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ATP11B deficiency leads to impairment of hippocampal synaptic plasticity
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| Zeitschriftentitel: | Journal of Molecular Cell Biology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Journal of Molecular Cell Biology, 11, 2019, 8, S. 688-702 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Wang, Jiao Li, Weihao Zhou, Fangfang Feng, Ruili Wang, Fushuai Zhang, Shibo Li, Jie Li, Qian Wang, Yajiang Xie, Jiang Wen, Tieqiao Wang, Jiao Li, Weihao Zhou, Fangfang Feng, Ruili Wang, Fushuai Zhang, Shibo Li, Jie Li, Qian Wang, Yajiang Xie, Jiang Wen, Tieqiao |
|---|---|
| author |
Wang, Jiao Li, Weihao Zhou, Fangfang Feng, Ruili Wang, Fushuai Zhang, Shibo Li, Jie Li, Qian Wang, Yajiang Xie, Jiang Wen, Tieqiao |
| spellingShingle |
Wang, Jiao Li, Weihao Zhou, Fangfang Feng, Ruili Wang, Fushuai Zhang, Shibo Li, Jie Li, Qian Wang, Yajiang Xie, Jiang Wen, Tieqiao Journal of Molecular Cell Biology ATP11B deficiency leads to impairment of hippocampal synaptic plasticity Cell Biology Genetics Molecular Biology General Medicine |
| author_sort |
wang, jiao |
| spelling |
Wang, Jiao Li, Weihao Zhou, Fangfang Feng, Ruili Wang, Fushuai Zhang, Shibo Li, Jie Li, Qian Wang, Yajiang Xie, Jiang Wen, Tieqiao 1759-4685 Oxford University Press (OUP) Cell Biology Genetics Molecular Biology General Medicine http://dx.doi.org/10.1093/jmcb/mjz042 <jats:title>Abstract</jats:title> <jats:p>Synaptic plasticity is known to regulate and support signal transduction between neurons, while synaptic dysfunction contributes to multiple neurological and other brain disorders; however, the specific mechanism underlying this process remains unclear. In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atp11b both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor expression, and intracellular Ca2+ concentration. Furthermore, experimental results also indicate that ATP11B regulated synaptic plasticity in hippocampal neurons through the MAPK14 signaling pathway. In conclusion, our data shed light on the possible mechanisms underlying the regulation of synaptic plasticity and lay the foundation for the exploration of proteins involved in signal transduction during this process.</jats:p> ATP11B deficiency leads to impairment of hippocampal synaptic plasticity Journal of Molecular Cell Biology |
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ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
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ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_full |
ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_fullStr |
ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
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ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_short |
ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_sort |
atp11b deficiency leads to impairment of hippocampal synaptic plasticity |
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Cell Biology Genetics Molecular Biology General Medicine |
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2019 |
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688-702 |
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<jats:title>Abstract</jats:title>
<jats:p>Synaptic plasticity is known to regulate and support signal transduction between neurons, while synaptic dysfunction contributes to multiple neurological and other brain disorders; however, the specific mechanism underlying this process remains unclear. In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atp11b both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor expression, and intracellular Ca2+ concentration. Furthermore, experimental results also indicate that ATP11B regulated synaptic plasticity in hippocampal neurons through the MAPK14 signaling pathway. In conclusion, our data shed light on the possible mechanisms underlying the regulation of synaptic plasticity and lay the foundation for the exploration of proteins involved in signal transduction during this process.</jats:p> |
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| author | Wang, Jiao, Li, Weihao, Zhou, Fangfang, Feng, Ruili, Wang, Fushuai, Zhang, Shibo, Li, Jie, Li, Qian, Wang, Yajiang, Xie, Jiang, Wen, Tieqiao |
| author_facet | Wang, Jiao, Li, Weihao, Zhou, Fangfang, Feng, Ruili, Wang, Fushuai, Zhang, Shibo, Li, Jie, Li, Qian, Wang, Yajiang, Xie, Jiang, Wen, Tieqiao, Wang, Jiao, Li, Weihao, Zhou, Fangfang, Feng, Ruili, Wang, Fushuai, Zhang, Shibo, Li, Jie, Li, Qian, Wang, Yajiang, Xie, Jiang, Wen, Tieqiao |
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| description | <jats:title>Abstract</jats:title> <jats:p>Synaptic plasticity is known to regulate and support signal transduction between neurons, while synaptic dysfunction contributes to multiple neurological and other brain disorders; however, the specific mechanism underlying this process remains unclear. In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atp11b both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor expression, and intracellular Ca2+ concentration. Furthermore, experimental results also indicate that ATP11B regulated synaptic plasticity in hippocampal neurons through the MAPK14 signaling pathway. In conclusion, our data shed light on the possible mechanisms underlying the regulation of synaptic plasticity and lay the foundation for the exploration of proteins involved in signal transduction during this process.</jats:p> |
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| spelling | Wang, Jiao Li, Weihao Zhou, Fangfang Feng, Ruili Wang, Fushuai Zhang, Shibo Li, Jie Li, Qian Wang, Yajiang Xie, Jiang Wen, Tieqiao 1759-4685 Oxford University Press (OUP) Cell Biology Genetics Molecular Biology General Medicine http://dx.doi.org/10.1093/jmcb/mjz042 <jats:title>Abstract</jats:title> <jats:p>Synaptic plasticity is known to regulate and support signal transduction between neurons, while synaptic dysfunction contributes to multiple neurological and other brain disorders; however, the specific mechanism underlying this process remains unclear. In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atp11b both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor expression, and intracellular Ca2+ concentration. Furthermore, experimental results also indicate that ATP11B regulated synaptic plasticity in hippocampal neurons through the MAPK14 signaling pathway. In conclusion, our data shed light on the possible mechanisms underlying the regulation of synaptic plasticity and lay the foundation for the exploration of proteins involved in signal transduction during this process.</jats:p> ATP11B deficiency leads to impairment of hippocampal synaptic plasticity Journal of Molecular Cell Biology |
| spellingShingle | Wang, Jiao, Li, Weihao, Zhou, Fangfang, Feng, Ruili, Wang, Fushuai, Zhang, Shibo, Li, Jie, Li, Qian, Wang, Yajiang, Xie, Jiang, Wen, Tieqiao, Journal of Molecular Cell Biology, ATP11B deficiency leads to impairment of hippocampal synaptic plasticity, Cell Biology, Genetics, Molecular Biology, General Medicine |
| title | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_full | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_fullStr | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_full_unstemmed | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_short | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| title_sort | atp11b deficiency leads to impairment of hippocampal synaptic plasticity |
| title_unstemmed | ATP11B deficiency leads to impairment of hippocampal synaptic plasticity |
| topic | Cell Biology, Genetics, Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1093/jmcb/mjz042 |