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Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation
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| Zeitschriftentitel: | NAR Genomics and Bioinformatics |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | NAR Genomics and Bioinformatics, 2, 2020, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
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| Schlagwörter: |
| author_facet |
Martinez-Gomez, Laura Abascal, Federico Jungreis, Irwin Pozo, Fernando Kellis, Manolis Mudge, Jonathan M Tress, Michael L Martinez-Gomez, Laura Abascal, Federico Jungreis, Irwin Pozo, Fernando Kellis, Manolis Mudge, Jonathan M Tress, Michael L |
|---|---|
| author |
Martinez-Gomez, Laura Abascal, Federico Jungreis, Irwin Pozo, Fernando Kellis, Manolis Mudge, Jonathan M Tress, Michael L |
| spellingShingle |
Martinez-Gomez, Laura Abascal, Federico Jungreis, Irwin Pozo, Fernando Kellis, Manolis Mudge, Jonathan M Tress, Michael L NAR Genomics and Bioinformatics Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation General Engineering |
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martinez-gomez, laura |
| spelling |
Martinez-Gomez, Laura Abascal, Federico Jungreis, Irwin Pozo, Fernando Kellis, Manolis Mudge, Jonathan M Tress, Michael L 2631-9268 Oxford University Press (OUP) General Engineering http://dx.doi.org/10.1093/nargab/lqz023 <jats:title>Abstract</jats:title> <jats:p>Transposable elements colonize genomes and with time may end up being incorporated into functional regions. SINE Alu elements, which appeared in the primate lineage, are ubiquitous in the human genome and more than a thousand overlap annotated coding exons. Although almost all Alu-derived coding exons appear to be in alternative transcripts, they have been incorporated into the main coding transcript in at least 11 genes. The extent to which Alu regions are incorporated into functional proteins is unclear, but we detected reliable peptide evidence to support the translation to protein of 33 Alu-derived exons. All but one of the Alu elements for which we detected peptides were frame-preserving and there was proportionally seven times more peptide evidence for Alu elements as for other primate exons. Despite this strong evidence for translation to protein we found no evidence of selection, either from cross species alignments or human population variation data, among these Alu-derived exons. Overall, our results confirm that SINE Alu elements have contributed to the expansion of the human proteome, and this contribution appears to be stronger than might be expected over such a relatively short evolutionary timeframe. Despite this, the biological relevance of these modifications remains open to question.</jats:p> Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation NAR Genomics and Bioinformatics |
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| title |
Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_unstemmed |
Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_full |
Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_fullStr |
Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_full_unstemmed |
Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_short |
Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_sort |
few sines of life: alu elements have little evidence for biological relevance despite elevated translation |
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General Engineering |
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http://dx.doi.org/10.1093/nargab/lqz023 |
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2020 |
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<jats:title>Abstract</jats:title>
<jats:p>Transposable elements colonize genomes and with time may end up being incorporated into functional regions. SINE Alu elements, which appeared in the primate lineage, are ubiquitous in the human genome and more than a thousand overlap annotated coding exons. Although almost all Alu-derived coding exons appear to be in alternative transcripts, they have been incorporated into the main coding transcript in at least 11 genes. The extent to which Alu regions are incorporated into functional proteins is unclear, but we detected reliable peptide evidence to support the translation to protein of 33 Alu-derived exons. All but one of the Alu elements for which we detected peptides were frame-preserving and there was proportionally seven times more peptide evidence for Alu elements as for other primate exons. Despite this strong evidence for translation to protein we found no evidence of selection, either from cross species alignments or human population variation data, among these Alu-derived exons. Overall, our results confirm that SINE Alu elements have contributed to the expansion of the human proteome, and this contribution appears to be stronger than might be expected over such a relatively short evolutionary timeframe. Despite this, the biological relevance of these modifications remains open to question.</jats:p> |
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| author | Martinez-Gomez, Laura, Abascal, Federico, Jungreis, Irwin, Pozo, Fernando, Kellis, Manolis, Mudge, Jonathan M, Tress, Michael L |
| author_facet | Martinez-Gomez, Laura, Abascal, Federico, Jungreis, Irwin, Pozo, Fernando, Kellis, Manolis, Mudge, Jonathan M, Tress, Michael L, Martinez-Gomez, Laura, Abascal, Federico, Jungreis, Irwin, Pozo, Fernando, Kellis, Manolis, Mudge, Jonathan M, Tress, Michael L |
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| description | <jats:title>Abstract</jats:title> <jats:p>Transposable elements colonize genomes and with time may end up being incorporated into functional regions. SINE Alu elements, which appeared in the primate lineage, are ubiquitous in the human genome and more than a thousand overlap annotated coding exons. Although almost all Alu-derived coding exons appear to be in alternative transcripts, they have been incorporated into the main coding transcript in at least 11 genes. The extent to which Alu regions are incorporated into functional proteins is unclear, but we detected reliable peptide evidence to support the translation to protein of 33 Alu-derived exons. All but one of the Alu elements for which we detected peptides were frame-preserving and there was proportionally seven times more peptide evidence for Alu elements as for other primate exons. Despite this strong evidence for translation to protein we found no evidence of selection, either from cross species alignments or human population variation data, among these Alu-derived exons. Overall, our results confirm that SINE Alu elements have contributed to the expansion of the human proteome, and this contribution appears to be stronger than might be expected over such a relatively short evolutionary timeframe. Despite this, the biological relevance of these modifications remains open to question.</jats:p> |
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| spelling | Martinez-Gomez, Laura Abascal, Federico Jungreis, Irwin Pozo, Fernando Kellis, Manolis Mudge, Jonathan M Tress, Michael L 2631-9268 Oxford University Press (OUP) General Engineering http://dx.doi.org/10.1093/nargab/lqz023 <jats:title>Abstract</jats:title> <jats:p>Transposable elements colonize genomes and with time may end up being incorporated into functional regions. SINE Alu elements, which appeared in the primate lineage, are ubiquitous in the human genome and more than a thousand overlap annotated coding exons. Although almost all Alu-derived coding exons appear to be in alternative transcripts, they have been incorporated into the main coding transcript in at least 11 genes. The extent to which Alu regions are incorporated into functional proteins is unclear, but we detected reliable peptide evidence to support the translation to protein of 33 Alu-derived exons. All but one of the Alu elements for which we detected peptides were frame-preserving and there was proportionally seven times more peptide evidence for Alu elements as for other primate exons. Despite this strong evidence for translation to protein we found no evidence of selection, either from cross species alignments or human population variation data, among these Alu-derived exons. Overall, our results confirm that SINE Alu elements have contributed to the expansion of the human proteome, and this contribution appears to be stronger than might be expected over such a relatively short evolutionary timeframe. Despite this, the biological relevance of these modifications remains open to question.</jats:p> Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation NAR Genomics and Bioinformatics |
| spellingShingle | Martinez-Gomez, Laura, Abascal, Federico, Jungreis, Irwin, Pozo, Fernando, Kellis, Manolis, Mudge, Jonathan M, Tress, Michael L, NAR Genomics and Bioinformatics, Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation, General Engineering |
| title | Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_full | Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_fullStr | Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_full_unstemmed | Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_short | Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| title_sort | few sines of life: alu elements have little evidence for biological relevance despite elevated translation |
| title_unstemmed | Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation |
| topic | General Engineering |
| url | http://dx.doi.org/10.1093/nargab/lqz023 |