Eintrag weiter verarbeiten
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence
Gespeichert in:
| Zeitschriftentitel: | The Journal of Infectious Diseases |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | The Journal of Infectious Diseases, 224, 2021, 1, S. 175-183 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Digitale, Jean C Callaway, Perri C Martin, Maureen Nelson, George Viard, Mathias Rek, John Arinaitwe, Emmanuel Dorsey, Grant Kamya, Moses Carrington, Mary Rodriguez-Barraquer, Isabel Feeney, Margaret E Digitale, Jean C Callaway, Perri C Martin, Maureen Nelson, George Viard, Mathias Rek, John Arinaitwe, Emmanuel Dorsey, Grant Kamya, Moses Carrington, Mary Rodriguez-Barraquer, Isabel Feeney, Margaret E |
|---|---|
| author |
Digitale, Jean C Callaway, Perri C Martin, Maureen Nelson, George Viard, Mathias Rek, John Arinaitwe, Emmanuel Dorsey, Grant Kamya, Moses Carrington, Mary Rodriguez-Barraquer, Isabel Feeney, Margaret E |
| spellingShingle |
Digitale, Jean C Callaway, Perri C Martin, Maureen Nelson, George Viard, Mathias Rek, John Arinaitwe, Emmanuel Dorsey, Grant Kamya, Moses Carrington, Mary Rodriguez-Barraquer, Isabel Feeney, Margaret E The Journal of Infectious Diseases Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence Infectious Diseases Immunology and Allergy |
| author_sort |
digitale, jean c |
| spelling |
Digitale, Jean C Callaway, Perri C Martin, Maureen Nelson, George Viard, Mathias Rek, John Arinaitwe, Emmanuel Dorsey, Grant Kamya, Moses Carrington, Mary Rodriguez-Barraquer, Isabel Feeney, Margaret E 0022-1899 1537-6613 Oxford University Press (OUP) Infectious Diseases Immunology and Allergy http://dx.doi.org/10.1093/infdis/jiaa698 <jats:title>Abstract</jats:title><jats:p>Killer cell immunoglobulin-like receptors (KIRs) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P. falciparum parasitemia in an additive manner. Individuals homozygous for HLA-C2, which mediates strong inhibition via KIR2DL1, had the highest odds of parasitemia, HLA-C1/C2 heterozygotes had intermediate odds, and individuals homozygous for HLA-C1, which mediates weaker inhibition through KIR2DL2/3, had the lowest odds of parasitemia. In addition, higher surface expression of HLA-C, the ligand for inhibitory KIR2DL1/2/3, was associated with a higher likelihood of parasitemia. Together these data indicate that stronger KIR-mediated inhibition confers a higher risk of P. falciparum parasitemia and suggest that KIR-expressing effector cells play a role in mediating antiparasite immunity.</jats:p> Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher<i>Plasmodium falciparum</i>Parasite Prevalence The Journal of Infectious Diseases |
| doi_str_mv |
10.1093/infdis/jiaa698 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9pbmZkaXMvamlhYTY5OA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9pbmZkaXMvamlhYTY5OA |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Oxford University Press (OUP), 2021 |
| imprint_str_mv |
Oxford University Press (OUP), 2021 |
| issn |
0022-1899 1537-6613 |
| issn_str_mv |
0022-1899 1537-6613 |
| language |
English |
| mega_collection |
Oxford University Press (OUP) (CrossRef) |
| match_str |
digitale2021associationofinhibitorykillercellimmunoglobulinlikereceptorligandswithhigherplasmodiumfalciparumparasiteprevalence |
| publishDateSort |
2021 |
| publisher |
Oxford University Press (OUP) |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Infectious Diseases |
| source_id |
49 |
| title |
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_unstemmed |
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_full |
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_fullStr |
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_full_unstemmed |
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_short |
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_sort |
association of inhibitory killer cell immunoglobulin-like receptor ligands with higher<i>plasmodium falciparum</i>parasite prevalence |
| topic |
Infectious Diseases Immunology and Allergy |
| url |
http://dx.doi.org/10.1093/infdis/jiaa698 |
| publishDate |
2021 |
| physical |
175-183 |
| description |
<jats:title>Abstract</jats:title><jats:p>Killer cell immunoglobulin-like receptors (KIRs) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P. falciparum parasitemia in an additive manner. Individuals homozygous for HLA-C2, which mediates strong inhibition via KIR2DL1, had the highest odds of parasitemia, HLA-C1/C2 heterozygotes had intermediate odds, and individuals homozygous for HLA-C1, which mediates weaker inhibition through KIR2DL2/3, had the lowest odds of parasitemia. In addition, higher surface expression of HLA-C, the ligand for inhibitory KIR2DL1/2/3, was associated with a higher likelihood of parasitemia. Together these data indicate that stronger KIR-mediated inhibition confers a higher risk of P. falciparum parasitemia and suggest that KIR-expressing effector cells play a role in mediating antiparasite immunity.</jats:p> |
| container_issue |
1 |
| container_start_page |
175 |
| container_title |
The Journal of Infectious Diseases |
| container_volume |
224 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348618923966469 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:14:03.408Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Association+of+Inhibitory+Killer+Cell+Immunoglobulin-like+Receptor+Ligands+With+HigherPlasmodium+falciparumParasite+Prevalence&rft.date=2021-07-02&genre=article&issn=1537-6613&volume=224&issue=1&spage=175&epage=183&pages=175-183&jtitle=The+Journal+of+Infectious+Diseases&atitle=Association+of+Inhibitory+Killer+Cell+Immunoglobulin-like+Receptor+Ligands+With+Higher%3Ci%3EPlasmodium+falciparum%3C%2Fi%3EParasite+Prevalence&aulast=Feeney&aufirst=Margaret+E&rft_id=info%3Adoi%2F10.1093%2Finfdis%2Fjiaa698&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348618923966469 |
| author | Digitale, Jean C, Callaway, Perri C, Martin, Maureen, Nelson, George, Viard, Mathias, Rek, John, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses, Carrington, Mary, Rodriguez-Barraquer, Isabel, Feeney, Margaret E |
| author_facet | Digitale, Jean C, Callaway, Perri C, Martin, Maureen, Nelson, George, Viard, Mathias, Rek, John, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses, Carrington, Mary, Rodriguez-Barraquer, Isabel, Feeney, Margaret E, Digitale, Jean C, Callaway, Perri C, Martin, Maureen, Nelson, George, Viard, Mathias, Rek, John, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses, Carrington, Mary, Rodriguez-Barraquer, Isabel, Feeney, Margaret E |
| author_sort | digitale, jean c |
| container_issue | 1 |
| container_start_page | 175 |
| container_title | The Journal of Infectious Diseases |
| container_volume | 224 |
| description | <jats:title>Abstract</jats:title><jats:p>Killer cell immunoglobulin-like receptors (KIRs) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P. falciparum parasitemia in an additive manner. Individuals homozygous for HLA-C2, which mediates strong inhibition via KIR2DL1, had the highest odds of parasitemia, HLA-C1/C2 heterozygotes had intermediate odds, and individuals homozygous for HLA-C1, which mediates weaker inhibition through KIR2DL2/3, had the lowest odds of parasitemia. In addition, higher surface expression of HLA-C, the ligand for inhibitory KIR2DL1/2/3, was associated with a higher likelihood of parasitemia. Together these data indicate that stronger KIR-mediated inhibition confers a higher risk of P. falciparum parasitemia and suggest that KIR-expressing effector cells play a role in mediating antiparasite immunity.</jats:p> |
| doi_str_mv | 10.1093/infdis/jiaa698 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9pbmZkaXMvamlhYTY5OA |
| imprint | Oxford University Press (OUP), 2021 |
| imprint_str_mv | Oxford University Press (OUP), 2021 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0022-1899, 1537-6613 |
| issn_str_mv | 0022-1899, 1537-6613 |
| language | English |
| last_indexed | 2024-03-01T18:14:03.408Z |
| match_str | digitale2021associationofinhibitorykillercellimmunoglobulinlikereceptorligandswithhigherplasmodiumfalciparumparasiteprevalence |
| mega_collection | Oxford University Press (OUP) (CrossRef) |
| physical | 175-183 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Oxford University Press (OUP) |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Infectious Diseases |
| source_id | 49 |
| spelling | Digitale, Jean C Callaway, Perri C Martin, Maureen Nelson, George Viard, Mathias Rek, John Arinaitwe, Emmanuel Dorsey, Grant Kamya, Moses Carrington, Mary Rodriguez-Barraquer, Isabel Feeney, Margaret E 0022-1899 1537-6613 Oxford University Press (OUP) Infectious Diseases Immunology and Allergy http://dx.doi.org/10.1093/infdis/jiaa698 <jats:title>Abstract</jats:title><jats:p>Killer cell immunoglobulin-like receptors (KIRs) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P. falciparum parasitemia in an additive manner. Individuals homozygous for HLA-C2, which mediates strong inhibition via KIR2DL1, had the highest odds of parasitemia, HLA-C1/C2 heterozygotes had intermediate odds, and individuals homozygous for HLA-C1, which mediates weaker inhibition through KIR2DL2/3, had the lowest odds of parasitemia. In addition, higher surface expression of HLA-C, the ligand for inhibitory KIR2DL1/2/3, was associated with a higher likelihood of parasitemia. Together these data indicate that stronger KIR-mediated inhibition confers a higher risk of P. falciparum parasitemia and suggest that KIR-expressing effector cells play a role in mediating antiparasite immunity.</jats:p> Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher<i>Plasmodium falciparum</i>Parasite Prevalence The Journal of Infectious Diseases |
| spellingShingle | Digitale, Jean C, Callaway, Perri C, Martin, Maureen, Nelson, George, Viard, Mathias, Rek, John, Arinaitwe, Emmanuel, Dorsey, Grant, Kamya, Moses, Carrington, Mary, Rodriguez-Barraquer, Isabel, Feeney, Margaret E, The Journal of Infectious Diseases, Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence, Infectious Diseases, Immunology and Allergy |
| title | Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_full | Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_fullStr | Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_full_unstemmed | Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_short | Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| title_sort | association of inhibitory killer cell immunoglobulin-like receptor ligands with higher<i>plasmodium falciparum</i>parasite prevalence |
| title_unstemmed | Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With HigherPlasmodium falciparumParasite Prevalence |
| topic | Infectious Diseases, Immunology and Allergy |
| url | http://dx.doi.org/10.1093/infdis/jiaa698 |