Eintrag weiter verarbeiten
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research
Gespeichert in:
| Zeitschriftentitel: | The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 43, 2018, 1, S. 83-114 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Walker, Rebecca L Cottingham, Marci D Fisher, Jill A Walker, Rebecca L Cottingham, Marci D Fisher, Jill A |
|---|---|
| author |
Walker, Rebecca L Cottingham, Marci D Fisher, Jill A |
| spellingShingle |
Walker, Rebecca L Cottingham, Marci D Fisher, Jill A The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research Philosophy General Medicine Issues, ethics and legal aspects |
| author_sort |
walker, rebecca l |
| spelling |
Walker, Rebecca L Cottingham, Marci D Fisher, Jill A 0360-5310 1744-5019 Oxford University Press (OUP) Philosophy General Medicine Issues, ethics and legal aspects http://dx.doi.org/10.1093/jmp/jhx033 <jats:title>Abstract</jats:title> <jats:p>Phase 1 healthy volunteer clinical trials—which financially compensate subjects in tests of drug toxicity levels and side effects—appear to place pressure on each joint of the moral framework justifying research. In this article, we review concerns about phase 1 trials as they have been framed in the bioethics literature, including undue inducement and coercion, unjust exploitation, and worries about compromised data validity. We then revisit these concerns in light of the lived experiences of serial participants who are income-dependent on phase 1 trials. We show how participant experiences shift attention from discrete exchanges, behaviors, and events in the research enterprise to the ongoing and dynamic patterns of serial participation in which individual decision-making is embedded in collective social and economic conditions and shaped by institutional policies. We argue in particular for the ethical significance of structurally diminished voluntariness, routine powerlessness in setting the terms of exchange, and incentive structures that may promote pharmaceutical interests but encourage phase 1 healthy volunteers to skirt important rules.</jats:p> Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
| doi_str_mv |
10.1093/jmp/jhx033 |
| facet_avail |
Online |
| finc_class_facet |
Philosophie Rechtswissenschaft |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9qbXAvamh4MDMz |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9qbXAvamh4MDMz |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-Ch1 DE-L229 |
| imprint |
Oxford University Press (OUP), 2018 |
| imprint_str_mv |
Oxford University Press (OUP), 2018 |
| issn |
0360-5310 1744-5019 |
| issn_str_mv |
0360-5310 1744-5019 |
| language |
English |
| mega_collection |
Oxford University Press (OUP) (CrossRef) |
| match_str |
walker2018serialparticipationandtheethicsofphase1healthyvolunteerresearch |
| publishDateSort |
2018 |
| publisher |
Oxford University Press (OUP) |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
| source_id |
49 |
| title |
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_unstemmed |
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_full |
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_fullStr |
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_full_unstemmed |
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_short |
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_sort |
serial participation and the ethics of phase 1 healthy volunteer research |
| topic |
Philosophy General Medicine Issues, ethics and legal aspects |
| url |
http://dx.doi.org/10.1093/jmp/jhx033 |
| publishDate |
2018 |
| physical |
83-114 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Phase 1 healthy volunteer clinical trials—which financially compensate subjects in tests of drug toxicity levels and side effects—appear to place pressure on each joint of the moral framework justifying research. In this article, we review concerns about phase 1 trials as they have been framed in the bioethics literature, including undue inducement and coercion, unjust exploitation, and worries about compromised data validity. We then revisit these concerns in light of the lived experiences of serial participants who are income-dependent on phase 1 trials. We show how participant experiences shift attention from discrete exchanges, behaviors, and events in the research enterprise to the ongoing and dynamic patterns of serial participation in which individual decision-making is embedded in collective social and economic conditions and shaped by institutional policies. We argue in particular for the ethical significance of structurally diminished voluntariness, routine powerlessness in setting the terms of exchange, and incentive structures that may promote pharmaceutical interests but encourage phase 1 healthy volunteers to skirt important rules.</jats:p> |
| container_issue |
1 |
| container_start_page |
83 |
| container_title |
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
| container_volume |
43 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792337934135853061 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:23:46.715Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Serial+Participation+and+the+Ethics+of+Phase+1+Healthy+Volunteer+Research&rft.date=2018-01-12&genre=article&issn=1744-5019&volume=43&issue=1&spage=83&epage=114&pages=83-114&jtitle=The+Journal+of+Medicine+and+Philosophy%3A+A+Forum+for+Bioethics+and+Philosophy+of+Medicine&atitle=Serial+Participation+and+the+Ethics+of+Phase+1+Healthy+Volunteer+Research&aulast=Fisher&aufirst=Jill+A&rft_id=info%3Adoi%2F10.1093%2Fjmp%2Fjhx033&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792337934135853061 |
| author | Walker, Rebecca L, Cottingham, Marci D, Fisher, Jill A |
| author_facet | Walker, Rebecca L, Cottingham, Marci D, Fisher, Jill A, Walker, Rebecca L, Cottingham, Marci D, Fisher, Jill A |
| author_sort | walker, rebecca l |
| container_issue | 1 |
| container_start_page | 83 |
| container_title | The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
| container_volume | 43 |
| description | <jats:title>Abstract</jats:title> <jats:p>Phase 1 healthy volunteer clinical trials—which financially compensate subjects in tests of drug toxicity levels and side effects—appear to place pressure on each joint of the moral framework justifying research. In this article, we review concerns about phase 1 trials as they have been framed in the bioethics literature, including undue inducement and coercion, unjust exploitation, and worries about compromised data validity. We then revisit these concerns in light of the lived experiences of serial participants who are income-dependent on phase 1 trials. We show how participant experiences shift attention from discrete exchanges, behaviors, and events in the research enterprise to the ongoing and dynamic patterns of serial participation in which individual decision-making is embedded in collective social and economic conditions and shaped by institutional policies. We argue in particular for the ethical significance of structurally diminished voluntariness, routine powerlessness in setting the terms of exchange, and incentive structures that may promote pharmaceutical interests but encourage phase 1 healthy volunteers to skirt important rules.</jats:p> |
| doi_str_mv | 10.1093/jmp/jhx033 |
| facet_avail | Online |
| finc_class_facet | Philosophie, Rechtswissenschaft |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9qbXAvamh4MDMz |
| imprint | Oxford University Press (OUP), 2018 |
| imprint_str_mv | Oxford University Press (OUP), 2018 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-Ch1, DE-L229 |
| issn | 0360-5310, 1744-5019 |
| issn_str_mv | 0360-5310, 1744-5019 |
| language | English |
| last_indexed | 2024-03-01T15:23:46.715Z |
| match_str | walker2018serialparticipationandtheethicsofphase1healthyvolunteerresearch |
| mega_collection | Oxford University Press (OUP) (CrossRef) |
| physical | 83-114 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Oxford University Press (OUP) |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
| source_id | 49 |
| spelling | Walker, Rebecca L Cottingham, Marci D Fisher, Jill A 0360-5310 1744-5019 Oxford University Press (OUP) Philosophy General Medicine Issues, ethics and legal aspects http://dx.doi.org/10.1093/jmp/jhx033 <jats:title>Abstract</jats:title> <jats:p>Phase 1 healthy volunteer clinical trials—which financially compensate subjects in tests of drug toxicity levels and side effects—appear to place pressure on each joint of the moral framework justifying research. In this article, we review concerns about phase 1 trials as they have been framed in the bioethics literature, including undue inducement and coercion, unjust exploitation, and worries about compromised data validity. We then revisit these concerns in light of the lived experiences of serial participants who are income-dependent on phase 1 trials. We show how participant experiences shift attention from discrete exchanges, behaviors, and events in the research enterprise to the ongoing and dynamic patterns of serial participation in which individual decision-making is embedded in collective social and economic conditions and shaped by institutional policies. We argue in particular for the ethical significance of structurally diminished voluntariness, routine powerlessness in setting the terms of exchange, and incentive structures that may promote pharmaceutical interests but encourage phase 1 healthy volunteers to skirt important rules.</jats:p> Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine |
| spellingShingle | Walker, Rebecca L, Cottingham, Marci D, Fisher, Jill A, The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research, Philosophy, General Medicine, Issues, ethics and legal aspects |
| title | Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_full | Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_fullStr | Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_full_unstemmed | Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_short | Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| title_sort | serial participation and the ethics of phase 1 healthy volunteer research |
| title_unstemmed | Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research |
| topic | Philosophy, General Medicine, Issues, ethics and legal aspects |
| url | http://dx.doi.org/10.1093/jmp/jhx033 |