Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in Chi...

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel:	Japanese Journal of Clinical Oncology
Personen und Körperschaften:	Mi, Yin, Lv, Pengwei, Wang, Fang, Li, Lin, Zhu, Mingzhi, Cao, Qinchen, Liu, Junqi, Dong, Meilian, Shi, Yonggang, Fan, Ruitai
In:	Japanese Journal of Clinical Oncology, 49, 2019, 12, S. 1120-1125
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Oxford University Press (OUP)
Schlagwörter:	Cancer Research Radiology, Nuclear Medicine and imaging Oncology General Medicine

author_facet	Mi, Yin Lv, Pengwei Wang, Fang Li, Lin Zhu, Mingzhi Cao, Qinchen Liu, Junqi Dong, Meilian Shi, Yonggang Fan, Ruitai Mi, Yin Lv, Pengwei Wang, Fang Li, Lin Zhu, Mingzhi Cao, Qinchen Liu, Junqi Dong, Meilian Shi, Yonggang Fan, Ruitai
author	Mi, Yin Lv, Pengwei Wang, Fang Li, Lin Zhu, Mingzhi Cao, Qinchen Liu, Junqi Dong, Meilian Shi, Yonggang Fan, Ruitai
spellingShingle	Mi, Yin Lv, Pengwei Wang, Fang Li, Lin Zhu, Mingzhi Cao, Qinchen Liu, Junqi Dong, Meilian Shi, Yonggang Fan, Ruitai Japanese Journal of Clinical Oncology Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China Cancer Research Radiology, Nuclear Medicine and imaging Oncology General Medicine
author_sort	mi, yin
spelling	Mi, Yin Lv, Pengwei Wang, Fang Li, Lin Zhu, Mingzhi Cao, Qinchen Liu, Junqi Dong, Meilian Shi, Yonggang Fan, Ruitai 1465-3621 Oxford University Press (OUP) Cancer Research Radiology, Nuclear Medicine and imaging Oncology General Medicine http://dx.doi.org/10.1093/jjco/hyz128 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to evaluate the efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy for the treatment of Chinese patients with early-stage breast cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Between September 2014 and May 2017, breast cancer patients undergoing targeted intraoperative radiotherapy at our facility were retrospectively recruited for this study. Intraoperative radiotherapy was performed with a 50-kV X-ray source in an Intrabeam system (Carl Zeiss Meditec, Oberkochen, Germany). The one-time prescribed irradiation dose to the tumour bed was 20 Gy. Recurrence, death, late complications, and cosmetic outcomes were recorded. Late radiotoxicity was assessed based on the grading criteria of the Radiation Therapy Oncology Group.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 77 patients who were treated with targeted intraoperative radiotherapy only were recruited. The cohort had a mean age of 58 years; patients with T1, N0, and invasive ductal carcinoma accounted for 75.3, 89.6, and 84.4%, respectively; the median follow-up duration was 40 months; there were 2 patients of recurrence and 2 patients of death. There were no patients of cardiac toxicity or skin or lung radiotoxicity of grade 2 or above. The main complications were breast oedema (18.2%), seroma (15.6%), chromatosis (9.1%), induration (7.8%), pain (5.2%), skin depression (2.6%), mild dry cough (2.6%), delayed wound healing (1.3%), and wound infection (1.3%). Seventy-three patients participated in the cosmetic outcome evaluation, which yielded an excellent or good rate of 95.9%.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Due to its low recurrence rates, lack of high-grade late radiotoxicity, and excellent cosmetic outcomes, targeted intraoperative radiotherapy may be a suitable treatment for select early-stage breast cancer patients in China.</jats:p> </jats:sec> Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China Japanese Journal of Clinical Oncology
doi_str_mv	10.1093/jjco/hyz128
facet_avail	Online Free
finc_class_facet	Medizin
format	ElectronicArticle
fullrecord	blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9qamNvL2h5ejEyOA
id	ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9qamNvL2h5ejEyOA
institution	DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14
imprint	Oxford University Press (OUP), 2019
imprint_str_mv	Oxford University Press (OUP), 2019
issn	1465-3621
issn_str_mv	1465-3621
language	English
mega_collection	Oxford University Press (OUP) (CrossRef)
match_str	mi2019efficacylatecomplicationsandcosmeticoutcomesoftargetedintraoperativeradiotherapyinbreastconservingsurgeryforearlystagebreastcancerasinglecentrestudyinchina
publishDateSort	2019
publisher	Oxford University Press (OUP)
recordtype	ai
record_format	ai
series	Japanese Journal of Clinical Oncology
source_id	49
title	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_unstemmed	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_full	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_fullStr	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_full_unstemmed	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_short	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_sort	efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in china
topic	Cancer Research Radiology, Nuclear Medicine and imaging Oncology General Medicine
url	http://dx.doi.org/10.1093/jjco/hyz128
publishDate	2019
physical	1120-1125
description	<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to evaluate the efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy for the treatment of Chinese patients with early-stage breast cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Between September 2014 and May 2017, breast cancer patients undergoing targeted intraoperative radiotherapy at our facility were retrospectively recruited for this study. Intraoperative radiotherapy was performed with a 50-kV X-ray source in an Intrabeam system (Carl Zeiss Meditec, Oberkochen, Germany). The one-time prescribed irradiation dose to the tumour bed was 20 Gy. Recurrence, death, late complications, and cosmetic outcomes were recorded. Late radiotoxicity was assessed based on the grading criteria of the Radiation Therapy Oncology Group.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 77 patients who were treated with targeted intraoperative radiotherapy only were recruited. The cohort had a mean age of 58 years; patients with T1, N0, and invasive ductal carcinoma accounted for 75.3, 89.6, and 84.4%, respectively; the median follow-up duration was 40 months; there were 2 patients of recurrence and 2 patients of death. There were no patients of cardiac toxicity or skin or lung radiotoxicity of grade 2 or above. The main complications were breast oedema (18.2%), seroma (15.6%), chromatosis (9.1%), induration (7.8%), pain (5.2%), skin depression (2.6%), mild dry cough (2.6%), delayed wound healing (1.3%), and wound infection (1.3%). Seventy-three patients participated in the cosmetic outcome evaluation, which yielded an excellent or good rate of 95.9%.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Due to its low recurrence rates, lack of high-grade late radiotoxicity, and excellent cosmetic outcomes, targeted intraoperative radiotherapy may be a suitable treatment for select early-stage breast cancer patients in China.</jats:p> </jats:sec>
container_issue	12
container_start_page	1120
container_title	Japanese Journal of Clinical Oncology
container_volume	49
format_de105	Article, E-Article
format_de14	Article, E-Article
format_de15	Article, E-Article
format_de520	Article, E-Article
format_de540	Article, E-Article
format_dech1	Article, E-Article
format_ded117	Article, E-Article
format_degla1	E-Article
format_del152	Buch
format_del189	Article, E-Article
format_dezi4	Article
format_dezwi2	Article, E-Article
format_finc	Article, E-Article
format_nrw	Article, E-Article
_version_	1792341108594835470
geogr_code	not assigned
last_indexed	2024-03-01T16:14:39.749Z
geogr_code_person	not assigned
openURL	url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Efficacy%2C+late+complications%2C+and+cosmetic+outcomes+of+targeted+intraoperative+radiotherapy+in+breast-conserving+surgery+for+early-stage+breast+cancer%3A+a+single-centre+study+in+China&rft.date=2019-12-27&genre=article&issn=1465-3621&volume=49&issue=12&spage=1120&epage=1125&pages=1120-1125&jtitle=Japanese+Journal+of+Clinical+Oncology&atitle=Efficacy%2C+late+complications%2C+and+cosmetic+outcomes+of+targeted+intraoperative+radiotherapy+in+breast-conserving+surgery+for+early-stage+breast+cancer%3A+a+single-centre+study+in+China&aulast=Fan&aufirst=Ruitai&rft_id=info%3Adoi%2F10.1093%2Fjjco%2Fhyz128&rft.language%5B0%5D=eng
SOLR
_version_	1792341108594835470
author	Mi, Yin, Lv, Pengwei, Wang, Fang, Li, Lin, Zhu, Mingzhi, Cao, Qinchen, Liu, Junqi, Dong, Meilian, Shi, Yonggang, Fan, Ruitai
author_facet	Mi, Yin, Lv, Pengwei, Wang, Fang, Li, Lin, Zhu, Mingzhi, Cao, Qinchen, Liu, Junqi, Dong, Meilian, Shi, Yonggang, Fan, Ruitai, Mi, Yin, Lv, Pengwei, Wang, Fang, Li, Lin, Zhu, Mingzhi, Cao, Qinchen, Liu, Junqi, Dong, Meilian, Shi, Yonggang, Fan, Ruitai
author_sort	mi, yin
container_issue	12
container_start_page	1120
container_title	Japanese Journal of Clinical Oncology
container_volume	49
description	<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to evaluate the efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy for the treatment of Chinese patients with early-stage breast cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Between September 2014 and May 2017, breast cancer patients undergoing targeted intraoperative radiotherapy at our facility were retrospectively recruited for this study. Intraoperative radiotherapy was performed with a 50-kV X-ray source in an Intrabeam system (Carl Zeiss Meditec, Oberkochen, Germany). The one-time prescribed irradiation dose to the tumour bed was 20 Gy. Recurrence, death, late complications, and cosmetic outcomes were recorded. Late radiotoxicity was assessed based on the grading criteria of the Radiation Therapy Oncology Group.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 77 patients who were treated with targeted intraoperative radiotherapy only were recruited. The cohort had a mean age of 58 years; patients with T1, N0, and invasive ductal carcinoma accounted for 75.3, 89.6, and 84.4%, respectively; the median follow-up duration was 40 months; there were 2 patients of recurrence and 2 patients of death. There were no patients of cardiac toxicity or skin or lung radiotoxicity of grade 2 or above. The main complications were breast oedema (18.2%), seroma (15.6%), chromatosis (9.1%), induration (7.8%), pain (5.2%), skin depression (2.6%), mild dry cough (2.6%), delayed wound healing (1.3%), and wound infection (1.3%). Seventy-three patients participated in the cosmetic outcome evaluation, which yielded an excellent or good rate of 95.9%.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Due to its low recurrence rates, lack of high-grade late radiotoxicity, and excellent cosmetic outcomes, targeted intraoperative radiotherapy may be a suitable treatment for select early-stage breast cancer patients in China.</jats:p> </jats:sec>
doi_str_mv	10.1093/jjco/hyz128
facet_avail	Online, Free
finc_class_facet	Medizin
format	ElectronicArticle
format_de105	Article, E-Article
format_de14	Article, E-Article
format_de15	Article, E-Article
format_de520	Article, E-Article
format_de540	Article, E-Article
format_dech1	Article, E-Article
format_ded117	Article, E-Article
format_degla1	E-Article
format_del152	Buch
format_del189	Article, E-Article
format_dezi4	Article
format_dezwi2	Article, E-Article
format_finc	Article, E-Article
format_nrw	Article, E-Article
geogr_code	not assigned
geogr_code_person	not assigned
id	ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9qamNvL2h5ejEyOA
imprint	Oxford University Press (OUP), 2019
imprint_str_mv	Oxford University Press (OUP), 2019
institution	DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14
issn	1465-3621
issn_str_mv	1465-3621
language	English
last_indexed	2024-03-01T16:14:39.749Z
match_str	mi2019efficacylatecomplicationsandcosmeticoutcomesoftargetedintraoperativeradiotherapyinbreastconservingsurgeryforearlystagebreastcancerasinglecentrestudyinchina
mega_collection	Oxford University Press (OUP) (CrossRef)
physical	1120-1125
publishDate	2019
publishDateSort	2019
publisher	Oxford University Press (OUP)
record_format	ai
recordtype	ai
series	Japanese Journal of Clinical Oncology
source_id	49
spelling	Mi, Yin Lv, Pengwei Wang, Fang Li, Lin Zhu, Mingzhi Cao, Qinchen Liu, Junqi Dong, Meilian Shi, Yonggang Fan, Ruitai 1465-3621 Oxford University Press (OUP) Cancer Research Radiology, Nuclear Medicine and imaging Oncology General Medicine http://dx.doi.org/10.1093/jjco/hyz128 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>The purpose of this study was to evaluate the efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy for the treatment of Chinese patients with early-stage breast cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Between September 2014 and May 2017, breast cancer patients undergoing targeted intraoperative radiotherapy at our facility were retrospectively recruited for this study. Intraoperative radiotherapy was performed with a 50-kV X-ray source in an Intrabeam system (Carl Zeiss Meditec, Oberkochen, Germany). The one-time prescribed irradiation dose to the tumour bed was 20 Gy. Recurrence, death, late complications, and cosmetic outcomes were recorded. Late radiotoxicity was assessed based on the grading criteria of the Radiation Therapy Oncology Group.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 77 patients who were treated with targeted intraoperative radiotherapy only were recruited. The cohort had a mean age of 58 years; patients with T1, N0, and invasive ductal carcinoma accounted for 75.3, 89.6, and 84.4%, respectively; the median follow-up duration was 40 months; there were 2 patients of recurrence and 2 patients of death. There were no patients of cardiac toxicity or skin or lung radiotoxicity of grade 2 or above. The main complications were breast oedema (18.2%), seroma (15.6%), chromatosis (9.1%), induration (7.8%), pain (5.2%), skin depression (2.6%), mild dry cough (2.6%), delayed wound healing (1.3%), and wound infection (1.3%). Seventy-three patients participated in the cosmetic outcome evaluation, which yielded an excellent or good rate of 95.9%.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Due to its low recurrence rates, lack of high-grade late radiotoxicity, and excellent cosmetic outcomes, targeted intraoperative radiotherapy may be a suitable treatment for select early-stage breast cancer patients in China.</jats:p> </jats:sec> Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China Japanese Journal of Clinical Oncology
spellingShingle	Mi, Yin, Lv, Pengwei, Wang, Fang, Li, Lin, Zhu, Mingzhi, Cao, Qinchen, Liu, Junqi, Dong, Meilian, Shi, Yonggang, Fan, Ruitai, Japanese Journal of Clinical Oncology, Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China, Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology, General Medicine
title	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_full	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_fullStr	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_full_unstemmed	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_short	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
title_sort	efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in china
title_unstemmed	Efficacy, late complications, and cosmetic outcomes of targeted intraoperative radiotherapy in breast-conserving surgery for early-stage breast cancer: a single-centre study in China
topic	Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology, General Medicine
url	http://dx.doi.org/10.1093/jjco/hyz128