 54.8%. Nearly half of patients with EBV+ T/NK-LPDs had genetic defects associated with immunodeficiency. However, hemophagocytic lymphohistiocytosis, and not genetic defects, was the only parameter correlated with poor prognosis of EBV+ T/NK-LPDs.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Determination of EBV-infected cell types among PBMCs is a valuable tool for the differential diagnosis of EBV+ hematological diseases.</jats:p> <jats:p>In this study, determination of Epstein-Barr virus-infected cell types in peripheral blood mononuclear cells of 291 patients with high Epstein-Barr virus loads were retrospectively investigated, which indicate it is a valuable tool for Epstein-Barr virus-associated hematological diseases.</jats:p> </jats:sec> Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases Open Forum Infectious Diseases |
| spellingShingle | Zhang, Peiling, Zeng, Chen, Cheng, Jiali, Zhou, Jing, Gu, Jia, Mao, Xia, Zhang, Wei, Cao, Yang, Luo, Hui, Xu, Bin, Li, Qinlu, Xiao, Min, Zhou, Jianfeng, Open Forum Infectious Diseases, Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases, Infectious Diseases, Oncology |
| title | Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_full | Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_fullStr | Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_full_unstemmed | Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_short | Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| title_sort | determination of epstein-barr virus–infected lymphocyte cell types in peripheral blood mononuclear cells as a valuable diagnostic tool in hematological diseases |
| title_unstemmed | Determination of Epstein-Barr Virus–Infected Lymphocyte Cell Types in Peripheral Blood Mononuclear Cells as a Valuable Diagnostic Tool in Hematological Diseases |
| topic | Infectious Diseases, Oncology |
| url | http://dx.doi.org/10.1093/ofid/ofz171 |